Details of the Target

General Information of Target

Target ID LDTP04971
Target Name Small ribosomal subunit protein uS12 (RPS23)
Gene Name RPS23
Gene ID 6228
Synonyms
Small ribosomal subunit protein uS12; 40S ribosomal protein S23
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MGKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIVLEKVGVEAK
QPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVLVAGFGRKGHAVGDIPGVRF
KVVKVANVSLLALYKGKKERPRS
Target Bioclass
Other
Family
Universal ribosomal protein uS12 family
Subcellular location
Cytoplasm, cytosol
Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays an important role in translational accuracy. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
P62266
Ensemble ID
ENST00000296674.13
HGNC ID
HGNC:10410

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 43 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.83  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.11  LDD0196  [2]
CY4
 Probe Info  		2.74  LDD0244  [3]
TH211
 Probe Info  		Y134(19.09)  LDD0257  [4]
TH214
 Probe Info  		Y134(20.00)  LDD0258  [4]
TH216
 Probe Info  		Y134(20.00); Y27(6.13)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
Probe 1
 Probe Info  		Y134(14.73)  LDD3495  [7]
AF-2
 Probe Info  		2.75  LDD0422  [8]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [9]
THZ1-DTB
 Probe Info  		C90(1.04)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C90(2.07)  LDD0171  [10]
EA-probe
 Probe Info  		C90(0.99)  LDD2210  [11]
HHS-482
 Probe Info  		Y134(0.44)  LDD0285  [12]
DBIA
 Probe Info  		C90(1.11)  LDD0078  [13]
ATP probe
 Probe Info  		K54(0.00); K108(0.00); K29(0.00); K48(0.00)  LDD0199  [14]
1d-yne
 Probe Info  		N.A.  LDD0358  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
ATP probe
 Probe Info  		K135(0.00); K108(0.00); K80(0.00); K25(0.00)  LDD0035  [19]
IPM
 Probe Info  		N.A.  LDD0025  [20]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		N.A.  LDD2226  [21]
TFBX
 Probe Info  		N.A.  LDD0027  [20]
OSF
 Probe Info  		H31(0.00); H46(0.00); H110(0.00)  LDD0029  [22]
SF
 Probe Info  		K48(0.00); K135(0.00); K29(0.00); K108(0.00)  LDD0028  [22]
STPyne
 Probe Info  		K54(0.00); K48(0.00)  LDD0009  [23]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [24]
Ox-W18
 Probe Info  		N.A.  LDD2175  [25]
1c-yne
 Probe Info  		K54(0.00); K124(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		H110(0.00); H31(0.00); H46(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		H46(0.00); H110(0.00)  LDD0219  [26]
Methacrolein
 Probe Info  		H110(0.00); K48(0.00); H46(0.00)  LDD0218  [26]
AOyne
 Probe Info  		12.90  LDD0443  [27]
MPP-AC
 Probe Info  		N.A.  LDD0428  [28]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
TER-AC
 Probe Info  		N.A.  LDD0426  [28]
TPP-AC
 Probe Info  		N.A.  LDD0427  [28]
HHS-475
 Probe Info  		Y134(1.50)  LDD2238  [29]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		10.27  LDD1868  [30]
C193
 Probe Info  		5.82  LDD1869  [30]
FFF probe3
 Probe Info  		5.97  LDD0465  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C90(2.07)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C90(0.91)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C90(0.98)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C90(1.45)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C90(1.03)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C90(0.91)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C90(1.25)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C90(0.98)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C90(0.88)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C90(1.23)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C90(1.10)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C90(1.16)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C90(1.05)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C90(0.94)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C90(1.17)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C90(1.34)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C90(1.22)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C90(0.89)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C90(0.72)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C90(0.82)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C90(0.75)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C90(0.98)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C90(0.82)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C90(0.72)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C90(0.88)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C90(0.63)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C90(1.14)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C90(0.74)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C90(1.19)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C90(0.93)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C90(0.66)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C90(0.84)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C90(0.85)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C90(0.86)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C90(0.79)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C90(0.83)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C90(1.06)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C90(1.14)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C90(0.96)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C90(0.98)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C90(0.91)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C90(1.07)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C90(0.89)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C90(1.17)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C90(1.17)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C90(0.92)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C90(1.30)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C90(1.29)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C90(0.98)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C90(1.03)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C90(1.06)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C90(0.92)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C90(1.01)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C90(1.16)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C90(1.17)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C90(1.20)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C90(0.84)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C90(1.31)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C90(1.01)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C90(1.15)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C90(1.38)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C90(1.02)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C90(1.23)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C90(1.27)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C90(1.44)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C90(0.94)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C90(1.12)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C90(0.98)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C90(0.85)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C90(1.19)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C90(0.87)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C90(0.84)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C90(0.75)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C90(1.14)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C90(0.99)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C90(0.94)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C90(1.14)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C90(1.33)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C90(1.21)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C90(0.87)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C90(1.16)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C90(0.91)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C90(1.23)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C90(0.99)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C90(1.27)  LDD0612  [13]
 LDCM0296  AC35 HEK-293T C90(0.86)  LDD0894  [13]
 LDCM0297  AC36 HEK-293T C90(0.78)  LDD0895  [13]
 LDCM0298  AC37 HEK-293T C90(0.77)  LDD0896  [13]
 LDCM0299  AC38 HEK-293T C90(0.83)  LDD0897  [13]
 LDCM0300  AC39 HEK-293T C90(1.09)  LDD0898  [13]
 LDCM0301  AC4 HCT 116 C90(0.85)  LDD0618  [13]
 LDCM0302  AC40 HEK-293T C90(0.91)  LDD0900  [13]
 LDCM0303  AC41 HEK-293T C90(0.77)  LDD0901  [13]
 LDCM0304  AC42 HEK-293T C90(0.74)  LDD0902  [13]
 LDCM0305  AC43 HEK-293T C90(0.94)  LDD0903  [13]
 LDCM0306  AC44 HEK-293T C90(0.78)  LDD0904  [13]
 LDCM0307  AC45 HEK-293T C90(0.64)  LDD0905  [13]
 LDCM0308  AC46 HCT 116 C90(0.99)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C90(0.94)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C90(0.80)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C90(1.07)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C90(0.75)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C90(1.29)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C90(1.28)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C90(1.03)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C90(1.27)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C90(0.95)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C90(1.39)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C90(1.00)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C90(0.95)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C90(1.13)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C90(1.13)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C90(0.87)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C90(1.02)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C90(0.86)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C90(1.29)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C90(0.92)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C90(1.02)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C90(0.90)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C90(1.02)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C90(1.06)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C90(0.97)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C90(1.19)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C90(0.82)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C90(1.00)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C90(0.97)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C90(1.22)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C90(1.35)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C90(1.28)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C90(1.54)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C90(1.20)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C90(1.19)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C90(1.05)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C90(1.07)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C90(1.06)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C90(1.17)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C90(0.97)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C90(1.32)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C90(1.07)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C90(1.07)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C90(1.06)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C90(1.01)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C90(0.91)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C90(0.95)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C90(0.93)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C90(1.01)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C90(0.95)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C90(1.06)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C90(0.89)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C90(0.81)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C90(1.07)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C90(1.09)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C90(0.92)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C90(0.87)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C90(1.09)  LDD0683  [13]
 LDCM0166  Afatinib A431 2.75  LDD0422  [8]
 LDCM0248  AKOS034007472 HCT 116 C90(0.85)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C90(0.87)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C90(0.98)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 12.26  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C90(1.11)  LDD0078  [13]
 LDCM0630  CCW28-3 231MFP C90(1.48)  LDD2214  [32]
 LDCM0108  Chloroacetamide HeLa H110(0.00); H46(0.00); H31(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C90(0.56); C90(0.37)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C90(0.95)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C90(1.15)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C90(0.94)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C90(0.95)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C90(0.87)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C90(1.03)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C90(1.00)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C90(0.83)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C90(0.83)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C90(0.91)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C90(0.93)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C90(0.88)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C90(0.83)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C90(0.75)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C90(0.97)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C90(1.09)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C90(1.09)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C90(1.03)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C90(1.04)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C90(0.92)  LDD0703  [13]
 LDCM0387  CL117 HEK-293T C90(0.81)  LDD0985  [13]
 LDCM0388  CL118 HEK-293T C90(0.72)  LDD0986  [13]
 LDCM0389  CL119 HEK-293T C90(0.82)  LDD0987  [13]
 LDCM0390  CL12 HCT 116 C90(1.11)  LDD0707  [13]
 LDCM0391  CL120 HEK-293T C90(0.72)  LDD0989  [13]
 LDCM0392  CL121 HCT 116 C90(1.00)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C90(0.98)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C90(0.79)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C90(1.19)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C90(0.82)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C90(0.82)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C90(0.86)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C90(0.88)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C90(0.97)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C90(1.05)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C90(1.08)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C90(1.04)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C90(0.95)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C90(1.49)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C90(1.28)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C90(1.06)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C90(1.30)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C90(1.12)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C90(1.42)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C90(1.33)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C90(1.32)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C90(1.15)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C90(1.22)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C90(1.10)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C90(1.32)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C90(1.24)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C90(1.07)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C90(1.12)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C90(1.06)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C90(1.14)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C90(0.90)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C90(1.30)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C90(1.75)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C90(1.31)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C90(1.39)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C90(1.17)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C90(0.97)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C90(0.94)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C90(1.17)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C90(1.16)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C90(1.50)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C90(1.17)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C90(1.23)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C90(1.06)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C90(0.84)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C90(0.94)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C90(0.92)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C90(1.19)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C90(0.88)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C90(0.94)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C90(1.11)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C90(1.41)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C90(0.86)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C90(0.87)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C90(1.25)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C90(0.89)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C90(1.16)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C90(1.10)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C90(1.20)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C90(1.01)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C90(0.77)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C90(0.72)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C90(0.76)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C90(0.73)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C90(0.67)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C90(0.83)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C90(1.16)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C90(0.74)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C90(0.82)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C90(1.15)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C90(0.98)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C90(0.76)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C90(0.66)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C90(0.82)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C90(0.83)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C90(1.25)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C90(1.25)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C90(0.96)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C90(1.38)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C90(0.75)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C90(1.52)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C90(1.38)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C90(1.47)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C90(1.52)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C90(1.63)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C90(1.17)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C90(0.94)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C90(1.15)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C90(1.18)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C90(2.19)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C90(0.99)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C90(0.96)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C90(0.90)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C90(0.77)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C90(0.83)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C90(0.83)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C90(0.71)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C90(0.85)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C90(0.90)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C90(0.83)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C90(0.78)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C90(1.06)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C90(1.01)  LDD1698  [33]
 LDCM0175  Ethacrynic acid HeLa C90(0.99)  LDD2210  [11]
 LDCM0625  F8 Ramos C90(0.44)  LDD2187  [34]
 LDCM0572  Fragment10 MDA-MB-231 C90(1.54)  LDD1389  [35]
 LDCM0573  Fragment11 MDA-MB-231 C90(1.48)  LDD1391  [35]
 LDCM0574  Fragment12 MDA-MB-231 C90(2.07)  LDD1393  [35]
 LDCM0575  Fragment13 MDA-MB-231 C90(1.12)  LDD1395  [35]
 LDCM0576  Fragment14 MDA-MB-231 C90(3.23)  LDD1397  [35]
 LDCM0577  Fragment15 MDA-MB-231 C90(2.41)  LDD1399  [35]
 LDCM0579  Fragment20 Ramos C90(1.48)  LDD1403  [35]
 LDCM0580  Fragment21 MDA-MB-231 C90(1.18)  LDD1404  [35]
 LDCM0581  Fragment22 MDA-MB-231 C90(1.17)  LDD1406  [35]
 LDCM0582  Fragment23 MDA-MB-231 C90(2.53)  LDD1408  [35]
 LDCM0583  Fragment24 Ramos C90(1.86)  LDD1410  [35]
 LDCM0584  Fragment25 MDA-MB-231 C90(0.98)  LDD1411  [35]
 LDCM0585  Fragment26 Ramos C90(0.93)  LDD1412  [35]
 LDCM0578  Fragment27 MDA-MB-231 C90(0.94)  LDD1401  [35]
 LDCM0586  Fragment28 MDA-MB-231 C90(0.93)  LDD1415  [35]
 LDCM0587  Fragment29 MDA-MB-231 C90(1.41)  LDD1417  [35]
 LDCM0588  Fragment30 MDA-MB-231 C90(0.84)  LDD1419  [35]
 LDCM0589  Fragment31 MDA-MB-231 C90(2.62)  LDD1421  [35]
 LDCM0590  Fragment32 MDA-MB-231 C90(2.01)  LDD1423  [35]
 LDCM0468  Fragment33 HCT 116 C90(0.63)  LDD0785  [13]
 LDCM0592  Fragment34 Ramos C90(1.19)  LDD1428  [35]
 LDCM0593  Fragment35 MDA-MB-231 C90(0.85)  LDD1429  [35]
 LDCM0594  Fragment36 MDA-MB-231 C90(1.62)  LDD1431  [35]
 LDCM0595  Fragment37 Ramos C90(0.96)  LDD1432  [35]
 LDCM0596  Fragment38 MDA-MB-231 C90(1.24)  LDD1433  [35]
 LDCM0597  Fragment39 MDA-MB-231 C90(0.91)  LDD1435  [35]
 LDCM0566  Fragment4 MDA-MB-231 C90(1.66)  LDD1378  [35]
 LDCM0598  Fragment40 MDA-MB-231 C90(0.81)  LDD1436  [35]
 LDCM0599  Fragment41 MDA-MB-231 C90(1.06)  LDD1438  [35]
 LDCM0600  Fragment42 Ramos C90(1.18)  LDD1440  [35]
 LDCM0601  Fragment43 MDA-MB-231 C90(1.48)  LDD1441  [35]
 LDCM0602  Fragment44 MDA-MB-231 C90(0.86)  LDD1443  [35]
 LDCM0604  Fragment46 MDA-MB-231 C90(0.86)  LDD1445  [35]
 LDCM0605  Fragment47 MDA-MB-231 C90(1.32)  LDD1446  [35]
 LDCM0606  Fragment48 MDA-MB-231 C90(1.23)  LDD1447  [35]
 LDCM0607  Fragment49 MDA-MB-231 C90(4.30)  LDD1448  [35]
 LDCM0608  Fragment50 MDA-MB-231 C90(2.05)  LDD1449  [35]
 LDCM0427  Fragment51 HCT 116 C90(1.21)  LDD0744  [13]
 LDCM0610  Fragment52 MDA-MB-231 C90(1.36)  LDD1452  [35]
 LDCM0611  Fragment53 MDA-MB-231 C90(0.98)  LDD1454  [35]
 LDCM0612  Fragment54 MDA-MB-231 C90(1.10)  LDD1456  [35]
 LDCM0613  Fragment55 MDA-MB-231 C90(0.96)  LDD1457  [35]
 LDCM0614  Fragment56 MDA-MB-231 C90(1.16)  LDD1458  [35]
 LDCM0568  Fragment6 MDA-MB-231 C90(1.29)  LDD1382  [35]
 LDCM0569  Fragment7 MDA-MB-231 C90(1.18)  LDD1383  [35]
 LDCM0570  Fragment8 MDA-MB-231 C90(1.35)  LDD1385  [35]
 LDCM0571  Fragment9 MDA-MB-231 C90(1.36)  LDD1387  [35]
 LDCM0015  HNE MDA-MB-231 C90(0.78)  LDD0346  [34]
 LDCM0107  IAA HeLa H110(0.00); H46(0.00); H31(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y134(0.44)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y134(0.32)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y134(0.65)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y134(3.25)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y134(1.08)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y134(0.58)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y134(0.16)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y134(0.92)  LDD0292  [12]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [9]
 LDCM0022  KB02 HCT 116 C90(1.62)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C90(6.75)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C90(3.92)  LDD0082  [13]
 LDCM0109  NEM HeLa H110(0.00); H46(0.00); H31(0.00)  LDD0223  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C90(0.53); C90(0.52); C90(0.43)  LDD2207  [36]
 LDCM0131  RA190 MM1.R C90(1.23)  LDD0304  [37]
 LDCM0021  THZ1 HeLa S3 C90(1.04)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Prolyl 3-hydroxylase OGFOD1 (OGFOD1) TPA1 family Q8N543
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Netrin receptor DCC (DCC) DCC family P43146

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
29 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
34 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
35 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
37 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.