Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Johansson_61  Probe Info 
Probe concentration 10 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name Fragment63-S  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Bone marrow
Disease Model T acute lymphoblastic leukemia [ICD-11:2A90]
Model Name Human T acute lymphoblastic leukemia cell lysate (Jurkat)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 20.0
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 20.0
 LDTP07208  Alpha/beta hydrolase domain-containing protein 17B (ABHD17B) 20.0
 LDTP02264  Asparagine synthetase [glutamine-hydrolyzing] (ASNS) 20.0
 LDTP04358  Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) 20.0
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 20.0
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 20.0
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 20.0
 LDTP02616  Creatine kinase B-type (CKB) 20.0
 LDTP02622  Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) 20.0
 LDTP00697  Cytochrome b5 type B (CYB5B) 20.0
 LDTP03350  DNA (cytosine-5)-methyltransferase 1 (DNMT1) 20.0
 LDTP01394  DNA fragmentation factor subunit beta (DFFB) 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) 20.0
 LDTP08232  Glycerol-3-phosphate acyltransferase 4 (GPAT4) 20.0
 LDTP09505  GPI ethanolamine phosphate transferase 3 (PIGO) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP10368  Methylthioribulose-1-phosphate dehydratase (APIP) 20.0
 LDTP07591  Neutral cholesterol ester hydrolase 1 (NCEH1) 20.0
 LDTP08456  Palmitoyltransferase ZDHHC17 (ZDHHC17) 20.0
 LDTP12362  Palmitoyltransferase ZDHHC4 (ZDHHC4) 20.0
 LDTP03831  Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4) 20.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 20.0
 LDTP01647  Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein (ASMTL) 20.0
 LDTP12040  Prostaglandin E synthase 2 (PTGES2) 20.0
 LDTP11294  Protein adenylyltransferase SelO, mitochondrial (SELENOO) 20.0
 LDTP05551  Quinone oxidoreductase (CRYZ) 20.0
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 20.0
 LDTP02248  Rho-related GTP-binding protein RhoC (RHOC) 20.0
 LDTP03592  Ribonucleoside-diphosphate reductase subunit M2 (RRM2) 20.0
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 20.0
 LDTP09976  Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) 20.0
 LDTP15725  Secernin-2 (SCRN2) 20.0
 LDTP17022  Secernin-3 (SCRN3) 20.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) 20.0
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) 20.0
 LDTP04988  Thioredoxin reductase-like selenoprotein T (SELENOT) 20.0
 LDTP04927  Transforming protein RhoA (RHOA) 20.0
 LDTP07875  Ubiquitin carboxyl-terminal hydrolase 34 (USP34) 20.0
 LDTP03904  Ubiquitin carboxyl-terminal hydrolase 8 (USP8) 20.0
 LDTP01704  Phosphatidylserine lipase ABHD16A (ABHD16A) 13.9
 LDTP09344  Prostamide/prostaglandin F synthase (PRXL2B) 12.2
 LDTP06211  Caspase-8 (CASP8) 12.0
 LDTP06658  Thioredoxin reductase 1, cytoplasmic (TXNRD1) 11.4
 LDTP13302  Nuclear prelamin A recognition factor (NARF) 10.8
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 10.4
 LDTP14213  Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG6) 8.6
 LDTP02852  Methylated-DNA--protein-cysteine methyltransferase (MGMT) 8.2
 LDTP05408  Antigen peptide transporter 1 (TAP1) 7.5
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 6.0
 LDTP19892  DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68) 6.0
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 5.9
 LDTP01141  E3 ubiquitin-protein ligase BRE1B (RNF40) 5.5
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 5.3
 LDTP13219  GTPase IMAP family member 2 (GIMAP2) 5.0
 LDTP10917  Selenide, water dikinase 2 (SEPHS2) 4.7
 LDTP04135  Glutamine--tRNA ligase (QARS1) 4.7
 LDTP12188  Arsenite methyltransferase (AS3MT) 4.7
 LDTP05845  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (PDE3B) 4.3
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 4.2
 LDTP13349  E3 ISG15--protein ligase HERC5 (HERC5) 4.1
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 4.0
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04849  CD81 antigen (CD81) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP00970  Gasdermin-E (GSDME) 20.0
 LDTP08029  Nucleoporin p54 (NUP54) 20.0
 LDTP07626  Rapamycin-insensitive companion of mTOR (RICTOR) 20.0
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 20.0
 LDTP10148  Store-operated calcium entry-associated regulatory factor (SARAF) 20.0
 LDTP01969  Transferrin receptor protein 1 (TFRC) 20.0
 LDTP05875  Transmembrane emp24 domain-containing protein 1 (TMED1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.6
 LDTP01060  PRA1 family protein 2 (PRAF2) 5.5
 LDTP12738  Ceroid-lipofuscinosis neuronal protein 6 (CLN6) 5.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00671  Tapasin (TAPBP) 12.3
Other
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP19476  AMMECR1-like protein (AMMECR1L) 20.0
 LDTP03399  CD82 antigen (CD82) 20.0
 LDTP04571  Coatomer subunit alpha (COPA) 20.0
 LDTP19860  Coiled-coil domain-containing protein 97 (CCDC97) 20.0
 LDTP06804  Girdin (CCDC88A) 20.0
 LDTP17802  Glutathione S-transferase C-terminal domain-containing protein (GSTCD) 20.0
 LDTP02308  Keratin, type I cytoskeletal 16 (KRT16) 20.0
 LDTP01522  Reticulon-3 (RTN3) 20.0
 LDTP05578  Retinoblastoma-like protein 2 (RBL2) 20.0
 LDTP10357  RUS family member 1 (RUSF1) 20.0
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 20.0
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 20.0
 LDTP13338  Vacuolar protein sorting-associated protein 51 homolog (VPS51) 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 17.4
 LDTP01012  Selenoprotein F (SELENOF) 16.4
 LDTP13664  Syntaxin-8 (STX8) 14.3
 LDTP12412  Reticulon-4 (RTN4) 11.9
 LDTP15714  Mdm2-binding protein (MTBP) 11.9
 LDTP11075  Selenoprotein S (SELENOS) 11.9
 LDTP06051  Kelch-like ECH-associated protein 1 (KEAP1) 8.4
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 8.1
 LDTP13323  Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) 5.1
 LDTP15852  Protein FAM118B (FAM118B) 4.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.