Details of the Target

General Information of Target

Target ID LDTP04363
Target Name Serpin H1 (SERPINH1)
Gene Name SERPINH1
Gene ID 871
Synonyms
CBP1; CBP2; HSP47; SERPINH2; Serpin H1; 47 kDa heat shock protein; Arsenic-transactivated protein 3; AsTP3; Cell proliferation-inducing gene 14 protein; Collagen-binding protein; Colligin; Rheumatoid arthritis-related antigen RA-A47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAK
DQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSN
STARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQT
TDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRT
GLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKK
AVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELD
TDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
Target Type
Clinical trial
Target Bioclass
Other
Family
Serpin family
Subcellular location
Endoplasmic reticulum lumen
Function Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.
TTD ID
T52034
Uniprot ID
P50454
DrugMap ID
TTXZ7W0
Ensemble ID
ENST00000358171.8
HGNC ID
HGNC:1546
ChEMBL ID
CHEMBL5286

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.18  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y55(7.02)  LDD0257  [4]
TH214
 Probe Info  		Y135(10.30)  LDD0258  [4]
TH216
 Probe Info  		Y135(20.00)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
OPA-S-S-alkyne
 Probe Info  		K217(1.17); K190(2.12); K334(2.28); K160(2.81)  LDD3494  [7]
Probe 1
 Probe Info  		Y246(30.40)  LDD3495  [8]
BTD
 Probe Info  		C156(1.60)  LDD1700  [9]
HHS-482
 Probe Info  		Y135(0.77)  LDD0285  [10]
DBIA
 Probe Info  		C156(1.55)  LDD0078  [11]
5E-2FA
 Probe Info  		H108(0.00); H315(0.00); H320(0.00); H386(0.00)  LDD2235  [12]
ATP probe
 Probe Info  		K300(0.00); K252(0.00)  LDD0199  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [15]
ATP probe
 Probe Info  		K380(0.00); K94(0.00)  LDD0035  [16]
WYneN
 Probe Info  		N.A.  LDD0021  [17]
WYneO
 Probe Info  		N.A.  LDD0022  [17]
ENE
 Probe Info  		N.A.  LDD0006  [17]
IPM
 Probe Info  		N.A.  LDD0147  [18]
NHS
 Probe Info  		K250(0.00); K94(0.00); K39(0.00); K217(0.00)  LDD0010  [17]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		N.A.  LDD0009  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [18]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [20]
Ox-W18
 Probe Info  		N.A.  LDD2175  [21]
1c-yne
 Probe Info  		K94(0.00); K380(0.00); K184(0.00); K86(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		H320(0.00); H273(0.00); H108(0.00); H274(0.00)  LDD0217  [23]
Crotonaldehyde
 Probe Info  		C156(0.00); H108(0.00); H153(0.00)  LDD0219  [23]
Methacrolein
 Probe Info  		N.A.  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		11.00  LDD0443  [25]
NAIA_5
 Probe Info  		N.A.  LDD2223  [26]
HHS-465
 Probe Info  		N.A.  LDD2240  [27]
HHS-475
 Probe Info  		Y154(0.69); Y55(0.66)  LDD2238  [28]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe12
 Probe Info  		12.02  LDD0473  [29]
FFF probe3
 Probe Info  		12.03  LDD0464  [29]
STS-2
 Probe Info  		22.86  LDD0138  [30]
DA-2
 Probe Info  		N.A.  LDD0070  [31]
STS-1
 Probe Info  		N.A.  LDD0068  [32]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C156(1.11)  LDD2130  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C156(1.50)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C156(1.57)  LDD2152  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C156(0.36)  LDD2132  [9]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C156(0.76)  LDD2131  [9]
 LDCM0214  AC1 HEK-293T C156(1.06)  LDD1507  [33]
 LDCM0215  AC10 HEK-293T C156(1.13)  LDD1508  [33]
 LDCM0216  AC100 HCT 116 C156(0.94)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C156(0.74)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C156(0.81)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C156(0.77)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C156(0.84)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C156(0.81)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C156(0.70)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C156(1.05)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C156(0.87)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C156(0.83)  LDD0542  [11]
 LDCM0226  AC11 HEK-293T C156(1.05)  LDD1509  [33]
 LDCM0227  AC110 HCT 116 C156(0.97)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C156(0.86)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C156(0.99)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C156(1.24)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C156(1.34)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C156(1.20)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C156(1.15)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C156(0.98)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C156(0.98)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C156(0.97)  LDD0553  [11]
 LDCM0237  AC12 HEK-293T C156(1.02)  LDD1510  [33]
 LDCM0238  AC120 HCT 116 C156(1.36)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C156(1.04)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C156(1.24)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C156(1.11)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C156(1.01)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C156(1.00)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C156(1.12)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C156(1.07)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C156(0.84)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C156(0.97)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C156(0.97)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C156(1.10)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C156(1.12)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C156(1.05)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C156(0.83)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C156(0.81)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C156(0.94)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C156(1.02)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C156(1.19)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C156(1.27)  LDD0575  [11]
 LDCM0259  AC14 HEK-293T C156(1.07)  LDD1512  [33]
 LDCM0260  AC140 HCT 116 C156(1.13)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C156(0.94)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C156(0.85)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C156(0.62)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C156(0.69)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C156(0.73)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C156(1.12)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C156(1.03)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C156(0.88)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C156(1.02)  LDD0586  [11]
 LDCM0270  AC15 HEK-293T C156(1.03)  LDD1513  [33]
 LDCM0271  AC150 HCT 116 C156(0.90)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C156(0.59)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C156(0.72)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C156(0.54)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C156(0.98)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C156(0.81)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C156(0.82)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C156(0.75)  LDD2161  [11]
 LDCM0276  AC17 PaTu 8988t C156(0.81)  LDD1155  [11]
 LDCM0277  AC18 PaTu 8988t C156(0.76)  LDD1156  [11]
 LDCM0278  AC19 PaTu 8988t C156(0.97)  LDD1157  [11]
 LDCM0279  AC2 HEK-293T C156(1.09)  LDD1518  [33]
 LDCM0280  AC20 PaTu 8988t C156(1.30)  LDD1159  [11]
 LDCM0281  AC21 PaTu 8988t C156(1.09)  LDD1160  [11]
 LDCM0282  AC22 PaTu 8988t C156(0.82)  LDD1161  [11]
 LDCM0283  AC23 PaTu 8988t C156(0.85)  LDD1162  [11]
 LDCM0284  AC24 PaTu 8988t C156(0.79)  LDD1163  [11]
 LDCM0285  AC25 HCT 116 C156(0.70)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C156(0.67)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C156(0.60)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C156(0.81)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C156(0.70)  LDD0606  [11]
 LDCM0290  AC3 HEK-293T C156(1.16)  LDD1529  [33]
 LDCM0291  AC30 HCT 116 C156(0.65)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C156(0.60)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C156(0.85)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C156(0.68)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C156(0.92)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C156(1.03)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C156(0.89)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C156(0.78)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C156(0.79)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C156(0.71)  LDD0617  [11]
 LDCM0301  AC4 HEK-293T C156(1.08)  LDD1540  [33]
 LDCM0302  AC40 HCT 116 C156(0.67)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C156(0.64)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C156(0.70)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C156(0.65)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C156(0.78)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C156(0.67)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C156(0.53)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C156(0.57)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C156(0.53)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C156(0.42)  LDD0628  [11]
 LDCM0312  AC5 HEK-293T C156(1.12)  LDD1551  [33]
 LDCM0313  AC50 HCT 116 C156(0.37)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C156(0.52)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C156(0.96)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C156(0.40)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C156(0.46)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C156(0.34)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C156(0.30)  LDD0636  [11]
 LDCM0320  AC57 HEK-293T C156(1.10)  LDD1559  [33]
 LDCM0321  AC58 HEK-293T C156(1.15)  LDD1560  [33]
 LDCM0322  AC59 HEK-293T C156(1.15)  LDD1561  [33]
 LDCM0323  AC6 HEK-293T C156(1.09)  LDD1562  [33]
 LDCM0324  AC60 HEK-293T C156(1.06)  LDD1563  [33]
 LDCM0325  AC61 HEK-293T C156(1.08)  LDD1564  [33]
 LDCM0326  AC62 HEK-293T C156(1.04)  LDD1565  [33]
 LDCM0327  AC63 HEK-293T C156(1.02)  LDD1566  [33]
 LDCM0328  AC64 HEK-293T C156(1.06)  LDD1567  [33]
 LDCM0332  AC68 HCT 116 C156(1.14)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C156(1.22)  LDD0650  [11]
 LDCM0334  AC7 HEK-293T C156(1.01)  LDD1568  [33]
 LDCM0335  AC70 HCT 116 C156(1.07)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C156(1.91)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C156(1.82)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C156(1.35)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C156(1.21)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C156(0.48)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C156(1.35)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C156(1.29)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C156(0.92)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C156(1.39)  LDD0661  [11]
 LDCM0345  AC8 HEK-293T C156(1.05)  LDD1569  [33]
 LDCM0346  AC80 HCT 116 C156(1.56)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C156(1.93)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C156(0.41)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C156(1.31)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C156(1.27)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C156(1.13)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C156(1.28)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C156(1.19)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C156(1.55)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C156(1.33)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C156(0.92)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C156(1.46)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C156(1.09)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C156(1.20)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C156(1.30)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C156(1.13)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C156(1.37)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C156(1.63)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C156(0.18)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C156(1.05)  LDD0683  [11]
 LDCM0545  Acetamide MDA-MB-231 C156(0.53)  LDD2138  [9]
 LDCM0520  AKOS000195272 MDA-MB-231 C156(0.89)  LDD2113  [9]
 LDCM0248  AKOS034007472 HEK-293T C156(1.11)  LDD1511  [33]
 LDCM0356  AKOS034007680 HEK-293T C156(1.07)  LDD1570  [33]
 LDCM0275  AKOS034007705 HEK-293T C156(1.05)  LDD1514  [33]
 LDCM0156  Aniline NCI-H1299 13.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C156(1.55)  LDD0078  [11]
 LDCM0498  BS-3668 MDA-MB-231 C156(0.57)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa H274(0.00); H273(0.00); H108(0.00); H320(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C156(2.58); C156(1.55)  LDD2227  [26]
 LDCM0367  CL1 HEK-293T C156(1.07)  LDD1571  [33]
 LDCM0368  CL10 HEK-293T C156(1.12)  LDD1572  [33]
 LDCM0370  CL101 HEK-293T C156(1.06)  LDD1574  [33]
 LDCM0371  CL102 HEK-293T C156(1.11)  LDD1575  [33]
 LDCM0372  CL103 HEK-293T C156(1.12)  LDD1576  [33]
 LDCM0374  CL105 PaTu 8988t C156(0.68)  LDD1253  [11]
 LDCM0375  CL106 PaTu 8988t C156(0.81)  LDD1254  [11]
 LDCM0376  CL107 PaTu 8988t C156(1.16)  LDD1255  [11]
 LDCM0377  CL108 PaTu 8988t C156(1.16)  LDD1256  [11]
 LDCM0378  CL109 PaTu 8988t C156(0.80)  LDD1257  [11]
 LDCM0379  CL11 HEK-293T C156(0.81)  LDD1583  [33]
 LDCM0380  CL110 PaTu 8988t C156(1.14)  LDD1259  [11]
 LDCM0381  CL111 PaTu 8988t C156(0.67)  LDD1260  [11]
 LDCM0382  CL112 HCT 116 C156(1.09)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C156(0.74)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C156(0.80)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C156(0.65)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C156(0.59)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C156(0.81)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C156(0.99)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C156(0.85)  LDD0706  [11]
 LDCM0390  CL12 HEK-293T C156(0.94)  LDD1594  [33]
 LDCM0391  CL120 HCT 116 C156(0.69)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C156(0.21)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C156(0.49)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C156(0.53)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C156(0.54)  LDD0712  [11]
 LDCM0396  CL125 HEK-293T C156(1.11)  LDD1600  [33]
 LDCM0397  CL126 HEK-293T C156(1.21)  LDD1601  [33]
 LDCM0398  CL127 HEK-293T C156(1.15)  LDD1602  [33]
 LDCM0400  CL13 HEK-293T C156(1.12)  LDD1604  [33]
 LDCM0401  CL14 HEK-293T C156(1.15)  LDD1605  [33]
 LDCM0402  CL15 HEK-293T C156(1.08)  LDD1606  [33]
 LDCM0403  CL16 PaTu 8988t C156(1.05)  LDD1282  [11]
 LDCM0404  CL17 PaTu 8988t C156(1.13)  LDD1283  [11]
 LDCM0405  CL18 PaTu 8988t C156(1.11)  LDD1284  [11]
 LDCM0406  CL19 PaTu 8988t C156(1.00)  LDD1285  [11]
 LDCM0407  CL2 HEK-293T C156(1.06)  LDD1611  [33]
 LDCM0408  CL20 PaTu 8988t C156(0.99)  LDD1287  [11]
 LDCM0409  CL21 PaTu 8988t C156(1.00)  LDD1288  [11]
 LDCM0410  CL22 PaTu 8988t C156(1.05)  LDD1289  [11]
 LDCM0411  CL23 PaTu 8988t C156(1.47)  LDD1290  [11]
 LDCM0412  CL24 PaTu 8988t C156(1.09)  LDD1291  [11]
 LDCM0413  CL25 PaTu 8988t C156(1.00)  LDD1292  [11]
 LDCM0414  CL26 PaTu 8988t C156(1.04)  LDD1293  [11]
 LDCM0415  CL27 PaTu 8988t C156(1.20)  LDD1294  [11]
 LDCM0416  CL28 PaTu 8988t C156(1.07)  LDD1295  [11]
 LDCM0417  CL29 PaTu 8988t C156(1.33)  LDD1296  [11]
 LDCM0418  CL3 HEK-293T C156(0.96)  LDD1622  [33]
 LDCM0419  CL30 PaTu 8988t C156(2.28)  LDD1298  [11]
 LDCM0420  CL31 PaTu 8988t C156(0.74)  LDD1299  [11]
 LDCM0421  CL32 PaTu 8988t C156(0.63)  LDD1300  [11]
 LDCM0422  CL33 PaTu 8988t C156(1.01)  LDD1301  [11]
 LDCM0423  CL34 PaTu 8988t C156(0.87)  LDD1302  [11]
 LDCM0424  CL35 PaTu 8988t C156(0.76)  LDD1303  [11]
 LDCM0425  CL36 PaTu 8988t C156(0.58)  LDD1304  [11]
 LDCM0426  CL37 PaTu 8988t C156(0.94)  LDD1305  [11]
 LDCM0428  CL39 PaTu 8988t C156(0.87)  LDD1307  [11]
 LDCM0430  CL40 PaTu 8988t C156(0.78)  LDD1309  [11]
 LDCM0431  CL41 PaTu 8988t C156(0.88)  LDD1310  [11]
 LDCM0432  CL42 PaTu 8988t C156(0.86)  LDD1311  [11]
 LDCM0433  CL43 PaTu 8988t C156(0.70)  LDD1312  [11]
 LDCM0434  CL44 PaTu 8988t C156(1.00)  LDD1313  [11]
 LDCM0435  CL45 PaTu 8988t C156(1.17)  LDD1314  [11]
 LDCM0436  CL46 HEK-293T C156(0.95)  LDD1640  [33]
 LDCM0437  CL47 HEK-293T C156(0.91)  LDD1641  [33]
 LDCM0438  CL48 HEK-293T C156(0.91)  LDD1642  [33]
 LDCM0439  CL49 HEK-293T C156(1.08)  LDD1643  [33]
 LDCM0440  CL5 HEK-293T C156(1.11)  LDD1644  [33]
 LDCM0441  CL50 HEK-293T C156(1.10)  LDD1645  [33]
 LDCM0444  CL53 HEK-293T C156(1.01)  LDD1647  [33]
 LDCM0445  CL54 HEK-293T C156(1.04)  LDD1648  [33]
 LDCM0446  CL55 HEK-293T C156(1.03)  LDD1649  [33]
 LDCM0447  CL56 HEK-293T C156(1.19)  LDD1650  [33]
 LDCM0448  CL57 HEK-293T C156(1.14)  LDD1651  [33]
 LDCM0449  CL58 HEK-293T C156(1.02)  LDD1652  [33]
 LDCM0450  CL59 HEK-293T C156(0.89)  LDD1653  [33]
 LDCM0451  CL6 HEK-293T C156(1.21)  LDD1654  [33]
 LDCM0452  CL60 HEK-293T C156(0.90)  LDD1655  [33]
 LDCM0453  CL61 HCT 116 C156(0.95)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C156(0.88)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C156(1.06)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C156(0.94)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C156(0.95)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C156(1.09)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C156(1.25)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C156(1.42)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C156(1.05)  LDD0778  [11]
 LDCM0462  CL7 HEK-293T C156(1.03)  LDD1665  [33]
 LDCM0463  CL70 HCT 116 C156(0.97)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C156(1.26)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C156(1.08)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C156(1.17)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C156(1.30)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C156(1.24)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C156(1.01)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C156(0.93)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C156(1.29)  LDD0789  [11]
 LDCM0473  CL8 HEK-293T C156(1.29)  LDD1676  [33]
 LDCM0474  CL80 HCT 116 C156(0.98)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C156(0.98)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C156(0.75)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C156(0.66)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C156(0.53)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C156(0.78)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C156(0.93)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C156(1.05)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C156(0.80)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C156(0.55)  LDD0800  [11]
 LDCM0484  CL9 HEK-293T C156(1.06)  LDD1687  [33]
 LDCM0485  CL90 HCT 116 C156(0.77)  LDD0802  [11]
 LDCM0486  CL91 HEK-293T C156(1.08)  LDD1689  [33]
 LDCM0487  CL92 HEK-293T C156(1.09)  LDD1690  [33]
 LDCM0488  CL93 HEK-293T C156(1.03)  LDD1691  [33]
 LDCM0489  CL94 HEK-293T C156(0.97)  LDD1692  [33]
 LDCM0490  CL95 HEK-293T C156(1.14)  LDD1693  [33]
 LDCM0491  CL96 HEK-293T C156(0.95)  LDD1694  [33]
 LDCM0492  CL97 HEK-293T C156(1.11)  LDD1695  [33]
 LDCM0493  CL98 HEK-293T C156(1.06)  LDD1696  [33]
 LDCM0494  CL99 HEK-293T C156(1.12)  LDD1697  [33]
 LDCM0634  CY-0357 Hep-G2 C156(1.42)  LDD2228  [26]
 LDCM0495  E2913 HEK-293T C156(1.19)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C156(1.89)  LDD1702  [9]
 LDCM0572  Fragment10 MDA-MB-231 C156(3.43)  LDD1389  [34]
 LDCM0574  Fragment12 MDA-MB-231 C156(20.00)  LDD1393  [34]
 LDCM0575  Fragment13 MDA-MB-231 C156(0.91)  LDD1395  [34]
 LDCM0576  Fragment14 MDA-MB-231 C156(2.07)  LDD1397  [34]
 LDCM0580  Fragment21 MDA-MB-231 C156(1.38)  LDD1404  [34]
 LDCM0581  Fragment22 MDA-MB-231 C156(1.28)  LDD1406  [34]
 LDCM0582  Fragment23 MDA-MB-231 C156(0.93)  LDD1408  [34]
 LDCM0584  Fragment25 MDA-MB-231 C156(0.82)  LDD1411  [34]
 LDCM0578  Fragment27 MDA-MB-231 C156(0.84)  LDD1401  [34]
 LDCM0586  Fragment28 MDA-MB-231 C156(1.01)  LDD1415  [34]
 LDCM0588  Fragment30 MDA-MB-231 C156(1.02)  LDD1419  [34]
 LDCM0589  Fragment31 MDA-MB-231 C156(2.20)  LDD1421  [34]
 LDCM0590  Fragment32 MDA-MB-231 C156(3.45)  LDD1423  [34]
 LDCM0468  Fragment33 HCT 116 C156(1.74)  LDD0785  [11]
 LDCM0596  Fragment38 MDA-MB-231 C156(1.15)  LDD1433  [34]
 LDCM0566  Fragment4 MDA-MB-231 C156(2.74)  LDD1378  [34]
 LDCM0599  Fragment41 MDA-MB-231 C156(1.29)  LDD1438  [34]
 LDCM0602  Fragment44 MDA-MB-231 C156(0.73)  LDD1443  [34]
 LDCM0604  Fragment46 MDA-MB-231 C156(1.04)  LDD1445  [34]
 LDCM0605  Fragment47 MDA-MB-231 C156(1.24)  LDD1446  [34]
 LDCM0606  Fragment48 MDA-MB-231 C156(1.31)  LDD1447  [34]
 LDCM0607  Fragment49 MDA-MB-231 C156(3.44)  LDD1448  [34]
 LDCM0608  Fragment50 MDA-MB-231 C156(2.41)  LDD1449  [34]
 LDCM0427  Fragment51 PaTu 8988t C156(0.70)  LDD1306  [11]
 LDCM0610  Fragment52 MDA-MB-231 C156(1.62)  LDD1452  [34]
 LDCM0611  Fragment53 MDA-MB-231 C156(0.98)  LDD1454  [34]
 LDCM0614  Fragment56 MDA-MB-231 C156(1.18)  LDD1458  [34]
 LDCM0570  Fragment8 MDA-MB-231 C156(4.16)  LDD1385  [34]
 LDCM0571  Fragment9 MDA-MB-231 C156(1.15)  LDD1387  [34]
 LDCM0107  IAA HeLa H320(0.00); H274(0.00); H273(0.00); H315(0.00)  LDD0221  [23]
 LDCM0123  JWB131 DM93 Y135(0.77)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y135(0.95)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y135(0.98)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y135(1.73)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y135(0.77)  LDD0289  [10]
 LDCM0129  JWB202 DM93 Y135(0.57)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y135(0.40)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C156(2.18)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C156(1.17)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C156(1.92)  LDD0082  [11]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C156(0.73)  LDD2121  [9]
 LDCM0109  NEM HeLa H320(0.00); H108(0.00); H274(0.00); H273(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C156(1.04)  LDD2089  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C156(0.34)  LDD2096  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C156(0.28)  LDD2098  [9]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C156(1.64)  LDD2101  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C156(0.38)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C156(0.76)  LDD2109  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C156(1.03)  LDD2111  [9]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C156(0.59)  LDD2115  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C156(0.78)  LDD2116  [9]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C156(0.65)  LDD2118  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C156(1.19)  LDD2119  [9]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C156(0.71)  LDD2120  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C156(0.61)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C156(0.94)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C156(0.53)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C156(0.98)  LDD2125  [9]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C156(0.65)  LDD2126  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C156(1.63)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C156(0.89)  LDD2129  [9]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C156(0.54)  LDD2133  [9]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C156(0.62)  LDD2134  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C156(0.90)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C156(1.84)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C156(0.95)  LDD2137  [9]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C156(1.60)  LDD1700  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C156(1.15)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C156(0.77)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C156(1.41)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C156(0.80)  LDD2146  [9]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C156(0.50)  LDD2148  [9]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C156(0.54)  LDD2149  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C156(0.66)  LDD2150  [9]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C156(0.74)  LDD2151  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 2, mitochondrial (AK2) Adenylate kinase family P54819
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Deoxyribonuclease-1-like 1 (DNASE1L1) DNase I family P49184
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) Isocitrate and isopropylmalate dehydrogenases family O75874
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Kell blood group glycoprotein (KEL) Peptidase M13 family P23276
Kallikrein-8 (KLK8) Peptidase S1 family O60259
Proprotein convertase subtilisin/kexin type 7 (PCSK7) Peptidase S8 family Q16549
GPI mannosyltransferase 2 (PIGV) PIGV family Q9NUD9
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Choline transporter-like protein 5 (SLC44A5) CTL (choline transporter-like) family Q8NCS7
Integrin alpha-V (ITGAV) Integrin alpha chain family P06756
Cadherin-1 (CDH1) . P12830
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein C-ets-2 (ETS2) ETS family P15036
Myoneurin (MYNN) Krueppel C2H2-type zinc-finger protein family Q9NPC7
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Large ribosomal subunit protein eL43 (RPL37A) Eukaryotic ribosomal protein eL43 family P61513
Protein VCF1 (VCF1) FAM104 family Q969W3
Pleiotrophin (PTN) Pleiotrophin family P21246
Alpha-sarcoglycan (SGCA) Sarcoglycan alpha/epsilon family Q16586
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
INO80 complex subunit C (INO80C) . Q6PI98
SERPINE1 mRNA-binding protein 1 (SERBP1) . Q8NC51

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bms-986263 Small interfering RNA D2H4RZ

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
21 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
28 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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Mass spectrometry data entry: PXD044402
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