Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0585
Competitor Name
Fragment26
Synonyms
N-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-3-PHENYL-2-PROPENAMIDE; SCHEMBL22196856; HAZXGZLAXKZRQX-VOTSOKGWSA-N; AKOS016621157
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 359.26
Lipid-water partition coefficient (xlogp) 5.4
Rotatable Bond Count (rotbonds) 3
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C17H11F6NO
IUPAC Name
(E)-N-[3,5-bis(trifluoromethyl)phenyl]-3-phenylprop-2-enamide
Canonical SMILES
C1=CC=C(C=C1)C=CC(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F
InChI
InChI=1S/C17H11F6NO/c18-16(19,20)12-8-13(17(21,22)23)10-14(9-12)24-15(25)7-6-11-4-2-1-3-5-11/h1-10H,(H,24,25)/b7-6+
InChIKey
HAZXGZLAXKZRQX-VOTSOKGWSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
IA-alkyne
 Probe Info  		100 uM Human burkitt lymphoma cell lysate (Ramos) [1]

Target(s) List of this Competitor

63 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) LDTP10954 0.80  LDD1412 
3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) LDTP03998 1.01  LDD1412 
5'-nucleotidase domain-containing protein 1 (NT5DC1) LDTP17247 0.96  LDD1412 
6-phosphogluconolactonase (PGLS) LDTP14535 0.87  LDD1412 
60 kDa heat shock protein, mitochondrial (HSPD1) LDTP02522 0.87  LDD1412 
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) LDTP03291 0.95; 1.01; 0.85 ...  LDD1412 
Acylamino-acid-releasing enzyme (APEH) LDTP02693 1.05  LDD1412 
Adenosine kinase (ADK) LDTP04689 0.91  LDD1412 
Aldo-keto reductase family 1 member B1 (AKR1B1) LDTP02765 0.85  LDD1412 
AMP deaminase 2 (AMPD2) LDTP05289 1.04  LDD1412 
ATP-dependent 6-phosphofructokinase, platelet type (PFKP) LDTP05314 20.00  LDD1412 
Bleomycin hydrolase (BLMH) LDTP05992 1.01  LDD1412 
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) LDTP02580 0.92; 0.85  LDD1412 
Cathepsin Z (CTSZ) LDTP13147 0.79  LDD1412 
Cell cycle checkpoint control protein RAD9A (RAD9A) LDTP10929 1.01  LDD1412 
Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) LDTP13449 1.03  LDD1412 
D-3-phosphoglycerate dehydrogenase (PHGDH) LDTP00701 0.94  LDD1412 
Deoxycytidine kinase (DCK) LDTP03400 1.04; 0.81  LDD1412 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 0.84  LDD1412 
Dual specificity protein phosphatase 12 (DUSP12) LDTP13663 0.91  LDD1412 
Dynamin-1-like protein (DNM1L) LDTP00273 0.99  LDD1412 
Dynamin-2 (DNM2) LDTP04374 0.91  LDD1412 
E3 ubiquitin-protein ligase UBR5 (UBR5) LDTP01495 0.93  LDD1412 
Elongation factor 2 (EEF2) LDTP02672 1.04; 0.93  LDD1412 
ERO1-like protein alpha (ERO1A) LDTP10386 0.48; 0.78  LDD1412 
Eukaryotic translation initiation factor 3 subunit F (EIF3F) LDTP00246 0.88  LDD1412 
Galactokinase (GALK1) LDTP04424 0.92  LDD1412 
Glutaredoxin-related protein 5, mitochondrial (GLRX5) LDTP08181 0.94  LDD1412 
Glutathione S-transferase omega-1 (GSTO1) LDTP05128 0.83  LDD1412 
Glutathione S-transferase P (GSTP1) LDTP02333 0.85  LDD1412 
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) LDTP02038 0.93  LDD1412 
Glycerol-3-phosphate phosphatase (PGP) LDTP00089 0.99  LDD1412 
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) LDTP02611 0.93; 0.95  LDD1412 
Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) LDTP17082 0.83  LDD1412 
Ketosamine-3-kinase (FN3KRP) LDTP16025 0.92  LDD1412 
Mannose-1-phosphate guanyltransferase alpha (GMPPA) LDTP10418 0.87  LDD1412 
Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) LDTP09598 0.82  LDD1412 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) LDTP07651 0.95  LDD1412 
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) LDTP11388 0.95  LDD1412 
NEDD8-activating enzyme E1 catalytic subunit (UBA3) LDTP09338 1.08  LDD1412 
Omega-amidase NIT2 (NIT2) LDTP12428 0.76  LDD1412 
Parkinson disease protein 7 (PARK7) LDTP10878 0.68  LDD1412 
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) LDTP05912 0.95  LDD1412 
Peroxiredoxin-4 (PRDX4) LDTP05773 0.91  LDD1412 
Peroxiredoxin-5, mitochondrial (PRDX5) LDTP03512 0.70; 0.50  LDD1412 
Prostaglandin E synthase 3 (PTGES3) LDTP06338 0.92  LDD1412 
Protein arginine N-methyltransferase 1 (PRMT1) LDTP10997 0.85  LDD1412 
Protein disulfide-isomerase (P4HB) LDTP02188 0.79  LDD1412 
Protein disulfide-isomerase A3 (PDIA3) LDTP03521 0.77  LDD1412 
Protein disulfide-isomerase A4 (PDIA4) LDTP02677 0.67; 0.77  LDD1412 
Protein disulfide-isomerase A6 (PDIA6) LDTP06314 0.90  LDD1412 
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) LDTP03152 0.87  LDD1412 
Serine--tRNA ligase, cytoplasmic (SARS1) LDTP04265 0.73  LDD1412 
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) LDTP06199 0.73  LDD1412 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 0.92  LDD1412 
Thioredoxin (TXN) LDTP02502 1.05  LDD1412 
Thioredoxin domain-containing protein 5 (TXNDC5) LDTP09067 0.78  LDD1412 
Thymidine kinase, cytosolic (TK1) LDTP02022 1.05; 1.04  LDD1412 
Tubulin alpha-1A chain (TUBA1A) LDTP07907 1.10; 0.92; 0.88  LDD1412 
Tubulin alpha-4A chain (TUBA4A) LDTP05075 1.00; 0.92; 0.90  LDD1412 
Tudor-interacting repair regulator protein (NUDT16L1) LDTP11111 0.95  LDD1412 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 0.70  LDD1412 
Ubiquitin-conjugating enzyme E2 S (UBE2S) LDTP06621 0.92  LDD1412 
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⏷ Show the Full List of 63 Enzyme
11 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ATP synthase subunit alpha, mitochondrial (ATP5F1A) LDTP03327 1.05  LDD1412 
Chloride intracellular channel protein 1 (CLIC1) LDTP00244 0.88  LDD1412 
Chloride intracellular channel protein 4 (CLIC4) LDTP14222 0.82  LDD1412 
Exportin-1 (XPO1) LDTP00501 0.92; 0.93  LDD1412 
Exportin-2 (CSE1L) LDTP04662 0.80  LDD1412 
Gasdermin-D (GSDMD) LDTP04801 0.98  LDD1412 
Protein SEC13 homolog (SEC13) LDTP04707 0.98  LDD1412 
Signal recognition particle 9 kDa protein (SRP9) LDTP04259 0.64  LDD1412 
Small ribosomal subunit protein RACK1 (RACK1) LDTP05057 0.97  LDD1412 
Thioredoxin domain-containing protein 17 (TXNDC17) LDTP11103 0.83  LDD1412 
THO complex subunit 6 homolog (THOC6) LDTP08315 0.82  LDD1412 
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⏷ Show the Full List of 11 Transporter and channel
4 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
eIF5-mimic protein 2 (BZW1) LDTP07940 0.95  LDD1412 
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 0.92  LDD1412 
Signal transducer and activator of transcription 1-alpha/beta (STAT1) LDTP03969 0.94  LDD1412 
SWI/SNF complex subunit SMARCC2 (SMARCC2) LDTP09311 0.90  LDD1412 
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56 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Actin-related protein 2/3 complex subunit 3 (ARPC3) LDTP00552 1.17  LDD1412 
AH receptor-interacting protein (AIP) LDTP00202 0.92  LDD1412 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) LDTP05770 1.00; 1.09  LDD1412 
Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) LDTP08573 1.16  LDD1412 
Ataxin-7-like protein 3B (ATXN7L3B) LDTP15730 0.86  LDD1412 
BRISC and BRCA1-A complex member 1 (BABAM1) LDTP12737 0.84  LDD1412 
Calponin-2 (CNN2) LDTP10864 1.04; 0.98  LDD1412 
Cleavage stimulation factor subunit 2 (CSTF2) LDTP03665 0.90  LDD1412 
Cofilin-1 (CFL1) LDTP03244 0.70  LDD1412 
Condensin complex subunit 2 (NCAPH) LDTP06268 1.12  LDD1412 
Crk-like protein (CRKL) LDTP04092 0.69  LDD1412 
Cytosolic iron-sulfur assembly component 2B (CIAO2B) LDTP13979 0.93  LDD1412 
Disks large-associated protein 5 (DLGAP5) LDTP06378 0.94  LDD1412 
DNA mismatch repair protein Msh2 (MSH2) LDTP04028 0.95  LDD1412 
Enhancer of mRNA-decapping protein 3 (EDC3) LDTP10299 0.97  LDD1412 
Eukaryotic translation initiation factor 3 subunit M (EIF3M) LDTP07947 1.10  LDD1412 
FH1/FH2 domain-containing protein 1 (FHOD1) LDTP14195 0.76  LDD1412 
GrpE protein homolog 1, mitochondrial (GRPEL1) LDTP12144 0.90  LDD1412 
H/ACA ribonucleoprotein complex subunit 2 (NHP2) LDTP12754 0.85  LDD1412 
Integrator complex subunit 13 (INTS13) LDTP12685 0.79  LDD1412 
KH domain-containing RNA-binding protein QKI (QKI) LDTP10700 0.70  LDD1412 
Large ribosomal subunit protein eL24 (RPL24) LDTP05186 1.06  LDD1412 
Large ribosomal subunit protein eL30 (RPL30) LDTP05021 0.75  LDD1412 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 0.89  LDD1412 
Large ribosomal subunit protein uL4 (RPL4) LDTP03815 1.05  LDD1412 
Mediator of RNA polymerase II transcription subunit 15 (MED15) LDTP10771 1.12  LDD1412 
MMS19 nucleotide excision repair protein homolog (MMS19) LDTP10843 0.92  LDD1412 
MOB-like protein phocein (MOB4) LDTP13964 0.97  LDD1412 
Nuclear migration protein nudC (NUDC) LDTP13817 0.66  LDD1412 
NudC domain-containing protein 1 (NUDCD1) LDTP10781 1.04  LDD1412 
Poly(rC)-binding protein 1 (PCBP1) LDTP06366 0.86; 1.04  LDD1412 
Programmed cell death 6-interacting protein (PDCD6IP) LDTP09580 0.90  LDD1412 
Proteasome activator complex subunit 1 (PSME1) LDTP05484 0.52  LDD1412 
Proteasome activator complex subunit 4 (PSME4) LDTP06250 1.14  LDD1412 
Protein misato homolog 1 (MSTO1) LDTP11239 0.96  LDD1412 
Protein PAXX (PAXX) LDTP11235 0.88  LDD1412 
Protein strawberry notch homolog 1 (SBNO1) LDTP14337 1.08  LDD1412 
Ribosomal protein eL42-like (RPL36AL) LDTP15677 0.99  LDD1412 
Sister chromatid cohesion protein PDS5 homolog A (PDS5A) LDTP06684 1.11  LDD1412 
Small ribosomal subunit protein eS27 (RPS27) LDTP03987 0.96  LDD1412 
Small ribosomal subunit protein eS4, X isoform (RPS4X) LDTP04997 0.98  LDD1412 
Small ribosomal subunit protein uS12 (RPS23) LDTP04971 0.93  LDD1412 
Small ribosomal subunit protein uS17 (RPS11) LDTP04975 0.99; 0.92  LDD1412 
Small ribosomal subunit protein uS7 (RPS5) LDTP04110 0.95  LDD1412 
SNW domain-containing protein 1 (SNW1) LDTP05930 0.89  LDD1412 
Stalled ribosome sensor GCN1 (GCN1) LDTP09821 1.01  LDD1412 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 0.99  LDD1412 
T-complex protein 1 subunit eta (CCT7) LDTP10990 1.05  LDD1412 
T-complex protein 1 subunit theta (CCT8) LDTP04390 0.92  LDD1412 
TBC1 domain family member 23 (TBC1D23) LDTP12651 0.89  LDD1412 
THUMP domain-containing protein 1 (THUMPD1) LDTP12780 0.82  LDD1412 
Transcription initiation factor IIA subunit 2 (GTF2A2) LDTP04517 0.74  LDD1412 
Treacle protein (TCOF1) LDTP05867 0.79; 0.80  LDD1412 
Tropomodulin-3 (TMOD3) LDTP18494 1.02  LDD1412 
Tubulin beta chain (TUBB) LDTP02205 0.90; 0.92  LDD1412 
ZW10 interactor (ZWINT) LDTP01532 0.86  LDD1412 
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⏷ Show the Full List of 56 Other

Full Information of The Labelling Profiles of This Competitor

IA-alkyne
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method Isotope tag
Competitor Name Fragment26
Competitor Concentration 500 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)
Interaction Atlas ID  LDD1412  Download The Altas

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.