Details of the Target

General Information of Target

Target ID LDTP01012
Target Name Selenoprotein F (SELENOF)
Gene Name SELENOF
Gene ID 9403
Synonyms
15-Sep; Selenoprotein F; 15 kDa selenoprotein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQ
FNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQ
IKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI
Target Bioclass
Other
Family
Selenoprotein M/F family
Subcellular location
Endoplasmic reticulum lumen
Function
May be involved in redox reactions associated with the formation of disulfide bonds. May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2.
Uniprot ID
O60613
Ensemble ID
ENST00000331835.10
HGNC ID
HGNC:17705

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAOV3 SNV: p.L20F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
Johansson_61
 Probe Info  		_(7.83)  LDD1485  [2]
YY4-yne
 Probe Info  		3.27  LDD0400  [3]
DBIA
 Probe Info  		C70(4.70); C71(4.70)  LDD0080  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		C41(0.00); C74(0.00)  LDD0218  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0237  AC12 HEK-293T C73(1.14)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C74(1.03)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C73(1.16)  LDD1513  [7]
 LDCM0280  AC20 HEK-293T C73(1.08)  LDD1519  [7]
 LDCM0282  AC22 HEK-293T C74(1.01)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C73(0.92)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C74(1.02)  LDD1523  [7]
 LDCM0288  AC28 HEK-293T C73(1.10)  LDD1527  [7]
 LDCM0291  AC30 HEK-293T C74(0.90)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C73(0.87)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C74(0.92)  LDD1532  [7]
 LDCM0297  AC36 HEK-293T C73(1.05)  LDD1536  [7]
 LDCM0299  AC38 HEK-293T C74(1.04)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C73(0.88)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C73(0.98)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C74(1.17)  LDD1541  [7]
 LDCM0306  AC44 HEK-293T C73(1.15)  LDD1545  [7]
 LDCM0308  AC46 HEK-293T C74(1.05)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C73(0.90)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C74(1.05)  LDD1549  [7]
 LDCM0315  AC52 HEK-293T C73(1.04)  LDD1554  [7]
 LDCM0317  AC54 HEK-293T C74(1.06)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C73(0.88)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C74(1.05)  LDD1558  [7]
 LDCM0323  AC6 HEK-293T C74(1.04)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C73(1.06)  LDD1563  [7]
 LDCM0326  AC62 HEK-293T C74(1.07)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C73(1.25)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C74(1.13)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C73(0.94)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C74(1.08)  LDD1569  [7]
 LDCM0275  AKOS034007705 HEK-293T C74(1.06)  LDD1514  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [5]
 LDCM0368  CL10 HEK-293T C74(1.46)  LDD1572  [7]
 LDCM0372  CL103 HEK-293T C74(1.19)  LDD1576  [7]
 LDCM0376  CL107 HEK-293T C74(1.21)  LDD1580  [7]
 LDCM0379  CL11 HEK-293T C73(0.91)  LDD1583  [7]
 LDCM0381  CL111 HEK-293T C74(1.05)  LDD1585  [7]
 LDCM0385  CL115 HEK-293T C74(1.12)  LDD1589  [7]
 LDCM0389  CL119 HEK-293T C74(1.13)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C74(1.16)  LDD1594  [7]
 LDCM0394  CL123 HEK-293T C74(1.06)  LDD1598  [7]
 LDCM0398  CL127 HEK-293T C74(1.04)  LDD1602  [7]
 LDCM0402  CL15 HEK-293T C74(1.27)  LDD1606  [7]
 LDCM0408  CL20 HEK-293T C73(1.53)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C74(1.48)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C73(0.99)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C74(1.36)  LDD1616  [7]
 LDCM0415  CL27 HEK-293T C74(1.21)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C74(1.26)  LDD1622  [7]
 LDCM0421  CL32 HEK-293T C73(1.12)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C74(1.30)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C73(0.84)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C74(1.30)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C74(1.08)  LDD1632  [7]
 LDCM0434  CL44 HEK-293T C73(1.13)  LDD1638  [7]
 LDCM0436  CL46 HEK-293T C74(1.17)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C73(1.04)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C74(1.21)  LDD1642  [7]
 LDCM0447  CL56 HEK-293T C73(1.47)  LDD1650  [7]
 LDCM0449  CL58 HEK-293T C74(1.27)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C73(0.93)  LDD1653  [7]
 LDCM0452  CL60 HEK-293T C74(1.32)  LDD1655  [7]
 LDCM0455  CL63 HEK-293T C74(1.14)  LDD1658  [7]
 LDCM0460  CL68 HEK-293T C73(1.17)  LDD1663  [7]
 LDCM0463  CL70 HEK-293T C74(1.22)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C73(1.25)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C74(1.29)  LDD1668  [7]
 LDCM0473  CL8 HEK-293T C73(1.13)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C73(1.11)  LDD1677  [7]
 LDCM0476  CL82 HEK-293T C74(1.22)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C73(0.83)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C74(1.23)  LDD1681  [7]
 LDCM0481  CL87 HEK-293T C74(1.16)  LDD1684  [7]
 LDCM0487  CL92 HEK-293T C73(1.07)  LDD1690  [7]
 LDCM0489  CL94 HEK-293T C74(1.38)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C73(1.04)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C74(1.12)  LDD1694  [7]
 LDCM0494  CL99 HEK-293T C74(1.17)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C74(1.26)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C74(1.12)  LDD1671  [7]
 LDCM0615  Fragment63-R Jurkat _(9.54)  LDD1487  [2]
 LDCM0617  Fragment63-S Jurkat _(16.42)  LDD1490  [2]
 LDCM0569  Fragment7 Jurkat _(7.83)  LDD1485  [2]
 LDCM0022  KB02 HCT 116 C70(4.70); C71(4.70)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C70(4.80); C71(4.80)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C70(3.30); C71(3.30)  LDD0082  [4]
 LDCM0154  YY4 T cell 3.27  LDD0400  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Retinol dehydrogenase 11 (RDH11) Short-chain dehydrogenases/reductases (SDR) family Q8TC12

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
3 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402