Details of the Target

General Information of Target

Target ID LDTP03671
Target Name Multidrug resistance-associated protein 1 (ABCC1)
Gene Name ABCC1
Gene ID 4363
Synonyms
MRP; MRP1; Multidrug resistance-associated protein 1; EC 7.6.2.2; ATP-binding cassette sub-family C member 1; Glutathione-S-conjugate-translocating ATPase ABCC1; EC 7.6.2.3; Leukotriene C(4) transporter; LTC4 transporter
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACFPFYFLYLSRH
DRGYIQMTPLNKTKTALGFLLWIVCWADLFYSFWERSRGIFLAPVFLVSPTLLGITMLLA
TFLIQLERRKGVQSSGIMLTFWLVALVCALAILRSKIMTALKEDAQVDLFRDITFYVYFS
LLLIQLVLSCFSDRSPLFSETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSD
LWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEAL
IVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPD
WQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTV
GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPVN
AVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLK
KSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILP
MVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPT
LNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQND
SLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLAR
AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV
MSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGM
LVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKL
SVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYG
ALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKEL
DTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQL
KRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLA
VRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVA
VERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGG
EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF
SGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCL
ARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVL
DKGEIQEYGAPSDLLQQRGLFYSMAKDAGLV
Target Type
Successful
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Subcellular location
Cell membrane
Function
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway.
TTD ID
T11288
Uniprot ID
P33527
DrugMap ID
TTQ79SU
Ensemble ID
ENST00000399408.7
HGNC ID
HGNC:51
ChEMBL ID
CHEMBL3004

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S1392G; p.G1509C DBIA    Probe Info 
EFO27 SNV: p.T826M DBIA    Probe Info 
HCC15 SNV: p.H1421R DBIA    Probe Info 
HCT15 SNV: p.V1101F .
HEC1 SNV: p.A543T DBIA    Probe Info 
NCIH1793 SNV: p.G762C DBIA    Probe Info 
NCIH446 SNV: p.L1440V DBIA    Probe Info 
WM115 SNV: p.T378I .
WM2664 Insertion: p.I1343DfsTer55
SNV: p.T378I		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K1181(0.56); K406(5.76)  LDD0277  [1]
Probe 1
 Probe Info  		Y869(8.08)  LDD3495  [2]
m-APA
 Probe Info  		10.76  LDD0403  [3]
DBIA
 Probe Info  		C991(1.63)  LDD3311  [4]
BTD
 Probe Info  		C1439(0.94)  LDD2099  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C730(0.00); C1479(0.00); C1047(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C744(0.00); C682(0.00); C1047(0.00); C1423(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C730(0.00); C1439(0.00); C744(0.00); C1047(0.00)  LDD0037  [7]
WYneN
 Probe Info  		C1423(0.00); C744(0.00)  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		C1439(0.00); C1047(0.00)  LDD0005  [8]
Acrolein
 Probe Info  		C1423(0.00); C730(0.00); H805(0.00); C744(0.00)  LDD0217  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [9]
AOyne
 Probe Info  		8.50  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		33.13  LDD1793  [12]
C107
 Probe Info  		7.21  LDD1794  [12]
C134
 Probe Info  		51.27  LDD1816  [12]
C153
 Probe Info  		39.67  LDD1834  [12]
C158
 Probe Info  		13.93  LDD1838  [12]
C208
 Probe Info  		4.92  LDD1883  [12]
C211
 Probe Info  		9.06  LDD1885  [12]
C212
 Probe Info  		7.01  LDD1886  [12]
C216
 Probe Info  		44.94  LDD1890  [12]
C218
 Probe Info  		22.01  LDD1892  [12]
C220
 Probe Info  		14.62  LDD1894  [12]
C320
 Probe Info  		5.78  LDD1986  [12]
C322
 Probe Info  		6.02  LDD1988  [12]
C326
 Probe Info  		66.72  LDD1990  [12]
C361
 Probe Info  		19.70  LDD2022  [12]
C413
 Probe Info  		36.25  LDD2069  [12]
C420
 Probe Info  		42.81  LDD2075  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1423(1.01); C1439(1.04); C730(1.06); C744(1.15)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C1423(1.13); C1439(0.90); C1047(1.02); C730(1.07)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C1423(1.05); C1439(0.98); C1047(1.00); C730(0.92)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C1423(0.98); C1439(0.87); C1047(1.04); C730(0.94)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C1423(0.88); C1439(0.95); C1047(0.89); C730(0.92)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C1423(1.02); C1439(1.05); C1047(0.95); C730(1.03)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C1423(0.99); C1439(0.99); C730(0.96); C744(1.01)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C1423(1.00); C1439(1.01); C1047(0.94); C730(1.15)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C1423(0.99); C1439(1.07); C1047(1.08); C730(0.99)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C1423(1.06); C1439(0.92); C1047(0.90); C730(1.04)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C1423(0.95); C1439(0.93); C1047(1.03); C730(0.97)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C1423(0.98); C1439(0.95); C1047(1.02); C730(1.04)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C1423(0.90); C1439(0.97); C1047(0.95); C730(0.91)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C1423(0.94); C1439(1.10); C1047(0.90); C730(1.00)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C1423(1.03); C1439(0.96); C1047(1.03); C730(0.97)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C1423(1.09); C1439(0.99); C730(1.03); C744(0.99)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C1423(1.03); C1439(1.01); C1047(0.93); C730(0.95)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C1423(0.83); C1439(1.03); C1047(1.06); C730(1.13)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C1423(1.00); C1439(0.87); C1047(0.95); C730(0.97)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C1423(0.98); C1439(0.92); C1047(0.90); C730(1.04)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C1423(0.91); C1439(1.04); C1047(1.11); C730(1.02)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C1423(0.93); C1439(0.97); C1047(0.94); C730(0.95)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C1423(0.99); C1439(0.95); C1047(0.99); C730(1.05)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C1423(0.98); C1439(0.95); C1047(0.97); C730(0.89)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C1423(1.01); C1439(1.00); C730(1.15); C744(1.09)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C1423(1.06); C1439(0.90); C1047(0.94); C730(1.05)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C1423(0.84); C1439(1.00); C1047(1.01); C730(1.01)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C1423(0.98); C1439(0.82); C1047(1.03); C730(0.95)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C1423(0.96); C1439(0.93); C1047(0.97); C730(1.04)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C1423(0.94); C1439(0.92); C1047(1.01); C730(1.00)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C1423(1.07); C1439(0.99); C1047(0.94); C730(0.96)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C1423(0.97); C1439(0.95); C1047(1.02); C730(1.02)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C1423(1.00); C1439(0.96); C1047(1.02); C730(0.94)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C1423(1.01); C1439(0.97); C730(1.01); C744(1.18)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C1423(1.11); C1439(0.94); C1047(1.07); C730(1.05)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C1423(0.85); C1439(0.98); C1047(1.02); C730(1.01)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C1423(0.98); C1439(0.89); C1047(0.99); C730(0.99)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C1423(0.96); C1439(0.94); C1047(0.94); C730(0.96)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C1423(0.96); C1439(0.90); C1047(1.02); C730(0.98)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C1423(0.95); C1439(1.10); C1047(0.95); C730(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C1423(0.99); C1439(0.95); C1047(0.94); C730(1.04)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C1423(0.99); C1439(1.03); C730(0.95); C744(1.11)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C1423(0.96); C1439(0.93); C1047(0.95); C730(0.97)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C1423(1.02); C1439(1.01); C1047(0.94); C730(0.96)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C1423(0.90); C1439(0.98); C1047(1.03); C730(1.11)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C1423(0.95); C1439(0.95); C1047(1.01); C730(1.06)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C1423(0.92); C1439(0.88); C1047(0.92); C730(1.00)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C1423(0.96); C1439(0.96); C1047(0.96); C730(0.94)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C1423(0.95); C1439(1.06); C1047(0.97); C730(1.00)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C1423(1.03); C1439(0.98); C1047(1.06); C730(0.97)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C1423(1.06); C1439(0.98); C730(1.04); C744(1.21)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C1423(1.08); C1439(0.95); C1047(0.98); C730(1.04)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C1423(0.83); C1439(1.03); C1047(1.08); C730(1.08)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C1423(0.96); C1439(0.94); C1047(0.96); C730(1.01)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C1423(0.96); C1439(0.89); C1047(1.00); C730(1.02)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C1423(0.97); C1439(0.92); C1047(0.99); C730(1.08)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C1423(0.92); C1439(0.95); C1047(0.99); C730(0.98)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C1423(0.98); C1439(1.01); C1047(1.04); C730(1.02)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C1423(0.94); C1439(0.95); C1047(0.99); C730(1.08)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C1423(1.00); C1439(0.96); C1047(0.99); C730(0.97)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C1423(0.99); C1439(0.95); C1047(1.01); C730(0.95)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C1423(1.00); C1439(0.98); C1047(1.00); C730(1.12)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C1423(0.98); C1439(0.96); C730(1.04); C744(0.93)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C1423(0.96); C1439(0.99); C1047(0.94); C730(0.93)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 10.76  LDD0403  [3]
 LDCM0108  Chloroacetamide HeLa C1423(0.00); C730(0.00); H805(0.00); H927(0.00)  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C1423(0.96); C1439(1.10); C1047(1.13); C730(0.97)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C1423(0.99); C1439(0.96); C1047(2.46); C730(0.99)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C1423(0.98); C1439(0.90); C1047(1.29); C730(0.93)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C1423(0.88); C1439(0.99); C1047(1.15); C730(0.96)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C1423(0.92); C1439(0.98); C1047(1.50); C730(0.94)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C1423(1.00); C1439(0.86); C1047(1.05); C730(1.00)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C1423(0.97); C1439(0.90); C1047(1.21); C730(0.98)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C1423(0.93); C1439(1.07); C1047(1.21); C730(0.98)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C1423(0.99); C1439(1.10); C1047(1.23); C730(0.99)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C1423(1.03); C1439(0.91); C1047(0.98); C730(1.04)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C1423(0.96); C1439(0.94); C1047(1.03); C730(1.03)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C1423(0.90); C1439(0.98); C1047(1.29); C730(0.92)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C1423(1.20); C1439(0.97); C1047(1.40); C730(1.11)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C1423(0.99); C1439(1.03); C1047(1.73); C730(0.84)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C1423(0.89); C1439(0.79); C1047(1.32); C730(0.90)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C1423(1.00); C1439(0.93); C1047(1.07); C730(1.05)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C1423(0.99); C1439(0.98); C1047(1.08); C730(0.99)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C1423(0.98); C1439(1.00); C1047(1.75); C730(1.03)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C1423(0.99); C1439(0.90); C1047(0.92); C730(0.96)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C1423(1.02); C1439(0.99); C1047(1.04); C730(1.04)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C1423(0.93); C1439(1.03); C1047(0.98); C730(0.98)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C1423(0.99); C1439(1.00); C1047(0.98); C730(1.02)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C1423(0.93); C1439(0.84); C1047(0.87); C730(1.01)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C1423(1.15); C1439(0.91); C1047(1.23); C730(1.14)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C1423(1.01); C1439(0.99); C1047(1.10); C730(1.03)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C1423(0.93); C1439(1.02); C1047(1.15); C730(1.01)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C1423(1.02); C1439(1.05); C1047(1.23); C730(0.93)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C1423(0.96); C1439(0.96); C1047(2.05); C730(0.94)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C1423(1.04); C1439(0.98); C1047(1.28); C730(1.06)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C1423(0.87); C1439(1.21); C1047(1.15); C730(1.01)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C1423(1.03); C1439(1.12); C1047(1.18); C730(1.00)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C1423(0.96); C1439(0.99); C1047(1.23); C730(0.99)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C1423(0.96); C1439(0.97); C1047(1.07); C730(1.14)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C1423(0.91); C1439(1.09); C1047(1.22); C730(0.96)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C1423(0.98); C1439(0.98); C1047(1.02); C730(0.98)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C1423(1.01); C1439(1.04); C1047(1.76); C730(1.00)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C1423(1.00); C1439(0.89); C1047(1.08); C730(1.07)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C1423(0.99); C1439(1.06); C730(0.97); C744(0.91)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C1423(1.08); C1439(0.96); C1047(0.98); C730(1.15)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C1423(1.06); C1439(0.96); C1047(1.21); C730(1.10)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C1423(1.07); C1439(1.05); C1047(1.00); C730(0.96)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C1423(1.02); C1439(0.91); C1047(1.12); C730(1.08)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C1423(1.02); C1439(0.94); C1047(1.81); C730(0.98)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C1423(1.14); C1439(0.93); C1047(1.09); C730(0.99)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C1423(1.25); C1439(0.97); C1047(1.02); C730(1.07)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C1423(1.18); C1439(1.00); C1047(1.22); C730(1.33)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C1423(1.01); C1439(1.09); C1047(1.60); C730(1.02)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C1423(0.99); C1439(0.94); C1047(1.05); C730(0.99)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C1423(0.94); C1439(0.93); C1047(1.18); C730(1.06)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C1423(1.03); C1439(0.96); C1047(1.16); C730(0.90)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C1423(1.00); C1439(0.98); C730(0.98); C744(0.89)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C1423(1.04); C1439(0.93); C1047(1.18); C730(1.04)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C1423(0.99); C1439(1.03); C1047(0.89); C730(1.00)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C1423(1.24); C1439(1.04); C1047(1.13); C730(0.95)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C1423(1.02); C1439(0.98); C1047(1.00); C730(0.98)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C1423(1.05); C1439(1.12); C1047(3.22); C730(1.03)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C1423(1.15); C1439(0.95); C1047(1.22); C730(1.07)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C1423(1.31); C1439(1.16); C1047(1.00); C730(1.04)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C1423(1.06); C1439(1.01); C1047(1.15); C730(0.98)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C1423(0.91); C1439(0.99); C1047(1.14); C730(1.06)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C1423(0.85); C1439(0.90); C1047(1.35); C730(1.02)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C1423(1.08); C1439(0.89); C1047(1.50); C730(1.11)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C1423(0.99); C1439(0.94); C1047(1.02); C730(1.03)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C1423(1.00); C1439(0.94); C730(0.93); C744(0.89)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C1423(0.96); C1439(1.07); C1047(0.87); C730(1.22)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C1423(1.22); C1439(0.90); C1047(0.98); C730(1.19)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C1423(1.01); C1439(0.97); C1047(1.00); C730(0.98)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C1423(1.06); C1439(1.03); C1047(1.23); C730(1.08)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C1423(1.17); C1439(1.00); C1047(1.09); C730(1.17)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C1423(1.21); C1439(0.95); C1047(1.09); C730(1.11)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C1423(1.36); C1439(0.99); C1047(1.08); C730(1.01)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C1423(0.94); C1439(1.05); C1047(1.23); C730(0.96)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C1423(1.06); C1439(0.98); C730(1.26); C744(1.12)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C1423(0.96); C1439(1.08); C1047(1.26); C730(1.04)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C1423(1.13); C1439(0.93); C1047(1.09); C730(0.98)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C1423(0.98); C1439(0.99); C730(0.99); C744(0.94)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C1423(1.00); C1439(1.06); C1047(1.87); C730(1.08)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C1423(1.32); C1439(0.94); C1047(1.00); C730(1.10)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C1423(1.00); C1439(0.89); C1047(1.11); C730(1.06)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C1423(1.02); C1439(0.88); C1047(1.36); C730(1.07)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C1423(1.11); C1439(0.93); C1047(1.32); C730(1.11)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C1423(1.16); C1439(1.08); C1047(1.17); C730(1.10)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C1423(1.01); C1439(1.06); C1047(1.47); C730(0.96)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C1423(1.14); C1439(0.93); C1047(1.20); C730(0.94)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C1423(0.89); C1439(1.08); C1047(1.09); C730(1.13)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C1423(1.03); C1439(1.00); C1047(0.99); C730(0.96)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C1423(1.06); C1439(0.91); C1047(0.87); C730(1.05)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C1423(0.92); C1439(0.99); C1047(1.82); C730(0.99)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C1423(1.02); C1439(0.96); C730(0.98); C744(1.02)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C1423(0.98); C1439(0.98); C1047(1.00); C730(1.13)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C1423(1.04); C1439(1.00); C1047(1.00); C730(1.03)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C1423(0.95); C1439(0.93); C1047(1.18); C730(1.05)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C1423(1.02); C1439(0.91); C1047(1.29); C730(1.09)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C1423(1.09); C1439(0.96); C1047(1.15); C730(0.94)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C1423(1.04); C1439(0.92); C1047(1.01); C730(1.06)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C1423(1.10); C1439(1.01); C1047(1.12); C730(1.01)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C1423(1.05); C1439(0.92); C1047(0.96); C730(1.00)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C1423(0.88); C1439(1.18); C1047(1.26); C730(0.94)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C1423(0.99); C1439(1.00); C1047(1.01); C730(1.03)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C1423(1.06); C1439(0.93); C1047(1.10); C730(1.00)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C1423(0.92); C1439(1.01); C730(0.90); C744(1.22)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C1423(1.03); C1439(0.93); C1047(0.99); C730(1.07)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C1423(1.19); C1439(1.02); C1047(1.07); C730(1.07)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C1423(0.92); C1439(1.00); C1047(3.38); C730(0.94)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C1423(0.97); C1439(0.97); C1047(0.91); C730(1.08)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C1423(1.06); C1439(0.96); C1047(1.00); C730(1.09)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C1423(1.03); C1439(0.97); C1047(1.02); C730(1.00)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C1423(1.14); C1439(1.04); C1047(1.29); C730(0.96)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C1423(1.08); C1439(0.98); C1047(1.57); C730(0.98)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C1423(0.83); C1439(1.08); C1047(1.20); C730(1.13)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C1423(1.10); C1439(1.07); C1047(1.27); C730(1.12)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C1423(1.15); C1439(1.29); C1047(1.18); C730(0.93)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C1423(0.95); C1439(1.06); C1047(1.11); C730(1.08)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C1423(1.05); C1439(0.92); C730(1.14); C744(1.04)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C1423(1.12); C1439(0.92); C1047(1.36); C730(1.27)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C1423(1.03); C1439(1.06); C1047(2.41); C730(1.10)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C1423(1.07); C1439(1.04); C1047(1.03); C730(1.11)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C1423(1.04); C1439(0.93); C1047(1.46); C730(0.98)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C1423(1.10); C1439(0.85); C1047(1.54); C730(0.97)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C1423(0.91); C1439(0.94); C1047(0.99); C730(0.95)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C1423(1.06); C1439(0.96); C1047(2.04); C730(0.97)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C1423(1.01); C1439(1.04); C1047(1.60); C730(1.06)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C1423(0.89); C1439(0.99); C1047(1.44); C730(0.94)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C1423(1.04); C1439(0.99); C1047(1.24); C730(0.94)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C1423(0.95); C1439(1.05); C1047(1.17); C730(1.03)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C1423(0.97); C1439(0.91); C1047(1.08); C730(0.93)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1439(4.10)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C1423(1.01); C1439(0.87); C1047(0.98); C730(1.07)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C1423(0.98); C1439(1.01); C1047(0.98); C730(1.07)  LDD1631  [13]
 LDCM0107  IAA HeLa C730(0.00); H805(0.00); H928(0.00)  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C1423(0.99); C1439(0.94); C1479(0.98); C208(1.06)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C1423(1.03); C1439(0.93); C1479(1.04); C208(0.97)  LDD1497  [13]
 LDCM0024  KB05 G361 C991(1.63)  LDD3311  [4]
 LDCM0109  NEM HeLa H805(0.00); H1154(0.00); H927(0.00); H1054(0.00)  LDD0223  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1439(0.94)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1439(0.90)  LDD2107  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1439(0.84)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1439(0.68)  LDD2126  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1439(0.76)  LDD2128  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1439(0.72)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1439(1.14)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1439(0.78); C1479(0.84)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1439(0.63)  LDD2140  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 57 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Belantamab Mafodotin Antibody drug conjugate DB15719
Abiraterone Small molecular drug DB05812
Amprenavir Small molecular drug DB00701
Atazanavir Small molecular drug DB01072
Atorvastatin Small molecular drug DB01076
Benzbromarone Small molecular drug D0Z3DY
Cannabidiol Small molecular drug DB09061
Cholic Acid Small molecular drug DB02659
Clofazimine Small molecular drug DB00845
Conjugated Estrogens Small molecular drug DB00286
Cyanocobalamin Small molecular drug DB00115
Dactinomycin Small molecular drug DB00970
Daunorubicin Small molecular drug DB00694
Dexibuprofen Small molecular drug DB09213
Diclofenac Small molecular drug DB00586
Docetaxel Small molecular drug DB01248
Doxorubicin Small molecular drug DB00997
Dronabinol Small molecular drug DB00470
Epirubicin Small molecular drug DB00445
Etoposide Small molecular drug DB00773
Fingolimod Small molecular drug DB08868
Fluorescein Small molecular drug DB00693
Flutamide Small molecular drug DB00499
Glutathione Small molecular drug DB00143
Glyburide Small molecular drug DB01016
Grepafloxacin Small molecular drug DB00365
Ibuprofen Small molecular drug DB01050
Idarubicin Small molecular drug DB01177
Imatinib Small molecular drug DB00619
Indinavir Small molecular drug DB00224
Indomethacin Small molecular drug DB00328
Irinotecan Small molecular drug DB00762
Lamivudine Small molecular drug DB00709
Methotrexate Small molecular drug DB00563
Mifepristone Small molecular drug DB00834
Mitoxantrone Small molecular drug DB01204
Ofloxacin Small molecular drug DB01165
Paclitaxel Small molecular drug DB01229
Phenobarbital Small molecular drug DB01174
Prasterone Small molecular drug DB01708
Probenecid Small molecular drug DB01032
Progesterone Small molecular drug DB00396
Rifampicin Small molecular drug DB01045
Ritonavir Small molecular drug DB00503
Romidepsin Small molecular drug DB06176
Saquinavir Small molecular drug DB01232
Saxagliptin Small molecular drug DB06335
Sulfinpyrazone Small molecular drug D03DEI
Taurocholic Acid Small molecular drug DB04348
Vandetanib Small molecular drug DB05294
Vemurafenib Small molecular drug DB08881
Verapamil Small molecular drug DB00661
Vinblastine Small molecular drug DB00570
Vincristine Small molecular drug DB00541
Zoledronic Acid Small molecular drug DB00399
Acemetacin . DB13783
Trastuzumab Deruxtecan . DB14962
Investigative
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Atp Small molecular drug DB00171
Biricodar Small molecular drug DB04851
Genistein Small molecular drug DB01645
Myricetin Small molecular drug DB02375
Nabiximols Small molecular drug DB14011
Naringenin Small molecular drug DB03467
Quercetin Small molecular drug DB04216
Xr-9456 Small molecular drug D04GYT
Xr-9504 Small molecular drug D09HIM
Xr-9544 Small molecular drug D0A4TF
Xr-9577 Small molecular drug D0S8CE
Leukotriene C4 . DB08855
Medical Cannabis . DB14009
Pyrrolopyrimidine . D0KX3H
Rhodamine 6g . DB03825

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402