Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C420  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 106 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 66.7
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 59.7
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 50.9
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 47.5
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 46.5
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 45.6
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 43.7
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 42.8
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 36.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 36.3
 LDTP01983  NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) 34.8
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 34.3
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 34.1
 LDTP00589  Peroxisomal acyl-coenzyme A oxidase 3 (ACOX3) 33.1
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 31.1
 LDTP02362  Dihydrolipoyl dehydrogenase, mitochondrial (DLD) 30.3
 LDTP05905  Acid ceramidase (ASAH1) 29.7
 LDTP01803  Adenosine deaminase (ADA) 29.4
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 29.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 28.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 27.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 27.1
 LDTP02505  Lysosomal protective protein (CTSA) 26.7
 LDTP15962  Protein-L-histidine N-pros-methyltransferase (METTL9) 26.5
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 26.2
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 26.2
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 25.3
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 23.1
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 21.9
 LDTP04689  Adenosine kinase (ADK) 21.7
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 21.7
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 21.6
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 20.4
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.1
 LDTP06849  Prolyl endopeptidase-like (PREPL) 20.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 19.8
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 19.8
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 19.7
 LDTP00988  Protein O-GlcNAcase (OGA) 19.2
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 19.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 18.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 18.3
 LDTP13751  Exonuclease 1 (EXO1) 18.3
 LDTP03854  Vitamin K-dependent gamma-carboxylase (GGCX) 18.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 17.8
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 17.6
 LDTP02837  Beta-galactosidase (GLB1) 17.5
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 17.5
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 17.4
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 16.7
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 16.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 15.9
 LDTP00497  Cyclin-G-associated kinase (GAK) 15.6
 LDTP02640  X-ray repair cross-complementing protein 6 (XRCC6) 15.6
 LDTP02141  Alpha-galactosidase A (GLA) 15.5
 LDTP02539  Lysosomal acid phosphatase (ACP2) 15.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 15.3
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 15.1
 LDTP10329  Ceramide synthase 2 (CERS2) 15.0
 LDTP10888  Legumain (LGMN) 15.0
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 15.0
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 14.9
 LDTP02713  Macrophage migration inhibitory factor (MIF) 14.9
 LDTP00316  Ribonuclease T2 (RNASET2) 14.6
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) 14.2
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 14.2
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 14.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 13.8
 LDTP03787  Choline kinase alpha (CHKA) 13.8
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 13.6
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 13.6
 LDTP03842  Squalene synthase (FDFT1) 13.5
 LDTP02260  Beta-glucuronidase (GUSB) 13.1
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 13.0
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.9
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 12.7
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 12.6
 LDTP06023  Calcium/calmodulin-dependent protein kinase type 1 (CAMK1) 12.4
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 12.4
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 12.3
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 12.1
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 12.0
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) 12.0
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 11.7
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 11.6
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 11.6
 LDTP03607  RAC-alpha serine/threonine-protein kinase (AKT1) 11.6
 LDTP11874  Thioredoxin-related transmembrane protein 1 (TMX1) 11.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 11.4
 LDTP00890  S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) 11.2
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 11.1
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 10.9
 LDTP03145  Catechol O-methyltransferase (COMT) 10.9
 LDTP11518  Histone-lysine N-methyltransferase NSD3 (NSD3) 10.9
 LDTP07961  Protein arginine methyltransferase NDUFAF7, mitochondrial (NDUFAF7) 10.9
 LDTP04925  Pterin-4-alpha-carbinolamine dehydratase (PCBD1) 10.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 10.6
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 10.6
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 10.6
 LDTP07762  Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) 10.3
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 10.3
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 10.2
 LDTP08265  N-alpha-acetyltransferase 40 (NAA40) 10.1
 LDTP06049  Septin-6 (SEPTIN6) 10.1
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 10.1
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 10.0
Transporter and channel
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 87.4
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 69.6
 LDTP02215  Prosaposin (PSAP) 64.9
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 64.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 44.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 42.5
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 29.4
 LDTP07236  Protein GPR107 (GPR107) 29.2
 LDTP11615  Protein tweety homolog 3 (TTYH3) 29.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 28.4
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.4
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 27.1
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 25.3
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 24.4
 LDTP16813  Tetraspanin-3 (TSPAN3) 23.1
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 22.8
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 22.2
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 20.5
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 20.4
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.9
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 18.8
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 18.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 18.4
 LDTP04501  Importin subunit alpha-1 (KPNA2) 18.0
 LDTP07531  Sideroflexin-4 (SFXN4) 17.3
 LDTP07667  Transmembrane protein 205 (TMEM205) 17.1
 LDTP15481  Transmembrane protein 87A (TMEM87A) 15.9
 LDTP00592  Surfeit locus protein 4 (SURF4) 15.7
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 14.7
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 14.5
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 14.0
 LDTP20002  Transmembrane protein 160 (TMEM160) 14.0
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 13.9
 LDTP11844  Protein spinster homolog 1 (SPNS1) 13.6
 LDTP09180  Zinc transporter 7 (SLC30A7) 13.6
 LDTP12383  Protein GPR108 (GPR108) 13.5
 LDTP05900  Metaxin-1 (MTX1) 13.3
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 13.0
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 12.4
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 12.0
 LDTP11824  Sodium-coupled neutral amino acid symporter 1 (SLC38A1) 11.2
 LDTP11213  Nucleoporin NDC1 (NDC1) 11.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 11.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 10.5
 LDTP10499  Lipid scramblase CLPTM1L (CLPTM1L) 10.3
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) 10.2
 LDTP04459  H(+)/Cl(-) exchange transporter 3 (CLCN3) 10.1
 LDTP04940  NPC intracellular cholesterol transporter 2 (NPC2) 10.1
Other
Click to Show/Hide to Show 74 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 99.7
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 45.3
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 42.8
 LDTP11076  Apolipoprotein L2 (APOL2) 40.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 32.4
 LDTP04951  Nuclear transport factor 2 (NUTF2) 31.8
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 25.1
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 24.6
 LDTP00105  Protein unc-119 homolog B (UNC119B) 24.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 23.8
 LDTP06097  Reticulocalbin-2 (RCN2) 22.6
 LDTP15714  Mdm2-binding protein (MTBP) 21.6
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 21.4
 LDTP13086  Syntaxin-18 (STX18) 21.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 20.5
 LDTP15623  Neuferricin (CYB5D2) 19.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 19.7
 LDTP08073  Tetratricopeptide repeat protein 21B (TTC21B) 19.7
 LDTP16080  Protein FAM114A2 (FAM114A2) 19.0
 LDTP10056  Protein FAM162A (FAM162A) 18.8
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 18.5
 LDTP02297  Vimentin (VIM) 18.0
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 16.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 16.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 16.6
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 16.3
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 15.9
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 15.2
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 15.1
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 15.1
 LDTP06887  Nuclear cap-binding protein subunit 3 (NCBP3) 14.9
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 14.9
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 14.8
 LDTP05558  Galectin-3-binding protein (LGALS3BP) 14.7
 LDTP08796  Protein SYS1 homolog (SYS1) 14.6
 LDTP13630  Neudesin (NENF) 14.5
 LDTP05160  Nucleobindin-2 (NUCB2) 14.4
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 14.4
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 14.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 14.1
 LDTP01522  Reticulon-3 (RTN3) 14.0
 LDTP00934  C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9) 13.2
 LDTP07031  Collectin-12 (COLEC12) 12.8
 LDTP02927  Ganglioside GM2 activator (GM2A) 12.8
 LDTP18135  Protein phosphatase 1 regulatory subunit 14B (PPP1R14B) 12.8
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 12.6
 LDTP03614  Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3) 12.4
 LDTP18132  Protein FAM136A (FAM136A) 12.4
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) 12.4
 LDTP01075  Protein CutA (CUTA) 12.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 12.2
 LDTP09920  Golgi apparatus protein 1 (GLG1) 11.9
 LDTP08094  Wings apart-like protein homolog (WAPL) 11.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 11.3
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 11.2
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 11.2
 LDTP03775  RNA-binding protein FUS (FUS) 11.0
 LDTP02205  Tubulin beta chain (TUBB) 10.8
 LDTP08735  Spartin (SPART) 10.6
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 10.6
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 10.6
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) 10.6
 LDTP05226  RNA-binding protein 3 (RBM3) 10.5
 LDTP01362  Survival of motor neuron-related-splicing factor 30 (SMNDC1) 10.5
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 10.4
 LDTP06527  Alpha-internexin (INA) 10.3
 LDTP04356  Emerin (EMD) 10.3
 LDTP05375  Nucleobindin-1 (NUCB1) 10.2
 LDTP01932  Prelamin-A/C (LMNA) 10.1
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 10.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 10.1
 LDTP01638  YEATS domain-containing protein 4 (YEATS4) 10.1
 LDTP06952  DBIRD complex subunit ZNF326 (ZNF326) 10.0
 LDTP05318  RNA-binding protein EWS (EWSR1) 10.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587