Details of the Target

General Information of Target

Target ID LDTP14264
Target Name Choline/ethanolaminephosphotransferase 1 (CEPT1)
Gene Name CEPT1
Gene ID 10390
Synonyms
Choline/ethanolaminephosphotransferase 1; hCEPT1; EC 2.7.8.1; EC 2.7.8.2; 1-alkenyl-2-acylglycerol choline phosphotransferase; EC 2.7.8.22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKR
RKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPK
GCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVAL
QDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVG
SVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADP
VRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQVKADGHKVYG
AILVAVERLLKMKAQAAEPNRGGPGGRGCRRLDDLPWDSLLFQESSSGGGAEPSFGSGLP
LPPGGAGPEDPSLSVTLADIYRELYAFFGDSLATRFGTGQPAPTAPRPPGDKKEPAAAPD
SVRKMPQLTASAIVSPHGDESPRGSGGGGPASASGPAASESRPLPRVHRARGAPRQQGPG
TGTRDVFQKSRFAPRGAPHFRFIIAGRQAGRRCRGRLFQTAFPAPYGPSPASRYVQKLPM
IGRTSRPARRWALSDYSLYLPL
Target Bioclass
Enzyme
Family
CDP-alcohol phosphatidyltransferase class-I family
Subcellular location
Endoplasmic reticulum membrane
Function
Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.
Uniprot ID
Q9Y6K0
Ensemble ID
ENST00000357172.9
HGNC ID
HGNC:24289
ChEMBL ID
CHEMBL4105740

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-5
 Probe Info  		10.00  LDD0394  [1]
BTD
 Probe Info  		C30(2.19)  LDD1700  [2]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [3]
YY4-yne
 Probe Info  		5.90  LDD0400  [4]
AHL-Pu-1
 Probe Info  		C30(2.41); C11(2.48)  LDD0169  [5]
DBIA
 Probe Info  		C11(1.44); C30(1.44)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
IPM
 Probe Info  		N.A.  LDD0147  [8]
AOyne
 Probe Info  		9.30  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		14.52  LDD1752  [10]
C056
 Probe Info  		31.12  LDD1753  [10]
C091
 Probe Info  		19.29  LDD1782  [10]
C092
 Probe Info  		30.70  LDD1783  [10]
C094
 Probe Info  		25.11  LDD1785  [10]
C134
 Probe Info  		35.02  LDD1816  [10]
C135
 Probe Info  		9.71  LDD1817  [10]
C159
 Probe Info  		10.06  LDD1839  [10]
C160
 Probe Info  		9.06  LDD1840  [10]
C161
 Probe Info  		14.22  LDD1841  [10]
C198
 Probe Info  		11.47  LDD1874  [10]
C210
 Probe Info  		49.18  LDD1884  [10]
C225
 Probe Info  		5.54  LDD1898  [10]
C228
 Probe Info  		25.46  LDD1901  [10]
FFF probe11
 Probe Info  		20.00  LDD0471  [11]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]
A-DA
 Probe Info  		2.51  LDD0145  [12]
OEA-DA
 Probe Info  		4.23  LDD0046  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C30(2.41); C11(2.48)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C317(1.02); C253(1.07)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C30(1.06); C317(0.92); C253(0.94); C253(0.85)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C30(1.16); C317(0.89); C253(1.15)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C30(1.22); C317(0.92); C253(0.87); C253(0.98)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C317(0.92); C253(0.83)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C317(0.86); C253(0.91)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C317(0.99); C253(1.05)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C30(1.05); C317(0.87); C253(1.00); C253(0.97)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C30(0.74); C317(0.91); C253(0.92)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C30(0.97); C317(0.84); C253(0.92); C253(0.73)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C30(1.07); C317(0.85); C253(0.96); C253(1.13)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C11(0.80); C30(1.06); C317(0.88); C253(0.84)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C317(0.83); C253(1.01)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C317(0.93); C253(0.79)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C11(1.07); C30(1.14); C317(0.93); C253(0.86)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C317(0.85); C253(1.05)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C30(0.97); C317(0.89); C253(0.92); C253(0.76)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C30(1.28); C317(0.88); C253(0.85)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C30(1.03); C317(0.95); C253(0.82); C253(1.05)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C11(0.74); C30(1.12); C317(0.99); C253(0.79)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C30(0.99); C317(0.90); C253(0.90)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C317(0.84); C253(0.87)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C317(0.95); C253(0.93)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C11(0.99); C30(0.98); C317(0.89); C253(0.77)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C317(0.91); C253(1.13)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C30(1.16); C317(0.82); C253(1.01); C253(0.77)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C30(1.13); C317(0.93); C253(0.89)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C30(1.19); C317(0.87); C253(0.99); C253(1.09)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C11(0.80); C30(1.11); C317(0.93); C253(0.90)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C317(0.84); C253(0.96)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C317(0.90); C253(0.92)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C30(1.06); C317(0.93); C253(0.85); C253(1.47)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C11(1.15); C30(1.15); C317(1.00); C253(0.95)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C317(0.95); C253(1.11)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C30(1.18); C317(0.80); C253(1.01); C253(0.84)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C30(1.25); C317(0.90); C253(1.03)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C30(1.03); C317(0.86); C253(1.30); C253(1.06)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C11(0.74); C30(1.22); C317(0.90); C253(0.89)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C317(0.81); C253(1.07)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C317(0.89); C253(0.93)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C11(0.96); C30(1.13); C317(0.91); C253(1.17)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C317(0.92); C253(0.97)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C11(0.84); C30(1.08); C317(0.96); C253(0.85)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C30(1.09); C317(0.79); C253(0.86); C253(1.12)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C30(1.29); C317(0.85); C253(1.02)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C30(0.98); C317(0.94); C253(0.89); C253(0.94)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C11(0.67); C30(1.10); C317(0.92); C253(0.95)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C317(0.77); C253(0.89)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C317(0.97); C253(1.16)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C11(0.97); C30(1.03); C317(0.96); C253(0.96)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C317(0.97); C253(1.16)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C30(1.00); C317(0.86); C253(1.08); C253(0.79)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C30(0.92); C317(1.05); C253(1.03)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C317(0.94); C253(0.72)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C30(0.94); C317(1.04); C253(0.95); C253(1.05)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C11(0.94); C30(1.01); C317(1.07); C253(1.03)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C317(0.90); C253(0.70)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C317(0.91); C253(1.27)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C11(1.05); C30(1.07); C317(0.98); C253(1.13)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C317(0.88); C253(0.92)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C11(1.08); C30(1.20); C317(0.97); C253(1.11)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C11(0.75); C30(1.15); C317(1.06); C253(0.97)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C317(0.90); C253(1.25)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C11(1.11); C30(1.21); C317(0.96); C253(0.85)  LDD1514  [14]
 LDCM0020  ARS-1620 HCC44 C11(1.44); C30(1.44)  LDD0078  [6]
 LDCM0367  CL1 HEK-293T C11(1.60); C30(2.07); C317(1.25); C253(1.08)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C317(1.65); C253(1.36)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C11(1.19); C30(1.35); C317(1.09)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C11(1.15); C30(1.25); C317(1.01); C253(1.18)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C11(1.30); C30(2.01); C317(1.22); C253(1.04)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C317(0.98); C253(0.99); C253(0.92); C262(0.92)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C11(1.00); C30(1.19); C317(0.93)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C11(1.14); C30(1.23); C317(1.11); C253(1.25)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C11(1.22); C30(1.80); C317(1.09); C253(0.83)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C317(0.86); C253(0.85); C253(0.81); C262(0.81)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C11(1.02); C30(1.11); C317(0.97)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C11(1.43); C30(2.14); C317(1.10); C253(1.16)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C317(1.62); C253(1.30)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C11(1.30); C30(2.40); C317(1.27); C253(0.64)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C317(1.00); C253(0.97); C253(0.80); C262(0.80)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C11(1.36); C30(1.37); C317(0.90)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C11(1.14); C30(1.18); C317(0.84); C253(1.01)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C11(1.37); C30(2.06); C317(1.16); C253(1.13)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C317(0.84); C253(0.93); C253(0.83); C262(0.83)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C11(0.90); C30(1.12); C317(0.80)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C11(1.14); C30(1.04); C317(0.88); C253(1.13)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C11(1.14); C30(0.98); C317(0.93); C253(1.21)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C317(0.91); C253(0.77); C253(1.12); C262(1.12)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C11(1.12); C30(1.45); C317(1.91); C253(1.60)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C11(0.97); C30(1.07); C317(0.81)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C11(1.03); C30(1.29); C317(0.89); C253(1.04)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C11(1.01); C30(1.38); C317(1.02); C253(0.97)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C317(1.14); C253(0.84); C253(1.04); C262(1.04)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C11(1.01); C30(1.51); C317(1.08)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C11(0.85); C30(0.84); C317(1.21); C253(1.38)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C11(1.11); C30(1.28); C317(1.13); C253(1.22)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C317(0.94); C253(0.89); C253(0.96); C262(0.96)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C11(0.93); C30(0.95); C317(0.95)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C11(0.90); C30(0.94); C317(1.02); C253(1.01)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C11(1.23); C30(1.28); C317(1.02); C253(1.30)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C317(1.36); C253(1.72); C253(1.28); C262(1.28)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C11(1.00); C30(1.10); C317(0.83)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C317(1.37); C253(1.45)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C30(1.15); C317(0.94); C253(1.03); C253(1.09)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C30(1.60); C317(1.01); C253(1.06)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C11(1.19); C30(1.19); C317(1.05); C253(1.20)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C30(1.15); C317(1.23); C253(0.87); C253(1.20)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C11(1.25); C30(3.26); C317(1.94); C253(1.27)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C317(1.34); C253(1.34)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C317(1.55); C253(1.11)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C11(0.95); C30(1.19); C317(1.61); C253(1.00)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C11(1.29); C30(2.00); C317(1.26); C253(1.25)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C11(0.98); C30(1.15); C317(1.07); C253(0.90)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C317(0.87); C253(0.75); C253(0.85); C262(0.85)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C11(1.26); C30(1.29); C317(0.95)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C317(0.95); C253(0.96)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C317(1.19); C253(1.21); C253(0.82); C262(0.82)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C30(1.13); C317(0.94); C253(1.04); C253(0.87)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C30(1.70); C317(1.09); C253(1.21)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C30(1.29); C317(1.23); C253(0.92); C253(1.00)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C11(1.20); C30(3.44); C317(2.14); C253(1.06)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C317(1.32); C253(0.91)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C317(1.39); C253(0.99)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C11(1.20); C30(1.50); C317(1.45); C253(1.06)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C11(1.06); C30(1.36); C317(0.92); C253(1.07)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C317(1.07); C253(0.75); C253(0.93); C262(0.93)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C11(1.09); C30(1.93); C317(0.97)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C11(0.98); C30(1.03); C317(0.92)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C317(1.03); C253(1.11)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C30(0.96); C317(0.89); C253(1.08); C253(0.87)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C30(1.90); C317(0.94); C253(1.02)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C30(1.20); C317(1.03); C253(0.95); C253(0.81)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C11(1.02); C30(2.18); C317(1.48); C253(1.18)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C317(1.11); C253(0.79)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C317(1.36); C253(0.96)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C11(0.96); C30(1.15); C317(1.53); C253(1.03)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C11(0.96); C30(1.14); C317(1.20); C253(1.14)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C317(0.98); C253(1.46)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C11(1.26); C30(1.59); C317(1.04); C253(1.05)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C11(1.16); C30(1.32); C317(0.92)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C317(1.07); C253(1.28)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C30(3.78); C317(1.68); C253(1.60); C253(1.20)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C30(1.41); C317(0.96); C253(0.92)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C30(1.31); C317(1.11); C253(1.07); C253(1.17)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C11(1.12); C30(1.85); C317(1.39); C253(0.96)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C317(1.32); C253(0.96)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C317(1.26); C253(1.72)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C30(1.88); C317(1.40); C253(1.56); C253(0.89)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C11(1.20); C30(1.56); C317(1.50); C253(1.20)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C11(0.91); C30(0.90); C317(1.00); C253(1.17)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C11(1.11); C30(1.01); C317(1.04); C253(0.90)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C317(0.90); C253(0.93); C253(0.83); C262(0.83)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C11(1.57); C30(2.61); C317(1.28)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C317(0.86); C253(1.00)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C30(1.36); C317(0.80); C253(1.03); C253(1.37)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C30(1.10); C317(0.95); C253(1.13)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C30(2.01); C317(1.04); C253(1.04); C253(1.44)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C11(0.88); C30(2.50); C317(1.54); C253(0.97)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C30(1.46); C317(1.13); C253(1.13)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C317(1.23); C253(1.08)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C317(1.29); C253(0.98)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C11(1.26); C30(1.39); C317(1.42); C253(1.37)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C11(1.14); C30(1.65); C317(1.10); C253(1.12)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C11(1.14); C30(1.05); C317(1.03); C253(1.14)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C11(1.04); C30(1.17); C317(1.05)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C317(1.18); C253(1.20)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C30(1.10); C317(0.80); C253(0.98); C253(1.11)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C30(1.42); C317(0.93); C253(1.17)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C30(3.07); C317(1.94); C253(1.28); C253(1.12)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C30(0.99); C317(0.98); C253(0.97); C253(1.25)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C11(0.62); C30(1.26); C317(1.09); C253(0.92)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C317(1.00); C253(0.92)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C317(1.47); C253(1.16)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C11(1.20); C30(2.38); C317(1.58); C253(1.11)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C11(0.85); C30(0.76); C317(1.12); C253(1.48)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C11(0.78); C30(0.85); C317(1.12); C253(1.15)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C317(1.04); C253(0.67); C253(0.73); C262(0.73)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C11(0.84); C30(0.96); C317(0.99)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C317(1.07); C253(1.16)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C11(1.14); C30(1.56); C317(1.63); C253(1.06)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C30(2.63); C317(2.13); C253(1.82); C253(0.84)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C30(1.11); C317(0.88); C253(1.09)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C30(2.85); C317(1.27); C253(1.04); C253(1.00)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C11(1.28); C30(2.75); C317(1.50); C253(1.27)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C317(1.00); C253(0.81)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C317(2.12); C253(3.01)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C11(1.34); C30(1.68); C317(2.01); C253(1.75)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C11(1.38); C30(2.16); C317(1.14); C253(0.97)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C11(1.16); C30(1.54); C317(1.26); C253(0.91)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C317(0.89); C253(0.81); C253(0.70); C262(0.70)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C317(0.84); C253(0.78); C253(1.11); C262(1.11)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C30(3.73)  LDD1702  [2]
 LDCM0625  F8 Ramos 4.55  LDD2187  [15]
 LDCM0573  Fragment11 Ramos 6.53  LDD2190  [15]
 LDCM0576  Fragment14 Ramos 1.42  LDD2193  [15]
 LDCM0582  Fragment23 Ramos 1.62  LDD2196  [15]
 LDCM0578  Fragment27 Ramos 2.51  LDD2197  [15]
 LDCM0468  Fragment33 HEK-293T C317(0.95); C253(0.98); C253(0.78); C262(0.78)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C11(1.07); C30(1.11); C317(1.11); C253(1.17)  LDD1631  [14]
 LDCM0614  Fragment56 Ramos 2.65  LDD2205  [15]
 LDCM0616  Fragment61 Jurkat _(14.43)  LDD1489  [3]
 LDCM0615  Fragment63-R Jurkat _(20.00)  LDD1487  [3]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1490  [3]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [3]
 LDCM0022  KB02 HEK-293T C11(0.63); C317(0.82); C253(1.04); C11(0.53)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C11(0.85); C317(0.82); C253(1.30); C11(0.33)  LDD1497  [14]
 LDCM0024  KB05 HEK-293T C11(0.76); C317(0.99); C253(1.14); C11(0.57)  LDD1502  [14]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C30(0.98)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C30(0.91)  LDD2099  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C30(0.68)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C30(0.88)  LDD2111  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C30(0.89)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C30(1.34)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C30(1.03)  LDD2129  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C30(1.18)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C30(0.98)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C30(2.19)  LDD1700  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C30(0.91)  LDD2141  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C30(2.08)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C30(1.03)  LDD2146  [2]
 LDCM0084  Ro 48-8071 A-549 2.51  LDD0145  [12]
 LDCM0021  THZ1 HCT 116 C11(1.41); C30(1.41)  LDD2173  [6]
 LDCM0154  YY4 T cell 5.90  LDD0400  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Choline Small molecular drug DB00122
Choline Salicylate Small molecular drug DB14006

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
13 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578