Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Johansson_61  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Fragment63-R  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 58 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02788  15-hydroxyprostaglandin dehydrogenase [NAD(+)] (HPGD) 20.0
 LDTP08482  3'-5' exoribonuclease 1 (ERI1) 20.0
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 20.0
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 20.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 20.0
 LDTP06471  Chitinase-3-like protein 2 (CHI3L2) 20.0
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 20.0
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 20.0
 LDTP02616  Creatine kinase B-type (CKB) 20.0
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 20.0
 LDTP09841  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (ALG3) 20.0
 LDTP09556  E3 ubiquitin-protein ligase RNF139 (RNF139) 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 20.0
 LDTP08232  Glycerol-3-phosphate acyltransferase 4 (GPAT4) 20.0
 LDTP09505  GPI ethanolamine phosphate transferase 3 (PIGO) 20.0
 LDTP01986  NADH-ubiquinone oxidoreductase chain 5 (MT-ND5) 20.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 20.0
 LDTP03831  Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) 20.0
 LDTP12064  Polyprenol reductase (SRD5A3) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP17022  Secernin-3 (SCRN3) 20.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 20.0
 LDTP04988  Thioredoxin reductase-like selenoprotein T (SELENOT) 20.0
 LDTP03258  Thymidylate kinase (DTYMK) 20.0
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 20.0
 LDTP01394  DNA fragmentation factor subunit beta (DFFB) 18.8
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 16.9
 LDTP03163  Sterol carrier protein 2 (SCP2) 16.6
 LDTP06211  Caspase-8 (CASP8) 15.2
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 14.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 14.1
 LDTP00697  Cytochrome b5 type B (CYB5B) 14.0
 LDTP12697  Androgen-induced gene 1 protein (AIG1) 13.0
 LDTP09344  Prostamide/prostaglandin F synthase (PRXL2B) 11.3
 LDTP10432  ATP synthase membrane subunit K, mitochondrial (ATP5MK) 11.1
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 10.8
 LDTP07932  Probable ATP-dependent RNA helicase DDX46 (DDX46) 10.3
 LDTP03298  DNA-directed RNA polymerase II subunit RPB1 (POLR2A) 10.3
 LDTP11294  Protein adenylyltransferase SelO, mitochondrial (SELENOO) 9.6
 LDTP14213  Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) 9.5
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 9.5
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 9.3
 LDTP09053  Xyloside xylosyltransferase 1 (XXYLT1) 8.7
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 8.6
 LDTP03458  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) 8.2
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 7.0
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 5.6
 LDTP13302  Nuclear prelamin A recognition factor (NARF) 5.3
 LDTP10917  Selenide, water dikinase 2 (SEPHS2) 5.0
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 4.8
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 4.8
 LDTP11990  Cytosolic iron-sulfur assembly component 3 (CIAO3) 4.7
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) 4.4
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 4.3
 LDTP07819  Rho family-interacting cell polarization regulator 1 (RIPOR1) 4.3
 LDTP06142  Squalene monooxygenase (SQLE) 4.2
 LDTP07208  Alpha/beta hydrolase domain-containing protein 17B (ABHD17B) 4.0
 LDTP07875  Ubiquitin carboxyl-terminal hydrolase 34 (USP34) 4.0
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09149  ATP-binding cassette sub-family F member 1 (ABCF1) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP13834  Sodium-dependent multivitamin transporter (SLC5A6) 20.0
 LDTP01454  SUN domain-containing protein 1 (SUN1) 20.0
 LDTP06170  Transmembrane protein 187 (TMEM187) 20.0
 LDTP08029  Nucleoporin p54 (NUP54) 20.0
 LDTP10073  Protein RFT1 homolog (RFT1) 16.2
 LDTP00970  Gasdermin-E (GSDME) 15.9
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 7.2
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 5.1
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 4.8
Other
Click to Show/Hide to Show 34 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16289  BTB/POZ domain-containing protein KCTD3 (KCTD3) 20.0
 LDTP07050  DDB1- and CUL4-associated factor 10 (DCAF10) 20.0
 LDTP18400  DENN domain-containing protein 2D (DENND2D) 20.0
 LDTP06804  Girdin (CCDC88A) 20.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) 20.0
 LDTP14591  Hemoglobin subunit theta-1 (HBQ1) 20.0
 LDTP02674  Keratin, type I cytoskeletal 10 (KRT10) 20.0
 LDTP19672  Selenoprotein H (SELENOH) 20.0
 LDTP14236  Selenoprotein K (SELENOK) 20.0
 LDTP03399  CD82 antigen (CD82) 19.4
 LDTP11140  Peroxiredoxin-like 2A (PRXL2A) 16.0
 LDTP15599  UPF0729 protein C18orf32 (C18orf32) 15.0
 LDTP19476  AMMECR1-like protein (AMMECR1L) 14.6
 LDTP10140  Calcineurin B homologous protein 3 (TESC) 13.5
 LDTP01522  Reticulon-3 (RTN3) 13.4
 LDTP13664  Syntaxin-8 (STX8) 13.1
 LDTP11075  Selenoprotein S (SELENOS) 12.7
 LDTP00430  Transcription elongation regulator 1 (TCERG1) 11.2
 LDTP13245  Zinc finger CCCH domain-containing protein 7B (ZC3H7B) 10.3
 LDTP13710  Trinucleotide repeat-containing gene 6B protein (TNRC6B) 10.3
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 9.8
 LDTP01012  Selenoprotein F (SELENOF) 9.5
 LDTP10357  RUS family member 1 (RUSF1) 8.3
 LDTP11280  Target of rapamycin complex subunit LST8 (MLST8) 7.4
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) 6.2
 LDTP05578  Retinoblastoma-like protein 2 (RBL2) 5.9
 LDTP07814  Protein MMS22-like (MMS22L) 5.9
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 5.1
 LDTP10221  TBC1 domain family member 31 (TBC1D31) 5.0
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 4.6
 LDTP00239  DNA fragmentation factor subunit alpha (DFFA) 4.6
 LDTP15852  Protein FAM118B (FAM118B) 4.6
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) 4.4
 LDTP14260  Calcineurin-binding protein cabin-1 (CABIN1) 4.2

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.