Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C220  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 203 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00697  Cytochrome b5 type B (CYB5B) 99.7
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 99.7
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 93.1
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 89.3
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 68.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 67.6
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 65.3
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 60.1
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 58.5
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 50.9
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 50.2
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 45.3
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 43.4
 LDTP12056  Thiol S-methyltransferase TMT1A (TMT1A) 43.4
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 41.6
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 41.6
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 41.4
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 40.8
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 39.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 39.7
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 37.3
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 36.8
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 36.8
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 36.3
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 36.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 35.0
 LDTP03730  Sepiapterin reductase (SPR) 34.3
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 34.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 32.7
 LDTP05905  Acid ceramidase (ASAH1) 32.4
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 32.4
 LDTP11127  ADP-dependent glucokinase (ADPGK) 32.2
 LDTP06617  Ceramide glucosyltransferase (UGCG) 32.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 32.0
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 31.8
 LDTP02505  Lysosomal protective protein (CTSA) 30.5
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 30.1
 LDTP09556  E3 ubiquitin-protein ligase RNF139 (RNF139) 29.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 29.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 28.8
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 28.8
 LDTP01562  Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9) 28.6
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 28.6
 LDTP12415  Adenosine 5'-monophosphoramidase HINT3 (HINT3) 28.4
 LDTP12610  Obg-like ATPase 1 (OLA1) 28.2
 LDTP00032  2-hydroxyacyl-CoA lyase 2 (ILVBL) 28.1
 LDTP04581  Holocytochrome c-type synthase (HCCS) 27.7
 LDTP03145  Catechol O-methyltransferase (COMT) 27.5
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 27.5
 LDTP12639  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) 26.5
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 26.4
 LDTP14814  CTD small phosphatase-like protein 2 (CTDSPL2) 25.8
 LDTP10329  Ceramide synthase 2 (CERS2) 25.6
 LDTP04246  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) 25.6
 LDTP01613  Sphingosine-1-phosphate lyase 1 (SGPL1) 25.6
 LDTP08385  NADH dehydrogenase 1 alpha subcomplex subunit 11 (NDUFA11) 25.3
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 25.1
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 25.1
 LDTP11867  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) 24.9
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 24.4
 LDTP09666  Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1) 24.1
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 23.9
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 23.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 23.8
 LDTP05408  Antigen peptide transporter 1 (TAP1) 23.6
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 23.3
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 22.5
 LDTP08859  Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) 22.5
 LDTP01219  NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1) 21.9
 LDTP11318  ADP-ribose pyrophosphatase, mitochondrial (NUDT9) 21.7
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 21.7
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 21.3
 LDTP08390  Kinesin-like protein KIF18B (KIF18B) 21.3
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 21.3
 LDTP06142  Squalene monooxygenase (SQLE) 21.3
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 21.1
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 21.1
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 21.1
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 21.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 21.0
 LDTP03842  Squalene synthase (FDFT1) 20.7
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 20.5
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 20.5
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 20.5
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 20.4
 LDTP02539  Lysosomal acid phosphatase (ACP2) 20.0
 LDTP17410  Cytochrome P450 20A1 (CYP20A1) 19.7
 LDTP11259  Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12) 19.7
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 19.7
 LDTP00783  Beta-1,4-glucuronyltransferase 1 (B4GAT1) 19.6
 LDTP04531  Hexokinase-2 (HK2) 19.4
 LDTP00877  Protein SCO2 homolog, mitochondrial (SCO2) 19.4
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 18.9
 LDTP03394  Ceramide synthase 1 (CERS1) 18.8
 LDTP09061  Retinol dehydrogenase 13 (RDH13) 18.8
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 18.6
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 18.4
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 18.4
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 18.3
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) 17.9
 LDTP10981  Mitochondrial intermediate peptidase (MIPEP) 17.9
 LDTP01649  Phosphatidate cytidylyltransferase 2 (CDS2) 17.6
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 17.6
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 17.4
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 17.4
 LDTP00597  Serine palmitoyltransferase 1 (SPTLC1) 17.3
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 17.0
 LDTP03769  Sterol O-acyltransferase 1 (SOAT1) 17.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 16.9
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 16.8
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 16.8
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 16.8
 LDTP19745  ADP-ribosylation factor-like protein 10 (ARL10) 16.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 16.3
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 16.3
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 16.2
 LDTP02067  Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) 16.2
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 16.1
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 16.1
 LDTP02837  Beta-galactosidase (GLB1) 16.0
 LDTP01502  NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) 15.9
 LDTP04120  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) 15.8
 LDTP10966  Microsomal glutathione S-transferase 2 (MGST2) 15.7
 LDTP02942  ADP-ribosylation factor 4 (ARF4) 15.5
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 15.5
 LDTP12763  Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2) 15.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 15.2
 LDTP03900  ADP-ribosylation factor-like protein 1 (ARL1) 15.1
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 15.0
 LDTP12233  Helicase MOV-10 (MOV10) 15.0
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 14.9
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 14.8
 LDTP13220  Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) 14.7
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 14.6
 LDTP15962  Protein-L-histidine N-pros-methyltransferase (METTL9) 14.6
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 14.5
 LDTP09063  Estradiol 17-beta-dehydrogenase 11 (HSD17B11) 14.3
 LDTP00344  Stearoyl-CoA desaturase (SCD) 14.3
 LDTP09251  Atlastin-2 (ATL2) 14.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 14.2
 LDTP10101  Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) 14.2
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 14.2
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 14.2
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 14.2
 LDTP02141  Alpha-galactosidase A (GLA) 14.0
 LDTP04243  Fatty acid synthase (FASN) 14.0
 LDTP04895  Ras-related protein Rab-10 (RAB10) 14.0
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 13.9
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 13.9
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 13.9
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 13.8
 LDTP10020  Ras-related protein Rab-24 (RAB24) 13.7
 LDTP07756  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) 13.5
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 13.5
 LDTP00464  Glutathione S-transferase 3, mitochondrial (MGST3) 13.5
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 13.5
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 13.4
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 13.4
 LDTP05733  Serine/threonine-protein kinase 4 (STK4) 13.4
 LDTP01514  NADH dehydrogenase 1 beta subcomplex subunit 4 (NDUFB4) 13.3
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 13.3
 LDTP11319  Threonine--tRNA ligase, mitochondrial (TARS2) 13.3
 LDTP01300  Cartilage-associated protein (CRTAP) 13.2
 LDTP01769  Dihydrofolate reductase (DHFR) 13.2
 LDTP08617  Patatin-like phospholipase domain-containing protein 6 (PNPLA6) 13.2
 LDTP12470  GTP-binding protein SAR1a (SAR1A) 13.1
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 13.0
 LDTP02883  Alpha-N-acetylgalactosaminidase (NAGA) 12.9
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 12.8
 LDTP10471  Protein disulfide-isomerase TMX3 (TMX3) 12.8
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 12.7
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 12.7
 LDTP06303  Kinesin-like protein KIF14 (KIF14) 12.6
 LDTP02223  Cathepsin B (CTSB) 12.6
 LDTP05624  Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1) 12.6
 LDTP09578  Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1) 12.5
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 12.4
 LDTP00400  Torsin-1B (TOR1B) 12.4
 LDTP00836  ATPase GET3 (GET3) 12.3
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 12.2
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 12.1
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) 12.1
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 12.1
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 12.1
 LDTP07015  Alanine--tRNA ligase, mitochondrial (AARS2) 12.0
 LDTP13131  7-dehydrocholesterol reductase (DHCR7) 12.0
 LDTP00186  Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS) 12.0
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 12.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 11.8
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 11.8
 LDTP15097  All-trans-retinol 13,14-reductase (RETSAT) 11.7
 LDTP02713  Macrophage migration inhibitory factor (MIF) 11.7
 LDTP06023  Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) 11.6
 LDTP11187  COP9 signalosome complex subunit 4 (COPS4) 11.6
 LDTP06427  Translin (TSN) 11.6
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 11.6
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 11.6
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) 11.6
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) 11.6
 LDTP03912  Trifunctional enzyme subunit alpha, mitochondrial (HADHA) 11.6
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 11.6
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 11.5
 LDTP13112  Phosphatidylinositol 4-kinase beta (PI4KB) 11.5
Transporter and channel
Click to Show/Hide to Show 143 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15648  BRI3-binding protein (BRI3BP) 99.7
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 99.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 93.7
 LDTP11615  Protein tweety homolog 3 (TTYH3) 86.8
 LDTP15948  Transmembrane protein 126A (TMEM126A) 76.1
 LDTP10036  BOS complex subunit NCLN (NCLN) 75.6
 LDTP08881  Transmembrane protein 199 (TMEM199) 73.5
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 67.2
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 65.8
 LDTP16813  Tetraspanin-3 (TSPAN3) 64.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 59.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 59.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 55.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 54.6
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 53.4
 LDTP01804  ATP synthase subunit a (MT-ATP6) 52.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 50.9
 LDTP07490  Zinc transporter 6 (SLC30A6) 48.8
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 48.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 47.8
 LDTP02215  Prosaposin (PSAP) 46.5
 LDTP07583  Transmembrane protein 65 (TMEM65) 45.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 43.1
 LDTP08981  Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) 42.8
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 41.4
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 39.9
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 38.6
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 38.3
 LDTP05900  Metaxin-1 (MTX1) 38.3
 LDTP07236  Protein GPR107 (GPR107) 37.5
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 37.3
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 35.0
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 33.1
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 32.9
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 32.2
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 31.6
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 31.3
 LDTP15481  Transmembrane protein 87A (TMEM87A) 31.1
 LDTP10065  Transmembrane protein 230 (TMEM230) 30.7
 LDTP08469  Complex I assembly factor TMEM126B, mitochondrial (TMEM126B) 30.5
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 30.1
 LDTP07467  Rhomboid domain-containing protein 2 (RHBDD2) 30.1
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 29.9
 LDTP02608  ADP/ATP translocase 1 (SLC25A4) 27.9
 LDTP15967  Tetraspanin-10 (TSPAN10) 27.3
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 26.9
 LDTP05116  CMP-sialic acid transporter (SLC35A1) 26.7
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 26.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 25.8
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 25.5
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 25.3
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 24.6
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 24.3
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 24.3
 LDTP00592  Surfeit locus protein 4 (SURF4) 23.1
 LDTP11213  Nucleoporin NDC1 (NDC1) 22.9
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 22.6
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 22.3
 LDTP11250  MICOS complex subunit MIC26 (APOO) 22.2
 LDTP09204  Nucleoporin NUP35 (NUP35) 21.6
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 21.1
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 21.1
 LDTP11406  Transmembrane protein 59 (TMEM59) 21.1
 LDTP03284  ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) 21.0
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 21.0
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 21.0
 LDTP10317  THO complex subunit 1 (THOC1) 21.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 20.4
 LDTP02609  ADP/ATP translocase 3 (SLC25A6) 20.1
 LDTP11634  Derlin-2 (DERL2) 20.1
 LDTP12451  Integral membrane protein 2C (ITM2C) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 19.8
 LDTP01380  Wolframin (WFS1) 19.8
 LDTP09288  Vang-like protein 1 (VANGL1) 19.6
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 19.4
 LDTP11626  Protein YIPF3 (YIPF3) 19.4
 LDTP11245  Derlin-1 (DERL1) 19.3
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 18.6
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 18.6
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 18.6
 LDTP12704  Anoctamin-10 (ANO10) 18.4
 LDTP06293  Metal cation symporter ZIP14 (SLC39A14) 18.4
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 18.1
 LDTP07477  Transmembrane protein 214 (TMEM214) 17.8
 LDTP07667  Transmembrane protein 205 (TMEM205) 17.6
 LDTP00590  Protein RER1 (RER1) 17.5
 LDTP09949  Transportin-1 (TNPO1) 17.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 17.4
 LDTP12210  Mitochondrial thiamine pyrophosphate carrier (SLC25A19) 17.1
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 17.1
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 17.0
 LDTP14084  Sorting and assembly machinery component 50 homolog (SAMM50) 16.9
 LDTP07058  Transmembrane protein 201 (TMEM201) 16.9
 LDTP10073  Protein RFT1 homolog (RFT1) 16.7
 LDTP06994  ER membrane protein complex subunit 4 (EMC4) 16.3
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 16.0
 LDTP02087  ADP/ATP translocase 2 (SLC25A5) 15.9
 LDTP11826  Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) 15.9
 LDTP00298  Importin subunit alpha-4 (KPNA3) 15.8
 LDTP04787  Transmembrane protein 33 (TMEM33) 15.6
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) 15.2
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 14.8
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 14.8
 LDTP12331  Endoplasmic reticulum membrane protein complex subunit 7 (EMC7) 14.5
 LDTP02562  Lysosome-associated membrane glycoprotein 1 (LAMP1) 14.5
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 14.4
 LDTP11136  Sugar transporter SWEET1 (SLC50A1) 14.3
 LDTP03380  Stomatin (STOM) 14.2
 LDTP13943  Thioredoxin-related transmembrane protein 2 (TMX2) 14.2
 LDTP05780  Syntaxin-5 (STX5) 14.1
 LDTP14181  Peroxisomal membrane protein PEX16 (PEX16) 13.9
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 13.8
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 13.7
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 13.7
 LDTP09144  Metal transporter CNNM3 (CNNM3) 13.6
 LDTP06855  Anoctamin-6 (ANO6) 13.5
 LDTP06499  V-type proton ATPase subunit S1 (ATP6AP1) 13.5
 LDTP17362  Magnesium transporter NIPA3 (NIPAL1) 13.4
 LDTP07472  Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) 13.4
 LDTP08279  Mitochondrial coenzyme A transporter SLC25A42 (SLC25A42) 13.4
 LDTP10804  Chloride channel CLIC-like protein 1 (CLCC1) 13.3
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 13.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 13.2
 LDTP01234  Erlin-1 (ERLIN1) 13.1
 LDTP11732  Magnesium transporter protein 1 (MAGT1) 12.7
 LDTP13953  Endophilin-B1 (SH3GLB1) 12.6
 LDTP04501  Importin subunit alpha-1 (KPNA2) 12.5
 LDTP10081  Leucine-rich repeat-containing protein 59 (LRRC59) 12.5
 LDTP01748  Mitochondrial import receptor subunit TOM40 homolog (TOMM40) 12.5
 LDTP01366  Flotillin-1 (FLOT1) 12.4
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 12.3
 LDTP08673  Calcium uptake protein 2, mitochondrial (MICU2) 12.2
 LDTP03405  Calnexin (CANX) 12.2
 LDTP07156  Protein wntless homolog (WLS) 12.2
 LDTP11116  45 kDa calcium-binding protein (SDF4) 12.1
 LDTP03546  Translocator protein (TSPO) 12.1
 LDTP00451  Secretory carrier-associated membrane protein 3 (SCAMP3) 12.0
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 12.0
 LDTP04426  B-cell receptor-associated protein 31 (BCAP31) 11.9
 LDTP07537  Metal transporter CNNM4 (CNNM4) 11.9
 LDTP05667  Syntaxin-4 (STX4) 11.8
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 11.6
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08006  PHD finger-like domain-containing protein 5A (PHF5A) 18.5
 LDTP05235  Transcription factor A, mitochondrial (TFAM) 14.7
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 12.3
Immunoglobulin
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05572  Leukocyte surface antigen CD47 (CD47) 26.5
 LDTP03772  Basigin (BSG) 22.3
 LDTP02491  HLA class I histocompatibility antigen, C alpha chain (HLA-C) 16.1
Other
Click to Show/Hide to Show 130 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 99.7
 LDTP10056  Protein FAM162A (FAM162A) 99.7
 LDTP01522  Reticulon-3 (RTN3) 90.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 80.4
 LDTP08594  Negative elongation factor C/D (NELFCD) 76.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 66.7
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 65.8
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 60.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 58.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 55.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 55.7
 LDTP05160  Nucleobindin-2 (NUCB2) 55.7
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 55.7
 LDTP05277  Protein SET (SET) 52.3
 LDTP13425  U6 snRNA-associated Sm-like protein LSm7 (LSM7) 48.5
 LDTP08224  Protein LYRIC (MTDH) 44.9
 LDTP05868  Protein unc-119 homolog A (UNC119) 44.6
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 43.7
 LDTP00986  Syntaxin-10 (STX10) 42.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 39.4
 LDTP13086  Syntaxin-18 (STX18) 38.3
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 38.1
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 37.0
 LDTP11076  Apolipoprotein L2 (APOL2) 36.8
 LDTP18467  LYR motif-containing protein 2 (LYRM2) 36.0
 LDTP08796  Protein SYS1 homolog (SYS1) 35.3
 LDTP12412  Reticulon-4 (RTN4) 33.6
 LDTP16006  Optic atrophy 3 protein (OPA3) 32.9
 LDTP07274  MICOS complex subunit MIC13 (MICOS13) 28.4
 LDTP06097  Reticulocalbin-2 (RCN2) 28.2
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 28.1
 LDTP01075  Protein CutA (CUTA) 27.5
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 27.1
 LDTP00859  Synaptogyrin-2 (SYNGR2) 26.9
 LDTP00105  Protein unc-119 homolog B (UNC119B) 26.5
 LDTP08130  Rab9 effector protein with kelch motifs (RABEPK) 26.5
 LDTP05375  Nucleobindin-1 (NUCB1) 26.0
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 25.5
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 25.3
 LDTP09255  Motile sperm domain-containing protein 2 (MOSPD2) 24.3
 LDTP14939  Membralin (TMEM259) 23.8
 LDTP03352  Splicing factor U2AF 65 kDa subunit (U2AF2) 23.8
 LDTP06391  Protein transport protein Sec23B (SEC23B) 23.6
 LDTP10033  WW domain-binding protein 2 (WBP2) 23.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 23.1
 LDTP10357  RUS family member 1 (RUSF1) 23.1
 LDTP19963  TraB domain-containing protein (TRABD) 23.1
 LDTP11906  Phosphatidylinositol glycan anchor biosynthesis class U protein (PIGU) 22.9
 LDTP15712  RING finger and SPRY domain-containing protein 1 (RSPRY1) 22.9
 LDTP01451  UBX domain-containing protein 7 (UBXN7) 22.5
 LDTP02927  Ganglioside GM2 activator (GM2A) 21.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 21.1
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 20.7
 LDTP08248  NLR family member X1 (NLRX1) 20.5
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 20.0
 LDTP10093  Mitochondrial calcium uniporter regulator 1 (MCUR1) 19.8
 LDTP01167  Reticulon-2 (RTN2) 19.4
 LDTP06291  ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) 18.9
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 18.9
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 18.6
 LDTP15398  Protein FAM177A1 (FAM177A1) 17.9
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 17.6
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 17.6
 LDTP09069  Kinetochore protein Spc24 (SPC24) 17.5
 LDTP14125  Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B) 17.5
 LDTP13802  DNA replication complex GINS protein PSF2 (GINS2) 16.9
 LDTP01494  Protein YIF1A (YIF1A) 16.9
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 16.8
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 16.8
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 16.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 16.6
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 16.2
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 16.0
 LDTP11981  Receptor expression-enhancing protein 4 (REEP4) 15.9
 LDTP04947  DDB1- and CUL4-associated factor 7 (DCAF7) 15.5
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 15.5
 LDTP01359  Dynactin subunit 3 (DCTN3) 15.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 15.2
 LDTP19005  SLC35A4 upstream open reading frame protein (SLC35A4) 15.2
 LDTP05715  Vesicle transport protein SEC20 (BNIP1) 15.1
 LDTP00417  Programmed cell death protein 5 (PDCD5) 15.0
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 14.6
 LDTP01259  Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA) 14.6
 LDTP16116  BSD domain-containing protein 1 (BSDC1) 14.1
 LDTP16577  DENN domain-containing protein 11 (DENND11) 13.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 13.8
 LDTP04356  Emerin (EMD) 13.7
 LDTP18272  Transmembrane protein 209 (TMEM209) 13.7
 LDTP15434  ADP-ribosylation factor-like protein 6-interacting protein 6 (ARL6IP6) 13.6
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 13.6
 LDTP15863  Large ribosomal subunit protein mL45 (MRPL45) 13.6
 LDTP12729  Required for meiotic nuclear division protein 1 homolog (RMND1) 13.6
 LDTP09787  Nicastrin (NCSTN) 13.5
 LDTP11326  FUN14 domain-containing protein 2 (FUNDC2) 13.3
 LDTP04425  Translocon-associated protein subunit delta (SSR4) 13.2
 LDTP01163  Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9) 13.2
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 13.1
 LDTP12764  MICOS complex subunit MIC19 (CHCHD3) 13.1
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 13.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 13.0
 LDTP00729  Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) 12.9
 LDTP07574  Superkiller complex protein 3 (SKIC3) 12.9
 LDTP04853  Eukaryotic translation initiation factor 3 subunit E (EIF3E) 12.8
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 12.8
 LDTP15887  Lipase maturation factor 2 (LMF2) 12.8
 LDTP16285  Transducin beta-like protein 2 (TBL2) 12.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 12.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 12.6
 LDTP08420  BLOC-2 complex member HPS6 (HPS6) 12.5
 LDTP03182  Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1) 12.5
 LDTP16322  Mitochondrial import inner membrane translocase subunit Tim8 B (TIMM8B) 12.5
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) 12.5
 LDTP07906  Mediator of RNA polymerase II transcription subunit 25 (MED25) 12.2
 LDTP07598  BRCA1-associated ATM activator 1 (BRAT1) 12.1
 LDTP16156  Protein PALS2 (PALS2) 12.1
 LDTP09644  m-AAA protease-interacting protein 1, mitochondrial (MAIP1) 12.0
 LDTP10013  Protein YIPF5 (YIPF5) 12.0
 LDTP15623  Neuferricin (CYB5D2) 11.9
 LDTP15793  Protein FAM210A (FAM210A) 11.9
 LDTP07718  MICOS complex subunit MIC27 (APOOL) 11.8
 LDTP06128  RNA-binding protein 39 (RBM39) 11.8
 LDTP00887  Calumenin (CALU) 11.7
 LDTP10408  Far upstream element-binding protein 3 (FUBP3) 11.7
 LDTP10908  Protein S100-A13 (S100A13) 11.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 11.6
 LDTP17652  Uncharacterized protein KIAA2013 (KIAA2013) 11.6
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 11.6
 LDTP06377  Pumilio homolog 3 (PUM3) 11.6
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 11.5
 LDTP02297  Vimentin (VIM) 11.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587