Details of the Target

General Information of Target

Target ID LDTP08238
Target Name Kinectin (KTN1)
Gene Name KTN1
Gene ID 3895
Synonyms
CG1; KIAA0004; Kinectin; CG-1 antigen; Kinesin receptor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Target Bioclass
Other
Family
Kinectin family
Subcellular location
Endoplasmic reticulum membrane
Function Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
Uniprot ID
Q86UP2
Ensemble ID
ENST00000395308.5
HGNC ID
HGNC:6467

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.V143Ter DBIA    Probe Info 
A172 SNV: p.L605Ter DBIA    Probe Info 
CASKI SNV: p.L795V DBIA    Probe Info 
DU145 Deletion: p.N220MfsTer4
SNV: p.E564K		 DBIA    Probe Info 
HEC1 SNV: p.R1191Ter DBIA    Probe Info 
HSC4 SNV: p.Q875K DBIA    Probe Info 
KU1919 Insertion: p.S133KfsTer2
SNV: p.D35N		 DBIA    Probe Info 
MDAMB468 SNV: p.E699Q DBIA    Probe Info 
MEWO SNV: p.T293I DBIA    Probe Info 
MFE319 SNV: p.E1317D DBIA    Probe Info 
NB4 SNV: p.F792C .
NCIH446 SNV: p.I574V; p.Q718R DBIA    Probe Info 
RL952 SNV: p.A91V DBIA    Probe Info 
SNU1 Deletion: p.P154LfsTer70 DBIA    Probe Info 
TKKK SNV: p.S323N DBIA    Probe Info 
YSCCC SNV: p.Q672E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.22  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K1028(2.44); K1053(3.23); K1100(4.51); K1101(7.16)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
OPA-S-S-alkyne
 Probe Info  		K617(1.17); K559(1.40); K1240(5.60); K543(5.74)  LDD3494  [5]
Probe 1
 Probe Info  		Y398(11.20); Y503(13.01); Y1245(15.10)  LDD3495  [6]
BTD
 Probe Info  		C1105(1.37)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C303(2.02)  LDD0168  [8]
BDBM50514113
 Probe Info  		1.80  LDD0041  [9]
DBIA
 Probe Info  		C1105(0.91)  LDD0078  [10]
5E-2FA
 Probe Info  		H917(0.00); H332(0.00); H666(0.00); H197(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K1123(0.00); K1285(0.00); K142(0.00); K670(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1136(0.00); C303(0.00); C736(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C736(0.00); C1105(0.00)  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C1136(0.00); C1105(0.00); C303(0.00); C736(0.00)  LDD0037  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
ENE
 Probe Info  		N.A.  LDD0006  [16]
IPM
 Probe Info  		C736(0.00); C1105(0.00)  LDD0147  [18]
NHS
 Probe Info  		K835(0.00); K285(0.00); K1296(0.00); K477(0.00)  LDD0010  [16]
TFBX
 Probe Info  		C736(0.00); C1105(0.00)  LDD0148  [18]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C303(0.00); C1105(0.00)  LDD0018  [19]
1c-yne
 Probe Info  		K1176(0.00); K653(0.00); K487(0.00); K1082(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		H511(0.00); H666(0.00); H910(0.00); H917(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [20]
Methacrolein
 Probe Info  		C1105(0.00); H511(0.00)  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [22]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		6.92  LDD1779  [23]
FFF probe11
 Probe Info  		20.00  LDD0471  [24]
FFF probe13
 Probe Info  		20.00  LDD0475  [24]
FFF probe14
 Probe Info  		20.00  LDD0477  [24]
FFF probe2
 Probe Info  		20.00  LDD0463  [24]
FFF probe3
 Probe Info  		20.00  LDD0464  [24]
FFF probe4
 Probe Info  		20.00  LDD0466  [24]
FFF probe6
 Probe Info  		9.45  LDD0467  [24]
JN0003
 Probe Info  		20.00  LDD0469  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]
OEA-DA
 Probe Info  		4.60  LDD0046  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1105(0.59)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C736(0.83)  LDD2112  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1105(0.86); C736(0.92)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1105(1.41)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1105(0.92)  LDD2103  [7]
 LDCM0025  4SU-RNA HEK-293T C303(2.02)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA DM93 C736(3.47); C303(3.96)  LDD0171  [8]
 LDCM0214  AC1 HCT 116 C1105(1.15)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C1105(1.21)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C1105(1.15)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C1105(1.15)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C1105(1.13)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C1105(1.50)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C1105(1.09)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C1105(1.32)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C1105(1.45)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C1105(1.45)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C1105(1.21)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C1105(1.01)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C1105(1.23)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C1105(1.09)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C1105(1.14)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C1105(1.29)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C1105(1.04)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C1105(1.18)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C1105(1.28)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C1105(1.37)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C1105(1.14)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C1105(1.09)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C1105(1.29)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C1105(1.02)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C1105(1.01)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C1105(1.18)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C1105(1.22)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C1105(0.99)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C1105(0.97)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C1105(1.22)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C1105(1.31)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C1105(1.25)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C1105(0.88)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C1105(1.05)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C1105(1.23)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C1105(0.98)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C1105(1.27)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C1105(1.04)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C1105(1.35)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C1105(1.14)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C1105(1.28)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C1105(1.27)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C1105(1.69)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C1105(1.41)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C1105(1.07)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C1105(1.70)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C1105(1.65)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C1105(1.30)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C1105(1.12)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C1105(1.22)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C1105(1.04)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C1105(1.31)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C1105(1.39)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C1105(1.75)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C1105(1.50)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C1105(1.16)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C1105(1.09)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C1105(1.06)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C1105(1.19)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C1105(1.90)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C1105(1.25)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C1105(1.25)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C1105(1.03)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C1105(0.92)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C1105(1.10)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C1105(1.30)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C1105(1.16)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C1105(1.15)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C1105(1.11)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C1105(1.20)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C1105(1.07)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C1105(1.11)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C1105(1.00)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C1105(1.07)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C1105(1.37)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C1105(1.49)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C1105(1.33)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C1105(1.32)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C1105(1.23)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C1105(1.42)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C1105(1.31)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C1105(1.79)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C1105(1.53)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C1105(1.78)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C1105(0.81)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C1105(0.86)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C1105(0.83)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C1105(0.94)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C1105(1.06)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C1105(1.28)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C1105(1.10)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C1105(0.96)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C1105(1.10)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C1105(1.06)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C1105(1.02)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C1105(1.20)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C1105(1.19)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C1105(1.13)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C1105(1.12)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C1105(1.56)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C1105(1.27)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C1105(1.59)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C1105(0.98)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C1105(1.19)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C1105(1.27)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C1105(1.24)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C1105(1.47)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C1105(2.20)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C1105(1.56)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C1105(1.72)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C1105(1.74)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C1105(1.30)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C1105(1.62)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C1105(1.45)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C1105(1.95)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C1105(1.62)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C1105(1.89)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C1105(1.67)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C1105(1.45)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C1105(1.88)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C1105(1.07)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C1105(1.15)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C1105(1.03)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C1105(1.32)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C1105(1.04)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C1105(1.24)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C1105(1.97)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C1105(1.57)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C1105(1.97)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C1105(1.40)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C1105(1.44)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C1105(1.12)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C1105(1.21)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C1105(1.19)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C1105(1.15)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C1105(0.99)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C1105(1.96)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C1105(1.72)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C1105(1.52)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C1105(1.36)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C1105(1.29)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C1105(1.10)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C1105(1.32)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C1105(1.39)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C1105(1.11)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C1105(1.92)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C1105(1.54)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C1105(1.22)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C1105(1.13)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C1105(1.17)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C1105(1.37)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C1105(1.59)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C1105(1.75)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C1105(1.11)  LDD0683  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C1105(0.64)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C1105(0.99)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C1105(1.14)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C1105(1.73)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C1105(0.91)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C1105(0.45)  LDD2091  [7]
 LDCM0108  Chloroacetamide HeLa H511(0.00); H666(0.00); H910(0.00); H917(0.00)  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C736(20.00); C1105(1.94)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C1105(0.88)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C1105(1.53)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C1105(1.37)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C1105(1.20)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C1105(1.00)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C1105(0.98)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C1105(1.02)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C1105(1.44)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C1105(1.73)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C1105(1.61)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C1105(1.79)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C1105(1.34)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C1105(1.70)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C1105(1.55)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C1105(1.27)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C1105(1.17)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C1105(1.48)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C1105(1.26)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C1105(1.38)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C1105(1.33)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C1105(1.84)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C1105(1.07)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C1105(1.07)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C1105(1.79)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C1105(1.04)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C1105(1.05)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C1105(1.14)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C1105(1.26)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C1105(1.46)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C1105(1.12)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C1105(1.15)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C1105(1.18)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C1105(1.67)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C1105(1.30)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C1105(1.23)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C1105(1.32)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C1105(1.10)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C1105(1.11)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C1105(1.05)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C1105(1.21)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C1105(0.93)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C1105(1.57)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C1105(1.79)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C1105(2.77)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C1105(1.39)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C1105(1.77)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C1105(1.63)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C1105(1.25)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C1105(1.49)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C1105(1.51)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C1105(1.55)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C1105(0.97)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C1105(1.14)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C1105(1.19)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C1105(1.13)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C1105(1.43)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C1105(1.51)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C1105(1.55)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C1105(1.63)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C1105(1.95)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C1105(1.75)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C1105(1.01)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C1105(1.63)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C1105(1.47)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C1105(2.66)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C1105(1.83)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C1105(1.54)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C1105(1.87)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C1105(0.93)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C1105(0.96)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C1105(1.20)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C1105(1.21)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C1105(1.06)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C1105(1.23)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C1105(1.10)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C1105(1.19)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C1105(1.05)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C1105(0.95)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C1105(1.09)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C1105(1.28)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C1105(1.12)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C1105(1.01)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C1105(1.11)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C1105(1.13)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C1105(1.15)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C1105(1.19)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C1105(1.12)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C1105(1.42)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C1105(1.53)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C1105(1.10)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C1105(1.82)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C1105(1.37)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C1105(1.34)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C1105(1.01)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C1105(1.37)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C1105(1.20)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C1105(1.42)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C1105(1.06)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C1105(1.34)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C1105(1.37)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C1105(1.21)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C1105(1.11)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C1105(1.28)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C1105(1.73)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C1105(2.15)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C1105(1.06)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C1105(1.36)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C1105(2.23)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C1105(1.84)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C1105(2.35)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C1105(1.35)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C1105(1.08)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C1105(1.36)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C1105(1.70)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C1105(2.75)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C1105(1.22)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C1105(1.04)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C1105(1.30)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C1105(1.12)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C1105(1.16)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C1105(1.31)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C1105(1.37)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C1105(1.31)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C1105(1.23)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C1105(1.36)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C1105(1.30)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C1105(0.89); C1136(1.01); C303(1.06)  LDD1698  [27]
 LDCM0572  Fragment10 MDA-MB-231 C303(1.25)  LDD1389  [28]
 LDCM0573  Fragment11 MDA-MB-231 C303(1.09)  LDD1391  [28]
 LDCM0575  Fragment13 MDA-MB-231 C303(0.96)  LDD1395  [28]
 LDCM0576  Fragment14 MDA-MB-231 C303(2.75)  LDD1397  [28]
 LDCM0577  Fragment15 MDA-MB-231 C303(1.28)  LDD1399  [28]
 LDCM0579  Fragment20 MDA-MB-231 C303(2.06)  LDD1402  [28]
 LDCM0580  Fragment21 MDA-MB-231 C303(1.06)  LDD1404  [28]
 LDCM0578  Fragment27 MDA-MB-231 C303(0.70)  LDD1401  [28]
 LDCM0586  Fragment28 MDA-MB-231 C303(0.91)  LDD1415  [28]
 LDCM0587  Fragment29 MDA-MB-231 C303(1.27)  LDD1417  [28]
 LDCM0588  Fragment30 MDA-MB-231 C303(1.08)  LDD1419  [28]
 LDCM0589  Fragment31 MDA-MB-231 C303(1.35)  LDD1421  [28]
 LDCM0468  Fragment33 HCT 116 C1105(1.32)  LDD0785  [10]
 LDCM0593  Fragment35 MDA-MB-231 C303(1.08)  LDD1429  [28]
 LDCM0596  Fragment38 MDA-MB-231 C303(1.10)  LDD1433  [28]
 LDCM0566  Fragment4 MDA-MB-231 C303(1.31)  LDD1378  [28]
 LDCM0601  Fragment43 MDA-MB-231 C303(2.11)  LDD1441  [28]
 LDCM0607  Fragment49 MDA-MB-231 C303(3.57)  LDD1448  [28]
 LDCM0608  Fragment50 MDA-MB-231 C303(4.59)  LDD1449  [28]
 LDCM0427  Fragment51 HCT 116 C1105(2.39)  LDD0744  [10]
 LDCM0614  Fragment56 MDA-MB-231 C303(0.98)  LDD1458  [28]
 LDCM0568  Fragment6 MDA-MB-231 C303(1.24)  LDD1382  [28]
 LDCM0569  Fragment7 MDA-MB-231 C303(1.14)  LDD1383  [28]
 LDCM0570  Fragment8 MDA-MB-231 C303(1.69)  LDD1385  [28]
 LDCM0571  Fragment9 MDA-MB-231 C303(1.71)  LDD1387  [28]
 LDCM0107  IAA HeLa H910(0.00); H666(0.00); H511(0.00); H917(0.00)  LDD0221  [20]
 LDCM0022  KB02 HCT 116 C1105(1.72)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C1105(1.25)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C1105(2.83)  LDD0082  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1105(0.92)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1105(0.93)  LDD2121  [7]
 LDCM0109  NEM HeLa H666(0.00); H511(0.00); H910(0.00); H917(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1105(0.76)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1105(1.28)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1105(0.79)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1105(0.89)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1105(1.09)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1105(0.81)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1105(0.87)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1105(0.54); C736(0.71)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1105(0.91); C736(0.97)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1105(0.36); C736(0.72)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1105(1.00)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1105(0.37); C736(0.53)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1105(1.34)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1105(0.44)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1105(1.05); C736(0.86)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1105(0.48); C736(0.82)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1105(0.75); C736(0.99)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1105(0.50)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1105(0.94)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1105(0.48); C736(0.63)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1105(0.50)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1105(1.24)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1105(2.20)  LDD2119  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1105(0.68); C736(0.97)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1105(1.71)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1105(0.81); C736(1.02)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1105(1.69)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1105(0.84); C736(1.02)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1105(1.04)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1105(0.92)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1105(0.36)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1105(0.43); C736(0.50)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1105(0.75)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1105(0.98); C736(0.98)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1105(0.71); C736(0.77)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1105(1.37)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1105(0.68); C736(0.90)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1105(0.83); C736(1.00)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1105(0.86)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1105(1.71)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C736(3.33)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1105(0.69)  LDD2146  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C1105(0.43); C736(0.49)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C1105(1.52)  LDD2149  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1105(1.11)  LDD2153  [7]
 LDCM0021  THZ1 HCT 116 C1105(1.28)  LDD2173  [10]
 LDCM0002  Ward_cp1 U2OS 1.80  LDD0041  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Cation-dependent mannose-6-phosphate receptor (M6PR) . P20645
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Programmed cell death 1 ligand 2 (PDCD1LG2) BTN/MOG family Q9BQ51
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Macrosialin (CD68) LAMP family P34810
Nesprin-4 (SYNE4) Nesprin family Q8N205
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Synaptoporin (SYNPR) Synaptophysin/synaptobrevin family Q8TBG9
C-type lectin domain family 4 member C (CLEC4C) . Q8WTT0
C-type lectin domain family 7 member A (CLEC7A) . Q9BXN2
Sushi domain-containing protein 3 (SUSD3) . Q96L08
T-cell surface glycoprotein CD3 gamma chain (CD3G) . P09693

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
22 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
23 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.