Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment45  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 20.0
 LDTP02198  Cathepsin D (CTSD) C117 20.0
 LDTP13147  Cathepsin Z (CTSZ) C92 20.0
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 20.0
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 20.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 20.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 20.0
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 20.0
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 20.0
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 20.0
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 20.0
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 20.0
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 19.7
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 16.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 12.4
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 9.3
 LDTP05859  Integrin-linked protein kinase (ILK) C346 6.9
 LDTP03496  Protein PML (PML) C389 5.6
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 5.4
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 5.1
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 4.7
 LDTP02223  Cathepsin B (CTSB) C211 4.7
 LDTP02672  Elongation factor 2 (EEF2) C41 4.6
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 4.5
 LDTP02223  Cathepsin B (CTSB) C319 4.1
 LDTP02911  Calpain-2 catalytic subunit (CAPN2) C640 3.7
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 3.7
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 3.6
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 3.5
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 3.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 3.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 3.1
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 3.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 2.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 2.8
 LDTP04374  Dynamin-2 (DNM2) C27 2.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 2.5
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 2.4
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 2.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 2.1
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.1
 LDTP04689  Adenosine kinase (ADK) C353 2.1
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.9
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.7
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.4
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.4
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.2
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) C914 1.2
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 1.0
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.9
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.7
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04801  Gasdermin-D (GSDMD) C268 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 6.7
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 5.3
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 2.8
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.8
 LDTP00501  Exportin-1 (XPO1) C34 1.8
 LDTP04662  Exportin-2 (CSE1L) C842 1.7
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.5
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.3
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.2
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 20.0
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 20.0
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 3.6
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 3.0
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.3
Other
Click to Show/Hide to Show 58 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 20.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 20.0
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 20.0
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 20.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 20.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 20.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 20.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 20.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 20.0
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 20.0
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 20.0
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 20.0
 LDTP03620  Protein S100-A11 (S100A11) C91 20.0
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 20.0
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 20.0
 LDTP00727  U4/U6.U5 tri-snRNP-associated protein 1 (SART1) C645 20.0
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 20.0
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 15.1
 LDTP05867  Treacle protein (TCOF1) C38 13.3
 LDTP12443  Anillin (ANLN) C712 6.2
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 6.2
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 5.8
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 5.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 5.5
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 5.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 4.7
 LDTP13580  Coronin-1C (CORO1C) C420 4.6
 LDTP10864  Calponin-2 (CNN2) C215 4.6
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 4.3
 LDTP10864  Calponin-2 (CNN2) C164 4.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 4.1
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 3.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 3.5
 LDTP02205  Tubulin beta chain (TUBB) C354 3.3
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 3.0
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 3.0
 LDTP06330  Plectin (PLEC) C3110 2.9
 LDTP02205  Tubulin beta chain (TUBB) C239 2.7
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 2.6
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 2.4
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 2.3
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.3
 LDTP13964  MOB-like protein phocein (MOB4) C134 2.1
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.0
 LDTP04487  Cyclin-H (CCNH) C244 1.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.5
 LDTP13580  Coronin-1C (CORO1C) C456 1.5
 LDTP02692  Plastin-3 (PLS3) C33 1.4
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.3
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.3
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.2
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 1.2
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.1
 LDTP03244  Cofilin-1 (CFL1) C80 0.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.