Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C198  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 94 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 91.8
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 55.3
 LDTP04568  Geranylgeranyl transferase type-1 subunit beta (PGGT1B) 52.7
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 44.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 43.1
 LDTP03805  ADP-ribosylation factor-like protein 2 (ARL2) 41.6
 LDTP14019  HBS1-like protein (HBS1L) 40.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 38.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 36.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 36.0
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 34.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 32.2
 LDTP06617  Ceramide glucosyltransferase (UGCG) 32.0
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 30.5
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 26.4
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 26.2
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 24.1
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 22.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 21.9
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 21.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 21.4
 LDTP02837  Beta-galactosidase (GLB1) 21.4
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 21.3
 LDTP03787  Choline kinase alpha (CHKA) 21.0
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 20.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.0
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 19.6
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 19.4
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 19.3
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 19.2
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 19.0
 LDTP10329  Ceramide synthase 2 (CERS2) 18.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 18.6
 LDTP05905  Acid ceramidase (ASAH1) 18.5
 LDTP02188  Protein disulfide-isomerase (P4HB) 18.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 18.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 18.1
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 18.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 18.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 17.8
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 17.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 17.0
 LDTP09799  DCN1-like protein 4 (DCUN1D4) 16.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 16.6
 LDTP02505  Lysosomal protective protein (CTSA) 16.3
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 16.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 16.0
 LDTP08390  Kinesin-like protein KIF18B (KIF18B) 16.0
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.5
 LDTP03842  Squalene synthase (FDFT1) 15.5
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 15.0
 LDTP11127  ADP-dependent glucokinase (ADPGK) 14.7
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 14.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.4
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 14.4
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 13.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 13.7
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 13.7
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 13.6
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 13.5
 LDTP13589  RNA-binding protein NOB1 (NOB1) 13.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 13.1
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 13.1
 LDTP10020  Ras-related protein Rab-24 (RAB24) 13.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 13.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 12.7
 LDTP01168  NADH dehydrogenase iron-sulfur protein 2, mitochondrial (NDUFS2) 12.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 12.6
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 12.1
 LDTP10649  28S rRNA (cytosine-C(5))-methyltransferase (NSUN5) 12.0
 LDTP06142  Squalene monooxygenase (SQLE) 11.9
 LDTP01513  NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3) 11.8
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 11.7
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 11.6
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 11.6
 LDTP14264  Choline/ethanolaminephosphotransferase 1 (CEPT1) 11.5
 LDTP06262  N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25) 11.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 11.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 11.3
 LDTP03145  Catechol O-methyltransferase (COMT) 11.2
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 11.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 11.1
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.9
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 10.6
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 10.6
 LDTP04032  Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2) 10.6
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 10.4
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 10.3
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 10.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) 10.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 9.8
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 9.6
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 9.6
Transporter and channel
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 65.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 58.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 54.2
 LDTP05900  Metaxin-1 (MTX1) 40.2
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 39.1
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 38.3
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 36.0
 LDTP12383  Protein GPR108 (GPR108) 29.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 27.9
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 27.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 26.0
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 25.6
 LDTP15948  Transmembrane protein 126A (TMEM126A) 25.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 25.1
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 24.3
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 23.9
 LDTP11812  Protein ARV1 (ARV1) 23.6
 LDTP07236  Protein GPR107 (GPR107) 22.3
 LDTP03546  Translocator protein (TSPO) 21.7
 LDTP10533  Sorting nexin-27 (SNX27) 21.3
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 20.4
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.1
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 19.7
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 19.4
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 19.0
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 18.9
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 18.9
 LDTP20002  Transmembrane protein 160 (TMEM160) 18.9
 LDTP10065  Transmembrane protein 230 (TMEM230) 18.3
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 17.4
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.3
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 17.1
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 16.6
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 16.4
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 16.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 16.0
 LDTP02215  Prosaposin (PSAP) 15.9
 LDTP11615  Protein tweety homolog 3 (TTYH3) 15.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 15.7
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 15.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 14.9
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 14.9
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 14.0
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 13.9
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 13.8
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 13.8
 LDTP03380  Stomatin (STOM) 13.6
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 13.4
 LDTP00592  Surfeit locus protein 4 (SURF4) 13.4
 LDTP02071  Amyloid-beta precursor protein (APP) 13.3
 LDTP11245  Derlin-1 (DERL1) 13.3
 LDTP11250  MICOS complex subunit MIC26 (APOO) 13.3
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 12.6
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 12.1
 LDTP01060  PRA1 family protein 2 (PRAF2) 12.1
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 12.0
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 11.8
 LDTP09288  Vang-like protein 1 (VANGL1) 11.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 11.6
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 11.3
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 11.3
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 11.2
 LDTP12451  Integral membrane protein 2C (ITM2C) 11.2
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 11.2
 LDTP01309  Renin receptor (ATP6AP2) 11.1
 LDTP02256  Amino acid transporter heavy chain SLC3A2 (SLC3A2) 10.8
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 10.7
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 10.7
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 10.6
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 10.5
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 10.2
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 10.1
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 9.8
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 9.7
 LDTP15000  Solute carrier family 35 member F1 (SLC35F1) 9.7
 LDTP07531  Sideroflexin-4 (SFXN4) 9.6
Other
Click to Show/Hide to Show 64 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 70.0
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 69.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 59.7
 LDTP02205  Tubulin beta chain (TUBB) 59.7
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 59.3
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 58.1
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 52.7
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 41.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 39.9
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 37.5
 LDTP08796  Protein SYS1 homolog (SYS1) 34.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 29.9
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 29.2
 LDTP01522  Reticulon-3 (RTN3) 28.1
 LDTP11233  Tubulin beta-6 chain (TUBB6) 28.1
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 23.9
 LDTP13086  Syntaxin-18 (STX18) 22.8
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 22.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 21.6
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 20.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 20.0
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 18.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 18.4
 LDTP13210  Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) 18.0
 LDTP05160  Nucleobindin-2 (NUCB2) 17.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 17.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 17.1
 LDTP14072  Telomere length regulation protein TEL2 homolog (TELO2) 17.1
 LDTP16080  Protein FAM114A2 (FAM114A2) 16.1
 LDTP18272  Transmembrane protein 209 (TMEM209) 16.1
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 16.0
 LDTP00859  Synaptogyrin-2 (SYNGR2) 15.3
 LDTP08577  SURP and G-patch domain-containing protein 1 (SUGP1) 15.0
 LDTP19963  TraB domain-containing protein (TRABD) 14.7
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 14.2
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 14.1
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 14.0
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 13.5
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 13.0
 LDTP04902  Actin-related protein 3 (ACTR3) 12.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) 12.9
 LDTP06097  Reticulocalbin-2 (RCN2) 12.8
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 12.5
 LDTP01359  Dynactin subunit 3 (DCTN3) 12.0
 LDTP06268  Condensin complex subunit 2 (NCAPH) 12.0
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 11.6
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 11.6
 LDTP15466  G patch domain-containing protein 11 (GPATCH11) 11.3
 LDTP09215  Torsin-1A-interacting protein 2 (TOR1AIP2) 11.3
 LDTP12287  Ran guanine nucleotide release factor (RANGRF) 10.7
 LDTP16006  Optic atrophy 3 protein (OPA3) 10.6
 LDTP14259  Testis-expressed protein 264 (TEX264) 10.4
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 10.3
 LDTP15623  Neuferricin (CYB5D2) 10.2
 LDTP10056  Protein FAM162A (FAM162A) 10.2
 LDTP04356  Emerin (EMD) 10.0
 LDTP12412  Reticulon-4 (RTN4) 10.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 9.7
 LDTP10203  RalBP1-associated Eps domain-containing protein 1 (REPS1) 9.7
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 9.7
 LDTP03775  RNA-binding protein FUS (FUS) 9.7
 LDTP04557  Arfaptin-2 (ARFIP2) 9.6
 LDTP08224  Protein LYRIC (MTDH) 9.6

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587