Details of the Target

General Information of Target

Target ID LDTP13979
Target Name Cytosolic iron-sulfur assembly component 2B (CIAO2B)
Gene Name CIAO2B
Gene ID 51647
Synonyms
CIAB; FAM96B; MIP18; Cytosolic iron-sulfur assembly component 2B; MSS19-interacting protein of 18 kDa; Mitotic spindle-associated MMXD complex subunit MIP18; Protein FAM96B
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNK
EGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDH
FKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ
Target Bioclass
Other
Family
MIP18 family
Subcellular location
Nucleus
Function
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.
Uniprot ID
Q9Y3D0
Ensemble ID
ENST00000422424.7
HGNC ID
HGNC:24261
ChEMBL ID
CHEMBL4295989

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.65  LDD0403  [1]
DBIA
 Probe Info  		C158(3.23)  LDD3314  [2]
Johansson_61
 Probe Info  		_(5.28)  LDD1485  [3]
EA-probe
 Probe Info  		C93(1.15)  LDD2210  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
5E-2FA
 Probe Info  		H130(0.00); H126(0.00); H150(0.00); H92(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
NAIA_4
 Probe Info  		C93(0.00); C158(0.00); 0.00  LDD2226  [9]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C158(0.00); C93(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C158(0.62)  LDD1093  [13]
 LDCM0215  AC10 HEK-293T C158(0.99)  LDD0813  [13]
 LDCM0216  AC100 PaTu 8988t C158(0.82)  LDD1095  [13]
 LDCM0217  AC101 PaTu 8988t C158(0.90)  LDD1096  [13]
 LDCM0218  AC102 PaTu 8988t C158(0.93)  LDD1097  [13]
 LDCM0219  AC103 PaTu 8988t C158(0.90)  LDD1098  [13]
 LDCM0220  AC104 PaTu 8988t C158(0.79)  LDD1099  [13]
 LDCM0221  AC105 PaTu 8988t C158(0.86)  LDD1100  [13]
 LDCM0222  AC106 PaTu 8988t C158(0.91)  LDD1101  [13]
 LDCM0223  AC107 PaTu 8988t C158(0.86)  LDD1102  [13]
 LDCM0224  AC108 PaTu 8988t C158(0.96)  LDD1103  [13]
 LDCM0225  AC109 PaTu 8988t C158(0.95)  LDD1104  [13]
 LDCM0226  AC11 HEK-293T C158(1.01)  LDD0824  [13]
 LDCM0227  AC110 PaTu 8988t C158(1.00)  LDD1106  [13]
 LDCM0228  AC111 PaTu 8988t C158(0.89)  LDD1107  [13]
 LDCM0229  AC112 PaTu 8988t C158(0.89)  LDD1108  [13]
 LDCM0230  AC113 HEK-293T C158(0.83)  LDD0828  [13]
 LDCM0231  AC114 HEK-293T C158(1.05)  LDD0829  [13]
 LDCM0232  AC115 HEK-293T C158(0.97)  LDD0830  [13]
 LDCM0233  AC116 HEK-293T C158(0.98)  LDD0831  [13]
 LDCM0234  AC117 HEK-293T C158(1.03)  LDD0832  [13]
 LDCM0235  AC118 HEK-293T C158(1.05)  LDD0833  [13]
 LDCM0236  AC119 HEK-293T C158(1.32)  LDD0834  [13]
 LDCM0237  AC12 HEK-293T C158(0.97)  LDD0835  [13]
 LDCM0238  AC120 HEK-293T C158(1.07)  LDD0836  [13]
 LDCM0239  AC121 HEK-293T C158(1.04)  LDD0837  [13]
 LDCM0240  AC122 HEK-293T C158(1.24)  LDD0838  [13]
 LDCM0241  AC123 HEK-293T C158(1.15)  LDD0839  [13]
 LDCM0242  AC124 HEK-293T C158(1.08)  LDD0840  [13]
 LDCM0243  AC125 HEK-293T C158(1.38)  LDD0841  [13]
 LDCM0244  AC126 HEK-293T C158(1.44)  LDD0842  [13]
 LDCM0245  AC127 HEK-293T C158(1.73)  LDD0843  [13]
 LDCM0246  AC128 HEK-293T C158(0.84)  LDD0844  [13]
 LDCM0247  AC129 HEK-293T C158(1.29)  LDD0845  [13]
 LDCM0249  AC130 HEK-293T C158(1.13)  LDD0847  [13]
 LDCM0250  AC131 HEK-293T C158(1.08)  LDD0848  [13]
 LDCM0251  AC132 HEK-293T C158(1.11)  LDD0849  [13]
 LDCM0252  AC133 HEK-293T C158(1.33)  LDD0850  [13]
 LDCM0253  AC134 HEK-293T C158(1.27)  LDD0851  [13]
 LDCM0254  AC135 HEK-293T C158(1.25)  LDD0852  [13]
 LDCM0255  AC136 HEK-293T C158(1.23)  LDD0853  [13]
 LDCM0256  AC137 HEK-293T C158(1.37)  LDD0854  [13]
 LDCM0257  AC138 HEK-293T C158(1.24)  LDD0855  [13]
 LDCM0258  AC139 HEK-293T C158(1.44)  LDD0856  [13]
 LDCM0259  AC14 HEK-293T C158(0.97)  LDD0857  [13]
 LDCM0260  AC140 HEK-293T C158(1.19)  LDD0858  [13]
 LDCM0261  AC141 HEK-293T C158(1.45)  LDD0859  [13]
 LDCM0262  AC142 HEK-293T C158(1.32)  LDD0860  [13]
 LDCM0270  AC15 HEK-293T C158(1.04)  LDD0868  [13]
 LDCM0276  AC17 HEK-293T C158(1.07)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C158(0.99)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C158(1.60)  LDD1517  [14]
 LDCM0279  AC2 PaTu 8988t C158(0.76)  LDD1158  [13]
 LDCM0280  AC20 HEK-293T C158(0.96)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C158(1.22)  LDD1520  [14]
 LDCM0283  AC23 HEK-293T C158(0.96); C93(1.08)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C158(0.97)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C158(1.22)  LDD0883  [13]
 LDCM0286  AC26 HEK-293T C158(1.19)  LDD0884  [13]
 LDCM0287  AC27 HEK-293T C158(1.13)  LDD0885  [13]
 LDCM0288  AC28 HEK-293T C158(1.88)  LDD0886  [13]
 LDCM0289  AC29 HEK-293T C158(1.46)  LDD0887  [13]
 LDCM0290  AC3 PaTu 8988t C158(0.82)  LDD1169  [13]
 LDCM0291  AC30 HEK-293T C158(1.28)  LDD0889  [13]
 LDCM0292  AC31 HEK-293T C158(1.25)  LDD0890  [13]
 LDCM0293  AC32 HEK-293T C158(1.28)  LDD0891  [13]
 LDCM0294  AC33 HEK-293T C158(1.43)  LDD0892  [13]
 LDCM0295  AC34 HEK-293T C158(1.34)  LDD0893  [13]
 LDCM0296  AC35 HEK-293T C158(0.72)  LDD0894  [13]
 LDCM0297  AC36 HEK-293T C158(0.87)  LDD0895  [13]
 LDCM0298  AC37 HEK-293T C158(0.80)  LDD0896  [13]
 LDCM0299  AC38 HEK-293T C158(0.87)  LDD0897  [13]
 LDCM0300  AC39 HEK-293T C158(0.87)  LDD0898  [13]
 LDCM0301  AC4 PaTu 8988t C158(0.76)  LDD1180  [13]
 LDCM0302  AC40 HEK-293T C158(0.97)  LDD0900  [13]
 LDCM0303  AC41 HEK-293T C158(1.11)  LDD0901  [13]
 LDCM0304  AC42 HEK-293T C158(1.01)  LDD0902  [13]
 LDCM0305  AC43 HEK-293T C158(1.05)  LDD0903  [13]
 LDCM0306  AC44 HEK-293T C158(0.95)  LDD0904  [13]
 LDCM0307  AC45 HEK-293T C158(0.83)  LDD0905  [13]
 LDCM0308  AC46 HEK-293T C158(0.88)  LDD0906  [13]
 LDCM0309  AC47 HEK-293T C158(0.90)  LDD0907  [13]
 LDCM0310  AC48 HEK-293T C158(0.83)  LDD0908  [13]
 LDCM0311  AC49 HEK-293T C158(1.11)  LDD0909  [13]
 LDCM0312  AC5 PaTu 8988t C158(0.70)  LDD1191  [13]
 LDCM0313  AC50 HEK-293T C158(0.81)  LDD0911  [13]
 LDCM0314  AC51 HEK-293T C158(0.91)  LDD0912  [13]
 LDCM0315  AC52 HEK-293T C158(1.10)  LDD0913  [13]
 LDCM0316  AC53 HEK-293T C158(1.01)  LDD0914  [13]
 LDCM0317  AC54 HEK-293T C158(0.86)  LDD0915  [13]
 LDCM0318  AC55 HEK-293T C158(1.02)  LDD0916  [13]
 LDCM0319  AC56 HEK-293T C158(0.88)  LDD0917  [13]
 LDCM0320  AC57 HEK-293T C158(1.15)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C158(1.12)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C158(0.96)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C158(1.13)  LDD0921  [13]
 LDCM0324  AC60 HEK-293T C158(0.99)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C158(0.91)  LDD1564  [14]
 LDCM0327  AC63 HEK-293T C158(1.06); C93(0.94)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C158(1.05)  LDD1567  [14]
 LDCM0332  AC68 HEK-293T C158(0.94)  LDD0930  [13]
 LDCM0333  AC69 HEK-293T C158(1.11)  LDD0931  [13]
 LDCM0334  AC7 HEK-293T C158(1.08)  LDD0932  [13]
 LDCM0335  AC70 HEK-293T C158(1.18)  LDD0933  [13]
 LDCM0336  AC71 HEK-293T C158(1.05)  LDD0934  [13]
 LDCM0337  AC72 HEK-293T C158(1.08)  LDD0935  [13]
 LDCM0338  AC73 HEK-293T C158(1.01)  LDD0936  [13]
 LDCM0339  AC74 HEK-293T C158(1.16)  LDD0937  [13]
 LDCM0340  AC75 HEK-293T C158(1.19)  LDD0938  [13]
 LDCM0341  AC76 HEK-293T C158(0.85)  LDD0939  [13]
 LDCM0342  AC77 HEK-293T C158(1.13)  LDD0940  [13]
 LDCM0343  AC78 HEK-293T C158(0.95)  LDD0941  [13]
 LDCM0344  AC79 HEK-293T C158(0.99)  LDD0942  [13]
 LDCM0345  AC8 HEK-293T C158(1.40)  LDD0943  [13]
 LDCM0346  AC80 HEK-293T C158(1.26)  LDD0944  [13]
 LDCM0347  AC81 HEK-293T C158(1.23)  LDD0945  [13]
 LDCM0348  AC82 HEK-293T C158(1.55)  LDD0946  [13]
 LDCM0349  AC83 HEK-293T C158(1.01)  LDD0947  [13]
 LDCM0350  AC84 HEK-293T C158(1.33)  LDD0948  [13]
 LDCM0351  AC85 HEK-293T C158(1.37)  LDD0949  [13]
 LDCM0352  AC86 HEK-293T C158(1.23)  LDD0950  [13]
 LDCM0353  AC87 HEK-293T C158(1.32)  LDD0951  [13]
 LDCM0354  AC88 HEK-293T C158(1.28)  LDD0952  [13]
 LDCM0355  AC89 HEK-293T C158(1.55)  LDD0953  [13]
 LDCM0357  AC90 HEK-293T C158(1.46)  LDD0955  [13]
 LDCM0358  AC91 HEK-293T C158(1.12)  LDD0956  [13]
 LDCM0359  AC92 HEK-293T C158(1.23)  LDD0957  [13]
 LDCM0360  AC93 HEK-293T C158(1.57)  LDD0958  [13]
 LDCM0361  AC94 HEK-293T C158(1.30)  LDD0959  [13]
 LDCM0362  AC95 HEK-293T C158(1.26)  LDD0960  [13]
 LDCM0363  AC96 HEK-293T C158(1.21)  LDD0961  [13]
 LDCM0364  AC97 HEK-293T C158(1.89)  LDD0962  [13]
 LDCM0365  AC98 PaTu 8988t C158(0.82)  LDD1244  [13]
 LDCM0366  AC99 PaTu 8988t C158(0.89)  LDD1245  [13]
 LDCM0248  AKOS034007472 HEK-293T C158(1.38)  LDD0846  [13]
 LDCM0356  AKOS034007680 HEK-293T C158(1.07)  LDD0954  [13]
 LDCM0275  AKOS034007705 HEK-293T C158(1.41)  LDD0873  [13]
 LDCM0156  Aniline NCI-H1299 12.65  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C158(1.87); C93(1.53)  LDD2214  [15]
 LDCM0632  CL-Sc Hep-G2 C158(0.75)  LDD2227  [9]
 LDCM0367  CL1 HEK-293T C158(1.02)  LDD0965  [13]
 LDCM0368  CL10 HEK-293T C158(1.45)  LDD0966  [13]
 LDCM0369  CL100 PaTu 8988t C158(0.63)  LDD1248  [13]
 LDCM0370  CL101 HEK-293T C158(1.38)  LDD0968  [13]
 LDCM0371  CL102 HEK-293T C158(1.09)  LDD0969  [13]
 LDCM0372  CL103 HEK-293T C158(1.08)  LDD0970  [13]
 LDCM0373  CL104 HEK-293T C158(1.21)  LDD0971  [13]
 LDCM0374  CL105 HEK-293T C158(0.91); C93(0.90)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C158(0.97)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C158(1.09)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C158(0.89)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C158(0.97); C93(1.07)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C158(1.42)  LDD0977  [13]
 LDCM0380  CL110 HEK-293T C158(0.97)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C158(1.11)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C158(1.34)  LDD0980  [13]
 LDCM0383  CL113 HEK-293T C158(1.36)  LDD0981  [13]
 LDCM0384  CL114 HEK-293T C158(1.37)  LDD0982  [13]
 LDCM0385  CL115 HEK-293T C158(1.43)  LDD0983  [13]
 LDCM0386  CL116 HEK-293T C158(1.33)  LDD0984  [13]
 LDCM0387  CL117 HEK-293T C158(0.74)  LDD0985  [13]
 LDCM0388  CL118 HEK-293T C158(0.83)  LDD0986  [13]
 LDCM0389  CL119 HEK-293T C158(0.91)  LDD0987  [13]
 LDCM0390  CL12 HEK-293T C158(0.92)  LDD0988  [13]
 LDCM0391  CL120 HEK-293T C158(0.87)  LDD0989  [13]
 LDCM0392  CL121 HEK-293T C158(1.06)  LDD0990  [13]
 LDCM0393  CL122 HEK-293T C158(0.91)  LDD0991  [13]
 LDCM0394  CL123 HEK-293T C158(0.76)  LDD0992  [13]
 LDCM0395  CL124 HEK-293T C158(1.11)  LDD0993  [13]
 LDCM0396  CL125 HEK-293T C158(0.92); C93(1.05)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C158(0.90)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C158(1.08)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C158(0.95)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C158(1.04)  LDD0998  [13]
 LDCM0401  CL14 HEK-293T C158(0.71)  LDD0999  [13]
 LDCM0402  CL15 HEK-293T C158(0.68)  LDD1000  [13]
 LDCM0403  CL16 PaTu 8988t C158(1.28)  LDD1282  [13]
 LDCM0404  CL17 PaTu 8988t C158(0.88)  LDD1283  [13]
 LDCM0405  CL18 PaTu 8988t C158(0.77)  LDD1284  [13]
 LDCM0406  CL19 PaTu 8988t C158(1.10)  LDD1285  [13]
 LDCM0407  CL2 HEK-293T C158(0.95)  LDD1005  [13]
 LDCM0408  CL20 PaTu 8988t C158(1.33)  LDD1287  [13]
 LDCM0409  CL21 PaTu 8988t C158(1.46)  LDD1288  [13]
 LDCM0410  CL22 PaTu 8988t C158(1.21)  LDD1289  [13]
 LDCM0411  CL23 PaTu 8988t C158(1.34)  LDD1290  [13]
 LDCM0412  CL24 PaTu 8988t C158(1.17)  LDD1291  [13]
 LDCM0413  CL25 PaTu 8988t C158(1.11)  LDD1292  [13]
 LDCM0414  CL26 PaTu 8988t C158(1.45)  LDD1293  [13]
 LDCM0415  CL27 PaTu 8988t C158(1.32)  LDD1294  [13]
 LDCM0416  CL28 PaTu 8988t C158(1.43)  LDD1295  [13]
 LDCM0417  CL29 PaTu 8988t C158(1.33)  LDD1296  [13]
 LDCM0418  CL3 HEK-293T C158(1.83)  LDD1016  [13]
 LDCM0419  CL30 PaTu 8988t C158(1.36)  LDD1298  [13]
 LDCM0420  CL31 HEK-293T C158(1.45)  LDD1018  [13]
 LDCM0421  CL32 HEK-293T C158(1.26)  LDD1019  [13]
 LDCM0422  CL33 HEK-293T C158(0.89)  LDD1020  [13]
 LDCM0423  CL34 HEK-293T C158(0.93)  LDD1021  [13]
 LDCM0424  CL35 HEK-293T C158(1.22)  LDD1022  [13]
 LDCM0425  CL36 HEK-293T C158(0.85)  LDD1023  [13]
 LDCM0426  CL37 HEK-293T C158(1.19)  LDD1024  [13]
 LDCM0428  CL39 HEK-293T C158(1.55)  LDD1026  [13]
 LDCM0429  CL4 HEK-293T C158(1.02)  LDD1027  [13]
 LDCM0430  CL40 HEK-293T C158(1.12)  LDD1028  [13]
 LDCM0431  CL41 HEK-293T C158(1.20)  LDD1029  [13]
 LDCM0432  CL42 HEK-293T C158(1.30)  LDD1030  [13]
 LDCM0433  CL43 HEK-293T C158(1.14)  LDD1031  [13]
 LDCM0434  CL44 HEK-293T C158(1.17)  LDD1032  [13]
 LDCM0435  CL45 HEK-293T C158(1.03)  LDD1033  [13]
 LDCM0436  CL46 HEK-293T C158(1.56)  LDD1034  [13]
 LDCM0437  CL47 HEK-293T C158(1.25)  LDD1035  [13]
 LDCM0438  CL48 HEK-293T C158(1.30)  LDD1036  [13]
 LDCM0439  CL49 HEK-293T C158(1.18)  LDD1037  [13]
 LDCM0440  CL5 HEK-293T C158(0.76)  LDD1038  [13]
 LDCM0441  CL50 HEK-293T C158(1.16)  LDD1039  [13]
 LDCM0442  CL51 HEK-293T C158(1.16)  LDD1040  [13]
 LDCM0443  CL52 HEK-293T C158(0.95)  LDD1041  [13]
 LDCM0444  CL53 HEK-293T C158(0.83)  LDD1042  [13]
 LDCM0445  CL54 HEK-293T C158(1.03)  LDD1043  [13]
 LDCM0446  CL55 HEK-293T C158(1.38)  LDD1044  [13]
 LDCM0447  CL56 HEK-293T C158(0.96)  LDD1045  [13]
 LDCM0448  CL57 HEK-293T C158(1.00)  LDD1046  [13]
 LDCM0449  CL58 HEK-293T C158(0.95)  LDD1047  [13]
 LDCM0450  CL59 HEK-293T C158(1.36)  LDD1048  [13]
 LDCM0451  CL6 HEK-293T C158(0.61)  LDD1049  [13]
 LDCM0452  CL60 HEK-293T C158(1.63)  LDD1050  [13]
 LDCM0453  CL61 HEK-293T C158(0.99); C93(1.03)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C158(0.99)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C158(0.98)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C158(1.18)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C158(1.13)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C158(0.96)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C158(1.03)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C158(0.94)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C158(1.21)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C158(2.48)  LDD1060  [13]
 LDCM0464  CL71 HEK-293T C158(0.99); C93(0.99)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C158(0.98)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C158(0.94); C93(1.03)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C158(1.07)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C158(0.82)  LDD1067  [13]
 LDCM0470  CL77 HEK-293T C158(0.82)  LDD1068  [13]
 LDCM0471  CL78 HEK-293T C158(0.67)  LDD1069  [13]
 LDCM0472  CL79 HEK-293T C158(0.96)  LDD1070  [13]
 LDCM0473  CL8 HEK-293T C158(0.94)  LDD1071  [13]
 LDCM0474  CL80 HEK-293T C158(0.75)  LDD1072  [13]
 LDCM0475  CL81 HEK-293T C158(0.96)  LDD1073  [13]
 LDCM0476  CL82 HEK-293T C158(1.07)  LDD1074  [13]
 LDCM0477  CL83 HEK-293T C158(1.04)  LDD1075  [13]
 LDCM0478  CL84 HEK-293T C158(0.74)  LDD1076  [13]
 LDCM0479  CL85 HEK-293T C158(0.64)  LDD1077  [13]
 LDCM0480  CL86 HEK-293T C158(0.64)  LDD1078  [13]
 LDCM0481  CL87 HEK-293T C158(0.89)  LDD1079  [13]
 LDCM0482  CL88 HEK-293T C158(1.00)  LDD1080  [13]
 LDCM0483  CL89 HEK-293T C158(0.86)  LDD1081  [13]
 LDCM0484  CL9 HEK-293T C158(1.27)  LDD1082  [13]
 LDCM0485  CL90 HEK-293T C158(0.95)  LDD1083  [13]
 LDCM0486  CL91 PaTu 8988t C158(0.73)  LDD1365  [13]
 LDCM0487  CL92 PaTu 8988t C158(0.60)  LDD1366  [13]
 LDCM0488  CL93 PaTu 8988t C158(0.73)  LDD1367  [13]
 LDCM0489  CL94 PaTu 8988t C158(0.76)  LDD1368  [13]
 LDCM0490  CL95 PaTu 8988t C158(0.80)  LDD1369  [13]
 LDCM0491  CL96 PaTu 8988t C158(0.58)  LDD1370  [13]
 LDCM0492  CL97 PaTu 8988t C158(0.67)  LDD1371  [13]
 LDCM0493  CL98 PaTu 8988t C158(0.73)  LDD1372  [13]
 LDCM0494  CL99 PaTu 8988t C158(0.63)  LDD1373  [13]
 LDCM0495  E2913 HEK-293T C158(1.11)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C158(1.54)  LDD1702  [16]
 LDCM0175  Ethacrynic acid HeLa C93(1.15)  LDD2210  [4]
 LDCM0625  F8 Ramos C158(0.46)  LDD2187  [17]
 LDCM0572  Fragment10 MDA-MB-231 C93(1.48)  LDD1389  [3]
 LDCM0573  Fragment11 MDA-MB-231 C93(20.00)  LDD1391  [3]
 LDCM0574  Fragment12 MDA-MB-231 C93(20.00)  LDD1393  [3]
 LDCM0575  Fragment13 Ramos C93(1.45)  LDD1396  [3]
 LDCM0576  Fragment14 MDA-MB-231 C93(2.32)  LDD1397  [3]
 LDCM0577  Fragment15 Ramos C93(1.78)  LDD1400  [3]
 LDCM0579  Fragment20 Ramos C158(1.21)  LDD2194  [17]
 LDCM0580  Fragment21 MDA-MB-231 C93(0.53)  LDD1473  [3]
 LDCM0581  Fragment22 Ramos C93(1.20)  LDD1407  [3]
 LDCM0582  Fragment23 MDA-MB-231 C93(1.09)  LDD1408  [3]
 LDCM0583  Fragment24 Ramos C93(1.31)  LDD1410  [3]
 LDCM0584  Fragment25 MDA-MB-231 C93(0.80)  LDD1411  [3]
 LDCM0585  Fragment26 Ramos C93(0.93)  LDD1412  [3]
 LDCM0578  Fragment27 MDA-MB-231 C93(0.90)  LDD1401  [3]
 LDCM0586  Fragment28 MDA-MB-231 C93(1.03)  LDD1415  [3]
 LDCM0587  Fragment29 Ramos C93(1.12)  LDD1418  [3]
 LDCM0588  Fragment30 MDA-MB-231 C93(1.18)  LDD1419  [3]
 LDCM0589  Fragment31 MDA-MB-231 C93(1.02)  LDD1421  [3]
 LDCM0590  Fragment32 MDA-MB-231 C93(7.13)  LDD1423  [3]
 LDCM0468  Fragment33 HEK-293T C158(1.12)  LDD1671  [14]
 LDCM0592  Fragment34 MDA-MB-231 C93(0.84)  LDD1427  [3]
 LDCM0596  Fragment38 MDA-MB-231 C93(1.26)  LDD1433  [3]
 LDCM0597  Fragment39 MDA-MB-231 C93(2.08)  LDD1435  [3]
 LDCM0566  Fragment4 MDA-MB-231 C93(20.00)  LDD1461  [3]
 LDCM0598  Fragment40 MDA-MB-231 C93(0.86)  LDD1436  [3]
 LDCM0599  Fragment41 MDA-MB-231 C93(1.14)  LDD1438  [3]
 LDCM0600  Fragment42 Ramos C93(0.89)  LDD1440  [3]
 LDCM0601  Fragment43 Ramos C93(20.00)  LDD1442  [3]
 LDCM0603  Fragment45 MDA-MB-231 C93(20.00)  LDD1482  [3]
 LDCM0604  Fragment46 MDA-MB-231 C93(0.86)  LDD1445  [3]
 LDCM0605  Fragment47 MDA-MB-231 C93(0.90)  LDD1446  [3]
 LDCM0606  Fragment48 MDA-MB-231 C93(1.13)  LDD1447  [3]
 LDCM0608  Fragment50 MDA-MB-231 C93(1.46)  LDD1449  [3]
 LDCM0427  Fragment51 HEK-293T C158(0.98)  LDD1025  [13]
 LDCM0610  Fragment52 Ramos C93(3.12)  LDD1453  [3]
 LDCM0611  Fragment53 Ramos C93(1.05)  LDD1455  [3]
 LDCM0614  Fragment56 MDA-MB-231 C93(1.56)  LDD1458  [3]
 LDCM0568  Fragment6 MDA-MB-231 C93(1.22)  LDD1382  [3]
 LDCM0569  Fragment7 Jurkat _(5.28)  LDD1485  [3]
 LDCM0570  Fragment8 Ramos C93(1.63)  LDD1386  [3]
 LDCM0571  Fragment9 MDA-MB-231 C93(1.18)  LDD1387  [3]
 LDCM0015  HNE MDA-MB-231 C158(0.92)  LDD0346  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0022  KB02 MDA-MB-231 C93(20.00)  LDD1374  [3]
 LDCM0023  KB03 Ramos C93(16.09)  LDD1377  [3]
 LDCM0024  KB05 IGR37 C158(3.23)  LDD3314  [2]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]
 LDCM0627  NUDT7-COV-1 HEK-293T C158(1.57); C93(0.71)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C93(0.70); C158(0.36)  LDD2207  [18]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) Helicase family P18074
Caspase-6 (CASP6) Peptidase C14A family P55212
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ras-related protein Rab-5A (RAB5A) Rab family P20339
GTP-binding nuclear protein Ran (RAN) Ran family P62826
Transthyretin (TTR) Transthyretin family P02766
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Wolframin (WFS1) . O76024
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet endothelial cell adhesion molecule (PECAM1) . P16284
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cholecystokinin (CCK) Gastrin/cholecystokinin family P06307
Progranulin (GRN) Granulin family P28799
Vimentin (VIM) Intermediate filament family P08670
MMS19 nucleotide excision repair protein homolog (MMS19) MET18/MMS19 family Q96T76
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Gelsolin (GSN) Villin/gelsolin family P06396
Probable cytosolic iron-sulfur protein assembly protein CIAO1 (CIAO1) WD repeat CIA1 family O76071

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.