Details of the Target

General Information of Target

Target ID LDTP05116
Target Name CMP-sialic acid transporter (SLC35A1)
Gene Name SLC35A1
Gene ID 10559
Synonyms
CMP-sialic acid transporter; CMP-SA-Tr; CMP-Sia-Tr; CST; Solute carrier family 35 member A1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAPRDNVTLLFKLYCLAVMTLMAAVYTIALRYTRTSDKELYFSTTAVCITEVIKLLLSV
GILAKETGSLGRFKASLRENVLGSPKELLKLSVPSLVYAVQNNMAFLALSNLDAAVYQVT
YQLKIPCTALCTVLMLNRTLSKLQWVSVFMLCAGVTLVQWKPAQATKVVVEQNPLLGFGA
IAIAVLCSGFAGVYFEKVLKSSDTSLWVRNIQMYLSGIIVTLAGVYLSDGAEIKEKGFFY
GYTYYVWFVIFLASVGGLYTSVVVKYTDNIMKGFSAAAAIVLSTIASVMLFGLQITLTFA
LGTLLVCVSIYLYGLPRQDTTSIQQGETASKERVIGV
Target Bioclass
Transporter and channel
Family
Nucleotide-sugar transporter family, SLC35A subfamily
Subcellular location
Golgi apparatus membrane
Function
Transports CMP-sialic acid from the cytosol into the Golgi apparatus, functioning as an antiporter that exchanges CMP-sialic acid for CMP. Binds both CMP-sialic acid and free CMP, but has higher affinity for free CMP. Also able to exchange CMP-sialic acid for AMP and UMP. Also mediates the transport of CDP-ribitol.
Uniprot ID
P78382
Ensemble ID
ENST00000369552.9
HGNC ID
HGNC:11021

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.A30P .
HCT116 SNV: p.A24T .
HT115 SNV: p.L215I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K74(3.03)  LDD0277  [1]
DBIA
 Probe Info  		C127(0.69); C131(0.69)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C153
 Probe Info  		39.67  LDD1834  [4]
C177
 Probe Info  		16.22  LDD1856  [4]
C178
 Probe Info  		19.97  LDD1857  [4]
C194
 Probe Info  		22.94  LDD1870  [4]
C197
 Probe Info  		8.22  LDD1873  [4]
C198
 Probe Info  		16.56  LDD1874  [4]
C218
 Probe Info  		12.73  LDD1892  [4]
C219
 Probe Info  		29.45  LDD1893  [4]
C220
 Probe Info  		26.72  LDD1894  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C127(0.69); C131(0.69)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C127(0.82); C131(0.82)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C127(0.40); C131(0.40)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C127(0.46); C131(0.46)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C127(0.49); C131(0.49)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C127(0.44); C131(0.44)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C127(0.35); C131(0.35)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C127(0.37); C131(0.37)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C127(0.35); C131(0.35)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C127(0.61); C131(0.36)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C127(0.38); C131(0.48)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C127(0.40); C131(0.49)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C127(0.87); C131(0.87)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C127(0.39); C131(0.56)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C127(0.39); C131(0.46)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C127(0.49); C131(0.41)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C127(1.15); C131(1.15)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C127(1.09); C131(1.09)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C127(0.82); C131(0.82)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C127(0.94); C131(0.94)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C127(1.04); C131(1.04)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C127(0.83); C131(0.83)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C127(0.84); C131(0.84)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C127(0.96); C131(0.96)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C127(0.96); C131(0.96)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C127(1.10); C131(1.10)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C127(0.77); C131(0.77)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C127(1.27); C131(1.27)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C127(1.00); C131(1.00)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C127(1.12); C131(1.12)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C127(0.82); C131(0.82)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C127(0.86); C131(0.86)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C127(0.91); C131(0.91)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C127(1.37); C131(1.37)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C127(0.93); C131(0.93)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C127(2.23); C131(2.23)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C127(1.12); C131(1.12)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C127(0.89); C131(0.89)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C127(0.92); C131(0.92)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C127(0.92); C131(0.92)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C127(0.89); C131(0.89)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C127(0.76); C131(0.76)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C127(0.68); C131(0.68)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C127(0.90); C131(0.90)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C127(0.73); C131(0.73)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C127(0.71); C131(0.71)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C127(0.92); C131(0.92)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C127(0.88); C131(0.88)  LDD0579  [2]
 LDCM0263  AC143 PaTu 8988t C127(0.75); C131(0.75)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C127(0.56); C131(0.56)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C127(0.76); C131(0.76)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C127(0.55); C131(0.55)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C127(0.91); C131(0.91)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C127(0.72); C131(0.72)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C127(0.63); C131(0.63)  LDD1148  [2]
 LDCM0270  AC15 HCT 116 C127(1.17); C131(1.17)  LDD0587  [2]
 LDCM0271  AC150 PaTu 8988t C127(0.66); C131(0.66)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C127(0.90); C131(0.90)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C127(0.58); C131(0.58)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C127(0.73); C131(0.73)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C127(0.78); C131(0.78)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C127(0.61); C131(0.61)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C127(0.51); C131(0.51)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C127(0.74); C131(0.74)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C127(0.95); C131(0.95)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C127(0.87); C131(0.87)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C127(1.24); C131(1.24)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C127(0.70); C131(0.70)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C127(0.97); C131(0.97)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C127(0.81); C131(0.81)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C127(1.20); C131(1.20)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C127(0.89); C131(0.89)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C127(1.17); C131(1.17)  LDD0601  [2]
 LDCM0285  AC25 PaTu 8988t C127(1.00); C131(1.00)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C127(0.81); C131(0.81)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C127(0.90); C131(0.90)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C127(0.82); C131(0.82)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C127(1.02); C131(1.02)  LDD1168  [2]
 LDCM0290  AC3 HCT 116 C127(0.76); C131(0.76)  LDD0607  [2]
 LDCM0291  AC30 PaTu 8988t C127(1.30); C131(1.30)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C127(0.83); C131(0.83)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C127(1.39); C131(1.39)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C127(1.09); C131(1.09)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C127(1.08); C131(1.08)  LDD1174  [2]
 LDCM0296  AC35 HCT 116 C127(0.77); C131(0.77)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C127(0.67); C131(0.67)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C127(0.98); C131(0.98)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C127(1.04); C131(1.04)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C127(0.61); C131(0.61)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C127(0.72); C131(0.72)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C127(0.88); C131(0.88)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C127(0.63); C131(0.63)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C127(0.79); C131(0.79)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C127(0.66); C131(0.66)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C127(0.74); C131(0.74)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C127(0.72); C131(0.72)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C127(1.11); C131(1.11)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C127(0.69); C131(0.69)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C127(0.60); C131(0.60)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C127(0.71); C131(0.71)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C127(0.65); C131(0.65)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C127(0.77); C131(0.77)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C127(0.83); C131(0.83)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C127(0.78); C131(0.78)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C127(0.79); C131(0.79)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C127(0.72); C131(0.72)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C127(0.80); C131(0.80)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C127(0.65); C131(0.65)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C127(0.57); C131(0.57)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C127(0.71); C131(0.71)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C127(0.56); C131(0.56)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C127(1.12); C131(1.12)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C127(0.59); C131(0.59)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C127(0.51); C131(0.51)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C127(0.86); C131(0.86)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C127(0.66); C131(0.66)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C127(0.59); C131(0.59)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C127(0.52); C131(0.52)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C127(0.58); C131(0.58)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C127(0.43); C131(0.43)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C127(1.10); C131(1.10)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C127(0.99); C131(0.99)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C127(0.98); C131(0.98)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C127(0.85); C131(0.85)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C127(1.01); C131(1.01)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C127(1.06); C131(1.06)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C127(1.28); C131(1.28)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C127(1.31); C131(1.31)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C127(1.25); C131(1.25)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C127(1.14); C131(1.14)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C127(0.90); C131(0.90)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C127(0.97); C131(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C127(1.07); C131(1.07)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C127(0.88); C131(0.88)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C127(1.18); C131(1.18)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C127(0.86); C131(0.86)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C127(1.12); C131(1.12)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C127(0.96); C131(0.96)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C127(1.01); C131(1.01)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C127(0.96); C131(0.96)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C127(1.07); C131(1.07)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C127(1.25); C131(1.25)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C127(1.25); C131(1.25)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C127(1.47); C131(1.47)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C127(1.32); C131(1.32)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C127(0.99); C131(0.99)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C127(1.22); C131(1.22)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C127(1.19); C131(1.19)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C127(1.04); C131(1.04)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C127(1.39); C131(1.39)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C127(0.90); C131(0.90)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C127(1.29); C131(1.29)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C127(0.29); C131(0.29)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C127(0.43); C131(0.43)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C127(0.97); C131(0.97)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C127(0.90); C131(0.90)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C127(0.74); C131(0.74)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C127(1.64); C131(1.64)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C127(1.23); C131(1.23)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C127(0.74); C131(0.74)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C127(0.80); C131(0.80)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C127(1.03); C131(1.03)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C127(0.94); C131(0.94)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C127(1.06); C131(1.06)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C127(0.80); C131(0.80)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C127(0.75); C131(0.75)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C127(0.82); C131(0.82)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C127(0.94); C131(0.94)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C127(0.81); C131(0.81)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C127(1.27); C131(1.27)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C127(0.92); C131(0.92)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C127(1.19); C131(1.19)  LDD0698  [2]
 LDCM0382  CL112 PaTu 8988t C127(0.92); C131(0.92)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C127(0.98); C131(0.98)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C127(0.96); C131(0.96)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C127(1.17); C131(1.17)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C127(0.91); C131(0.91)  LDD1265  [2]
 LDCM0387  CL117 HCT 116 C127(0.91); C131(0.91)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C127(0.84); C131(0.84)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C127(0.77); C131(0.77)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C127(1.28); C131(1.28)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C127(0.64); C131(0.64)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C127(0.76); C131(0.76)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C127(0.64); C131(0.64)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C127(0.67); C131(0.67)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C127(0.78); C131(0.78)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C127(0.78); C131(0.78)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C127(1.08); C131(1.08)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C127(0.61); C131(0.61)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C127(0.67); C131(0.67)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C127(1.21); C131(1.21)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C127(1.60); C131(1.60)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C127(0.96); C131(0.96)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C127(0.89); C131(0.89)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C127(0.88); C131(0.88)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C127(1.03); C131(1.03)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C127(0.83); C131(0.83)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C127(1.18); C131(1.18)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C127(1.05); C131(1.05)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C127(0.99); C131(0.99)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C127(1.21); C131(1.21)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C127(1.33); C131(1.33)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C127(1.14); C131(1.14)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C127(0.94); C131(0.94)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C127(1.16); C131(1.16)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C127(0.77); C131(0.77)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C127(0.98); C131(0.98)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C127(0.88); C131(0.88)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C127(1.36); C131(1.36)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C127(1.18); C131(1.18)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C127(0.80); C131(0.80)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C127(0.83); C131(0.83)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C127(0.96); C131(0.96)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C127(0.92); C131(0.92)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C127(1.12); C131(1.12)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C127(0.95); C131(0.95)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C127(0.98); C131(0.98)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C127(0.78); C131(0.78)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C127(1.42); C131(1.42)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C127(0.81); C131(0.81)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C127(0.93); C131(0.93)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C127(0.76); C131(0.76)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C127(0.95); C131(0.95)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C127(0.75); C131(0.75)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C127(0.77); C131(0.77)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C127(1.13); C131(1.13)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C127(1.30); C131(1.30)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C127(1.25); C131(1.25)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C127(1.80); C131(1.80)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C127(1.20); C131(1.20)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C127(1.44); C131(1.44)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C127(1.16); C131(1.16)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C127(1.03); C131(1.03)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C127(1.23); C131(1.23)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C127(1.45); C131(1.45)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C127(1.57); C131(1.57)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C127(0.86); C131(0.86)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C127(1.55); C131(1.55)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C127(1.27); C131(1.27)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C127(1.08); C131(1.08)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C127(0.88); C131(0.88)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C127(1.62); C131(1.62)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C127(0.86); C131(0.86)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C127(0.91); C131(0.91)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C127(0.76); C131(0.76)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C127(0.76); C131(0.76)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C127(0.62); C131(0.62)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C127(0.59); C131(0.59)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C127(0.83); C131(0.83)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C127(0.62); C131(0.62)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C127(0.84); C131(0.84)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C127(1.40); C131(1.40)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C127(0.83); C131(0.83)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C127(0.66); C131(0.66)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C127(1.00); C131(1.00)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C127(1.56); C131(1.56)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C127(0.88); C131(0.88)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C127(1.03); C131(1.03)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C127(3.22); C131(3.22)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C127(0.89); C131(0.89)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C127(1.27); C131(1.27)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C127(1.39); C131(1.39)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C127(1.38); C131(1.38)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C127(1.31); C131(1.31)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C127(1.09); C131(1.09)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C127(1.02); C131(1.02)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C127(1.32); C131(1.32)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C127(0.97); C131(0.97)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C127(0.71); C131(0.71)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C127(1.19); C131(1.19)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C127(1.18); C131(1.18)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C127(1.13); C131(1.13)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C127(1.57); C131(1.57)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C127(1.22); C131(1.22)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C127(0.65); C131(0.65)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C127(0.71); C131(0.71)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C127(0.69); C131(0.69)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C127(0.65); C131(0.65)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C127(0.58); C131(0.58)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C127(0.71); C131(0.71)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C127(0.87); C131(0.87)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C127(0.73); C131(0.73)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C127(0.66); C131(0.66)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C49(0.91)  LDD1698  [5]
 LDCM0468  Fragment33 HCT 116 C127(0.70); C131(0.70)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C127(0.95); C131(0.95)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Phospholipid phosphatase 4 (PLPP4) PA-phosphatase related phosphoesterase family Q5VZY2
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Ceramide synthase 4 (CERS4) . Q9HA82
Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1) . Q96FE7
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Excitatory amino acid transporter 3 (SLC1A1) Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family P43005
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Multiple coagulation factor deficiency protein 2 (MCFD2) . Q8NI22
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 139 (TMEM139) . Q8IV31
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Killer cell immunoglobulin-like receptor 3DL3 (KIR3DL3) Immunoglobulin superfamily Q8N743
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RELT-like protein 2 (RELL2) RELT family Q8NC24
Synaptotagmin-2 (SYT2) Synaptotagmin family Q8N9I0
T-cell leukemia translocation-altered gene protein (TCTA) TCTA family P57738
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (ASZ1) . Q8WWH4
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402