Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment44  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02502  Thioredoxin (TXN) C32 2.2
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.0
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 0.9
 LDTP13147  Cathepsin Z (CTSZ) C92 0.9
 LDTP04374  Dynamin-2 (DNM2) C27 0.9
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 0.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 0.9
 LDTP14155  Serine/threonine-protein kinase MRCK beta (CDC42BPB) C1517 0.9
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 0.8
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.8
 LDTP02223  Cathepsin B (CTSB) C319 0.8
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 0.8
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 0.8
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 0.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 0.8
 LDTP05289  AMP deaminase 2 (AMPD2) C107 0.8
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.8
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.8
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.8
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 0.8
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.8
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.8
 LDTP03496  Protein PML (PML) C389 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 0.8
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.8
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.8
 LDTP10002  Ribonuclease P/MRP protein subunit POP5 (POP5) C146 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.8
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 0.8
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 0.8
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 0.8
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.8
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 0.8
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.8
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 0.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.8
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.8
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 0.8
 LDTP09912  DNA repair protein RAD50 (RAD50) C1296 0.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.8
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.8
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 0.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 0.8
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 0.8
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.8
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.8
 LDTP13147  Cathepsin Z (CTSZ) C173 0.8
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 0.8
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.8
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.8
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 0.8
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 0.8
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 0.8
 LDTP02672  Elongation factor 2 (EEF2) C136 0.7
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 0.7
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.7
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.7
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 0.7
 LDTP03644  Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1) C120 0.7
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.7
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 0.7
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.7
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.6
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 0.5
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 0.5
 LDTP01005  Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3) C691 0.3
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 0.9
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 0.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.8
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.8
 LDTP04707  Protein SEC13 homolog (SEC13) C187 0.8
 LDTP00501  Exportin-1 (XPO1) C34 0.8
 LDTP04801  Gasdermin-D (GSDMD) C268 0.8
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.7
 LDTP00196  Unconventional myosin-Ic (MYO1C) C802 0.7
 LDTP04662  Exportin-2 (CSE1L) C842 0.7
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 0.0
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.0
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 0.9
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 0.9
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.8
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.8
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.8
Other
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.1
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.9
 LDTP12443  Anillin (ANLN) C712 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.9
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 0.9
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.9
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 0.9
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.9
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.8
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 0.8
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 0.8
 LDTP10864  Calponin-2 (CNN2) C164 0.8
 LDTP10864  Calponin-2 (CNN2) C215 0.8
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 0.8
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 0.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 0.8
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 0.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.8
 LDTP13925  Nucleolar protein 58 (NOP58) C106 0.8
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.8
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 0.8
 LDTP02692  Plastin-3 (PLS3) C33 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 0.8
 LDTP03620  Protein S100-A11 (S100A11) C91 0.8
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.8
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.8
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 0.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.8
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 0.8
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 0.8
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 0.8
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 0.8
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 0.8
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 0.8
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 0.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 0.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.8
 LDTP11235  Protein PAXX (PAXX) C180 0.8
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 0.7
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 0.7
 LDTP04363  Serpin H1 (SERPINH1) C156 0.7
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 0.7
 LDTP12412  Reticulon-4 (RTN4) C1101 0.7
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 0.7
 LDTP04092  Crk-like protein (CRKL) C249 0.7
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.7
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 0.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.7
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 0.6
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.