Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	KB03					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	20.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	20.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	20.0
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	20.0
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	20.0
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	20.0
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	20.0
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	20.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	18.7
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	18.3
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	16.9
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	16.9
LDTP03786	Glutaredoxin-1 (GLRX)				C23	16.8
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	16.2
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	16.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	16.1
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	14.9
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	14.7
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	12.6
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	12.4
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	12.1
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	10.1
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	9.3
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	8.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	7.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	7.6
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	7.4
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	7.0
LDTP04424	Galactokinase (GALK1)				C182	6.7
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	6.5
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	6.1
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	6.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	5.9
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	5.8
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	5.5
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	5.3
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	5.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	4.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	4.4
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	4.3
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	4.3
LDTP05859	Integrin-linked protein kinase (ILK)				C346	4.2
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	3.7
LDTP10774	Elongation factor G, mitochondrial (GFM1)				C153	3.7
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	3.3
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	3.3
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	3.2
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	3.1
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	3.1
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	3.0
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	2.8
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	2.8
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	2.7
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	2.6
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	2.6
LDTP04374	Dynamin-2 (DNM2)				C27	2.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	2.5
LDTP02502	Thioredoxin (TXN)				C32	2.4
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	2.4
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	2.4
LDTP15311	Deaminated glutathione amidase (NIT1)				C203	2.4
LDTP08135	E3 ubiquitin-protein ligase HUWE1 (HUWE1)				C4367	2.4
LDTP05289	AMP deaminase 2 (AMPD2)				C107	2.3
LDTP03806	ADP-ribosylation factor-like protein 3 (ARL3)				C174	2.3
LDTP06211	Caspase-8 (CASP8)				C360	2.3
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	2.3
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	2.3
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	2.3
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	2.1
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	2.1
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	2.1
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	2.0
LDTP14888	Pre-rRNA-processing protein TSR1 homolog (TSR1)				C126	2.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	2.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	2.0
LDTP11030	Serine/threonine-protein kinase VRK1 (VRK1)				C50	1.8
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.8
LDTP04689	Adenosine kinase (ADK)				C353	1.7
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.7
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.7
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.7
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.6
LDTP02672	Elongation factor 2 (EEF2)				C41	1.6
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.5
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.5
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	1.5
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.5
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.5
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.4
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.4
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.4
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.4
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.3
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.3
LDTP02672	Elongation factor 2 (EEF2)				C136	1.3
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.2
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	1.1
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.1
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	1.0
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	1.0
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C179	0.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00501	Exportin-1 (XPO1)				C528	20.0
LDTP04801	Gasdermin-D (GSDMD)				C268	20.0
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	20.0
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	16.5
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	11.9
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	6.6
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	5.7
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	5.6
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	4.7
LDTP04707	Protein SEC13 homolog (SEC13)				C187	4.0
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	3.1
LDTP13661	Sorting nexin-6 (SNX6)				C264	2.2
LDTP00501	Exportin-1 (XPO1)				C34	1.6
LDTP04662	Exportin-2 (CSE1L)				C842	1.1
LDTP01574	Importin-7 (IPO7)				C757	1.0
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03393	Aryl hydrocarbon receptor nuclear translocator (ARNT)				C119	20.0
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	6.6
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	3.5
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	2.2
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.7

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	20.0
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	20.0
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	20.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	20.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	20.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	20.0
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	20.0
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	20.0
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	20.0
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	20.0
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	20.0
LDTP05867	Treacle protein (TCOF1)				C1298	20.0
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	16.1
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	15.8
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	15.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	14.9
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	13.8
LDTP05867	Treacle protein (TCOF1)				C38	13.1
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	12.9
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	12.8
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	12.5
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	12.3
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	12.3
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	11.0
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	10.3
LDTP11718	Cleavage stimulation factor subunit 2 tau variant (CSTF2T)				C150	10.1
LDTP04092	Crk-like protein (CRKL)				C249	9.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	7.9
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	5.8
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	5.7
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	5.6
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	5.3
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	5.3
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	5.1
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	4.9
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	4.7
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	4.5
LDTP01532	ZW10 interactor (ZWINT)				C54	4.5
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	4.5
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	4.4
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	3.9
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	3.8
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	3.7
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	3.6
LDTP02205	Tubulin beta chain (TUBB)				C354	3.6
LDTP12571	LanC-like protein 2 (LANCL2)				C187	3.5
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C660	3.4
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	3.2
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	3.2
LDTP00202	AH receptor-interacting protein (AIP)				C122	3.1
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	3.1
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	3.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	3.0
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	2.9
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	2.8
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	2.8
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	2.8
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	2.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	2.7
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	2.6
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	2.5
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	2.5
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	2.4
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	2.4
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	2.4
LDTP02205	Tubulin beta chain (TUBB)				C239	2.3
LDTP10864	Calponin-2 (CNN2)				C164	2.3
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	2.3
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	2.2
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	2.2
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	2.2
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	2.2
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C684	2.1
LDTP11235	Protein PAXX (PAXX)				C180	2.1
LDTP11212	Tubulin-specific chaperone D (TBCD)				C850	2.0
LDTP10864	Calponin-2 (CNN2)				C215	2.0
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	2.0
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	1.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.9
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.9
LDTP13580	Coronin-1C (CORO1C)				C456	1.8
LDTP01320	Eukaryotic translation initiation factor 3 subunit J (EIF3J)				C207	1.8
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	1.6
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.6
LDTP02511	cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)				C18	1.6
LDTP13580	Coronin-1C (CORO1C)				C420	1.5
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.5
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	1.5
LDTP04518	DNA mismatch repair protein Msh6 (MSH6)				C1117	1.4
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	1.4
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.3
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C122	1.3
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.2
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.0
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.0
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	0.8
LDTP03244	Cofilin-1 (CFL1)				C80	0.7
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	0.5

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.