Details of the Target

General Information of Target

Target ID LDTP07367
Target Name Nucleoredoxin (NXN)
Gene Name NXN
Gene ID 64359
Synonyms
NRX; Nucleoredoxin; EC 1.8.1.8
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGFLEELLGEKLVTGGGEEVDVHSLGARGISLLGLYFGCSLSAPCAQLSASLAAFYGRL
RGDAAAGPGPGAGAGAAAEPEPRRRLEIVFVSSDQDQRQWQDFVRDMPWLALPYKEKHRK
LKLWNKYRISNIPSLIFLDATTGKVVCRNGLLVIRDDPEGLEFPWGPKPFREVIAGPLLR
NNGQSLESSSLEGSHVGVYFSAHWCPPCRSLTRVLVESYRKIKEAGQNFEIIFVSADRSE
ESFKQYFSEMPWLAVPYTDEARRSRLNRLYGIQGIPTLIMLDPQGEVITRQGRVEVLNDE
DCREFPWHPKPVLELSDSNAAQLNEGPCLVLFVDSEDDGESEAAKQLIQPIAEKIIAKYK
AKEEEAPLLFFVAGEDDMTDSLRDYTNLPEAAPLLTILDMSARAKYVMDVEEITPAIVEA
FVNDFLAEKLKPEPI
Target Bioclass
Enzyme
Family
Nucleoredoxin family
Subcellular location
Cytoplasm, cytosol
Function
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A).
Uniprot ID
Q6DKJ4
Ensemble ID
ENST00000336868.8
HGNC ID
HGNC:18008

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R403W .
HT115 SNV: p.S185F .
Ishikawa (Heraklio) 02 ER SNV: p.G226D .
MDAMB468 SNV: p.E304G .
NCIH1703 SNV: p.A47S .
NCIH358 SNV: p.F90V .
NCIH661 SNV: p.V407L .
RKO SNV: p.V146M .
SNU1 SNV: p.G10D .
TOV21G SNV: p.P177H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-5
 Probe Info  		6.80  LDD0394  [1]
STPyne
 Probe Info  		K115(10.00); K122(9.38); K126(5.26)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BDBM50514113
 Probe Info  		8.29  LDD0041  [4]
DBIA
 Probe Info  		C302(1.03)  LDD0532  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
W1
 Probe Info  		N.A.  LDD0236  [3]
AOyne
 Probe Info  		14.70  LDD0443  [10]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C141
 Probe Info  		8.94  LDD1823  [11]
C153
 Probe Info  		24.42  LDD1834  [11]
C277
 Probe Info  		12.04  LDD1947  [11]
C343
 Probe Info  		14.12  LDD2005  [11]
FFF probe13
 Probe Info  		14.07  LDD0475  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe2
 Probe Info  		20.00  LDD0463  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C147(1.11); C205(1.00)  LDD1507  [13]
 LDCM0215  AC10 HCT 116 C302(1.03)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C302(1.54)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C302(1.26)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C302(1.35)  LDD0576  [5]
 LDCM0270  AC15 HCT 116 C302(1.10)  LDD0587  [5]
 LDCM0276  AC17 HEK-293T C147(0.92); C205(0.98)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C147(0.90); C328(0.92); C205(0.94)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C147(0.70); C205(0.81)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C147(0.70); C328(1.14); C205(0.93)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C147(1.13); C205(1.09)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C147(0.85); C205(0.93)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C147(0.86); C205(1.00)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C147(0.93); C205(1.17)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C147(0.89); C205(0.95)  LDD1523  [13]
 LDCM0285  AC25 HCT 116 C302(0.99)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C302(0.89)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C302(0.93)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C302(0.98)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C302(1.07)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C147(0.92); C205(1.11)  LDD1529  [13]
 LDCM0291  AC30 HCT 116 C302(0.98)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C302(1.01)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C302(0.87)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C302(0.96)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C302(0.80)  LDD0612  [5]
 LDCM0296  AC35 HEK-293T C147(0.93); C205(1.01)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C147(1.26); C205(1.05)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C147(1.11); C205(1.08)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C147(0.80); C205(0.92)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C147(1.13); C205(0.98)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C147(1.22); C205(1.11)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C147(0.97); C205(1.00)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C147(1.06); C205(1.09)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C147(1.30); C328(1.07); C205(1.25)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C147(1.00); C205(1.02)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C147(1.30); C205(1.61)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C147(1.16); C205(1.23)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C147(0.86); C205(1.00)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C147(1.18); C205(1.12)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C147(0.98); C205(1.18)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C147(1.02); C205(1.19)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C147(1.03); C205(1.07)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C147(0.98); C328(1.35); C205(1.10)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C147(1.14); C205(1.05)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C147(1.00); C205(1.08)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C147(1.05); C205(1.11)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C147(0.87); C205(0.97)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C147(1.00); C205(1.05)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C147(0.86); C205(1.00)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C147(1.04); C205(0.91)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C147(0.95); C328(0.90); C205(0.96)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C147(0.99); C205(1.02)  LDD1561  [13]
 LDCM0323  AC6 HCT 116 C302(0.87)  LDD0640  [5]
 LDCM0324  AC60 HEK-293T C147(1.29); C205(1.18)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C147(1.00); C205(1.02)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C147(0.91); C205(0.99)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C147(1.07); C205(0.94)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C147(0.90); C205(0.93)  LDD1567  [13]
 LDCM0334  AC7 HCT 116 C302(1.02)  LDD0651  [5]
 LDCM0345  AC8 HCT 116 C302(0.99)  LDD0662  [5]
 LDCM0248  AKOS034007472 HCT 116 C302(1.34)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C302(1.23)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C302(0.89)  LDD0592  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C302(0.69)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C302(0.93)  LDD0685  [5]
 LDCM0369  CL100 HEK-293T C147(1.10); C205(0.93)  LDD1573  [13]
 LDCM0370  CL101 HCT 116 C302(0.95)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C302(0.80)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C302(1.23)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C302(1.06)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C147(1.00); C328(1.09); C205(1.01)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C147(1.11)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C147(0.96); C205(0.86)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C147(1.11); C205(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C147(1.03); C328(1.07); C205(1.15)  LDD1582  [13]
 LDCM0379  CL11 HCT 116 C302(0.60)  LDD0696  [5]
 LDCM0380  CL110 HEK-293T C147(1.04)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C147(0.96); C205(1.37)  LDD1585  [13]
 LDCM0382  CL112 HCT 116 C302(0.81)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C302(0.88)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C302(0.66)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C302(0.90)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C302(1.07)  LDD0703  [5]
 LDCM0387  CL117 HEK-293T C147(1.08); C328(1.27); C205(1.03)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C147(1.05)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C147(0.92); C205(0.99)  LDD1593  [13]
 LDCM0390  CL12 HCT 116 C302(1.54)  LDD0707  [5]
 LDCM0391  CL120 HEK-293T C147(0.95); C205(0.94)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C147(1.12); C328(1.27); C205(1.00)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C147(1.03)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C147(1.53); C205(1.09)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C147(0.92); C205(1.11)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C147(1.06); C328(1.08); C205(0.95)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C147(0.96)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C147(0.97); C205(0.89)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C147(0.83); C205(0.90)  LDD1603  [13]
 LDCM0400  CL13 HCT 116 C302(1.14)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C302(1.28)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C302(0.38)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C302(1.06)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C302(0.41)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C302(0.90)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C302(0.99)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C302(0.83)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C302(1.10)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C302(0.64)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C302(0.78)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C302(0.99)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C302(1.10)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C302(1.02)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C302(0.90)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C302(1.09)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C302(0.98)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C302(1.67)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C302(0.85)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C302(1.20)  LDD0736  [5]
 LDCM0420  CL31 HEK-293T C147(0.95); C205(0.90)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C147(0.95); C205(1.25)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C147(1.69); C205(0.95)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C147(0.95); C205(1.03)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C147(0.96); C205(1.06)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C147(0.79); C205(0.90)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C147(1.08); C328(0.98); C205(0.95)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C147(1.12); C205(1.29)  LDD1632  [13]
 LDCM0429  CL4 HCT 116 C302(0.92)  LDD0746  [5]
 LDCM0430  CL40 HEK-293T C147(0.87); C205(0.89)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C147(1.02); C205(0.99)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C147(1.43); C328(1.09); C205(0.92)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C147(1.11); C205(0.99)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C147(0.97); C205(1.22)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C147(5.63); C205(1.11)  LDD1639  [13]
 LDCM0436  CL46 HCT 116 C302(1.24)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C302(0.85)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C302(0.40)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C302(1.20)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C302(0.98)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C302(0.97)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C302(1.23)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C302(1.01)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C302(0.67)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C302(0.77)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C302(1.23)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C302(0.76)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C302(0.58)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C302(1.48)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C302(0.89)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C302(0.75)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C302(1.18)  LDD0769  [5]
 LDCM0453  CL61 HEK-293T C147(1.14); C328(1.27); C205(1.04)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C147(1.17)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C147(0.88); C205(1.08)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C147(1.12); C205(1.11)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C147(1.02); C205(0.92)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C147(0.82); C328(1.00); C205(0.93)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C147(0.74); C205(0.96)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C147(1.37); C205(0.92)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C147(1.60); C205(0.97)  LDD1664  [13]
 LDCM0462  CL7 HCT 116 C302(1.22)  LDD0779  [5]
 LDCM0463  CL70 HEK-293T C147(0.67); C205(1.11)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C147(0.99); C205(0.87)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C147(0.92); C205(0.97)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C147(0.95); C328(1.23); C205(0.94)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C147(1.02)  LDD1670  [13]
 LDCM0469  CL76 HCT 116 C302(0.92)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C302(0.38)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C302(0.61)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C302(0.69)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C302(0.38)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C302(1.00)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C302(0.76)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C302(0.59)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C302(0.29)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C302(0.48)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C302(0.66)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C302(0.86)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C302(0.87)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C302(0.84)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C302(0.39)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C302(1.00)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C302(0.18)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C147(0.62); C205(0.81)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C147(1.61); C205(0.89)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C147(1.79); C205(1.01)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C147(0.83); C205(1.10)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C147(0.91); C205(0.82)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C147(0.68); C205(0.77)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C147(0.90); C328(0.82); C205(1.10)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C147(1.95)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C147(1.39); C205(1.32)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C147(1.03); C205(1.39)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C147(1.04); C205(1.18)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C147(1.03)  LDD1631  [13]
 LDCM0107  IAA HeLa N.A.  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C302(1.00)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C302(1.00)  LDD1497  [13]
 LDCM0024  KB05 HMCB C302(1.08)  LDD3312  [14]
 LDCM0002  Ward_cp1 U2OS 8.29  LDD0041  [4]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840