Details of the Probe

General Information of Probe

Probe ID
LDPC0205
Probe Name
AZ-5
Probe Type
ABPP Probe
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 305.333
Lipid-water partition coefficient (xlogp) 3.0292
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H15NO3
Canonical SMILES
C#CCOc1ccc(C2N=C2c2ccc(C(=O)OC)cc2)cc1
InChI
InChI=1S/C19H15NO3/c1-3-12-23-16-10-8-14(9-11-16)18-17(20-18)13-4-6-15(7-5-13)19(21)22-2/h1,4-11,18H,12H2,2H3
InChIKey
UDZBSTMSIRADCW-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

9 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 3 (PSMD3) LDTP00714 10.00  LDD0394 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 10.00  LDD0394 
Choline/ethanolaminephosphotransferase 1 (CEPT1) LDTP14264 10.00  LDD0394 
Cytosolic purine 5'-nucleotidase (NT5C2) LDTP04327 10.00  LDD0394 
Guanine nucleotide-binding protein-like 3 (GNL3) LDTP11297 4.13  LDD0394 
Histidine--tRNA ligase, cytoplasmic (HARS1) LDTP02602 10.00  LDD0394 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 6.34  LDD0394 
Nucleoredoxin (NXN) LDTP07367 6.80  LDD0394 
Secernin-1 (SCRN1) LDTP05640 10.00  LDD0394 
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⏷ Show the Full List of 9 Enzyme
6 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Gasdermin-E (GSDME) LDTP00970 7.49  LDD0394 
Metal cation symporter ZIP14 (SLC39A14) LDTP06293 10.00  LDD0394 
Neutral amino acid transporter A (SLC1A4) LDTP04013 5.81  LDD0394 
Nuclear pore glycoprotein p62 (NUP62) LDTP03839 3.73  LDD0394 
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) LDTP14274 10.00  LDD0394 
Sorting nexin-8 (SNX8) LDTP14173 10.00  LDD0394 
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⏷ Show the Full List of 6 Transporter and channel
12 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
26S proteasome non-ATPase regulatory subunit 11 (PSMD11) LDTP00223 10.00  LDD0394 
Alpha-2-antiplasmin (SERPINF2) LDTP02300 10.00  LDD0394 
Histone-binding protein RBBP4 (RBBP4) LDTP05590 2.35  LDD0394 
Keratin, type I cytoskeletal 17 (KRT17) LDTP05424 5.04  LDD0394 
Keratin, type I cytoskeletal 18 (KRT18) LDTP02124 3.52  LDD0394 
Keratin, type II cytoskeletal 6C (KRT6C) LDTP04205 4.18  LDD0394 
Keratin, type II cytoskeletal 7 (KRT7) LDTP02305 2.66  LDD0394 
Polyadenylate-binding protein-interacting protein 1 (PAIP1) LDTP11682 10.00  LDD0394 
Sequestosome-1 (SQSTM1) LDTP05898 2.10  LDD0394 
Tubulin beta chain (TUBB) LDTP02205 2.44  LDD0394 
Tubulin beta-4B chain (TUBB4B) LDTP05076 2.33  LDD0394 
Tubulin beta-8 chain (TUBB8) LDTP06809 2.43  LDD0394 
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⏷ Show the Full List of 12 Other

Full Information of The Labelling Profiles of This Probe

Quantification: Probe vs DMSO
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
2.5 uM
Quantitative Method
LFQ
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Breast
Disease Model
Invasive breast carcinoma [ICD-11:2C60]
Model Name
Human invasive breast carcinoma cells (MCF-7)
Interaction Atlas ID
 LDD0394 
Download The Altas

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.