Details of the Target

General Information of Target

Target ID LDTP06023
Target Name Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)
Gene Name CAMK1
Gene ID 8536
Synonyms
Calcium/calmodulin-dependent protein kinase type 1; EC 2.7.11.17; CaM kinase I; CaM-KI; CaM kinase I alpha; CaMKI-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKE
GSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASR
LIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACG
TPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSP
YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAK
SKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGT
ELSPTLPHQL
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Subcellular location
Cytoplasm
Function
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I.
Uniprot ID
Q14012
Ensemble ID
ENST00000256460.8
HGNC ID
HGNC:1459
ChEMBL ID
CHEMBL2493

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y195(20.00)  LDD0257  [1]
STPyne
 Probe Info  		K259(1.32); K49(7.69)  LDD0277  [2]
DBIA
 Probe Info  		C354(1.80); C355(1.80)  LDD0080  [3]
AMP probe
 Probe Info  		N.A.  LDD0200  [4]
ATP probe
 Probe Info  		K49(0.00); K143(0.00)  LDD0199  [4]
IA-alkyne
 Probe Info  		C267(0.00); C179(0.00)  LDD0165  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C056
 Probe Info  		17.39  LDD1753  [10]
C220
 Probe Info  		11.63  LDD1894  [10]
C284
 Probe Info  		23.43  LDD1954  [10]
C313
 Probe Info  		16.80  LDD1980  [10]
C354
 Probe Info  		7.16  LDD2015  [10]
C403
 Probe Info  		14.22  LDD2061  [10]
C420
 Probe Info  		12.38  LDD2075  [10]
C431
 Probe Info  		13.64  LDD2086  [10]
FFF probe13
 Probe Info  		17.09  LDD0475  [11]
FFF probe2
 Probe Info  		20.00  LDD0463  [11]
Probe 12
 Probe Info  		N.A.  LDD0420  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C179(1.12); C349(1.25); C350(1.23); C351(1.26)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C350(0.99); C349(0.82); C351(0.83)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C349(0.87); C351(0.87)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C349(0.78); C351(0.78)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C349(0.93); C351(0.93)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C349(1.13); C351(1.13)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C349(1.22); C351(1.22)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C349(0.98); C351(0.98)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C349(0.99); C351(0.99)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C349(0.91); C351(1.35)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C349(0.80); C351(1.03)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C349(0.87); C351(0.91)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C350(1.17); C349(1.10); C351(1.14)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C349(0.90); C351(0.86)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C349(0.93); C351(0.95)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C349(0.86); C351(1.20)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C350(0.91); C349(0.91); C351(0.84)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C350(1.19); C349(1.18); C351(1.04)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C350(1.11); C349(1.25); C351(0.80)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C350(1.32); C349(1.37); C351(0.95)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C350(1.11); C349(1.10); C351(1.21)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C350(1.07); C349(1.00); C351(1.54)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C350(1.22); C349(1.37); C351(1.03)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C350(1.16); C349(0.83); C351(0.94)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C350(1.24); C349(1.44); C351(1.05)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C350(0.96); C349(0.98); C351(1.38)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C350(1.07); C349(1.12); C351(1.08)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C350(1.03); C349(1.05); C351(1.81)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C350(1.04); C349(1.04); C351(1.19)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C350(1.07); C349(1.37); C351(1.22)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C350(1.38); C349(1.43); C351(1.12)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C350(1.04); C349(1.16); C351(1.15)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C350(0.72); C349(0.49); C351(0.72)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C350(0.60); C349(0.42); C351(0.60)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C350(0.94); C349(0.50); C351(0.94)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C350(0.73); C349(0.54); C351(0.73)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C350(0.81); C349(0.60); C351(0.81)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C350(0.69); C349(0.62); C351(0.69)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C350(0.93); C349(0.68); C351(0.93)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C350(0.87); C349(0.50); C351(0.87)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C350(0.86); C349(0.51); C351(0.86)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C350(0.85); C349(0.64); C351(0.85)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C350(0.79); C349(0.57); C351(0.79)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C350(0.92); C349(0.70); C351(0.92)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C350(1.10); C349(0.89); C351(0.90)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C350(0.98); C349(0.58); C351(0.98)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C350(0.87); C349(0.68); C351(0.87)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C350(0.74); C349(0.61); C351(0.74)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C350(1.27); C349(1.27)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C350(1.31); C349(1.31)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C350(0.82); C349(0.82)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C350(0.84); C349(0.84)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C350(1.01); C349(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C350(0.97); C349(0.97)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C350(0.79); C349(0.79)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C350(0.81); C349(0.83); C351(0.84)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C350(0.85); C349(0.85)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C350(1.19); C349(1.19)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C350(0.74); C349(0.74)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C350(0.98); C349(0.98)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C350(0.93); C349(0.93)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C350(0.90); C349(0.90)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C350(0.99); C349(0.99)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C350(0.77); C349(0.77)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C350(1.11); C349(1.11); C351(1.11)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C350(1.29); C349(1.29); C351(1.29)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C350(1.53); C349(1.53); C351(1.53)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C179(1.01); C349(1.11); C350(1.06); C351(1.15)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C350(0.93); C349(0.93); C351(0.93)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C350(1.34); C349(1.34); C351(1.34)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C350(1.32); C349(1.32); C351(1.32)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C350(1.22); C349(1.22); C351(1.22)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C350(1.35); C349(1.35); C351(1.35)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C350(0.71); C349(1.02); C351(1.02)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C350(0.63); C349(0.70); C351(0.70)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C349(0.75); C351(0.75); C350(0.81)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C350(0.71); C349(0.76); C351(0.76)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C349(0.71); C351(0.71); C350(0.81)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C179(0.96); C349(0.96); C350(1.01); C351(0.91)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C349(0.75); C351(0.75); C350(0.85)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C349(0.70); C351(0.70); C350(0.80)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C349(0.64); C351(0.64); C350(0.68)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C349(0.85); C351(0.85); C350(0.87)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C350(0.72); C349(0.81); C351(0.81)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C350(0.84); C349(0.84); C351(0.84)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C350(1.01); C349(1.01); C351(1.01)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C350(1.41); C349(1.41); C351(1.41)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C350(0.91); C349(0.91); C351(0.91)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C350(1.09); C349(1.09); C351(1.09)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C179(0.98); C349(1.18); C350(1.24); C351(1.11)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C350(0.91); C349(0.91); C351(0.91)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C350(0.88); C349(0.88); C351(0.88)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C350(0.81); C349(0.81); C351(0.81)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C350(0.98); C349(0.98); C351(0.98)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C350(0.87); C349(0.87); C351(0.87)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C350(0.76); C349(0.76); C351(0.76)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C350(0.76); C349(0.85); C351(0.92)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C350(0.91); C349(1.01); C351(1.16)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C350(0.65); C349(0.76); C351(0.87)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C351(1.04); C350(1.04); C349(1.05)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C179(0.99); C349(1.07); C350(1.15); C351(0.99)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C350(0.92); C349(0.96); C351(0.98)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C350(0.92); C349(1.01); C351(1.15)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C351(0.82); C349(0.89); C350(0.92)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C350(1.00); C349(1.09); C351(1.18)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C351(1.24); C349(1.30); C350(1.35)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C350(1.07); C351(1.09); C349(1.10)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C350(1.05); C349(1.15); C351(1.30)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C350(0.62); C349(0.62)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C350(0.50); C349(0.50)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C350(0.66); C349(0.66)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C349(0.98); C351(1.04); C350(1.15)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C350(0.86); C349(0.86)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C350(0.69); C349(0.69)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C350(0.57); C349(0.57)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C350(0.51); C349(0.51)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C350(0.93); C349(0.93)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C350(0.57); C349(0.57)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C350(0.49); C349(0.49)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C350(0.53); C349(0.53)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C350(1.14); C351(1.15); C349(1.16)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C349(1.05); C350(1.05); C351(1.11)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C349(0.95); C351(1.05); C350(1.17)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C349(1.28); C351(1.39); C350(1.45)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C350(0.89); C349(1.02); C351(1.11)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C350(0.90); C349(0.99); C351(1.03)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C349(0.99); C350(1.07); C351(1.14)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C350(0.96); C349(1.02); C351(1.12)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C349(1.25); C350(1.33); C351(1.43)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C350(1.03); C349(1.13); C351(1.15)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C349(1.04); C350(1.08); C351(1.13)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C350(0.78); C349(0.79); C351(0.88)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C349(0.81); C350(0.87); C351(0.95)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C351(0.75); C349(0.76); C350(0.96)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C350(0.97); C349(1.01); C351(1.08)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C350(0.89); C349(1.12); C351(1.18)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C349(1.20); C350(1.26); C351(1.45)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C350(1.13); C351(1.29); C349(1.30)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C350(1.14); C349(1.27); C351(1.29)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C350(1.07); C349(1.14); C351(1.17)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C350(0.99); C349(1.05); C351(1.05)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C351(0.82); C349(0.90); C350(1.01)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C351(1.06); C350(1.18); C349(1.20)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C351(1.13); C349(1.13); C350(1.23)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C351(0.77); C349(0.82); C350(1.02)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C350(1.06); C349(1.38); C351(1.39)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C349(1.16); C351(1.16); C350(1.33)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C351(1.08); C349(1.12); C350(1.30)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C351(1.07); C350(1.09); C349(1.15)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C351(0.99); C350(1.01); C349(1.06)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C350(1.11); C351(1.26); C349(1.32)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C350(1.17); C351(1.35); C349(1.36)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C349(1.49); C351(1.49)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C349(0.88); C351(0.88)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C350(1.06); C349(0.90); C351(0.97)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C349(0.95); C351(1.03); C350(1.12)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C350(0.93); C349(0.95); C351(0.97)  LDD0592  [3]
 LDCM0367  CL1 HCT 116 C349(1.21); C351(1.21); C350(1.23)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C349(1.19); C351(1.19); C350(1.38)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C179(1.28); C349(1.31); C350(1.53); C351(1.09)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C349(1.05); C351(1.24); C350(1.40)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C349(1.03); C351(1.13); C350(1.19)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C349(0.94); C350(1.00); C351(1.02)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C349(0.82); C351(0.91); C350(1.07)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C350(1.31); C349(1.31); C351(1.31)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C350(1.03); C349(1.03); C351(1.03)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C350(0.84); C349(0.84); C351(0.84)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C350(1.03); C349(1.03); C351(1.03)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C350(1.16); C349(1.16); C351(1.16)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C350(0.77); C349(0.91); C351(0.91)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C350(1.13); C349(1.13); C351(1.13)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C350(1.55); C349(1.55); C351(1.55)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C349(1.04); C351(1.04); C350(1.06)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C349(0.68); C351(0.68); C350(0.75)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C350(0.66); C349(0.77); C351(0.77)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C349(0.78); C351(0.78); C350(0.89)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C350(0.72); C349(0.80); C351(0.80)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C350(0.96); C349(0.96); C351(0.96)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C350(1.10); C349(1.10); C351(1.10)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C350(0.80); C349(0.80); C351(0.80)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C350(0.94); C349(1.16); C351(1.16)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C350(0.85); C349(0.85); C351(0.85)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C351(2.55); C349(3.45); C350(4.77)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C350(0.76); C351(0.80); C349(0.81)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C349(1.14); C350(1.15); C351(1.22)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C350(0.97); C349(1.09); C351(1.23)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C350(0.77); C349(0.77)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C350(0.41); C349(0.41)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C350(0.52); C349(0.52)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C350(0.48); C349(0.48)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C350(0.88); C349(1.05); C351(1.05)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C350(1.09); C349(1.19); C351(1.19)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C349(1.15); C351(1.15); C350(1.25)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C349(0.85); C351(0.85); C350(0.99)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C350(0.94); C349(0.98); C351(0.98)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C349(0.73); C351(0.73); C350(0.80)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C350(0.68); C349(0.75); C351(0.75)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C350(0.87); C349(0.90); C351(0.90)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C350(0.64); C349(0.74); C351(0.74)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C350(0.59); C349(0.85); C351(0.85)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C350(0.71); C349(0.78); C351(0.78)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C349(0.97); C351(0.97); C350(1.03)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C349(0.86); C351(0.86); C350(0.91)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C350(1.00); C349(0.88); C351(0.88)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C350(1.08); C349(0.95); C351(0.95)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C350(0.83); C349(0.83); C351(0.83)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C350(0.88); C349(0.93); C351(0.93)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C350(0.75); C349(0.76); C351(0.76)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C350(1.21); C349(1.08); C351(1.08)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C350(0.78); C349(0.73); C351(0.73)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C179(1.00); C354(1.00); C355(0.86)  LDD1018  [3]
 LDCM0421  CL32 HCT 116 C349(0.65); C351(0.65)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C349(0.73); C351(0.73)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C349(0.94); C351(0.94)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C349(0.86); C351(0.86)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C349(0.78); C351(0.78)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C349(0.96); C351(0.96)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C349(0.92); C351(0.92)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C350(1.52); C349(1.33); C351(1.33)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C349(1.07); C351(1.07)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C349(0.83); C351(0.83)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C349(0.91); C351(0.91)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C349(0.89); C351(0.89)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C349(1.23); C351(1.23)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C349(0.97); C351(0.97)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C350(1.04); C349(1.01); C351(1.04)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C350(0.85); C349(0.81); C351(0.85)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C350(0.81); C349(0.62); C351(0.81)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C350(0.89); C349(0.87); C351(0.89)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C350(1.08); C349(1.07); C351(1.07)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C350(0.81); C349(0.75); C351(0.81)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C350(0.89); C349(0.78); C351(0.89)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C350(1.23); C349(1.05); C351(1.23)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C350(1.10); C349(0.85); C351(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C350(1.38); C349(0.98); C351(1.38)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C350(1.02); C349(1.05); C351(1.02)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C350(0.95); C349(0.90); C351(0.95)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C350(0.82); C349(0.68); C351(0.82)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C350(1.12); C349(1.01); C351(1.12)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C350(0.87); C349(0.88); C351(0.87)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C350(0.82); C349(1.02); C351(1.02)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C350(0.85); C349(0.86); C351(0.85)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C350(0.92); C349(0.92)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C350(1.72); C349(1.72)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C350(1.54); C349(1.54)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C350(0.99); C349(0.99)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C350(1.23); C349(1.23)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C350(1.30); C349(1.30)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C350(1.24); C349(1.24)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C350(0.96); C349(0.96)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C350(1.05); C349(1.05)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C350(1.15); C349(1.06); C351(1.06)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C350(1.24); C349(1.24)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C350(1.21); C349(1.21)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C350(1.02); C349(1.02)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C350(1.05); C349(1.05)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C350(1.20); C349(1.20)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C179(0.87); C349(0.75); C350(0.75); C351(0.74)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C179(1.08); C349(0.92); C350(0.92); C351(1.10)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C179(0.66); C349(0.77); C350(0.77); C351(0.88)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C179(0.84); C349(0.79); C350(0.79); C351(0.63)  LDD1070  [3]
 LDCM0473  CL8 HCT 116 C350(0.89); C349(1.26); C351(1.26)  LDD0790  [3]
 LDCM0474  CL80 HEK-293T C179(0.78); C349(0.77); C350(0.77); C351(0.90)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C179(0.89); C349(0.99); C350(0.99); C351(0.91)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C179(1.07); C349(0.87); C350(0.87); C351(0.89)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C179(1.04); C349(0.76); C350(0.76); C351(0.84)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C179(0.86); C349(0.93); C350(0.93); C351(0.89)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C179(0.80); C349(0.90); C350(0.90); C351(0.98)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C179(0.76); C349(0.87); C350(0.87); C351(0.87)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C179(1.00); C349(0.82); C350(0.82); C351(0.76)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C179(0.97); C349(0.83); C350(0.83); C351(0.87)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C179(0.83); C349(0.94); C350(0.94); C351(0.83)  LDD1081  [3]
 LDCM0484  CL9 HCT 116 C350(1.13); C349(1.12); C351(1.12)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C179(1.29); C349(1.14); C350(1.14); C351(1.17)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C179(0.72); C349(1.13); C350(1.11); C351(1.15)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C179(1.03); C349(1.75); C350(2.08); C351(1.43)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C179(0.85); C349(1.26); C350(1.53); C351(0.99)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C179(1.06); C349(1.20); C350(1.31); C351(1.10)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C179(1.57); C349(2.49); C350(3.54); C351(1.44)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C179(1.13); C349(1.50); C350(1.72); C351(1.28)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C179(0.93); C349(1.70); C350(2.19); C351(1.21)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C179(1.06); C349(1.28); C350(1.21); C351(1.36)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C179(1.00); C349(1.33); C350(1.06); C351(1.59)  LDD1092  [3]
 LDCM0165  Compound 9 HL-60 N.A.  LDD0420  [12]
 LDCM0495  E2913 HEK-293T C267(1.03); C179(0.83); C354(0.86); C351(0.95)  LDD1698  [13]
 LDCM0468  Fragment33 HCT 116 C350(1.30); C349(1.30)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C349(1.14); C351(1.14)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C354(1.80); C355(1.80)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C354(1.49); C355(1.49)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C354(1.56); C355(1.56)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D) CAMK Ser/Thr protein kinase family Q8IU85
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family. Angew Chem Int Ed Engl. 2019 Nov 25;58(48):17322-17327. doi: 10.1002/anie.201906321. Epub 2019 Oct 31.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402