Details of the Target

General Information of Target

Target ID LDTP05314
Target Name ATP-dependent 6-phosphofructokinase, platelet type (PFKP)
Gene Name PFKP
Gene ID 5214
Synonyms
PFKF; ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; PFK-P; EC 2.7.1.11; 6-phosphofructokinase type C; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphohexokinase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDADDSRAPKGSLRKFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFI
YEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTREGRLKAACNLLQRGIT
NLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCG
TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLP
ESPPEEGWEEQMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDT
RVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACVVSLNGNHAVRLPLMEC
VQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGA
PAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTK
RVLPGKYLEEIATQMRTHSINALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVS
NNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIETMGGYCGYLANMGGLAAGA
DAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKG
VFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVL
GISKRNVIFQPVAELKKQTDFEHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQ
PWSV
Target Bioclass
Enzyme
Family
Phosphofructokinase type A (PFKA) family, ATP-dependent PFK group I subfamily, Eukaryotic two domain clade 'E' sub-subfamily
Subcellular location
Cytoplasm
Function Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Uniprot ID
Q01813
Ensemble ID
ENST00000381125.9
HGNC ID
HGNC:8878
ChEMBL ID
CHEMBL2972

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 Substitution: p.A427V DBIA    Probe Info 
CCK81 SNV: p.G471C DBIA    Probe Info 
DEL SNV: p.I605V DBIA    Probe Info 
DETROIT562 SNV: p.D2E DBIA    Probe Info 
DU145 Deletion: p.G468AfsTer37 DBIA    Probe Info 
LNCaP clone FGC SNV: p.S499N DBIA    Probe Info 
LS180 Deletion: p.R265GfsTer2 DBIA    Probe Info 
MCC13 SNV: p.I605F DBIA    Probe Info 
MOLT4 SNV: p.A492T IA-alkyne    Probe Info 
NCIH358 Deletion: p.K710NfsTer13 DBIA    Probe Info 
NUGC3 SNV: p.G24C DBIA    Probe Info 
RKO SNV: p.Y223C DBIA    Probe Info 
SHP77 SNV: p.D2E DBIA    Probe Info 
SKOV3 SNV: p.T294A DBIA    Probe Info 
SUPT1 SNV: p.V668M DBIA    Probe Info 
SW403 SNV: p.G34R; p.K400T DBIA    Probe Info 
SW756 SNV: p.V367M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 42 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.43  LDD0402  [1]
A-EBA
 Probe Info  		2.65  LDD0215  [2]
CY4
 Probe Info  		13.85  LDD0244  [3]
N1
 Probe Info  		18.18  LDD0242  [3]
TH211
 Probe Info  		Y394(5.18)  LDD0257  [4]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [5]
ONAyne
 Probe Info  		K10(1.00); K109(0.78); K15(0.53); K156(1.03)  LDD0274  [6]
STPyne
 Probe Info  		K10(2.00); K109(10.00); K139(9.48); K15(5.51)  LDD0277  [6]
OPA-S-S-alkyne
 Probe Info  		K395(0.45); K109(1.50); K688(1.74)  LDD3494  [7]
Probe 1
 Probe Info  		Y298(13.18); Y394(27.16); Y487(12.96)  LDD3495  [8]
THZ1-DTB
 Probe Info  		C718(1.01); C123(1.02); C641(1.07)  LDD0460  [9]
BTD
 Probe Info  		C112(1.44)  LDD1700  [10]
AHL-Pu-1
 Probe Info  		C112(3.77)  LDD0170  [11]
EA-probe
 Probe Info  		C343(1.66); C360(1.39)  LDD2210  [12]
DBIA
 Probe Info  		C112(1.27); C360(0.99); C641(0.96)  LDD0078  [13]
5E-2FA
 Probe Info  		H19(0.00); H671(0.00)  LDD2235  [14]
AMP probe
 Probe Info  		N.A.  LDD0200  [15]
ATP probe
 Probe Info  		K688(0.00); K724(0.00); K736(0.00); K737(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C112(0.00); C718(0.00); C123(0.00); C360(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C112(0.00); C718(0.00); C123(0.00); C360(0.00)  LDD0036  [16]
IPIAA_H
 Probe Info  		C718(0.00); C343(0.00)  LDD0030  [17]
IPIAA_L
 Probe Info  		C343(0.00); C179(0.00); C718(0.00); C123(0.00)  LDD0031  [17]
Lodoacetamide azide
 Probe Info  		C112(0.00); C718(0.00); C123(0.00); C664(0.00)  LDD0037  [16]
IPM
 Probe Info  		N.A.  LDD0025  [18]
NAIA_4
 Probe Info  		C123(0.00); C179(0.00); C343(0.00); C360(0.00)  LDD2226  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
KY-26
 Probe Info  		N.A.  LDD0301  [21]
NHS
 Probe Info  		K688(0.00); K736(0.00)  LDD0010  [20]
SF
 Probe Info  		Y394(0.00); K688(0.00)  LDD0028  [22]
TFBX
 Probe Info  		C360(0.00); C641(0.00); C123(0.00); C411(0.00)  LDD0148  [18]
VSF
 Probe Info  		N.A.  LDD0007  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [23]
Acrolein
 Probe Info  		C360(0.00); C411(0.00); C718(0.00); H208(0.00)  LDD0217  [24]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [24]
Crotonaldehyde
 Probe Info  		C112(0.00); C411(0.00); H307(0.00)  LDD0219  [24]
Methacrolein
 Probe Info  		C411(0.00); C718(0.00); C112(0.00); C360(0.00)  LDD0218  [24]
AOyne
 Probe Info  		8.80  LDD0443  [25]
NAIA_5
 Probe Info  		C112(0.00); C718(0.00); C123(0.00); C664(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		N.A.  LDD2240  [26]
HHS-475
 Probe Info  		Y52(1.44)  LDD2238  [27]
HHS-482
 Probe Info  		Y394(1.30); Y52(1.10); Y645(0.75); Y654(1.36)  LDD2239  [27]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		10.13  LDD1733  [28]
FFF probe3
 Probe Info  		7.18  LDD0465  [29]
STS-2
 Probe Info  		N.A.  LDD0138  [30]
VE-P
 Probe Info  		N.A.  LDD0396  [31]
DA-2
 Probe Info  		N.A.  LDD0070  [32]
STS-1
 Probe Info  		N.A.  LDD0068  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C718(0.56)  LDD2142  [10]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C112(0.79)  LDD2112  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C112(0.57)  LDD2095  [10]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C112(0.91); C664(1.02)  LDD2130  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C112(0.79); C360(1.22)  LDD2117  [10]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C112(1.00)  LDD2152  [10]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C112(1.09)  LDD2103  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C112(0.47); C718(0.42)  LDD2132  [10]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C112(0.65); C718(0.78)  LDD2131  [10]
 LDCM0025  4SU-RNA DM93 C112(3.77)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA DM93 C112(2.23)  LDD0171  [11]
 LDCM0214  AC1 HCT 116 C112(1.36); C123(0.63); C179(1.22); C360(1.13)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C112(1.09); C360(1.20); C411(0.92); C641(1.32)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C112(1.13); C123(0.43); C360(1.00); C411(1.07)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C112(1.07); C123(0.38); C360(1.08); C411(0.73)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C112(1.18); C123(0.36); C360(0.98); C411(0.61)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C112(1.31); C123(0.24); C360(1.12); C411(0.59)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C112(1.13); C123(0.24); C360(1.07); C411(0.63)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C112(1.41); C123(0.25); C360(0.99); C411(0.65)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C112(1.20); C123(0.23); C360(1.10); C411(0.60)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C112(1.22); C123(0.35); C360(1.12); C411(0.51)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C112(1.31); C123(0.19); C360(1.13); C411(0.54)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C112(1.08); C123(0.34); C360(1.00); C411(0.77)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C112(1.00); C360(1.36); C411(0.70); C641(1.12)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C112(1.22); C123(0.43); C360(1.07); C411(0.68)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C112(1.20); C123(0.34); C360(1.01); C411(0.57)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C112(1.17); C123(0.28); C360(1.14); C411(0.56)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C112(1.04); C179(1.15); C360(1.07); C411(1.03)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C112(1.03); C179(1.29); C360(1.10); C411(1.00)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C112(1.14); C179(1.43); C360(1.16); C411(1.06)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C112(0.79); C179(1.38); C360(1.12); C411(0.83)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C112(1.19); C179(1.21); C360(1.10); C411(0.95)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C112(0.92); C179(1.28); C360(1.04); C411(1.15)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C112(1.06); C179(1.56); C360(1.10); C411(1.10)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C112(1.05); C360(1.37); C411(1.09); C641(1.21)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C112(0.87); C179(1.48); C360(1.13); C411(0.85)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C112(1.10); C179(1.13); C360(1.05); C411(0.87)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C112(0.91); C179(1.42); C360(1.25); C411(1.11)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C112(0.83); C179(1.27); C360(1.19); C411(0.73)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C112(1.10); C179(1.04); C360(1.02); C411(0.98)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C112(0.82); C179(1.27); C360(1.12); C411(0.90)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C112(1.07); C179(1.51); C360(1.13); C411(0.76)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C112(0.95); C179(1.42); C360(1.15); C411(0.88)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C112(1.47); C360(1.00); C411(0.75); C641(1.04)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C112(1.56); C360(0.92); C411(2.16); C641(1.03)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C112(0.94); C360(0.95); C411(1.35); C641(1.07)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C112(0.77); C360(0.91); C411(1.15); C641(1.14)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C112(1.00); C360(0.91); C411(1.02); C641(1.03)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C112(1.58); C360(0.96); C411(1.05); C641(1.00)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C112(1.66); C360(1.03); C411(1.23); C641(1.29)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C112(0.93); C360(0.97); C411(0.91); C641(1.08)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C112(1.11); C360(0.89); C411(0.92); C641(0.92)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C112(1.25); C360(0.97); C411(0.98); C641(0.99)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C112(1.27); C360(0.88); C411(0.90); C641(1.05)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C112(1.07); C360(1.02); C411(0.76); C641(1.12)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C112(0.98); C360(1.32); C411(1.00); C641(1.08)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C112(1.12); C360(1.02); C411(1.16); C641(1.18)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C112(1.17); C360(1.04); C411(1.18); C641(1.13)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C112(1.23); C360(0.93); C411(1.26); C641(0.98)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C179(0.78); C641(0.90); C360(0.95); C411(1.02)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C360(1.05); C112(1.11); C411(1.14); C641(1.19)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C411(0.81); C360(0.98); C112(1.00); C641(1.01)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C112(0.89); C360(0.98); C411(0.99); C641(0.99)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C411(0.96); C360(1.06); C641(1.15); C112(1.18)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C411(0.82); C112(0.93); C360(1.17); C641(1.24)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C112(0.98); C641(1.08); C360(1.09); C411(1.09)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C112(1.02); C411(1.05); C641(1.18); C360(1.42)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C179(1.00); C641(1.01); C360(1.02); C112(1.02)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C179(0.86); C641(0.99); C360(1.03); C411(1.22)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C411(0.86); C112(0.97); C641(1.05); C360(1.11)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C112(0.73); C411(0.85); C641(1.17); C360(1.19)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C112(0.90); C179(1.22); C360(1.13); C411(1.10)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C112(0.98); C179(1.22); C360(1.12); C411(1.08)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C112(0.87); C179(1.15); C360(1.19); C411(1.01)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C112(0.90); C179(0.77); C360(0.99); C411(1.49)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C112(0.90); C360(0.99); C718(1.02); C641(1.06)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C664(0.52); C718(0.56); C641(0.83); C112(0.89)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C360(0.92); C718(1.04); C112(1.16); C641(1.30)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C123(0.67); C718(0.95); C411(0.97); C641(1.09)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C112(0.86); C641(1.02); C718(1.09); C360(1.10)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C112(0.84); C360(0.87); C664(0.90); C718(0.95)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C179(1.00); C112(1.02); C718(1.06); C641(1.14)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C179(0.69); C641(0.94); C112(0.95); C718(0.99)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C179(0.86); C112(0.93); C360(1.09); C641(1.14)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C718(0.94); C411(1.08); C112(1.09); C641(1.15)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C718(0.91); C411(1.02); C112(1.10); C641(1.12)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C718(0.97); C112(1.01); C641(1.19); C411(1.24)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C718(0.84); C112(1.13); C641(1.14); C411(1.14)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C718(0.97); C411(1.11); C641(1.16); C112(1.22)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C123(0.66); C411(0.73); C718(0.81); C641(0.95)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C718(0.80); C411(1.03); C112(1.05); C641(1.16)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C718(0.76); C112(1.05); C411(1.14); C641(1.17)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C718(0.53); C411(1.04); C641(1.07); C112(1.21)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C718(0.63); C112(0.96); C411(1.04); C641(1.04)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C718(0.57); C411(1.06); C112(1.11); C641(1.12)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C411(0.88); C112(0.93); C360(1.07); C641(1.11)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C112(0.93); C360(1.10); C411(1.13); C641(1.19)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C360(1.11); C411(1.17); C112(1.17); C641(1.28)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C112(0.94); C360(1.04); C411(1.11); C641(1.35)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C411(0.87); C112(1.07); C360(1.09); C641(1.21)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C123(0.47); C411(0.64); C718(0.69); C641(0.97)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C411(0.87); C360(0.97); C641(1.22); C112(1.42)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C411(0.91); C360(1.01); C112(1.07); C641(1.07)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C360(0.95); C112(0.98); C411(1.01); C641(1.24)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C411(0.89); C360(1.02); C641(1.05); C112(1.21)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C411(0.94); C641(1.01); C360(1.01); C112(1.03)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C360(0.96); C411(0.98); C641(1.19); C112(1.43)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C718(1.03); C411(1.06); C360(1.08); C641(1.16)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C112(0.96); C123(0.96); C411(1.02); C641(1.06)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C641(1.05); C718(1.05); C360(1.07); C112(1.08)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C411(0.88); C123(0.89); C718(1.11); C112(1.13)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C123(0.41); C718(0.64); C411(0.71); C641(0.94)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C123(0.85); C718(1.00); C411(1.08); C112(1.14)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C112(0.92); C360(1.10); C718(1.10); C641(1.15)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C123(0.88); C360(1.04); C641(1.04); C411(1.16)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C123(0.99); C360(1.03); C641(1.05); C112(1.14)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C123(0.85); C641(0.99); C360(1.05); C411(1.06)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C123(0.99); C411(1.01); C641(1.05); C360(1.08)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C123(0.69); C411(0.78); C641(0.96); C360(1.03)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C123(0.32); C112(0.75); C411(0.77); C718(0.95)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C123(0.34); C411(0.72); C718(0.75); C112(0.80)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C123(0.35); C411(0.66); C112(0.74); C718(0.83)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C411(1.08); C641(1.10); C112(1.11); C360(1.23)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C123(0.35); C411(0.57); C112(0.84); C718(0.84)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C123(0.60); C112(0.70); C411(0.90); C718(0.96)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C123(0.34); C411(0.64); C718(0.75); C112(0.79)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C123(0.39); C112(0.76); C411(0.76); C718(0.94)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C123(0.32); C411(0.49); C112(0.74); C718(0.84)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C123(0.34); C411(0.54); C112(0.80); C718(0.87)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C123(0.43); C411(0.69); C112(0.73); C718(0.91)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C411(0.23); C123(0.24); C718(0.72); C641(0.87)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C123(0.71); C112(0.72); C411(0.75); C718(0.77)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C718(0.49); C123(0.69); C112(0.74); C411(0.79)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C112(0.89); C411(0.96); C641(0.97); C360(1.15)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C718(0.39); C123(0.55); C411(0.68); C360(0.86)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C718(0.77); C123(0.79); C411(0.79); C112(0.80)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C718(0.52); C123(0.62); C112(0.79); C411(0.84)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C718(0.23); C123(0.54); C411(0.66); C112(0.83)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C718(0.23); C411(0.61); C123(0.61); C112(0.79)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C718(0.20); C123(0.63); C411(0.64); C360(0.88)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C718(0.50); C112(0.76); C411(0.88); C123(0.91)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C718(0.49); C112(0.65); C123(0.70); C411(0.73)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C718(0.74); C411(0.81); C123(0.85); C112(1.03)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C718(0.67); C123(0.70); C411(0.71); C112(0.84)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C411(0.83); C112(1.01); C641(1.19); C360(1.34)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C718(0.66); C411(0.66); C123(0.83); C360(0.94)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C718(0.71); C411(0.76); C123(0.80); C112(0.82)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C718(0.11); C123(0.48); C360(0.50); C411(0.50)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C123(0.38); C641(0.83); C360(1.27); C112(1.69)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C123(0.50); C641(0.82); C360(1.34); C112(1.45)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C123(0.72); C641(0.93); C360(1.23); C112(1.62)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C123(0.57); C641(0.91); C360(1.25); C112(1.43)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C641(0.85); C360(1.19); C123(1.21); C112(1.63)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C123(0.57); C641(0.81); C360(1.28); C112(1.58)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C123(0.45); C641(0.79); C360(1.24); C112(1.82)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C641(0.91); C360(1.27); C112(1.51); C123(1.99)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C123(0.42); C641(0.90); C360(1.34); C112(1.54)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C123(0.46); C641(0.84); C360(1.30); C112(1.47)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C123(0.60); C641(0.81); C360(1.26); C112(1.65)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C123(0.74); C641(0.99); C360(1.21); C112(1.39)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C123(0.92); C641(0.93); C360(1.28); C112(1.59)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C123(0.43); C641(0.88); C360(1.14); C112(1.58)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C123(0.33); C641(1.02); C360(1.10); C112(1.92)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C123(0.13); C411(0.13); C641(0.78); C360(0.94)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C123(0.47); C411(0.63); C641(0.91); C360(1.05)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C112(0.54); C411(0.88)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C112(1.04); C360(0.84)  LDD2113  [10]
 LDCM0248  AKOS034007472 HCT 116 C112(0.96); C360(1.34); C411(1.33); C641(1.05)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C641(0.90); C411(1.14); C360(1.21); C112(1.46)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C411(0.77); C112(1.15); C641(1.19); C360(1.56)  LDD0592  [13]
 LDCM0020  ARS-1620 HCC44 C112(1.27); C360(0.99); C641(0.96)  LDD0078  [13]
 LDCM0102  BDHI 8 Jurkat C123(4.14)  LDD0204  [34]
 LDCM0498  BS-3668 MDA-MB-231 C112(0.38); C664(0.92); C718(0.90); C411(0.31)  LDD2091  [10]
 LDCM0630  CCW28-3 231MFP C641(3.24); C179(1.54)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C360(0.00); C411(0.00); C123(0.00); C641(0.00)  LDD0222  [24]
 LDCM0632  CL-Sc Hep-G2 C123(3.32); C718(1.56); C718(1.37); C112(1.36)  LDD2227  [19]
 LDCM0367  CL1 HCT 116 C112(0.98); C641(1.01); C718(1.05); C664(1.06)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C123(0.74); C411(0.88); C360(1.27); C718(1.37)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C123(0.49); C411(0.72); C718(0.83); C641(0.93)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C112(0.87); C411(0.89); C641(1.07); C360(1.13)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C411(0.79); C112(0.97); C641(1.05); C360(1.31)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C411(0.91); C112(0.95); C641(1.03); C360(1.21)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C112(1.01); C641(1.03); C360(1.24); C411(1.28)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C718(0.73); C179(0.76); C664(0.86); C641(0.88)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C718(0.39); C112(0.91); C641(0.93); C360(1.03)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C718(0.61); C641(1.03); C112(1.05); C360(1.07)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C718(0.51); C112(0.89); C360(0.96); C664(1.07)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C718(0.84); C641(1.04); C360(1.07); C112(1.15)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C123(0.84); C411(0.95); C360(1.16); C718(1.17)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C718(0.55); C641(0.85); C664(0.97); C360(0.97)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C718(0.85); C179(0.86); C360(0.94); C641(0.99)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C411(0.97); C112(0.98); C718(1.00); C641(1.03)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C718(0.64); C411(0.96); C112(1.04); C641(1.09)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C718(0.77); C411(0.91); C641(1.07); C360(1.16)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C718(0.83); C112(0.88); C411(0.89); C641(1.08)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C718(0.83); C411(1.06); C641(1.07); C112(1.25)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C411(0.68); C360(0.82); C641(1.02); C112(1.26)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C411(0.83); C360(0.96); C112(0.99); C641(1.02)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C411(0.81); C641(1.03); C360(1.04); C112(1.19)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C123(0.75); C718(1.02); C411(1.05); C112(1.09)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C411(0.98); C641(1.06); C360(1.08); C112(1.13)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C641(0.84); C112(0.93); C360(0.96); C123(1.10)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C123(0.73); C411(0.82); C360(0.91); C641(0.96)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C123(0.72); C411(0.88); C360(0.91); C641(0.99)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C123(0.91); C641(0.96); C411(0.99); C360(1.04)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C123(0.67); C112(0.86); C641(0.98); C411(1.01)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C123(0.44); C411(0.64); C112(0.71); C641(0.96)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C411(0.61); C123(0.63); C112(0.93); C641(1.04)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C123(0.32); C411(0.63); C112(0.79); C641(0.90)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C123(0.80); C112(0.89); C360(1.34); C411(1.37)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C123(1.01); C112(1.10); C411(1.24); C360(1.43)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C123(0.65); C411(0.70); C112(1.01); C641(1.29)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C664(0.63); C718(0.79); C641(0.84); C360(0.96)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C718(0.64); C360(0.81); C664(0.89); C112(0.93)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C718(0.62); C112(0.94); C360(0.99); C641(1.20)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C718(0.67); C112(0.86); C360(0.97); C411(1.08)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C112(0.99); C641(1.13); C360(1.15); C718(1.23)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C718(0.59); C112(0.99); C360(1.15); C411(1.23)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C718(0.39); C112(0.96); C411(1.02); C360(1.03)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C718(0.30); C411(0.85); C112(0.86); C360(1.25)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C718(0.77); C360(1.06); C641(1.09); C664(1.22)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C718(0.52); C411(1.03); C112(1.04); C360(1.15)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C112(0.95); C360(1.13); C411(1.01); C641(1.11)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C112(0.97); C360(1.10); C411(1.94); C641(1.01)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C112(1.02); C360(1.17); C411(1.49); C641(1.52)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C112(0.90); C360(1.29); C411(1.54); C641(1.20)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C112(0.97); C360(1.22); C411(1.18); C641(1.42)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C112(1.31); C123(0.94); C360(1.11); C411(1.30)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C112(1.04); C360(1.15); C411(0.89); C641(1.01)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C112(1.12); C123(0.55); C360(1.08); C411(1.08)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C112(1.51); C123(0.61); C360(1.08); C411(1.07)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C112(1.36); C123(0.61); C360(0.91); C411(0.98)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C112(1.38); C123(0.48); C360(0.99); C411(0.88)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C112(1.32); C123(0.36); C360(1.07); C411(1.33)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C112(1.30); C123(0.38); C360(1.15); C411(1.08)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C112(1.31); C123(0.40); C360(1.04); C411(1.27)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C112(1.46); C123(0.36); C360(1.00); C411(0.94)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C112(0.90); C123(0.97); C360(1.14); C411(1.22)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C112(1.23); C123(0.38); C360(1.13); C411(1.29)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C112(1.12); C123(0.35); C360(1.08); C411(1.16)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C112(1.74); C123(0.28); C360(0.97); C411(0.83)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C112(1.48); C123(0.45); C360(1.11); C411(1.03)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C112(1.42); C123(0.45); C360(1.06); C411(0.98)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C112(1.52); C123(0.37); C360(1.13); C411(0.79)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C112(1.03); C360(1.02); C411(1.28); C641(1.33)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C112(1.21); C360(1.03); C411(1.36); C641(1.12)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C112(1.35); C360(0.94); C411(1.14); C641(1.52)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C112(1.09); C360(1.04); C411(1.11); C641(1.32)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C112(0.92); C123(1.01); C360(1.23); C411(1.63)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C112(1.00); C360(0.97); C411(1.10); C641(1.34)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C112(1.07); C360(1.01); C411(1.18); C641(1.41)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C112(1.01); C360(1.00); C411(1.15); C641(1.37)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C112(0.79); C360(0.93); C411(1.26); C641(1.29)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C112(0.97); C360(0.91); C411(1.02); C641(1.20)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C112(1.09); C360(0.94); C411(1.09); C641(1.73)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C112(1.22); C360(1.08); C411(1.33); C641(1.06)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C112(1.28); C360(1.06); C411(1.25); C641(1.28)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C112(1.25); C360(1.11); C411(1.48); C641(1.62)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C112(1.02); C360(1.06); C411(1.15); C641(1.12)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C112(0.98); C123(0.93); C360(1.28); C411(0.86)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C112(1.06); C360(1.00); C411(1.14); C641(1.18)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C112(0.98); C123(0.44); C360(1.03); C411(1.06)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C112(1.10); C123(0.38); C360(0.98); C411(0.85)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C112(0.97); C123(0.20); C360(1.07); C411(1.09)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C112(0.91); C123(0.18); C360(1.14); C411(1.85)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C112(0.90); C123(0.80); C360(1.00); C411(1.03)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C112(1.04); C123(0.26); C360(1.13); C411(1.09)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C112(0.91); C123(0.19); C360(1.05); C411(1.08)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C112(1.09); C123(0.19); C360(0.89); C411(0.98)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C112(0.95); C123(0.79); C360(1.31); C411(1.26)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C112(1.27); C123(0.86); C360(1.34); C411(1.02)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C112(1.07); C123(0.37); C360(1.08); C411(0.95)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C112(0.97); C123(0.23); C360(1.01); C411(0.93)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C112(0.99); C123(0.30); C360(1.26); C411(1.06)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C112(0.97); C123(0.21); C360(1.03); C411(0.95)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C112(0.92); C123(0.22); C360(1.07); C411(1.00)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C112(1.01); C123(0.55); C360(0.80); C411(1.02)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C112(1.15); C123(0.47); C360(0.77); C411(1.14)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C112(1.02); C123(0.41); C360(0.90); C411(0.96)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C112(1.00); C123(0.45); C360(1.12); C411(1.24)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C112(1.14); C123(0.66); C360(0.95); C411(0.87)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C112(0.94); C123(0.74); C360(0.90); C411(1.06)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C112(0.91); C123(0.41); C360(1.04); C411(1.00)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C112(1.04); C123(0.44); C360(1.06); C411(0.92)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C112(1.01); C123(0.46); C360(1.05); C411(1.02)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C112(1.07); C123(0.36); C360(0.91); C411(0.68)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C112(0.95); C123(0.55); C360(1.10); C411(1.09)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C112(1.02); C123(0.70); C360(1.20); C411(0.99)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C112(1.02); C123(0.58); C360(1.02); C411(1.18)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C112(1.01); C123(0.46); C360(1.08); C411(0.90)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C112(1.13); C123(0.37); C360(1.08); C411(0.72)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C112(1.13); C123(0.90); C360(1.17); C411(1.24)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C112(0.94); C123(0.84); C360(0.76); C411(0.89)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C112(1.29); C123(0.55); C179(1.07); C360(1.28)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C112(1.03); C123(0.46); C179(0.88); C360(1.16)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C112(1.02); C123(0.61); C179(1.01); C360(1.04)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C112(0.87); C123(0.37); C179(0.94); C360(1.18)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C112(1.26); C123(0.38); C179(1.15); C360(1.19)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C112(1.26); C123(0.43); C179(1.07); C360(1.16)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C112(1.23); C123(0.53); C179(1.33); C360(1.27)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C112(1.56); C123(0.39); C179(1.04); C360(1.00)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C112(1.20); C123(0.50); C179(1.14); C360(0.98)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C112(2.84); C179(2.23); C641(1.20); C360(0.70)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C112(0.86); C411(0.94); C360(0.87); C718(0.96)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C664(3.64); C112(1.35)  LDD1702  [10]
 LDCM0175  Ethacrynic acid HeLa C343(1.66); C360(1.39)  LDD2210  [12]
 LDCM0625  F8 Ramos C112(1.45); C360(1.09); C411(1.15); C718(0.58)  LDD2187  [37]
 LDCM0572  Fragment10 MDA-MB-231 C641(2.23); C179(1.23)  LDD1389  [38]
 LDCM0573  Fragment11 MDA-MB-231 C641(2.00); C179(1.30)  LDD1391  [38]
 LDCM0574  Fragment12 Ramos C112(0.71); C360(1.60); C411(0.77); C123(0.51)  LDD2191  [37]
 LDCM0575  Fragment13 MDA-MB-231 C641(1.11); C179(1.73)  LDD1395  [38]
 LDCM0576  Fragment14 MDA-MB-231 C641(1.60); C179(1.39)  LDD1397  [38]
 LDCM0577  Fragment15 MDA-MB-231 C641(5.92); C179(4.27)  LDD1399  [38]
 LDCM0579  Fragment20 MDA-MB-231 C641(2.13); C179(1.62)  LDD1402  [38]
 LDCM0580  Fragment21 MDA-MB-231 C641(1.23); C179(1.28)  LDD1404  [38]
 LDCM0581  Fragment22 MDA-MB-231 C641(1.26); C179(1.13)  LDD1406  [38]
 LDCM0582  Fragment23 MDA-MB-231 C641(1.54); C179(5.59)  LDD1408  [38]
 LDCM0584  Fragment25 MDA-MB-231 C641(0.71); C179(1.33)  LDD1411  [38]
 LDCM0585  Fragment26 Ramos C641(20.00)  LDD1412  [38]
 LDCM0578  Fragment27 MDA-MB-231 C641(0.57); C179(1.31)  LDD1401  [38]
 LDCM0586  Fragment28 MDA-MB-231 C641(1.26); C179(1.25)  LDD1415  [38]
 LDCM0587  Fragment29 MDA-MB-231 C641(1.23); C179(0.99)  LDD1417  [38]
 LDCM0588  Fragment30 MDA-MB-231 C641(1.10); C179(1.57)  LDD1419  [38]
 LDCM0589  Fragment31 MDA-MB-231 C641(3.14); C179(2.17)  LDD1421  [38]
 LDCM0590  Fragment32 MDA-MB-231 C641(2.55); C179(8.56)  LDD1423  [38]
 LDCM0468  Fragment33 HCT 116 C112(0.96); C123(0.20); C360(1.15); C411(1.18)  LDD0785  [13]
 LDCM0592  Fragment34 MDA-MB-231 C641(0.82); C179(0.89)  LDD1427  [38]
 LDCM0593  Fragment35 MDA-MB-231 C641(0.70)  LDD1429  [38]
 LDCM0594  Fragment36 MDA-MB-231 C641(1.55)  LDD1431  [38]
 LDCM0595  Fragment37 Ramos C641(0.48); C179(0.60)  LDD1432  [38]
 LDCM0596  Fragment38 MDA-MB-231 C641(1.20); C179(1.00)  LDD1433  [38]
 LDCM0597  Fragment39 MDA-MB-231 C179(1.42)  LDD1435  [38]
 LDCM0566  Fragment4 MDA-MB-231 C641(2.12); C179(2.69)  LDD1378  [38]
 LDCM0598  Fragment40 MDA-MB-231 C641(0.64); C179(0.88)  LDD1436  [38]
 LDCM0599  Fragment41 MDA-MB-231 C179(1.28)  LDD1438  [38]
 LDCM0601  Fragment43 MDA-MB-231 C641(1.61)  LDD1441  [38]
 LDCM0602  Fragment44 MDA-MB-231 C641(0.85); C179(0.87)  LDD1443  [38]
 LDCM0604  Fragment46 MDA-MB-231 C641(0.61); C179(0.76)  LDD1445  [38]
 LDCM0605  Fragment47 MDA-MB-231 C179(0.83)  LDD1446  [38]
 LDCM0606  Fragment48 MDA-MB-231 C641(1.11); C179(1.17)  LDD1447  [38]
 LDCM0607  Fragment49 MDA-MB-231 C179(13.41)  LDD1448  [38]
 LDCM0608  Fragment50 MDA-MB-231 C641(1.63); C179(2.42)  LDD1449  [38]
 LDCM0427  Fragment51 HCT 116 C112(1.63); C123(0.39); C360(0.97); C411(0.70)  LDD0744  [13]
 LDCM0610  Fragment52 MDA-MB-231 C641(1.34)  LDD1452  [38]
 LDCM0611  Fragment53 MDA-MB-231 C641(1.10); C179(1.09)  LDD1454  [38]
 LDCM0612  Fragment54 MDA-MB-231 C641(1.16); C179(1.07)  LDD1456  [38]
 LDCM0613  Fragment55 MDA-MB-231 C641(1.02); C179(1.12)  LDD1457  [38]
 LDCM0614  Fragment56 MDA-MB-231 C641(0.97); C179(1.08)  LDD1458  [38]
 LDCM0569  Fragment7 MDA-MB-231 C641(2.38)  LDD1383  [38]
 LDCM0570  Fragment8 MDA-MB-231 C641(1.15); C179(5.53)  LDD1385  [38]
 LDCM0571  Fragment9 MDA-MB-231 C641(1.22); C179(0.86)  LDD1387  [38]
 LDCM0015  HNE MDA-MB-231 C112(0.78)  LDD0346  [37]
 LDCM0107  IAA HeLa H208(0.00); C411(0.00); C641(0.00); C718(0.00)  LDD0221  [24]
 LDCM0022  KB02 HCT 116 C112(1.39); C641(2.09); C360(1.53)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C112(1.19); C641(1.28); C360(1.22)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C112(1.10); C641(0.91); C360(0.78)  LDD0082  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C112(1.04)  LDD2102  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C112(0.39); C718(0.58)  LDD2121  [10]
 LDCM0109  NEM HeLa H208(0.00); H671(0.00); H19(0.00); H621(0.00)  LDD0223  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C112(0.48); C664(1.01)  LDD2089  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C112(0.94)  LDD2090  [10]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C112(1.36)  LDD2092  [10]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C112(0.88)  LDD2093  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C112(0.84)  LDD2094  [10]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C112(0.76)  LDD2097  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C112(0.83)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C112(0.74); C664(1.42); C360(1.13)  LDD2099  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C112(0.69)  LDD2104  [10]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C112(1.29)  LDD2105  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C664(1.18); C411(1.08)  LDD2107  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C112(0.52); C360(0.79)  LDD2109  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C112(0.81)  LDD2111  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C112(0.33)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C664(0.59)  LDD2118  [10]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C112(2.95)  LDD2119  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C664(0.90)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C664(0.30)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C112(0.63); C411(0.84); C360(1.10)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C664(0.31)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C112(0.63); C664(1.17); C411(0.72)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C112(0.09); C664(0.50)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C112(0.80); C664(1.32)  LDD2127  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C112(0.84)  LDD2129  [10]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C360(0.56)  LDD2134  [10]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C112(0.92)  LDD2135  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C112(0.93); C664(1.63); C411(0.98)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C112(0.88); C360(1.11)  LDD2137  [10]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C112(1.44)  LDD1700  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C112(0.58); C664(0.98); C411(0.54)  LDD2140  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C112(0.75); C664(1.03)  LDD2143  [10]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C112(3.02); C664(2.18)  LDD2144  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C112(0.75); C360(1.12)  LDD2146  [10]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C112(2.60); C664(1.35)  LDD2147  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C112(0.43); C360(0.52)  LDD2148  [10]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C718(0.92)  LDD2150  [10]
 LDCM0627  NUDT7-COV-1 HEK-293T C360(1.40)  LDD2206  [39]
 LDCM0021  THZ1 HeLa S3 C718(1.01); C123(1.02); C641(1.07)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear transport factor 2 (NUTF2) . P61970

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
27 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
31 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
32 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
33 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
34 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
35 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
39 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.