Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment49  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 18.5
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 15.3
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 13.4
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 12.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 12.1
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 12.0
 LDTP02672  Elongation factor 2 (EEF2) C41 9.6
 LDTP05859  Integrin-linked protein kinase (ILK) C346 8.3
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 7.3
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 7.0
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 6.9
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 6.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 5.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 5.8
 LDTP03400  Deoxycytidine kinase (DCK) C9 5.7
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 5.6
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 5.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 5.0
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 4.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 4.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 4.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 4.7
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 4.7
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) C691 4.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 4.3
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 4.1
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 4.0
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 3.8
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 3.7
 LDTP13147  Cathepsin Z (CTSZ) C173 3.7
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 3.6
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 3.5
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 3.4
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 3.3
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 3.2
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 3.1
 LDTP02502  Thioredoxin (TXN) C32 3.1
 LDTP13080  GMP reductase 2 (GMPR2) C186 3.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 2.8
 LDTP07317  Tensin-3 (TNS3) C888 2.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 2.6
 LDTP02223  Cathepsin B (CTSB) C319 2.4
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 2.4
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 2.3
 LDTP05992  Bleomycin hydrolase (BLMH) C73 2.2
 LDTP02672  Elongation factor 2 (EEF2) C136 2.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 2.0
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 2.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 2.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.9
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.7
 LDTP04689  Adenosine kinase (ADK) C353 1.6
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 1.6
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.6
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.3
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.2
 LDTP04374  Dynamin-2 (DNM2) C27 1.2
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.0
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.8
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) C522 0.3
Transporter and channel
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 14.1
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 4.6
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 2.0
 LDTP00501  Exportin-1 (XPO1) C34 1.9
 LDTP01574  Importin-7 (IPO7) C757 1.7
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.4
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 2.1
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.3
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 1.0
Other
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06681  Inverted formin-2 (INF2) C332 20.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C280 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 20.0
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 12.9
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 11.8
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 11.3
 LDTP12412  Reticulon-4 (RTN4) C1101 11.2
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 10.9
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 10.6
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 8.8
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 7.8
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 6.4
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 6.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 5.9
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 5.4
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 5.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 5.3
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 5.1
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 5.1
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 5.0
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 5.0
 LDTP00202  AH receptor-interacting protein (AIP) C122 4.8
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 4.7
 LDTP01532  ZW10 interactor (ZWINT) C54 4.6
 LDTP18494  Tropomodulin-3 (TMOD3) C132 4.4
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 4.3
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 3.7
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 3.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 3.6
 LDTP08238  Kinectin (KTN1) C303 3.6
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 3.6
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 3.5
 LDTP02205  Tubulin beta chain (TUBB) C239 3.5
 LDTP04363  Serpin H1 (SERPINH1) C156 3.4
 LDTP03620  Protein S100-A11 (S100A11) C91 3.4
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 3.3
 LDTP04902  Actin-related protein 3 (ACTR3) C235 3.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 3.2
 LDTP13580  Coronin-1C (CORO1C) C420 3.1
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 3.1
 LDTP10864  Calponin-2 (CNN2) C164 3.1
 LDTP10864  Calponin-2 (CNN2) C215 2.9
 LDTP02692  Plastin-3 (PLS3) C33 2.8
 LDTP06330  Plectin (PLEC) C3110 2.8
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 2.8
 LDTP06330  Plectin (PLEC) C992 2.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 2.6
 LDTP04487  Cyclin-H (CCNH) C244 1.9
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.7
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 1.6
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.6
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.6
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.5
 LDTP13580  Coronin-1C (CORO1C) C456 1.4
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.4
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.3
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.3
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.3
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 0.7
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.5
 LDTP03244  Cofilin-1 (CFL1) C80 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.