Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment35  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04424  Galactokinase (GALK1) C182 1.3
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.3
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.2
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.1
 LDTP02502  Thioredoxin (TXN) C32 1.1
 LDTP13147  Cathepsin Z (CTSZ) C92 1.1
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 0.9
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 0.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 0.9
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 0.9
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 0.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 0.9
 LDTP02672  Elongation factor 2 (EEF2) C41 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 0.8
 LDTP04374  Dynamin-2 (DNM2) C27 0.8
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.8
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.8
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 0.8
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 0.8
 LDTP02223  Cathepsin B (CTSB) C319 0.8
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.8
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.7
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 0.7
 LDTP02223  Cathepsin B (CTSB) C211 0.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.7
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 0.7
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.7
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.7
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.7
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.6
 LDTP09446  Ribonuclease H2 subunit C (RNASEH2C) C34 0.4
Transporter and channel
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 4.4
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.9
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 0.9
 LDTP01574  Importin-7 (IPO7) C757 0.8
 LDTP00501  Exportin-1 (XPO1) C34 0.8
 LDTP04801  Gasdermin-D (GSDMD) C268 0.6
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 0.9
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 0.8
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.7
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 0.6
Other
Click to Show/Hide to Show 40 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12412  Reticulon-4 (RTN4) C1101 1.4
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.1
 LDTP06681  Inverted formin-2 (INF2) C971 1.1
 LDTP08238  Kinectin (KTN1) C303 1.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.1
 LDTP05867  Treacle protein (TCOF1) C38 1.1
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 0.9
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 0.9
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.9
 LDTP13580  Coronin-1C (CORO1C) C456 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 0.9
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.9
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 0.9
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 0.9
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.9
 LDTP02205  Tubulin beta chain (TUBB) C239 0.9
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.9
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1059 0.8
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 0.8
 LDTP02205  Tubulin beta chain (TUBB) C354 0.8
 LDTP02692  Plastin-3 (PLS3) C33 0.8
 LDTP04487  Cyclin-H (CCNH) C244 0.8
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 0.8
 LDTP13580  Coronin-1C (CORO1C) C420 0.8
 LDTP06330  Plectin (PLEC) C4071 0.8
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 0.8
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.8
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 0.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.8
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 0.8
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 0.8
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.7
 LDTP12443  Anillin (ANLN) C712 0.7
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 0.6
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 0.6
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.