Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment26					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C641	20.0
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.1
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.1
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.1
LDTP02502	Thioredoxin (TXN)				C32	1.1
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.1
LDTP05289	AMP deaminase 2 (AMPD2)				C107	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP02672	Elongation factor 2 (EEF2)				C41	1.0
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.0
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.0
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.0
LDTP05992	Bleomycin hydrolase (BLMH)				C73	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.0
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.0
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.0
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.0
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.0
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.0
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.0
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	1.0
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	0.9
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	0.9
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	0.9
LDTP02672	Elongation factor 2 (EEF2)				C136	0.9
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	0.9
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	0.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	0.9
LDTP04424	Galactokinase (GALK1)				C182	0.9
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	0.9
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	0.9
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	0.9
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.9
LDTP04689	Adenosine kinase (ADK)				C353	0.9
LDTP13663	Dual specificity protein phosphatase 12 (DUSP12)				C265	0.9
LDTP04374	Dynamin-2 (DNM2)				C27	0.9
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	0.9
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	0.9
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	0.9
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	0.9
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	0.9
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	0.9
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	0.9
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	0.9
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	0.9
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	0.9
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	0.9
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	0.9
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	0.9
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	0.9
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	0.8
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	0.8
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	0.8
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	0.8
LDTP03400	Deoxycytidine kinase (DCK)				C45	0.8
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	0.8
LDTP13147	Cathepsin Z (CTSZ)				C92	0.8
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	0.8
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	0.8
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	0.8
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	0.8
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	0.8
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	0.8
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	0.7
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	0.7
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	0.7
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	0.7
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	0.7
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	0.7
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	0.5
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	0.5

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	1.1
LDTP04801	Gasdermin-D (GSDMD)				C268	1.0
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.0
LDTP00501	Exportin-1 (XPO1)				C528	0.9
LDTP00501	Exportin-1 (XPO1)				C34	0.9
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	0.9
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	0.8
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	0.8
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	0.8
LDTP04662	Exportin-2 (CSE1L)				C842	0.8
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.0
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	0.9
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	0.9
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	0.9

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.2
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	1.2
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	1.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.1
LDTP10771	Mediator of RNA polymerase II transcription subunit 15 (MED15)				C618	1.1
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	1.1
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.1
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.1
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	1.1
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.1
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.1
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP18494	Tropomodulin-3 (TMOD3)				C132	1.0
LDTP09821	Stalled ribosome sensor GCN1 (GCN1)				C1692	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.0
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.0
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.0
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.0
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.0
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	1.0
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.0
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.0
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.0
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	0.9
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	0.9
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	0.9
LDTP00202	AH receptor-interacting protein (AIP)				C122	0.9
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	0.9
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	0.9
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	0.9
LDTP02205	Tubulin beta chain (TUBB)				C354	0.9
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	0.9
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	0.9
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	0.9
LDTP02205	Tubulin beta chain (TUBB)				C239	0.9
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	0.9
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	0.9
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	0.9
LDTP11235	Protein PAXX (PAXX)				C180	0.9
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	0.9
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	0.9
LDTP01532	ZW10 interactor (ZWINT)				C54	0.9
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	0.9
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	0.8
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	0.8
LDTP05867	Treacle protein (TCOF1)				C1298	0.8
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	0.8
LDTP05867	Treacle protein (TCOF1)				C38	0.8
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	0.8
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	0.8
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	0.7
LDTP03244	Cofilin-1 (CFL1)				C80	0.7
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	0.7
LDTP04092	Crk-like protein (CRKL)				C249	0.7
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	0.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	0.5

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.