Details of the Target

General Information of Target

Target ID LDTP03496
Target Name Protein PML (PML)
Gene Name PML
Gene ID 5371
Synonyms
MYL; PP8675; RNF71; TRIM19; Protein PML; E3 SUMO-protein ligase PML; EC 2.3.2.-; Promyelocytic leukemia protein; RING finger protein 71; RING-type E3 SUMO transferase PML; Tripartite motif-containing protein 19; TRIM19
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ
HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS
LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA
FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS
Target Type
Literature-reported
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Inhibits EIF4E-mediated mRNA nuclear export by reducing EIF4E affinity for the 5' 7-methylguanosine (m7G) cap of target mRNAs. Isoform PML-4 has a multifaceted role in the regulation of apoptosis and growth suppression: activates RB1 and inhibits AKT1 via interactions with PP1 and PP2A phosphatases respectively, negatively affects the PI3K pathway by inhibiting MTOR and activating PTEN, and positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Isoform PML-4 also: acts as a transcriptional repressor of TBX2 during cellular senescence and the repression is dependent on a functional RBL2/E2F4 repressor complex, regulates double-strand break repair in gamma-irradiation-induced DNA damage responses via its interaction with WRN, acts as a negative regulator of telomerase by interacting with TERT, and regulates PER2 nuclear localization and circadian function. Isoform PML-6 inhibits specifically the activity of the tetrameric form of PKM. The nuclear isoforms (isoform PML-1, isoform PML-2, isoform PML-3, isoform PML-4 and isoform PML-5) in concert with SATB1 are involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Isoform PML-2 is required for efficient IFN-gamma induced MHC II gene transcription via regulation of CIITA. Cytoplasmic PML is involved in the regulation of the TGF-beta signaling pathway. PML also regulates transcription activity of ELF4 and can act as an important mediator for TNF-alpha- and IFN-alpha-mediated inhibition of endothelial cell network formation and migration.; Exhibits antiviral activity against both DNA and RNA viruses. The antiviral activity can involve one or several isoform(s) and can be enhanced by the permanent PML-NB-associated protein DAXX or by the recruitment of p53/TP53 within these structures. Isoform PML-4 restricts varicella zoster virus (VZV) via sequestration of virion capsids in PML-NBs thereby preventing their nuclear egress and inhibiting formation of infectious virus particles. The sumoylated isoform PML-4 restricts rabies virus by inhibiting viral mRNA and protein synthesis. The cytoplasmic isoform PML-14 can restrict herpes simplex virus-1 (HHV-1) replication by sequestering the viral E3 ubiquitin-protein ligase ICP0 in the cytoplasm. Isoform PML-6 shows restriction activity towards human cytomegalovirus (HHV-5) and influenza A virus strains PR8(H1N1) and ST364(H3N2). Sumoylated isoform PML-4 and isoform PML-12 show antiviral activity against encephalomyocarditis virus (EMCV) by promoting nuclear sequestration of viral polymerase (P3D-POL) within PML NBs. Isoform PML-3 exhibits antiviral activity against poliovirus by inducing apoptosis in infected cells through the recruitment and the activation of p53/TP53 in the PML-NBs. Isoform PML-3 represses human foamy virus (HFV) transcription by complexing the HFV transactivator, bel1/tas, preventing its binding to viral DNA. PML may positively regulate infectious hepatitis C viral (HCV) production and isoform PML-2 may enhance adenovirus transcription. Functions as an E3 SUMO-protein ligase that sumoylates (HHV-5) immediate early protein IE1, thereby participating in the antiviral response. Isoforms PML-3 and PML-6 display the highest levels of sumoylation activity.
TTD ID
T01683
Uniprot ID
P29590
DrugMap ID
TTLH9NY
Ensemble ID
ENST00000268058.8
HGNC ID
HGNC:9113

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E420Q DBIA    Probe Info 
CCK81 Deletion: p.E27RfsTer71;p.E551RfsTer8
SNV: p.A300V		 DBIA    Probe Info 
COLO678 SNV: p.Y823S DBIA    Probe Info 
COLO792 SNV: p.S341L; p.R424K DBIA    Probe Info 
HCC1143 SNV: p.E633K DBIA    Probe Info 
HCT116 SNV: p.A263T DBIA    Probe Info 
HCT15 SNV: p.L713R DBIA    Probe Info 
IGROV1 Deletion: p.E551RfsTer8 DBIA    Probe Info 
JURKAT SNV: p.A16T; p.A331T Compound 10    Probe Info 
MDAMB453 SNV: p.S518Ter DBIA    Probe Info 
MFE319 Deletion: p.P761RfsTer43 DBIA    Probe Info 
NALM6 SNV: p.Y305C DBIA    Probe Info 
OVK18 SNV: p.V265I DBIA    Probe Info 
RKO Insertion: p.E27RfsTer5 DBIA    Probe Info 
SG231 SNV: p.A787V DBIA    Probe Info 
SUPT1 SNV: p.S341L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K380(7.69); K394(2.87); K476(9.52); K478(7.38)  LDD0277  [3]
ONAyne
 Probe Info  		K478(10.00)  LDD0275  [3]
Probe 1
 Probe Info  		Y309(51.76)  LDD3495  [4]
BTD
 Probe Info  		C479(0.72)  LDD2092  [5]
Sulforaphane-probe2
 Probe Info  		2.48  LDD0160  [6]
AHL-Pu-1
 Probe Info  		C389(2.13)  LDD0169  [7]
DBIA
 Probe Info  		C338(1.28); C227(1.06); C479(1.04); C484(1.04)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C227(0.00); C151(0.00); C338(0.00); C777(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C227(0.00); C151(0.00); C338(0.00); C189(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C227(0.00); C151(0.00); C338(0.00); C189(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		C338(0.00); C389(0.00)  LDD2226  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
Compound 10
 Probe Info  		C389(0.00); C479(0.00)  LDD2216  [13]
Compound 11
 Probe Info  		C389(0.00); C479(0.00)  LDD2213  [13]
ENE
 Probe Info  		N.A.  LDD0006  [12]
IPM
 Probe Info  		C479(0.00); C484(0.00)  LDD0005  [12]
PF-06672131
 Probe Info  		N.A.  LDD0017  [14]
PPMS
 Probe Info  		N.A.  LDD0008  [12]
VSF
 Probe Info  		C479(0.00); C389(0.00)  LDD0007  [12]
YN-1
 Probe Info  		N.A.  LDD0446  [15]
Phosphinate-6
 Probe Info  		C479(0.00); C389(0.00); C357(0.00); C338(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
W1
 Probe Info  		C389(0.00); C204(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C338(0.00); C189(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C479(0.78); C213(0.82)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C676(1.27); C479(1.04); C213(1.06)  LDD2112  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C676(0.75)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C66(1.47); C213(0.97)  LDD2103  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C389(2.13)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C479(0.79); C484(0.79); C151(0.86); C189(1.39)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C479(1.28); C484(1.28); C129(0.99); C151(0.95)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C479(0.85); C484(1.06); C151(1.02); C189(0.69)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C479(0.90); C484(1.10); C151(0.96); C189(0.83)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C479(0.89); C484(0.93); C151(0.95); C189(0.90)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C479(1.06); C484(1.34); C151(0.94); C189(1.01)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C479(0.85); C484(0.98); C151(1.01); C189(0.90)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C479(1.08); C484(1.33); C151(0.97); C189(0.90)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C479(1.38); C484(1.55); C151(1.07); C189(0.89)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C479(1.16); C484(1.27); C151(1.06); C189(0.94)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C479(0.80); C484(1.12); C151(1.01); C189(0.86)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C479(0.77); C484(1.00); C151(0.96); C189(0.75)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C479(1.28); C484(1.28); C129(0.95); C151(1.02)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C479(0.84); C484(1.09); C151(0.97); C189(0.77)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C479(0.86); C484(1.11); C151(0.99); C189(0.83)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C479(1.02); C484(1.23); C151(1.03); C189(0.94)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C479(0.78); C484(0.78); C151(0.99); C189(0.92)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C479(1.59); C484(1.59); C151(0.91); C189(0.98)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C479(1.73); C484(1.73); C151(0.79); C189(1.08)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C479(1.99); C484(1.99); C151(0.95); C189(1.08)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C479(1.53); C484(1.53); C151(0.82); C189(1.06)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C479(1.56); C484(1.56); C151(0.82); C189(1.01)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C479(1.63); C484(1.63); C151(0.97); C189(0.93)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C479(1.12); C484(1.12); C129(0.98); C151(1.00)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C479(0.78); C484(0.78); C151(0.96); C189(0.92)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C479(1.47); C484(1.47); C151(1.03); C189(0.89)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C479(1.67); C484(1.67); C151(0.81); C189(0.95)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C479(1.46); C484(1.46); C151(1.14); C189(0.94)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C479(1.44); C484(1.44); C151(0.78); C189(0.92)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C479(1.48); C484(1.48); C151(0.97); C189(1.05)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C479(1.98); C484(1.98); C151(0.89); C189(0.90)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C479(2.35); C484(2.35); C151(0.91); C189(1.00)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C479(0.22); C484(0.22); C189(1.88); C204(0.58)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C479(0.25); C484(0.25); C189(1.29); C204(0.46)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C479(0.26); C484(0.26); C189(1.23); C204(0.47)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C479(0.26); C484(0.26); C189(1.22); C204(0.59)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C479(0.29); C484(0.29); C189(1.28); C204(0.54)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C479(0.26); C484(0.26); C189(2.03); C204(0.47)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C479(0.29); C484(0.29); C189(1.42); C204(0.59)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C479(0.35); C484(0.35); C189(1.88); C204(0.55)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C479(0.32); C484(0.32); C189(1.09); C204(0.53)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C479(0.29); C484(0.29); C189(1.09); C204(0.59)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C479(0.34); C484(0.34); C189(1.50); C204(0.94)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C479(0.29); C484(0.29); C189(1.72); C204(0.61)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C479(0.92); C484(0.92); C129(0.79); C151(1.00)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C479(0.33); C484(0.33); C189(1.78); C204(0.78)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C479(0.38); C484(0.38); C189(1.32); C204(0.74)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C479(0.25); C484(0.25); C189(1.82); C204(0.52)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C479(1.27); C484(1.26); C227(0.97); C57(1.10)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C338(0.98); C227(1.06); C213(1.13); C215(1.13)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C227(0.87); C151(0.97); C60(1.06); C338(1.08)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C227(0.82); C338(0.94); C151(1.02); C213(1.06)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C151(1.01); C213(1.04); C215(1.04); C338(1.05)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C338(0.76); C227(0.80); C151(0.92); C60(1.36)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C227(0.75); C338(0.77); C151(1.00); C60(1.24)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C189(0.75); C129(0.88); C57(1.00); C60(1.00)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C227(0.82); C338(0.89); C213(0.92); C215(0.92)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C338(0.83); C151(0.98); C213(1.03); C215(1.03)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C227(0.78); C338(0.84); C151(1.01); C60(1.20)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C338(0.74); C227(0.79); C151(1.04); C60(1.71)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C479(1.68); C484(1.70); C151(1.01); C189(1.32)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C479(1.51); C484(1.67); C151(1.10); C189(1.10)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C479(1.19); C484(1.15); C151(1.03); C189(0.94)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C479(1.43); C484(1.65); C151(1.09); C189(1.05)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C57(0.53); C60(0.53); C213(0.62); C215(0.62)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C57(0.62); C60(0.62); C338(0.72); C213(0.73)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C57(0.52); C60(0.52); C338(0.66); C213(0.66)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C204(0.86); C338(0.98); C389(1.01); C479(1.03)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C213(0.51); C215(0.51); C57(0.55); C60(0.55)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C57(0.50); C60(0.50); C338(0.60); C213(0.80)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C213(0.50); C215(0.50); C57(0.54); C60(0.54)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C57(0.40); C60(0.40); C213(0.56); C215(0.56)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C57(0.49); C60(0.49); C213(0.60); C215(0.60)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C189(0.68); C129(0.72); C227(0.89); C204(1.12)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C129(0.70); C189(0.77); C227(1.08); C204(1.12)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C189(0.88); C129(0.89); C227(1.16); C204(1.21)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C189(0.67); C129(0.85); C338(1.07); C204(1.08)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C129(0.66); C189(0.85); C338(1.09); C227(1.16)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C338(0.79); C204(0.82); C389(0.87); C479(0.89)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C129(0.59); C204(1.10); C189(1.14); C227(1.16)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C189(0.75); C129(0.79); C204(1.07); C227(1.08)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C189(0.79); C129(0.80); C204(1.14); C151(1.29)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C189(0.64); C129(0.96); C227(1.06); C204(1.41)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C189(0.69); C129(0.78); C227(0.90); C338(1.27)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C227(0.74); C57(0.83); C60(0.83); C204(0.90)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C204(0.77); C227(0.91); C189(0.91); C57(1.01)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C204(0.68); C227(0.90); C189(0.94); C57(1.19)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C204(0.89); C227(1.03); C57(1.08); C60(1.08)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C204(0.81); C189(1.07); C227(1.08); C57(1.69)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C338(0.78); C389(0.81); C204(0.89); C57(0.92)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C189(0.97); C204(1.03); C227(1.05); C57(1.35)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C204(0.71); C189(0.93); C227(0.97); C57(1.05)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C204(0.88); C189(0.88); C227(1.12); C57(1.21)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C204(0.85); C227(0.90); C189(0.94); C57(1.30)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C204(0.81); C189(0.97); C227(1.09); C57(1.41)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C189(0.95); C204(0.98); C227(1.20); C57(1.52)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C204(0.79); C189(1.02); C151(1.05); C57(1.23)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C204(0.89); C189(0.97); C151(1.07); C227(1.08)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C204(0.81); C151(0.99); C189(1.13); C227(1.18)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C151(1.00); C189(1.10); C57(1.15); C60(1.15)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C338(0.67); C204(0.81); C389(0.84); C479(0.86)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C151(1.09); C57(1.14); C60(1.14); C189(1.15)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C204(0.77); C151(1.07); C189(1.09); C227(1.18)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C189(0.94); C204(1.01); C151(1.04); C227(1.25)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C227(0.92); C189(0.92); C151(0.99); C204(1.14)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C189(0.92); C151(1.00); C227(1.07); C204(1.26)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C189(0.93); C227(0.94); C151(1.13); C204(1.59)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C189(1.09); C151(1.13); C227(1.26); C57(1.74)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C338(0.82); C204(0.88); C227(0.95); C479(1.07)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C227(0.90); C338(0.93); C204(1.05); C57(1.13)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C204(0.80); C57(1.10); C60(1.10); C338(1.14)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C129(0.85); C204(1.04); C227(1.06); C57(1.11)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C204(0.83); C338(0.99); C57(1.11); C60(1.11)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C338(0.79); C204(1.03); C57(1.07); C60(1.07)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C204(0.66); C227(0.96); C338(1.05); C57(1.18)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C338(0.77); C204(0.90); C227(1.04); C57(1.07)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C338(0.84); C204(0.97); C479(1.08); C484(1.08)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C479(0.57); C484(0.57); C204(0.69); C57(0.82)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C479(0.56); C484(0.56); C204(0.64); C338(0.72)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C204(0.60); C479(0.77); C484(0.77); C338(0.97)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C338(0.74); C129(0.88); C204(0.93); C189(0.94)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C338(0.70); C227(0.96); C151(0.97); C189(1.06)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C57(0.82); C60(0.82); C129(0.92); C204(0.98)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C129(0.80); C189(0.87); C151(0.92); C338(0.92)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C129(0.69); C338(0.83); C151(0.94); C189(0.96)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C129(0.92); C151(0.96); C189(1.01); C338(1.06)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C129(1.04); C151(1.11); C338(1.14); C189(1.15)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C151(0.97); C129(0.99); C338(1.02); C189(1.16)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C338(0.93); C227(1.03); C151(1.20); C129(1.25)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C129(0.87); C338(0.97); C227(0.98); C151(1.00)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C129(0.90); C151(1.01); C338(1.05); C227(1.09)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C189(0.74); C129(0.77); C151(0.90); C338(0.96)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C129(0.71); C189(0.87); C338(0.87); C151(0.90)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C129(0.96); C57(0.98); C60(0.98); C151(1.02)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C151(0.94); C129(0.99); C189(1.06); C204(1.13)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C338(0.80); C129(0.83); C151(0.83); C479(0.84)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C338(0.80); C189(0.96); C227(1.10); C129(1.12)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C57(1.06); C60(1.06); C189(1.06); C151(1.07)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C189(1.00); C151(1.00); C57(1.01); C60(1.01)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C151(0.90); C204(0.93); C189(1.00); C479(1.09)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C204(0.85); C151(0.95); C57(1.07); C60(1.07)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C151(0.88); C204(0.91); C479(0.95); C484(0.95)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C151(0.89); C204(0.90); C189(0.98); C338(1.07)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C151(0.99); C189(1.03); C204(1.10); C57(1.12)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C213(0.72); C215(0.72); C204(0.84); C389(0.84)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C479(1.05); C484(1.05); C189(1.07); C227(1.07)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C204(1.05); C57(1.05); C60(1.05); C227(1.09)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C479(0.92); C484(0.92); C57(0.94); C60(0.94)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C479(0.57); C484(0.57); C151(0.90); C204(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C151(0.83); C204(0.84); C189(1.05); C213(1.08)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C479(0.70); C484(0.70); C57(0.94); C60(0.94)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C151(0.95); C204(1.07); C189(1.14); C57(1.17)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C204(0.85); C151(1.05); C389(1.08); C189(1.12)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C204(0.64); C189(0.72); C479(0.74); C389(0.84)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C189(0.18)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C479(1.01); C484(1.01); C129(0.87); C151(0.93)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C129(0.92); C57(0.93); C60(0.93); C204(0.97)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C129(0.98); C189(1.10); C57(1.13); C60(1.13)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 C213(0.00); C389(0.00)  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C338(1.28); C227(1.06); C479(1.04); C484(1.04)  LDD0078  [8]
 LDCM0108  Chloroacetamide HeLa C389(0.00); C189(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C338(0.79)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C204(0.79); C57(0.96); C60(0.96); C189(1.04)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C189(0.86); C338(0.92); C227(1.10); C204(1.13)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C338(0.79); C204(0.86); C479(0.90); C484(0.90)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C129(0.56); C189(0.99); C227(1.06); C57(1.08)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C129(0.41); C57(0.75); C60(0.75); C227(0.79)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C129(0.71); C57(0.77); C60(0.77); C189(0.98)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C129(0.81); C57(0.88); C60(0.88); C189(0.95)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C57(0.53); C60(0.53); C338(0.68); C213(0.80)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C213(0.47); C215(0.47); C57(0.48); C60(0.48)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C57(0.52); C60(0.52); C213(0.63); C215(0.63)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C57(0.52); C60(0.52); C213(0.73); C215(0.73)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C57(0.58); C60(0.58); C338(0.71); C189(0.94)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C338(0.85); C189(0.86); C227(0.98); C204(1.00)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C57(0.53); C60(0.53); C338(0.69); C213(0.73)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C57(0.48); C60(0.48); C338(0.74); C204(0.88)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C129(0.50); C189(0.80); C204(0.92); C227(0.98)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C129(0.67); C189(0.75); C204(1.20); C227(1.31)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C129(0.69); C189(0.81); C227(1.07); C204(1.08)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C129(0.70); C189(0.86); C227(1.23); C204(1.30)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C129(0.54); C189(0.81); C227(0.97); C204(1.08)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C189(1.02); C227(1.05); C204(1.23); C57(1.82)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C204(0.80); C57(0.84); C60(0.84); C189(1.05)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C189(0.96); C204(1.02); C227(1.02); C57(1.10)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C189(0.94); C479(1.09); C338(1.11); C227(1.16)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C204(0.77); C227(1.00); C189(1.06); C57(1.31)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C227(0.94); C189(0.98); C151(1.19); C57(2.02)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C204(0.82); C189(0.94); C227(1.00); C151(1.14)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C189(0.92); C151(0.94); C204(1.05); C227(1.20)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C189(0.96); C151(1.12); C227(1.25); C204(1.42)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C204(0.77); C338(0.83); C57(0.95); C60(0.95)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C338(0.77); C227(0.82); C479(0.84); C484(0.84)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C204(0.77); C338(0.87); C227(0.97); C57(1.00)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C338(0.73); C204(0.94); C227(1.22); C57(1.25)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C338(0.89); C189(0.91); C227(1.09); C57(1.23)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C189(0.90); C204(0.91); C338(0.97); C57(1.04)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C189(0.83); C338(0.86); C227(0.94); C204(1.05)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C189(0.89); C227(1.00); C151(1.00); C338(1.01)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C57(0.85); C60(0.85); C338(0.92); C151(0.98)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C57(0.99); C60(0.99); C151(1.00); C338(1.00)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C338(0.82); C151(0.94); C57(0.95); C60(0.95)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C204(0.82); C338(0.92); C189(0.93); C227(0.98)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C338(0.87); C57(0.98); C60(0.98); C151(1.00)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C57(0.80); C60(0.80); C338(0.89); C151(0.95)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C57(0.78); C60(0.78); C151(0.93); C189(0.94)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C189(0.95); C151(1.05); C338(1.05); C57(1.16)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C338(0.94); C189(0.98); C151(1.12); C57(1.22)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C479(1.44); C484(1.44); C151(0.94); C189(0.97)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C479(1.88); C484(1.88); C151(1.01); C189(1.00)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C479(1.13); C484(1.13); C151(1.05); C189(1.04)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C479(1.59); C484(1.59); C151(1.21); C189(1.16)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C479(1.47); C484(1.47); C151(1.14); C189(1.14)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C479(0.91); C484(1.26); C129(1.07); C189(1.00)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C479(1.26); C484(1.26); C151(1.02); C189(1.02)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C151(0.97); C189(0.98); C204(1.15); C227(0.97)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C479(1.01); C484(1.01); C151(0.97); C189(1.13)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C479(1.36); C484(1.36); C151(1.04); C189(1.26)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C479(0.98); C484(0.98); C151(1.01); C189(0.94)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C479(1.18); C484(1.18); C151(0.94); C189(1.12)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C479(0.89); C484(0.89); C151(0.93); C189(1.05)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C479(0.87); C484(0.87); C151(0.96); C189(0.90)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C479(1.17); C484(1.17); C151(1.02); C189(0.89)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C479(0.86); C484(1.21); C129(1.00); C189(0.80)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C479(1.13); C484(1.13); C151(0.98); C189(0.91)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C479(1.16); C484(1.16); C151(0.95); C189(0.91)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C479(0.66); C484(0.66); C151(0.99); C189(0.85)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C479(0.97); C484(0.97); C151(1.06); C189(0.90)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C479(1.05); C484(1.05); C151(1.08); C189(0.94)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C479(0.95); C484(0.95); C151(0.90); C189(0.80)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C479(1.31); C484(1.31); C129(1.07); C189(1.10)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C479(1.48); C484(1.48); C129(1.04); C189(1.05)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C479(1.36); C484(1.36); C129(1.07); C189(1.03)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C479(0.84); C484(0.84); C129(1.23); C189(1.04)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C479(1.22); C484(1.74); C129(1.19); C189(0.97)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C479(1.23); C484(1.23); C129(1.07); C189(1.01)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C479(1.14); C484(1.14); C129(1.09); C189(0.88)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C479(2.23); C484(2.23); C129(1.01); C189(0.81)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C479(1.51); C484(1.51); C129(0.86); C189(0.82)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C479(1.23); C484(1.23); C129(0.90); C189(0.87)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C479(1.03); C484(1.03); C129(1.07); C189(0.90)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C479(1.15); C484(1.15); C129(0.95); C189(0.79)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C479(1.29); C484(1.29); C129(0.97); C189(0.96)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C479(1.45); C484(1.45); C129(1.01); C189(0.92)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C479(1.58); C484(1.58); C129(1.17); C189(0.83)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C479(1.82); C484(2.93); C129(1.27); C189(1.06)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C479(1.15); C484(1.15); C129(1.05); C189(0.88)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C479(0.93); C484(0.93); C151(1.40); C189(1.24)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C479(1.15); C484(1.15); C151(1.34); C189(1.10)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C479(1.85); C484(1.85); C151(1.32); C189(1.33)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C479(0.69); C484(0.69); C151(1.51); C189(1.38)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C479(1.22); C484(1.22); C151(1.25); C189(1.02)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C479(1.50); C484(1.50); C151(1.35); C189(1.53)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C479(0.90); C484(0.90); C151(1.58); C189(1.43)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C479(0.83); C484(0.83); C151(1.28); C189(1.35)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C479(1.18); C484(1.18); C151(1.64); C189(1.28)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C479(1.07); C484(1.50); C129(1.44); C189(0.94)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C479(1.40); C484(1.40); C151(1.45); C189(1.58)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C479(1.16); C484(1.16); C151(1.58); C189(1.16)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C479(1.62); C484(1.62); C151(1.59); C189(1.21)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C479(1.43); C484(1.43); C151(1.47); C189(1.19)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C479(1.59); C484(1.59); C151(1.31); C189(1.36)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C479(0.97); C484(0.97); C151(1.00); C204(1.13)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C479(0.78); C484(0.78); C151(0.97); C204(1.38)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C479(1.13); C484(1.13); C151(1.32); C204(1.23)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C479(0.94); C484(0.94); C151(1.30); C204(1.22)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C479(20.00); C484(20.00); C129(1.13); C189(0.96)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C479(0.91); C484(0.91); C151(1.09); C204(1.07)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C479(0.82); C484(0.82); C151(1.15); C204(1.11)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C479(0.71); C484(0.71); C151(1.39); C204(1.32)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C479(0.91); C484(0.91); C151(1.22); C204(1.20)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C479(0.99); C484(0.99); C151(1.42); C204(1.45)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C479(1.06); C484(1.06); C151(1.13); C204(1.07)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C479(0.95); C484(0.95); C151(1.00); C204(1.04)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C479(0.94); C484(0.94); C151(0.97); C204(1.22)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C479(0.88); C484(0.88); C151(1.23); C204(1.48)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C479(0.92); C484(0.92); C151(1.53); C204(1.45)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C479(1.52); C484(1.84); C129(1.27); C189(0.90)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C479(1.14); C484(1.14); C151(0.75); C204(0.79)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C479(1.28); C484(1.28); C151(1.11); C189(1.09)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C479(1.01); C484(1.01); C151(0.96); C189(1.20)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C479(0.98); C484(0.98); C151(0.93); C189(1.34)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C479(1.25); C484(1.25); C151(1.14); C189(1.17)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C479(1.55); C484(1.55); C151(1.01); C189(1.18)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C479(1.14); C484(1.14); C151(1.06); C189(1.23)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C479(1.08); C484(1.08); C151(1.07); C189(1.34)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C479(1.01); C484(1.01); C151(1.10); C189(1.16)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C479(1.05); C484(1.05); C151(1.09); C189(1.24)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C227(1.07); C129(0.93); C204(1.04); C389(0.90)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C213(2.56); C479(1.99); C484(1.96); C338(1.89)  LDD1702  [5]
 LDCM0625  F8 Ramos 1.37; C189(1.46); C338(3.36)  LDD2187  [22]
 LDCM0572  Fragment10 MDA-MB-231 C389(1.51)  LDD1389  [23]
 LDCM0573  Fragment11 MDA-MB-231 C389(0.52)  LDD1467  [23]
 LDCM0574  Fragment12 Ramos 0.74  LDD2191  [22]
 LDCM0575  Fragment13 MDA-MB-231 C389(1.19)  LDD1395  [23]
 LDCM0576  Fragment14 MDA-MB-231 C389(2.47)  LDD1397  [23]
 LDCM0577  Fragment15 MDA-MB-231 C389(2.38)  LDD1399  [23]
 LDCM0579  Fragment20 MDA-MB-231 C389(3.22)  LDD1402  [23]
 LDCM0580  Fragment21 MDA-MB-231 C389(1.58)  LDD1404  [23]
 LDCM0581  Fragment22 MDA-MB-231 C389(1.24)  LDD1406  [23]
 LDCM0582  Fragment23 MDA-MB-231 C389(5.51)  LDD1408  [23]
 LDCM0584  Fragment25 MDA-MB-231 C389(0.87)  LDD1411  [23]
 LDCM0578  Fragment27 MDA-MB-231 C389(0.94)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C389(1.04)  LDD1415  [23]
 LDCM0587  Fragment29 MDA-MB-231 C389(1.14)  LDD1417  [23]
 LDCM0588  Fragment30 MDA-MB-231 C389(1.20)  LDD1419  [23]
 LDCM0589  Fragment31 MDA-MB-231 C389(1.05)  LDD1477  [23]
 LDCM0590  Fragment32 MDA-MB-231 C389(1.56)  LDD1423  [23]
 LDCM0468  Fragment33 HCT 116 C479(0.93); C484(0.93); C151(1.49); C189(1.51)  LDD0785  [8]
 LDCM0596  Fragment38 MDA-MB-231 C389(1.49)  LDD1433  [23]
 LDCM0566  Fragment4 MDA-MB-231 C389(1.64)  LDD1378  [23]
 LDCM0598  Fragment40 MDA-MB-231 C389(0.88)  LDD1436  [23]
 LDCM0599  Fragment41 MDA-MB-231 C389(1.78)  LDD1438  [23]
 LDCM0601  Fragment43 MDA-MB-231 C389(1.10)  LDD1441  [23]
 LDCM0602  Fragment44 MDA-MB-231 C389(0.82)  LDD1443  [23]
 LDCM0603  Fragment45 MDA-MB-231 C389(5.58)  LDD1444  [23]
 LDCM0604  Fragment46 MDA-MB-231 C389(1.10)  LDD1445  [23]
 LDCM0605  Fragment47 MDA-MB-231 C389(2.17)  LDD1446  [23]
 LDCM0608  Fragment50 MDA-MB-231 C389(1.82)  LDD1449  [23]
 LDCM0427  Fragment51 HCT 116 C479(1.02); C484(1.02); C151(0.93); C189(0.92)  LDD0744  [8]
 LDCM0610  Fragment52 MDA-MB-231 C389(1.09)  LDD1452  [23]
 LDCM0611  Fragment53 MDA-MB-231 C389(1.00)  LDD1454  [23]
 LDCM0612  Fragment54 MDA-MB-231 C389(1.05)  LDD1456  [23]
 LDCM0613  Fragment55 MDA-MB-231 C389(1.02)  LDD1457  [23]
 LDCM0614  Fragment56 MDA-MB-231 C389(1.57)  LDD1458  [23]
 LDCM0569  Fragment7 MDA-MB-231 C389(1.68)  LDD1383  [23]
 LDCM0570  Fragment8 MDA-MB-231 C389(2.08)  LDD1385  [23]
 LDCM0571  Fragment9 MDA-MB-231 C389(1.17)  LDD1387  [23]
 LDCM0022  KB02 HCT 116 C389(1.71); C227(1.59); C57(1.31); C60(1.31)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C389(2.87); C227(2.65); C57(1.61); C60(1.61)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C389(5.39); C227(1.56); C57(1.17); C60(1.17)  LDD0082  [8]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C212(1.32)  LDD2102  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C479(0.72)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C66(2.63); C479(0.80); C212(1.13); C213(1.13)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C66(0.19)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C66(2.48)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C676(0.97); C189(2.59)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C212(0.90); C213(1.16); C215(0.77)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C676(0.81); C212(1.08); C213(1.08)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C66(3.45); C479(1.21); C212(1.05); C213(0.98)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C676(0.35)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C676(1.13); C189(2.11)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C479(0.79); C213(0.94)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C676(0.63)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C676(0.61)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C189(0.97)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C479(0.68); C213(0.79)  LDD2114  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C66(0.23)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C66(0.27); C212(2.61)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C189(0.35); C66(0.34)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C676(1.07)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C66(0.22); C213(2.15)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C129(1.01)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C66(0.49)  LDD2126  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C129(1.20)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C676(1.08); C129(0.99)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C676(0.93); C479(0.93); C212(0.80); C213(0.80)  LDD2141  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C66(0.95)  LDD2143  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C189(3.68)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C66(0.64)  LDD2145  [5]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C189(0.95)  LDD2147  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C66(0.38)  LDD2149  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C66(2.09)  LDD2151  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C66(5.22)  LDD2153  [5]
 LDCM0170  Structure8 Ramos 20.00  LDD0433  [24]
 LDCM0003  Sulforaphane MDA-MB-231 2.48  LDD0160  [6]
 LDCM0021  THZ1 HCT 116 C57(1.03); C60(1.03); C479(1.35); C484(1.35)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Proteasome subunit alpha type-3 (PSMA3) Peptidase T1A family P25788
Mitogen-activated protein kinase 7 (MAPK7) CMGC Ser/Thr protein kinase family Q13164
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Telomerase reverse transcriptase (TERT) Reverse transcriptase family O14746
Methylcytosine dioxygenase TET2 (TET2) TET family Q6N021
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
T-box transcription factor TBX2 (TBX2) . Q13207
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 6 (FAS) . P25445
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Kelch-like protein 20 (KLHL20) . Q9Y2M5
Period circadian protein homolog 2 (PER2) . O15055

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Arsenic Trioxide Small molecular drug DB01169

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.