Details of the Target

General Information of Target

Target ID LDTP00501
Target Name Exportin-1 (XPO1)
Gene Name XPO1
Gene ID 7514
Synonyms
CRM1; Exportin-1; Exp1; Chromosome region maintenance 1 protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAIMTMLADHAARQLLDFSQKLDINLLDNVVNCLYHGEGAQQRMAQEVLTHLKEHPDAW
TRVDTILEFSQNMNTKYYGLQILENVIKTRWKILPRNQCEGIKKYVVGLIIKTSSDPTCV
EKEKVYIGKLNMILVQILKQEWPKHWPTFISDIVGASRTSESLCQNNMVILKLLSEEVFD
FSSGQITQVKSKHLKDSMCNEFSQIFQLCQFVMENSQNAPLVHATLETLLRFLNWIPLGY
IFETKLISTLIYKFLNVPMFRNVSLKCLTEIAGVSVSQYEEQFVTLFTLTMMQLKQMLPL
NTNIRLAYSNGKDDEQNFIQNLSLFLCTFLKEHDQLIEKRLNLRETLMEALHYMLLVSEV
EETEIFKICLEYWNHLAAELYRESPFSTSASPLLSGSQHFDVPPRRQLYLPMLFKVRLLM
VSRMAKPEEVLVVENDQGEVVREFMKDTDSINLYKNMRETLVYLTHLDYVDTERIMTEKL
HNQVNGTEWSWKNLNTLCWAIGSISGAMHEEDEKRFLVTVIKDLLGLCEQKRGKDNKAII
ASNIMYIVGQYPRFLRAHWKFLKTVVNKLFEFMHETHDGVQDMACDTFIKIAQKCRRHFV
QVQVGEVMPFIDEILNNINTIICDLQPQQVHTFYEAVGYMIGAQTDQTVQEHLIEKYMLL
PNQVWDSIIQQATKNVDILKDPETVKQLGSILKTNVRACKAVGHPFVIQLGRIYLDMLNV
YKCLSENISAAIQANGEMVTKQPLIRSMRTVKRETLKLISGWVSRSNDPQMVAENFVPPL
LDAVLIDYQRNVPAAREPEVLSTMAIIVNKLGGHITAEIPQIFDAVFECTLNMINKDFEE
YPEHRTNFFLLLQAVNSHCFPAFLAIPPTQFKLVLDSIIWAFKHTMRNVADTGLQILFTL
LQNVAQEEAAAQSFYQTYFCDILQHIFSVVTDTSHTAGLTMHASILAYMFNLVEEGKIST
SLNPGNPVNNQIFLQEYVANLLKSAFPHLQDAQVKLFVTGLFSLNQDIPAFKEHLRDFLV
QIKEFAGEDTSDLFLEEREIALRQADEEKHKRQMSVPGIFNPHEIPEEMCD
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Exportin family
Subcellular location
Cytoplasm
Function
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap.; (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
TTD ID
T51407
Uniprot ID
O14980
DrugMap ID
TTCJUR4
Ensemble ID
ENST00000401558.7
HGNC ID
HGNC:12825
ChEMBL ID
CHEMBL5661

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.14  LDD0402  [1]
A-EBA
 Probe Info  		4.17  LDD0215  [2]
CHEMBL5175495
 Probe Info  		5.49  LDD0196  [3]
CY-1
 Probe Info  		8.72  LDD0243  [4]
CY4
 Probe Info  		8.54  LDD0244  [4]
N1
 Probe Info  		23.72  LDD0242  [4]
TH211
 Probe Info  		Y36(6.89)  LDD0257  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [7]
BTD
 Probe Info  		C99(4.50)  LDD1699  [8]
ONAyne
 Probe Info  		N.A.  LDD0273  [9]
Probe 1
 Probe Info  		Y308(290.40); Y454(97.99); Y841(20.00)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C119(0.00); C164(0.00); C327(0.00); C34(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C164(1.16)  LDD0460  [11]
AHL-Pu-1
 Probe Info  		C34(2.34); C119(2.27); C1070(2.00)  LDD0169  [12]
EA-probe
 Probe Info  		N.A.  LDD0440  [13]
HHS-482
 Probe Info  		Y77(0.80)  LDD0285  [14]
HHS-475
 Probe Info  		Y463(0.50); Y77(0.59); Y36(0.83)  LDD0264  [15]
DBIA
 Probe Info  		C1070(1.24); C498(1.06); C528(0.98)  LDD0078  [16]
5E-2FA
 Probe Info  		H704(0.00); H988(0.00)  LDD2235  [17]
ATP probe
 Probe Info  		K686(0.00); K700(0.00); K531(0.00); K54(0.00)  LDD0199  [18]
4-Iodoacetamidophenylacetylene
 Probe Info  		C723(0.00); C528(0.00); C369(0.00); C327(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		C34(0.00); C119(0.00); C164(0.00); C528(0.00)  LDD0032  [20]
IPIAA_H
 Probe Info  		C498(0.00); C34(0.00)  LDD0030  [21]
IPIAA_L
 Probe Info  		C119(0.00); C34(0.00); C498(0.00)  LDD0031  [21]
Lodoacetamide azide
 Probe Info  		C723(0.00); C327(0.00); C528(0.00); C369(0.00)  LDD0037  [19]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [22]
NAIA_4
 Probe Info  		C34(0.00); C528(0.00); C699(0.00); 0.00  LDD2226  [23]
TFBX
 Probe Info  		C164(0.00); C119(0.00)  LDD0027  [22]
WYneN
 Probe Info  		C528(0.00); C34(0.00); C723(0.00); C164(0.00)  LDD0021  [24]
WYneO
 Probe Info  		C99(0.00); C119(0.00); C528(0.00); C164(0.00)  LDD0022  [24]
Compound 10
 Probe Info  		C119(0.00); C34(0.00)  LDD2216  [25]
Compound 11
 Probe Info  		N.A.  LDD2213  [25]
ENE
 Probe Info  		C528(0.00); C164(0.00); C119(0.00)  LDD0006  [24]
IPM
 Probe Info  		C528(0.00); C164(0.00); C723(0.00); C498(0.00)  LDD0005  [24]
NHS
 Probe Info  		K680(0.00); K339(0.00); K446(0.00); K693(0.00)  LDD0010  [24]
PF-06672131
 Probe Info  		C119(0.00); C528(0.00)  LDD0017  [26]
SF
 Probe Info  		N.A.  LDD0028  [27]
STPyne
 Probe Info  		K693(0.00); K190(0.00); K700(0.00); K531(0.00)  LDD0009  [24]
VSF
 Probe Info  		C164(0.00); C528(0.00); C119(0.00); C723(0.00)  LDD0007  [24]
Phosphinate-6
 Probe Info  		C119(0.00); C34(0.00); C528(0.00); C699(0.00)  LDD0018  [28]
Ox-W18
 Probe Info  		N.A.  LDD2175  [29]
1c-yne
 Probe Info  		K479(0.00); K680(0.00); K54(0.00); K426(0.00)  LDD0228  [30]
Acrolein
 Probe Info  		C164(0.00); H466(0.00); H56(0.00); H52(0.00)  LDD0217  [31]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [31]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [31]
Methacrolein
 Probe Info  		C164(0.00); C119(0.00); C528(0.00)  LDD0218  [31]
W1
 Probe Info  		C119(0.00); C164(0.00); C99(0.00); C498(0.00)  LDD0236  [32]
AOyne
 Probe Info  		9.10  LDD0443  [33]
NAIA_5
 Probe Info  		C723(0.00); C267(0.00); C528(0.00); C327(0.00)  LDD2223  [23]
HHS-465
 Probe Info  		Y77(0.00); Y36(0.00)  LDD2240  [34]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C213
 Probe Info  		25.28  LDD1887  [35]
FFF probe13
 Probe Info  		5.86  LDD0475  [36]
FFF probe2
 Probe Info  		5.08  LDD0463  [36]
FFF probe3
 Probe Info  		6.42  LDD0465  [36]
JN0003
 Probe Info  		5.96  LDD0469  [36]
STS-1
 Probe Info  		8.67  LDD0136  [37]
STS-2
 Probe Info  		22.00  LDD0138  [37]
VE-P
 Probe Info  		N.A.  LDD0396  [38]
Staurosporine capture compound
 Probe Info  		2.67  LDD0083  [39]
DA-2
 Probe Info  		N.A.  LDD0070  [40]
OEA-DA
 Probe Info  		3.33  LDD0046  [41]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C99(0.79)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C119(1.11); C528(0.95); C99(0.91)  LDD2112  [8]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C119(0.75)  LDD2095  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C119(0.96); C99(1.08)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C119(1.19); C99(0.70)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C119(1.38); C99(1.19)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C528(0.95); C99(1.01)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C119(0.51); C99(0.47)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C119(1.06); C99(0.68)  LDD2131  [8]
 LDCM0025  4SU-RNA DM93 C585(4.04)  LDD0170  [12]
 LDCM0026  4SU-RNA+native RNA HEK-293T C34(2.34); C119(2.27); C1070(2.00)  LDD0169  [12]
 LDCM0214  AC1 HCT 116 C528(1.12); C1070(1.04); C119(0.92); C164(0.98)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C528(1.01); C1070(1.63); C119(0.94); C164(1.03)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C528(0.91); C1070(1.22); C119(0.88); C164(0.88)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C528(0.86); C1070(1.17); C119(0.88); C164(0.74)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C528(0.88); C1070(1.30); C119(0.83); C164(0.80)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C528(0.88); C1070(1.68); C119(0.88); C164(0.97)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C528(0.82); C1070(1.55); C119(0.83); C164(0.87)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C528(0.94); C1070(1.69); C119(0.86); C164(0.87)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C528(1.00); C1070(1.54); C119(0.91); C164(1.03)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C528(0.99); C1070(1.24); C119(0.87); C164(0.89)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C528(1.18); C1070(0.96); C119(0.96); C164(1.07)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C528(1.01); C1070(0.81); C119(0.87); C164(0.82)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C528(0.99); C1070(1.61); C119(0.97); C164(0.99)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C528(1.16); C1070(1.05); C119(0.84); C164(0.74)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C528(0.93); C1070(1.04); C119(0.86); C164(0.89)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C528(1.00); C1070(1.13); C119(0.85); C164(0.78)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C528(1.00); C1070(1.07); C119(0.98); C164(0.98)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C528(0.99); C1070(1.29); C119(0.94); C164(1.05)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C528(1.10); C1070(1.83); C119(0.97); C164(1.03)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C528(1.11); C1070(1.83); C119(0.95); C164(1.06)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C528(1.04); C1070(1.17); C119(1.16); C164(1.02)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C528(0.95); C1070(1.34); C119(1.04); C164(1.01)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C528(1.09); C1070(1.46); C119(1.00); C164(0.99)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C528(1.02); C1070(1.18); C119(0.98); C164(1.00)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C528(1.06); C1070(1.71); C119(0.73); C164(1.04)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C528(1.08); C1070(1.20); C119(1.18); C164(0.98)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C528(1.17); C1070(1.31); C119(0.96); C164(1.08)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C528(1.07); C1070(1.06); C119(0.90); C164(0.97)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C528(1.05); C1070(1.13); C119(1.07); C164(1.05)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C528(1.27); C1070(1.25); C119(0.80); C164(1.01)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C528(1.40); C1070(1.67); C119(0.97); C164(1.10)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C528(1.41); C1070(1.39); C119(1.02); C164(1.06)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C528(1.11); C1070(0.63); C119(1.31); C164(1.29)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C528(0.88); C1070(0.73); C119(1.17); C164(1.02)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C528(1.10); C1070(0.97); C119(1.11); C164(1.11)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C528(0.90); C1070(0.83); C119(0.97); C164(1.00)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C528(1.04); C1070(1.05); C119(1.32); C164(1.15)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C528(1.04); C1070(0.86); C119(1.10); C164(1.06)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C528(1.11); C1070(1.13); C119(1.10); C164(1.14)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C528(1.15); C1070(0.79); C119(1.19); C164(1.11)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C528(0.95); C1070(1.07); C119(1.21); C164(1.18)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C528(0.96); C1070(0.89); C119(1.18); C164(1.12)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C528(0.90); C1070(1.40); C119(1.33); C164(1.12)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C528(1.01); C1070(1.27); C119(1.31); C164(1.18)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C528(0.91); C1070(1.54); C119(0.90); C164(0.86)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C528(1.05); C1070(1.39); C119(1.29); C164(1.23)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C528(1.17); C1070(1.37); C119(1.23); C164(1.15)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C528(0.96); C1070(1.12); C119(1.13); C164(1.08)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C528(0.94); C99(0.81); C498(0.82); C369(0.85)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C369(0.58); C99(0.71); C498(0.81); C528(0.84)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C369(0.71); C498(0.75); C99(0.87); C164(0.94)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C99(0.76); C369(0.77); C498(0.80); C119(1.03)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C369(0.72); C99(0.89); C498(0.95); C119(1.04)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C369(0.67); C99(0.78); C498(1.03); C119(1.13)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C369(0.59); C99(0.81); C498(0.96); C119(1.01)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C99(0.81); C369(0.88); C119(0.95); C498(0.99)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C498(0.70); C369(0.79); C99(0.82); C528(0.93)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C498(0.76); C99(0.85); C119(0.97); C164(1.01)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C99(0.69); C369(0.74); C498(0.83); C119(1.02)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C99(0.85); C369(0.87); C498(0.92); C119(1.26)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C528(1.04); C119(1.06); C164(1.02); C34(0.99)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C528(1.05); C119(1.01); C164(1.14); C34(0.92)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C528(1.06); C119(1.01); C164(1.05); C34(1.08)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C528(0.98); C119(0.92); C164(1.01); C34(0.88)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C34(0.75); C1070(0.93); C164(0.99); C119(1.01)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C34(0.63); C369(0.82); C1070(0.95); C119(1.00)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C34(0.92); C369(0.92); C164(0.95); C119(0.95)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C119(0.85); C369(0.88); C1070(0.92); C164(0.93)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C119(0.94); C164(0.96); C99(0.97); C528(1.02)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C1070(0.89); C164(0.99); C34(1.01); C119(1.02)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C34(0.87); C1070(1.00); C119(1.01); C164(1.02)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C34(0.84); C1070(0.89); C164(1.00); C723(1.00)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C34(0.73); C119(0.93); C528(0.95); C164(0.96)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C498(0.86); C723(0.87); C1070(0.91); C164(0.97)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C164(0.95); C498(0.96); C1070(0.96); C723(1.04)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C1070(0.88); C528(0.90); C164(0.92); C498(0.96)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C498(0.80); C1070(0.93); C164(0.95); C723(1.04)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C99(0.92); C164(0.92); C528(0.97); C119(1.00)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C498(0.86); C369(0.89); C1070(0.89); C119(0.91)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C164(0.90); C99(0.93); C528(0.97); C119(1.01)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C1070(0.93); C164(0.94); C528(1.01); C498(1.03)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C498(0.72); C164(0.97); C99(1.03); C528(1.07)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C498(0.77); C99(0.88); C164(0.90); C528(0.92)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C498(0.88); C723(0.90); C99(0.90); C164(0.94)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C723(0.75); C1070(0.81); C34(0.85); C528(0.91)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C34(0.83); C723(0.85); C119(0.96); C1070(0.97)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C723(0.77); C369(0.96); C528(0.97); C164(0.99)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C119(0.91); C723(0.96); C369(1.01); C528(1.02)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C34(0.83); C1070(0.87); C723(0.88); C164(0.99)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C369(0.73); C1070(0.83); C119(0.95); C164(0.98)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C369(0.78); C34(0.89); C723(0.95); C119(1.01)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C723(0.86); C369(0.97); C528(0.97); C164(1.08)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C119(0.93); C34(0.97); C99(0.97); C528(0.98)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C723(0.93); C369(1.01); C34(1.02); C164(1.03)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C723(0.83); C34(0.87); C99(0.99); C119(1.01)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C723(0.85); C34(0.90); C119(1.02); C99(1.03)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C369(0.66); C164(1.00); C528(1.02); C119(1.03)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C369(0.54); C99(1.07); C164(1.07); C723(1.11)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C369(0.57); C164(0.99); C34(1.04); C99(1.13)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C369(0.79); C99(1.05); C164(1.12); C723(1.21)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C369(0.76); C1070(0.91); C119(0.98); C498(1.05)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C369(0.75); C99(1.05); C119(1.15); C164(1.15)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C369(0.75); C164(0.94); C528(0.99); C119(1.02)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C369(0.77); C164(0.99); C34(1.02); C119(1.05)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C369(0.69); C99(0.89); C723(1.01); C119(1.03)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C369(0.60); C164(1.05); C119(1.07); C528(1.08)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C369(0.69); C99(0.96); C723(1.05); C164(1.11)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C369(0.82); C723(1.08); C99(1.13); C119(1.23)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C1070(0.95); C119(0.96); C164(1.09); C99(1.15)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C119(0.86); C99(0.92); C1070(0.95); C164(1.08)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C119(0.93); C99(0.94); C164(1.06); C528(1.08)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C369(0.82); C99(0.88); C498(0.88); C164(0.93)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C99(0.95); C119(0.98); C164(1.02); C528(1.07)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C164(0.98); C1070(1.02); C528(1.03); C99(1.07)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C119(0.95); C99(1.10); C164(1.12); C1070(1.15)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C164(0.98); C119(0.98); C1070(1.18); C99(1.30)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C119(1.07); C1070(1.10); C99(1.12); C528(1.14)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C119(1.04); C1070(1.04); C164(1.11); C99(1.12)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C1070(0.89); C119(0.99); C99(1.09); C164(1.10)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C119(0.97); C99(1.08); C164(1.21); C528(1.25)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C119(0.78); C1070(0.92); C327(0.96); C99(0.99)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C1070(0.77); C119(0.83); C723(0.95); C99(1.11)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C369(0.84); C119(0.90); C99(0.94); C164(1.00)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C119(0.76); C369(0.86); C327(1.03); C1070(1.06)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C1070(0.74); C119(0.85); C369(0.97); C723(1.03)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C119(0.98); C723(0.98); C99(1.07); C369(1.08)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C528(1.51); C119(0.91); C723(1.22); C1070(1.22)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C119(0.84); C1070(0.90); C369(1.15); C99(1.23)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C119(0.89); C723(1.30); C369(1.32); C1070(1.33)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C1070(0.83); C119(0.83); C723(1.07); C327(1.17)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C119(0.86); C1070(0.95); C369(0.98); C99(1.13)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C723(0.84); C369(1.01); C498(1.05); C1070(1.06)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C119(0.87); C99(0.98); C723(1.06); C1070(1.09)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C99(0.86); C369(0.91); C498(0.92); C119(0.98)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C723(0.90); C1070(0.95); C119(0.97); C99(1.05)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C369(0.46); C119(0.82); C327(0.86); C498(0.97)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C119(0.94); C1070(1.01); C369(1.33); C327(1.55)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C327(0.86); C99(1.02); C164(1.19); C528(1.20)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C99(1.03); C164(1.14); C327(1.14); C528(1.17)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C327(0.63); C99(0.95); C164(1.06); C528(1.08)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C99(0.88); C528(0.95); C164(0.99); C119(1.16)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C1070(0.90); C327(0.93); C164(0.99); C99(1.02)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C99(0.98); C327(0.99); C164(0.99); C528(1.05)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C327(0.86); C99(0.96); C528(1.01); C164(1.02)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C1070(0.86); C327(0.88); C164(1.01); C723(1.10)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C327(0.73); C99(1.13); C164(1.14); C528(1.19)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C327(0.65); C99(1.05); C528(1.09); C164(1.14)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C164(0.98); C327(1.00); C119(1.02); C99(1.02)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C327(0.92); C164(1.02); C528(1.02); C119(1.06)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C327(0.71); C164(0.92); C528(1.02); C99(1.03)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C327(0.53); C164(1.06); C99(1.08); C528(1.09)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C327(0.95); C99(1.00); C164(1.02); C119(1.08)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C498(0.66); C99(0.69); C119(0.96); C34(1.03)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C498(0.70); C99(0.73); C34(0.78); C119(0.88)  LDD0683  [16]
 LDCM0545  Acetamide MDA-MB-231 C119(0.58); C99(0.29)  LDD2138  [8]
 LDCM0248  AKOS034007472 HCT 116 C528(1.01); C1070(1.03); C119(1.08); C164(0.96)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C99(0.85); C369(0.86); C498(0.93); C528(0.95)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C369(0.88); C99(0.92); C119(1.01); C164(1.22)  LDD0592  [16]
 LDCM0020  ARS-1620 HCC44 C1070(1.24); C498(1.06); C528(0.98)  LDD0078  [16]
 LDCM0498  BS-3668 MDA-MB-231 C119(0.64); C99(0.35); C164(0.68)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C34(1.54); C528(0.56)  LDD2214  [42]
 LDCM0108  Chloroacetamide HeLa C498(0.00); H466(0.00); C164(0.00); H52(0.00)  LDD0222  [31]
 LDCM0632  CL-Sc Hep-G2 C119(3.27); C1070(2.77); C164(2.75); C99(1.42)  LDD2227  [23]
 LDCM0367  CL1 HCT 116 C498(0.86); C119(0.89); C164(0.95); C723(0.98)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C498(1.02); C164(1.11); C528(1.15); C1070(1.17)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C369(0.84); C119(0.88); C164(1.04); C528(1.12)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C99(0.68); C369(0.84); C164(0.87); C498(0.91)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C99(0.83); C164(0.86); C119(0.91); C369(0.94)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C164(0.89); C99(0.91); C369(0.94); C723(1.02)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C369(0.77); C99(0.83); C164(0.86); C498(0.86)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C34(0.95); C1070(0.98); C369(0.99); C164(1.00)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C1070(0.96); C34(1.03); C119(1.18); C164(1.19)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C34(0.94); C369(0.97); C1070(1.03); C99(1.16)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C1070(0.86); C119(1.05); C99(1.12); C369(1.12)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C34(0.73); C164(0.91); C119(0.94); C528(0.97)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C1070(0.93); C119(0.99); C498(1.13); C164(1.17)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C1070(0.87); C119(0.94); C164(0.94); C99(1.02)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C369(0.83); C34(0.89); C164(0.94); C99(0.95)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C1070(0.90); C723(0.90); C528(0.96); C164(0.96)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C498(0.90); C99(0.95); C164(0.98); C528(1.02)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C498(0.72); C164(0.89); C99(0.95); C723(0.98)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C99(0.78); C164(0.86); C119(0.91); C528(0.92)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C498(0.84); C164(0.89); C723(0.93); C528(0.95)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C34(0.85); C1070(0.95); C723(1.06); C99(1.13)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C723(0.94); C1070(1.00); C369(1.01); C119(1.02)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C369(0.87); C723(0.88); C119(1.08); C528(1.09)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C119(1.02); C1070(1.03); C99(1.10); C164(1.22)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C34(0.89); C723(0.91); C164(1.06); C119(1.12)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C164(0.70); C99(0.73); C369(0.83); C119(0.96)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C369(0.67); C723(1.05); C164(1.05); C119(1.07)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C369(0.68); C99(0.93); C723(1.02); C164(1.02)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C369(0.70); C99(1.00); C723(1.07); C164(1.08)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C528(0.97); C164(0.99); C119(1.06); C723(1.08)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C164(0.89); C119(0.89); C528(0.93); C99(0.94)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C164(0.95); C119(0.98); C528(1.01); C99(1.09)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C119(0.94); C99(0.96); C1070(0.98); C164(1.09)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C528(0.84); C119(0.94); C498(0.99); C99(1.00)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C498(0.86); C528(0.92); C99(0.96); C164(1.00)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C1070(0.87); C119(0.90); C498(0.93); C528(0.96)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C164(0.92); C119(0.95); C99(0.96); C327(1.00)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C119(0.96); C164(0.97); C723(1.03); C327(1.06)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C327(0.84); C164(0.95); C119(1.02); C1070(1.07)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C164(0.93); C99(0.94); C1070(0.99); C119(0.99)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C528(0.87); C164(0.96); C327(0.97); C119(0.99)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C99(0.98); C164(1.05); C327(1.10); C119(1.11)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C1070(1.00); C164(1.02); C99(1.03); C119(1.07)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C99(0.90); C1070(1.07); C164(1.29); C119(1.35)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C99(0.85); C164(0.93); C119(1.04); C327(1.05)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C528(1.47); C1070(1.10); C119(1.22); C164(1.10)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C528(1.67); C1070(1.17); C119(1.29); C164(0.95)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C528(1.28); C1070(1.16); C119(1.09); C164(1.03)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C528(1.20); C1070(0.99); C119(1.03); C164(0.93)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C528(1.22); C1070(1.19); C119(1.07); C164(0.99)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C528(1.17); C1070(1.19); C119(1.12); C164(1.00)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C528(0.97); C1070(0.99); C119(1.17); C164(1.01)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C528(1.20); C1070(0.94); C119(1.00); C164(0.93)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C528(1.14); C1070(0.97); C119(1.00); C164(1.07)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C528(1.09); C1070(1.17); C119(1.17); C164(1.03)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C528(1.44); C1070(1.32); C119(0.94); C164(1.00)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C528(1.33); C1070(1.12); C119(0.98); C164(1.16)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C528(1.06); C1070(1.08); C119(0.98); C164(1.14)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C528(1.09); C1070(1.13); C119(0.91); C164(1.16)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C528(1.33); C1070(1.01); C119(0.96); C164(1.18)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C528(1.29); C1070(1.00); C119(0.94); C164(1.21)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C528(1.68); C1070(0.99); C119(0.94); C164(0.93)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C528(1.77); C1070(1.21); C119(0.94); C164(1.16)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C528(1.02); C1070(0.97); C119(0.95); C164(1.23)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C528(1.45); C1070(1.00); C119(0.97); C164(1.50)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C528(1.10); C1070(1.00); C119(0.99); C164(1.21)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C528(1.14); C1070(0.96); C119(0.98); C164(1.10)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C528(1.47); C1070(0.90); C119(1.04); C164(1.19)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C528(0.96); C1070(0.84); C119(1.01); C164(0.85)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C528(0.91); C1070(0.96); C119(0.95); C164(0.89)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C528(0.89); C1070(0.78); C119(0.95); C164(0.90)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C528(0.92); C1070(0.81); C119(1.00); C164(0.91)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C528(0.85); C1070(0.92); C119(0.94); C164(1.04)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C528(0.90); C1070(0.79); C119(0.96); C164(0.85)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C528(0.93); C1070(0.74); C119(1.10); C164(0.88)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C528(0.88); C1070(0.90); C119(1.06); C164(0.87)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C528(0.84); C1070(0.92); C119(0.86); C164(0.82)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C528(2.94); C1070(0.84); C119(1.00); C164(0.83)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C528(1.31); C1070(0.72); C119(0.94); C164(0.88)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C528(0.93); C1070(0.89); C119(1.00); C164(0.93)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C528(0.87); C1070(0.85); C119(0.91); C164(0.78)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C528(0.86); C1070(0.83); C119(0.93); C164(0.83)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C528(0.93); C1070(0.85); C119(0.92); C164(0.84)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C528(0.87); C1070(1.02); C119(0.90); C164(1.02)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C528(0.89); C1070(0.90); C119(0.96); C164(0.86)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C528(1.06); C1070(1.46); C119(1.20); C164(1.06)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C528(1.05); C1070(1.19); C119(1.00); C164(1.09)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C528(1.01); C1070(1.23); C119(1.03); C164(1.03)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C528(1.02); C1070(1.31); C119(1.14); C164(0.99)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C528(1.03); C1070(1.35); C119(1.08); C164(1.03)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C528(1.24); C1070(1.37); C119(1.14); C164(1.09)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C528(0.97); C1070(1.13); C119(0.99); C164(1.09)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C528(1.20); C1070(1.47); C119(1.03); C164(0.98)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C528(1.13); C1070(1.30); C119(1.02); C164(0.89)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C528(0.96); C1070(1.05); C119(1.03); C164(1.15)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C528(1.10); C1070(1.25); C119(1.14); C164(1.03)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C528(1.04); C1070(1.23); C119(1.05); C164(1.07)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C528(1.05); C1070(1.34); C119(1.00); C164(1.04)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C528(1.03); C1070(1.41); C119(0.98); C164(1.00)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C528(1.02); C1070(1.13); C119(1.04); C164(1.03)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C528(0.94); C1070(0.81); C119(0.83); C164(0.99)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C528(0.97); C1070(0.75); C119(0.86); C164(0.97)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C528(0.96); C1070(0.93); C119(0.81); C164(1.07)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C528(1.11); C1070(0.80); C119(0.84); C164(1.10)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C528(13.95); C1070(1.37); C119(0.88); C164(1.21)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C528(0.98); C1070(0.77); C119(0.92); C164(0.99)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C528(1.03); C1070(0.79); C119(0.94); C164(1.08)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C528(1.25); C1070(0.63); C119(0.89); C164(1.26)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C528(1.17); C1070(0.76); C119(0.81); C164(1.27)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C528(1.61); C1070(0.90); C119(0.87); C164(1.42)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C528(0.90); C1070(0.91); C119(0.86); C164(1.08)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C528(0.92); C1070(0.75); C119(0.78); C164(1.06)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C528(1.09); C1070(0.75); C119(0.80); C164(1.06)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C528(1.15); C1070(0.64); C119(0.78); C164(1.15)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C528(1.42); C1070(0.73); C119(0.92); C164(1.50)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C528(1.01); C1070(1.28); C119(0.99); C164(1.09)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C528(2.35); C1070(0.75); C119(0.77); C164(1.02)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C528(1.14); C1070(0.94); C119(0.87); C164(1.03)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C528(1.44); C1070(0.92); C119(0.77); C164(0.97)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C528(1.47); C1070(0.82); C119(0.88); C164(1.02)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C528(1.04); C1070(1.07); C119(0.84); C164(0.89)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C528(1.33); C1070(0.79); C119(0.81); C164(0.91)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C528(1.18); C1070(0.85); C119(0.80); C164(0.91)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C528(1.11); C1070(0.94); C119(0.89); C164(0.91)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C528(1.30); C1070(1.08); C119(0.90); C164(0.97)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C528(1.12); C1070(1.03); C119(0.95); C164(0.99)  LDD0811  [16]
 LDCM0634  CY-0357 Hep-G2 C164(1.62); C1070(0.95); C528(0.42)  LDD2228  [23]
 LDCM0495  E2913 HEK-293T C99(0.89); C119(0.92); C528(0.97); C164(1.02)  LDD1698  [43]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C585(1.89)  LDD1702  [8]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [13]
 LDCM0625  F8 Ramos C119(1.64); C99(1.53); C528(0.90); C164(1.19)  LDD2187  [44]
 LDCM0572  Fragment10 MDA-MB-231 C34(1.16); C528(0.84)  LDD1389  [45]
 LDCM0573  Fragment11 MDA-MB-231 C34(1.19); C528(0.98)  LDD1391  [45]
 LDCM0574  Fragment12 MDA-MB-231 C34(1.20); C528(1.10)  LDD1393  [45]
 LDCM0575  Fragment13 MDA-MB-231 C34(0.92)  LDD1395  [45]
 LDCM0576  Fragment14 MDA-MB-231 C34(1.11); C528(20.00)  LDD1397  [45]
 LDCM0577  Fragment15 MDA-MB-231 C528(0.79)  LDD1399  [45]
 LDCM0579  Fragment20 MDA-MB-231 C34(1.03); C528(1.38)  LDD1402  [45]
 LDCM0580  Fragment21 MDA-MB-231 C34(0.93); C528(0.85)  LDD1404  [45]
 LDCM0581  Fragment22 MDA-MB-231 C34(1.06)  LDD1406  [45]
 LDCM0582  Fragment23 MDA-MB-231 C34(3.37)  LDD1408  [45]
 LDCM0583  Fragment24 Ramos C34(1.09); C528(20.00)  LDD1410  [45]
 LDCM0584  Fragment25 MDA-MB-231 C34(0.90)  LDD1411  [45]
 LDCM0585  Fragment26 Ramos C34(0.92); C528(0.93)  LDD1412  [45]
 LDCM0578  Fragment27 MDA-MB-231 C34(0.85); C528(1.22)  LDD1401  [45]
 LDCM0586  Fragment28 MDA-MB-231 C34(0.84)  LDD1415  [45]
 LDCM0587  Fragment29 MDA-MB-231 C34(1.30); C528(1.02)  LDD1417  [45]
 LDCM0588  Fragment30 MDA-MB-231 C34(0.74)  LDD1419  [45]
 LDCM0589  Fragment31 MDA-MB-231 C34(0.99); C528(5.19)  LDD1421  [45]
 LDCM0590  Fragment32 MDA-MB-231 C34(1.19); C528(1.68)  LDD1423  [45]
 LDCM0468  Fragment33 HCT 116 C528(1.04); C1070(1.07); C119(1.00); C164(0.98)  LDD0785  [16]
 LDCM0592  Fragment34 MDA-MB-231 C34(0.84)  LDD1427  [45]
 LDCM0593  Fragment35 MDA-MB-231 C34(0.81)  LDD1429  [45]
 LDCM0594  Fragment36 MDA-MB-231 C34(1.28)  LDD1431  [45]
 LDCM0595  Fragment37 Ramos C34(0.85); C528(0.88)  LDD1432  [45]
 LDCM0596  Fragment38 MDA-MB-231 C34(0.97); C528(1.04)  LDD1433  [45]
 LDCM0597  Fragment39 MDA-MB-231 C34(1.25)  LDD1435  [45]
 LDCM0566  Fragment4 MDA-MB-231 C34(1.01); C528(0.87)  LDD1378  [45]
 LDCM0598  Fragment40 MDA-MB-231 C34(0.82)  LDD1436  [45]
 LDCM0599  Fragment41 MDA-MB-231 C34(3.12); C528(0.64)  LDD1438  [45]
 LDCM0600  Fragment42 Ramos C34(0.89)  LDD1440  [45]
 LDCM0601  Fragment43 MDA-MB-231 C34(1.07); C528(4.57)  LDD1441  [45]
 LDCM0602  Fragment44 MDA-MB-231 C34(0.79)  LDD1443  [45]
 LDCM0603  Fragment45 MDA-MB-231 C34(1.78)  LDD1444  [45]
 LDCM0604  Fragment46 MDA-MB-231 C34(0.98); C528(0.71)  LDD1445  [45]
 LDCM0605  Fragment47 MDA-MB-231 C34(0.99); C528(2.20)  LDD1446  [45]
 LDCM0606  Fragment48 MDA-MB-231 C34(1.13)  LDD1447  [45]
 LDCM0607  Fragment49 MDA-MB-231 C34(1.88)  LDD1448  [45]
 LDCM0608  Fragment50 MDA-MB-231 C34(1.22)  LDD1449  [45]
 LDCM0427  Fragment51 HCT 116 C528(1.65); C1070(1.31); C119(1.06); C164(1.36)  LDD0744  [16]
 LDCM0610  Fragment52 MDA-MB-231 C34(1.03); C528(1.30)  LDD1452  [45]
 LDCM0611  Fragment53 MDA-MB-231 C34(0.86)  LDD1454  [45]
 LDCM0612  Fragment54 MDA-MB-231 C34(1.06)  LDD1456  [45]
 LDCM0613  Fragment55 MDA-MB-231 C34(0.94)  LDD1457  [45]
 LDCM0614  Fragment56 MDA-MB-231 C34(0.92); C528(20.00)  LDD1458  [45]
 LDCM0568  Fragment6 MDA-MB-231 C34(1.19); C528(0.69)  LDD1382  [45]
 LDCM0569  Fragment7 MDA-MB-231 C34(1.66); C528(0.70)  LDD1383  [45]
 LDCM0570  Fragment8 MDA-MB-231 C34(2.36); C528(1.81)  LDD1385  [45]
 LDCM0571  Fragment9 MDA-MB-231 C34(1.24); C528(0.84)  LDD1387  [45]
 LDCM0116  HHS-0101 DM93 Y463(0.50); Y77(0.59); Y36(0.83)  LDD0264  [15]
 LDCM0117  HHS-0201 DM93 Y36(0.75); Y77(1.21); Y463(1.51)  LDD0265  [15]
 LDCM0118  HHS-0301 DM93 Y36(0.66); Y77(0.75); Y463(0.98)  LDD0266  [15]
 LDCM0119  HHS-0401 DM93 Y36(0.72); Y77(0.79); Y463(1.60)  LDD0267  [15]
 LDCM0120  HHS-0701 DM93 Y36(0.76); Y77(0.81); Y463(1.58)  LDD0268  [15]
 LDCM0015  HNE MDA-MB-231 C119(1.00); C164(1.28)  LDD0346  [44]
 LDCM0107  IAA HeLa H466(0.00); H333(0.00); H52(0.00); C164(0.00)  LDD0221  [31]
 LDCM0123  JWB131 DM93 Y77(0.80)  LDD0285  [14]
 LDCM0124  JWB142 DM93 Y36(0.54); Y77(0.65)  LDD0286  [14]
 LDCM0125  JWB146 DM93 Y36(0.97); Y77(0.72)  LDD0287  [14]
 LDCM0126  JWB150 DM93 Y36(4.34); Y77(2.91)  LDD0288  [14]
 LDCM0127  JWB152 DM93 Y36(1.81); Y77(2.61)  LDD0289  [14]
 LDCM0128  JWB198 DM93 Y36(1.01); Y77(0.23)  LDD0290  [14]
 LDCM0129  JWB202 DM93 Y36(0.30); Y77(0.90)  LDD0291  [14]
 LDCM0130  JWB211 DM93 Y36(0.88); Y77(3.01)  LDD0292  [14]
 LDCM0179  JZ128 PC-3 C119(0.00); C164(0.00); C327(0.00); C34(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C528(2.42); C99(3.31); C723(1.12); C164(1.40)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C528(20.00); C99(3.74); C723(1.14); C164(1.87)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C528(20.00); C99(3.87); C723(1.84); C164(1.42)  LDD0082  [16]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C528(0.93); C99(1.21)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C119(1.17); C99(0.37); C164(0.63)  LDD2121  [8]
 LDCM0109  NEM HeLa H466(0.00); H333(0.00); H844(0.00); H56(0.00)  LDD0223  [31]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C119(0.78)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C119(0.92); C528(0.78); C99(1.35)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C528(0.63); C99(0.87)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C119(0.96); C528(1.29); C99(0.78)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C99(1.31)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C119(0.36); C99(0.41)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C99(0.72)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C119(0.93); C528(1.22); C99(0.99)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C119(1.16); C528(1.06); C99(0.93); C164(0.80)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C119(0.82); C99(1.17)  LDD2100  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C99(0.75)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C119(0.88); C99(1.70)  LDD2105  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C119(0.73)  LDD2106  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C119(1.16); C528(1.03); C99(0.81); C164(0.83)  LDD2107  [8]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C119(0.89); C99(0.73)  LDD2108  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C119(0.97); C528(0.85); C99(0.53); C164(0.84)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C119(1.20); C528(1.13); C99(0.54); C164(1.04)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C528(0.86); C99(0.56)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C528(0.31); C99(0.47)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C99(0.75)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C99(0.63); C164(0.30)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C119(2.47); C99(2.84)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C119(1.00); C99(0.93); C164(1.00)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C119(0.39); C99(0.43); C164(0.34)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C119(1.02); C528(0.76); C99(0.51); C164(0.82)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C119(0.33); C99(0.63)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C119(0.86); C528(0.62); C99(0.52); C164(0.65)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C528(0.75); C99(0.83)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C119(1.20); C528(1.17); C99(0.85); C164(1.20)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C119(0.64); C99(0.90)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C119(1.18); C528(1.04); C99(0.62)  LDD2129  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C119(1.19); C528(1.27); C99(0.70)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C119(1.47); C528(1.95); C99(0.97); C164(1.37)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C119(1.11); C528(1.04); C99(0.66); C164(1.04)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C119(2.35); C99(1.28)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C119(0.96); C528(0.62); C99(0.44); C164(0.80)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C119(1.03); C528(0.81); C99(0.63)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C119(1.03); C99(1.23); C164(1.39)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C119(3.05); C99(2.63)  LDD2144  [8]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C99(4.62)  LDD2145  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C119(1.06); C99(0.53); C164(0.78)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C119(1.37); C99(4.90); C164(1.61)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C99(0.65)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C119(0.49); C99(0.88)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C119(0.69); C99(0.30)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C99(0.60)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C119(2.60); C528(2.00)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C723(1.15); C34(0.73); C164(0.71); C99(0.68)  LDD2206  [46]
 LDCM0628  OTUB2-COV-1 HEK-293T C119(1.32); C723(1.24); C498(1.22); C528(1.15)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C164(1.61); C528(1.60); C34(1.32); C1070(1.32)  LDD0304  [47]
 LDCM0019  Staurosporine Hep-G2 2.67  LDD0083  [39]
 LDCM0021  THZ1 HeLa S3 C164(1.16)  LDD0460  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase A (DHX9) DEAD box helicase family Q08211
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Cellular tumor antigen p53 (TP53) P53 family P04637
Prohibitin 1 (PHB1) Prohibitin family P35232
Snurportin-1 (SNUPN) Snurportin family O95149
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) Nuclear hormone receptor family P22736
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Baculoviral IAP repeat-containing protein 5 (BIRC5) IAP family O15392
cAMP-dependent protein kinase inhibitor alpha (PKIA) PKI family P61925

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Selinexor Small molecular drug D00LNW
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Eltanexor Oral . D0JF6C
Selinexor Oral . D0VI7R
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sl-801 . D0SP6A
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Kos-1815 . D0Z8EJ
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Octahydrocurcumin Small molecular drug D3GD1L
S109 Small molecular drug D2U4RX

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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15 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
18 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
19 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
20 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
21 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
24 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
25 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
26 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
27 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
28 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
29 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
30 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
31 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
32 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
33 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
34 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
35 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
36 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
37 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
38 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
39 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
40 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
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Mass spectrometry data entry: PXD007570
42 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
44 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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