Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment30  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 18.2
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 15.2
 LDTP03786  Glutaredoxin-1 (GLRX) C23 11.1
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 9.8
 LDTP06211  Caspase-8 (CASP8) C360 5.2
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 4.3
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 3.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 2.9
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 2.5
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 2.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 2.3
 LDTP05992  Bleomycin hydrolase (BLMH) C73 2.2
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.1
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 2.0
 LDTP02502  Thioredoxin (TXN) C32 1.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.9
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 1.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 1.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.7
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.6
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.6
 LDTP04689  Adenosine kinase (ADK) C353 1.6
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.5
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.5
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.5
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.5
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.5
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.4
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.4
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.4
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.4
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.3
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 1.3
 LDTP02672  Elongation factor 2 (EEF2) C41 1.3
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.3
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.3
 LDTP04424  Galactokinase (GALK1) C182 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.3
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.2
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.2
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.2
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.2
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.2
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.2
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 1.2
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.2
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.2
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.2
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.1
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.1
 LDTP02672  Elongation factor 2 (EEF2) C136 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.1
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.1
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.1
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.9
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 17.6
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.9
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 3.2
 LDTP04801  Gasdermin-D (GSDMD) C268 2.3
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.7
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.6
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.6
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.4
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.3
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.2
 LDTP00501  Exportin-1 (XPO1) C34 1.1
Transcription factor
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 3.4
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 2.1
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.8
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.7
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07755  Dynamin-binding protein (DNMBP) C691 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 3.8
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 3.3
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 3.0
 LDTP04092  Crk-like protein (CRKL) C249 3.0
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 2.5
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.5
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 2.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 2.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.0
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.9
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.9
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.8
 LDTP01532  ZW10 interactor (ZWINT) C54 1.8
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.7
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.7
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.7
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.6
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.6
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.6
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.5
 LDTP13580  Coronin-1C (CORO1C) C420 1.5
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.5
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 1.5
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.4
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.4
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.4
 LDTP02205  Tubulin beta chain (TUBB) C239 1.4
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.3
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.3
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 1.3
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.3
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.3
 LDTP10864  Calponin-2 (CNN2) C215 1.3
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.3
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.2
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 1.2
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.2
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.2
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.2
 LDTP02205  Tubulin beta chain (TUBB) C354 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.1
 LDTP03244  Cofilin-1 (CFL1) C80 1.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.1
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.1
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.1
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.1
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.1
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.0
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 0.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.