General Information of Target

Target ID LDTP06293
Target Name Metal cation symporter ZIP14 (SLC39A14)
Gene Name SLC39A14
Gene ID 23516
Synonyms
KIAA0062; ZIP14; Metal cation symporter ZIP14; LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLLLLHPAFQSCLLLTLLGLWRTTPEAHASSLGAPAISAASFLQDLIHRYGEGDSLTLQ
QLKALLNHLDVGVGRGNVTQHVQGHRNLSTCFSSGDLFTAHNFSEQSRIGSSELQEFCPT
ILQQLDSRACTSENQENEENEQTEEGRPSAVEVWGYGLLCVTVISLCSLLGASVVPFMKK
TFYKRLLLYFIALAIGTLYSNALFQLIPEAFGFNPLEDYYVSKSAVVFGGFYLFFFTEKI
LKILLKQKNEHHHGHSHYASESLPSKKDQEEGVMEKLQNGDLDHMIPQHCSSELDGKAPM
VDEKVIVGSLSVQDLQASQSACYWLKGVRYSDIGTLAWMITLSDGLHNFIDGLAIGASFT
VSVFQGISTSVAILCEEFPHELGDFVILLNAGMSIQQALFFNFLSACCCYLGLAFGILAG
SHFSANWIFALAGGMFLYISLADMFPEMNEVCQEDERKGSILIPFIIQNLGLLTGFTIMV
VLTMYSGQIQIG
Target Bioclass
Transporter and channel
Family
ZIP transporter (TC 2.A.5) family
Subcellular location
Cell membrane
Function
Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity. Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions. Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic. Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability. Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation. Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin. Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress. Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake. Also involved in manganese extracellular uptake by cells of the blood-brain barrier. May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion. Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin. Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages.
Uniprot ID
Q15043
Ensemble ID
ENST00000240095.10
HGNC ID
HGNC:20858

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.T58A .
NCIH1944 SNV: p.S149R .
RL952 SNV: p.T474I .
SKMEL24 SNV: p.L482V .
SNU869 SNV: p.G20C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info 
7.19  LDD0402  [1]
AZ-5
 Probe Info 
10.00  LDD0394  [2]
IPM
 Probe Info 
N.A.  LDD0241  [3]
Johansson_61
 Probe Info 
_(20.00)  LDD1485  [4]
AHL-Pu-1
 Probe Info 
C290(5.39)  LDD0171  [5]
Acrolein
 Probe Info 
N.A.  LDD0226  [6]
DBIA
 Probe Info 
C322(8.04)  LDD0080  [7]
CY-1
 Probe Info 
N.A.  LDD0246  [8]
4-Iodoacetamidophenylacetylene
 Probe Info 
N.A.  LDD0038  [9]
IA-alkyne
 Probe Info 
N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info 
N.A.  LDD0037  [9]
TFBX
 Probe Info 
N.A.  LDD0148  [10]
W1
 Probe Info 
N.A.  LDD0236  [3]
NAIA_5
 Probe Info 
N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info 
6.68  LDD1714  [12]
C022
 Probe Info 
8.63  LDD1728  [12]
C053
 Probe Info 
5.78  LDD1751  [12]
C091
 Probe Info 
10.48  LDD1782  [12]
C092
 Probe Info 
18.13  LDD1783  [12]
C106
 Probe Info 
16.91  LDD1793  [12]
C108
 Probe Info 
7.94  LDD1795  [12]
C112
 Probe Info 
24.76  LDD1799  [12]
C134
 Probe Info 
20.53  LDD1816  [12]
C143
 Probe Info 
12.38  LDD1825  [12]
C153
 Probe Info 
14.62  LDD1834  [12]
C160
 Probe Info 
13.09  LDD1840  [12]
C161
 Probe Info 
12.47  LDD1841  [12]
C170
 Probe Info 
8.46  LDD1850  [12]
C201
 Probe Info 
34.78  LDD1877  [12]
C208
 Probe Info 
5.06  LDD1883  [12]
C218
 Probe Info 
13.93  LDD1892  [12]
C219
 Probe Info 
8.69  LDD1893  [12]
C220
 Probe Info 
18.38  LDD1894  [12]
C225
 Probe Info 
5.28  LDD1898  [12]
C228
 Probe Info 
15.67  LDD1901  [12]
C310
 Probe Info 
7.62  LDD1977  [12]
C349
 Probe Info 
9.06  LDD2010  [12]
C350
 Probe Info 
24.93  LDD2011  [12]
C356
 Probe Info 
9.92  LDD2017  [12]
C390
 Probe Info 
23.26  LDD2049  [12]
STS-2
 Probe Info 
N.A.  LDD0138  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C290(5.39)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C322(1.08)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C322(1.03)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C322(0.90)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C322(0.81)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C322(0.87)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C322(1.11)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C322(1.14)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C322(0.90)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C322(0.87)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C322(0.54)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C322(1.28)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C322(1.13)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C322(1.00)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C322(1.47)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C322(1.42)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C322(1.06)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C322(0.94)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C322(1.09)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C322(1.17)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C322(1.13)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C322(1.06)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C322(0.99)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C322(1.03)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C322(0.99)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C322(1.04)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C322(0.89)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C322(0.86)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C322(0.90)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C322(0.91)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C322(1.07)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C322(1.24)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C322(1.09)  LDD0562  [7]
 LDCM0246  AC128 HEK-293T C322(0.95)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C322(0.94)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C322(1.14)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C322(0.96)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C322(1.16)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C322(1.36)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C322(1.23)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C322(1.20)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C322(1.07)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C322(1.42)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C322(1.43)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C322(1.26)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C322(0.85)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C322(1.26)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C322(1.44)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C322(1.04)  LDD0860  [7]
 LDCM0263  AC143 HCT 116 C322(1.08)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C322(1.45)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C322(1.21)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C322(1.22)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C322(1.34)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C322(1.81)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C322(1.54)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C322(0.98)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C322(1.04)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C322(1.07)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C322(1.50)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C322(2.05)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C322(1.28)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C322(1.28)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C322(1.11)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C322(1.37)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C322(1.20)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C322(1.27)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C322(1.90)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C322(0.97)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C322(1.56)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C322(1.04)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C322(1.07)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C322(1.53)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C322(1.18)  LDD0601  [7]
 LDCM0285  AC25 PaTu 8988t C322(0.96)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C322(0.94)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C322(1.24)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C322(1.37)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C322(1.10)  LDD1168  [7]
 LDCM0290  AC3 HCT 116 C322(0.88)  LDD0607  [7]
 LDCM0291  AC30 PaTu 8988t C322(1.06)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C322(1.07)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C322(1.00)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C322(1.55)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C322(1.26)  LDD1174  [7]
 LDCM0296  AC35 HCT 116 C322(0.92)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C322(0.71)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C322(0.90)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C322(0.95)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C322(0.81)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C322(1.07)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C322(1.16)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C322(0.81)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C322(0.93)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C322(1.00)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C322(0.94)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C322(1.03)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C322(0.92)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C322(1.12)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C322(0.98)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C322(1.47)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C322(0.90)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C322(1.28)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C322(0.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C322(1.13)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C322(1.13)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C322(1.23)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C322(1.42)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C322(1.84)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C322(1.13)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C322(1.53)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C322(0.99)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C322(1.13)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C322(1.07)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C322(0.93)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C322(1.41)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C322(1.10)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C322(1.32)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C322(1.29)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C322(1.25)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C322(1.37)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C322(1.03)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C322(1.27)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C322(0.93)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C322(1.21)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C322(1.07)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C322(1.30)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C322(1.72)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C322(1.65)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C322(1.89)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C322(1.33)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C322(1.18)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C322(1.17)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C322(1.27)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C322(1.03)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C322(1.33)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C322(0.66)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C322(1.83)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C322(1.48)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C322(1.23)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C322(1.12)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C322(1.07)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C322(1.08)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C322(1.12)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C322(1.38)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C322(1.13)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C322(1.57)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C322(1.29)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C322(1.24)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C322(1.48)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C322(1.13)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C322(1.65)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C322(1.71)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C322(0.95)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C322(0.84)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C322(0.80)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C322(0.92)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C322(1.41)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C322(1.16)  LDD2171  [7]
 LDCM0367  CL1 HCT 116 C322(1.75)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C322(1.47)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C322(1.05)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C322(0.90)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C322(0.92)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C322(1.33)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C322(1.14)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C322(1.30)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C322(1.16)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C322(1.32)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C322(2.21)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C322(1.20)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C322(1.49)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C322(1.33)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C322(1.13)  LDD0698  [7]
 LDCM0382  CL112 PaTu 8988t C322(0.90)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C322(0.86)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C322(1.49)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C322(0.86)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C322(1.11)  LDD1265  [7]
 LDCM0387  CL117 HCT 116 C322(1.50)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C322(0.84)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C322(1.10)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C322(2.37)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C322(0.78)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C322(1.06)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C322(1.12)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C322(1.76)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C322(1.27)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C322(0.77)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C322(1.13)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C322(1.19)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C322(1.18)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C322(1.55)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C322(1.61)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C322(1.48)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C322(1.29)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C322(1.82)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C322(1.35)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C322(1.32)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C322(1.01)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C322(1.35)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C322(2.01)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C322(2.14)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C322(1.59)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C322(1.82)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C322(1.74)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C322(1.44)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C322(1.13)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C322(1.49)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C322(1.35)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C322(1.22)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C322(1.35)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C322(0.74)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C322(0.75)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C322(0.87)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C322(1.08)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C322(1.00)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C322(0.98)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C322(1.08)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C322(0.94)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C322(1.67)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C322(0.91)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C322(0.91)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C322(1.14)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C322(1.11)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C322(0.88)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C322(0.79)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C322(1.11)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C322(1.28)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C322(1.37)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C322(1.21)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C322(1.09)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C322(1.43)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C322(1.38)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C322(1.26)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C322(1.75)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C322(1.24)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C322(1.23)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C322(0.77)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C322(1.88)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C322(1.54)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C322(1.68)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C322(1.45)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C322(1.51)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C322(0.80)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C322(0.88)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C322(0.86)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C322(1.14)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C322(0.88)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C322(0.98)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C322(0.98)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C322(0.93)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C322(0.88)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C322(1.67)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C322(1.10)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C322(0.83)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C322(0.72)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C322(1.30)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C322(1.06)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C322(1.27)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C322(3.88)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C322(0.89)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C322(1.14)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C322(1.65)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C322(1.30)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C322(0.99)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C322(1.38)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C322(1.33)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C322(1.42)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C322(0.97)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C322(0.95)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C322(1.29)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C322(1.32)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C322(1.71)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C322(1.35)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C322(0.99)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C322(0.87)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C322(1.11)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C322(1.16)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C322(1.29)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C322(1.21)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C322(0.98)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C322(1.18)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C322(1.02)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C322(1.07)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C290(0.90); C118(0.94); C322(1.03)  LDD1698  [14]
 LDCM0468  Fragment33 HCT 116 C322(1.04)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C322(1.00)  LDD0744  [7]
 LDCM0615  Fragment63-R Jurkat _(7.16)  LDD1487  [4]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [4]
 LDCM0022  KB02 HCT 116 C322(8.04)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C322(7.01)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C322(9.64)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0226  [6]
 LDCM0021  THZ1 HCT 116 C322(1.16)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neuronal-specific septin-3 (SEPTIN3) Septin GTPase family Q9UH03
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402