Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name BDBM50514113  Probe Info 
Probe concentration 125 nM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Ward_cp1  Competitor Info 
Competitor Concentration 625 nM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Osteosarcoma [ICD-11:2B51]
Model Name Human osteosarcoma cells (U2OS)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 110.7
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) 8.7
 LDTP07367  Nucleoredoxin (NXN) 8.3
 LDTP09517  Ubiquitin carboxyl-terminal hydrolase 33 (USP33) 8.1
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) 4.6
 LDTP11070  Vitamin K epoxide reductase complex subunit 1 (VKORC1) 4.6
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 4.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 3.9
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) 3.6
 LDTP05749  Ubiquitin carboxyl-terminal hydrolase 4 (USP4) 2.4
 LDTP00758  Thioredoxin-like protein 1 (TXNL1) 2.0
 LDTP10973  Thioredoxin, mitochondrial (TXN2) 1.8
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 1.7
 LDTP03564  DNA-directed RNA polymerase II subunit RPB2 (POLR2B) 1.7
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 1.6
 LDTP01474  Ubiquitin carboxyl-terminal hydrolase 19 (USP19) 1.5
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11855  Pinin (PNN) 8.9
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) 2.7
 LDTP08030  Autophagy-related protein 9A (ATG9A) 1.8
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05644  Sterol regulatory element-binding protein 2 (SREBF2) 8.3
 LDTP02489  Retinoic acid receptor alpha (RARA) 2.2
Other
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) 11.6
 LDTP19476  AMMECR1-like protein (AMMECR1L) 2.9
 LDTP11737  Nonsense-mediated mRNA decay factor SMG9 (SMG9) 1.8
 LDTP08238  Kinectin (KTN1) 1.8
 LDTP01522  Reticulon-3 (RTN3) 1.5

References

1 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.