Details of the Probe-central Interaction Altas
General Information of Experiment
| Probe Name | C216 | Probe Info | ||||
|---|---|---|---|---|---|---|
| Probe concentration | Probe:50uM; negative probe:50uM | |||||
| Criteria | Quantification: AfBPP Probe vs Negative Probe | |||||
| Quantitative Method |
TMT
|
|||||
| In Vivo Experiment Model | Model Type |
|
Living cell | |||
| Derived Tissue |
|
Peripheral blood | ||||
| Disease Model | Normal | |||||
| Model Name | Human normal cells (HEK-293T) | |||||
| Note | Negative probe:C#CCCC1(CCC(NC)=O)N=N1 | |||||
Interaction Altas of This Experiment [1]
Enzyme
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03671 | Multidrug resistance-associated protein 1 (ABCC1) | 44.9 | ||||
| LDTP10032 | 7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) | 28.8 | ||||
| LDTP03198 | Ferrochelatase, mitochondrial (FECH) | 17.4 | ||||
| LDTP10188 | FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) | 17.3 | ||||
| LDTP05396 | Histone-lysine N-methyltransferase 2A (KMT2A) | 15.9 | ||||
| LDTP12628 | Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) | 13.3 | ||||
| LDTP11187 | COP9 signalosome complex subunit 4 (COPS4) | 12.9 | ||||
| LDTP03257 | Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) | 12.7 | ||||
| LDTP15484 | Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) | 12.6 | ||||
| LDTP02713 | Macrophage migration inhibitory factor (MIF) | 11.2 | ||||
| LDTP14218 | Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) | 10.1 | ||||
| LDTP11273 | N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) | 9.4 | ||||
| LDTP04285 | Proteasome subunit beta type-2 (PSMB2) | 9.1 | ||||
| LDTP09088 | Phospholipase A2 group XV (PLA2G15) | 9.1 | ||||
| LDTP03418 | Proteasome subunit beta type-6 (PSMB6) | 8.6 | ||||
| LDTP03540 | Heme oxygenase 2 (HMOX2) | 8.2 | ||||
| LDTP13358 | Leucyl-cystinyl aminopeptidase (LNPEP) | 8.1 | ||||
| LDTP05588 | RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) | 8.1 | ||||
| LDTP04253 | Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) | 7.9 | ||||
| LDTP01039 | Protein-S-isoprenylcysteine O-methyltransferase (ICMT) | 7.7 | ||||
| LDTP01328 | CAAX prenyl protease 1 homolog (ZMPSTE24) | 7.4 | ||||
| LDTP00988 | Protein O-GlcNAcase (OGA) | 7.3 | ||||
| LDTP07259 | N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) | 7.2 | ||||
| LDTP12020 | Histone-lysine N-methyltransferase SMYD3 (SMYD3) | 7.1 | ||||
| LDTP13282 | Prenylcysteine oxidase 1 (PCYOX1) | 7.0 | ||||
| LDTP07831 | Transmembrane protein with metallophosphoesterase domain (TMPPE) | 7.0 | ||||
| LDTP03680 | DNA replication licensing factor MCM4 (MCM4) | 6.9 | ||||
| LDTP03842 | Squalene synthase (FDFT1) | 6.9 | ||||
| LDTP06546 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E) | 6.6 | ||||
| LDTP05920 | Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G) | 6.5 | ||||
| LDTP04008 | Endothelin-converting enzyme 1 (ECE1) | 6.5 | ||||
| LDTP01687 | Apoptosis-inducing factor 1, mitochondrial (AIFM1) | 6.3 | ||||
| LDTP04712 | Puromycin-sensitive aminopeptidase (NPEPPS) | 6.3 | ||||
| LDTP08790 | Mitochondrial cardiolipin hydrolase (PLD6) | 6.3 | ||||
| LDTP16007 | Lipid droplet-associated hydrolase (LDAH) | 6.1 | ||||
| LDTP12868 | Endoplasmic reticulum aminopeptidase 1 (ERAP1) | 6.1 | ||||
| LDTP13814 | Phospholipase A-2-activating protein (PLAA) | 5.9 | ||||
| LDTP00697 | Cytochrome b5 type B (CYB5B) | 5.8 | ||||
| LDTP12013 | dCTP pyrophosphatase 1 (DCTPP1) | 5.7 | ||||
| LDTP04581 | Holocytochrome c-type synthase (HCCS) | 5.6 | ||||
| LDTP00890 | S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) | 5.6 | ||||
| LDTP04004 | Lysosomal Pro-X carboxypeptidase (PRCP) | 5.6 | ||||
| LDTP11388 | N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) | 5.5 | ||||
| LDTP12279 | Endoplasmic reticulum transmembrane helix translocase (ATP13A1) | 5.4 | ||||
| LDTP03060 | Proteasome subunit beta type-1 (PSMB1) | 5.4 | ||||
| LDTP09251 | Atlastin-2 (ATL2) | 5.2 | ||||
| LDTP01004 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) | 5.1 | ||||
| LDTP04884 | Proteasome subunit alpha type-6 (PSMA6) | 5.0 | ||||
| LDTP06375 | Delta(24)-sterol reductase (DHCR24) | 5.0 | ||||
Transporter and channel
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP01804 | ATP synthase subunit a (MT-ATP6) | 20.0 | ||||
| LDTP14952 | Mpv17-like protein 2 (MPV17L2) | 19.7 | ||||
| LDTP10913 | Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) | 18.4 | ||||
| LDTP01059 | Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) | 16.6 | ||||
| LDTP16069 | Peroxisomal membrane protein 2 (PXMP2) | 16.3 | ||||
| LDTP05900 | Metaxin-1 (MTX1) | 13.0 | ||||
| LDTP00865 | Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) | 12.9 | ||||
| LDTP07236 | Protein GPR107 (GPR107) | 12.7 | ||||
| LDTP17362 | Magnesium transporter NIPA3 (NIPAL1) | 12.1 | ||||
| LDTP08881 | Transmembrane protein 199 (TMEM199) | 11.3 | ||||
| LDTP17641 | Solute carrier family 35 member F2 (SLC35F2) | 10.8 | ||||
| LDTP01217 | Metaxin-2 (MTX2) | 10.5 | ||||
| LDTP15948 | Transmembrane protein 126A (TMEM126A) | 9.7 | ||||
| LDTP15648 | BRI3-binding protein (BRI3BP) | 9.4 | ||||
| LDTP11826 | Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) | 8.9 | ||||
| LDTP09547 | Scavenger receptor class B member 1 (SCARB1) | 7.3 | ||||
| LDTP01671 | STARD3 N-terminal-like protein (STARD3NL) | 7.1 | ||||
| LDTP11615 | Protein tweety homolog 3 (TTYH3) | 6.9 | ||||
| LDTP03277 | ER lumen protein-retaining receptor 1 (KDELR1) | 6.7 | ||||
| LDTP11162 | Solute carrier family 25 member 33 (SLC25A33) | 6.2 | ||||
| LDTP11041 | Calcium uptake protein 1, mitochondrial (MICU1) | 6.0 | ||||
| LDTP08981 | Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) | 5.9 | ||||
| LDTP18448 | Transmembrane 9 superfamily member 3 (TM9SF3) | 5.9 | ||||
| LDTP15481 | Transmembrane protein 87A (TMEM87A) | 5.9 | ||||
| LDTP07885 | Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) | 5.8 | ||||
| LDTP03064 | Cytochrome c oxidase subunit 5A, mitochondrial (COX5A) | 5.7 | ||||
| LDTP13262 | Signal recognition particle subunit SRP68 (SRP68) | 5.7 | ||||
| LDTP08673 | Calcium uptake protein 2, mitochondrial (MICU2) | 5.5 | ||||
| LDTP03132 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 5.5 | ||||
| LDTP18153 | Major facilitator superfamily domain-containing protein 3 (MFSD3) | 5.3 | ||||
| LDTP03061 | Cation-dependent mannose-6-phosphate receptor (M6PR) | 5.0 | ||||
Immunoglobulin
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP04720 | IgG receptor FcRn large subunit p51 (FCGRT) | 5.1 | ||||
Other
| Target ID | Target Name | Binding Ratio | ||||
|---|---|---|---|---|---|---|
| LDTP03520 | Phosphatidylethanolamine-binding protein 1 (PEBP1) | 23.3 | ||||
| LDTP14792 | Small ribosomal subunit protein uS9m (MRPS9) | 14.6 | ||||
| LDTP14486 | Clustered mitochondria protein homolog (CLUH) | 13.0 | ||||
| LDTP15067 | Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) | 11.6 | ||||
| LDTP15623 | Neuferricin (CYB5D2) | 11.2 | ||||
| LDTP04652 | Eukaryotic translation initiation factor 5 (EIF5) | 10.5 | ||||
| LDTP13902 | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) | 9.8 | ||||
| LDTP10469 | Engulfment and cell motility protein 2 (ELMO2) | 9.6 | ||||
| LDTP06174 | Pumilio homolog 1 (PUM1) | 9.1 | ||||
| LDTP10056 | Protein FAM162A (FAM162A) | 8.8 | ||||
| LDTP04094 | Large proline-rich protein BAG6 (BAG6) | 7.4 | ||||
| LDTP05868 | Protein unc-119 homolog A (UNC119) | 7.0 | ||||
| LDTP13425 | U6 snRNA-associated Sm-like protein LSm7 (LSM7) | 7.0 | ||||
| LDTP05641 | WASH complex subunit 5 (WASHC5) | 6.9 | ||||
| LDTP19021 | EF-hand calcium-binding domain-containing protein 14 (EFCAB14) | 6.8 | ||||
| LDTP01522 | Reticulon-3 (RTN3) | 6.8 | ||||
| LDTP03678 | ER lumen protein-retaining receptor 2 (KDELR2) | 6.5 | ||||
| LDTP12565 | Mitochondrial import receptor subunit TOM22 homolog (TOMM22) | 6.5 | ||||
| LDTP09787 | Nicastrin (NCSTN) | 6.3 | ||||
| LDTP13828 | Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) | 6.0 | ||||
| LDTP00871 | Microtubule nucleation factor SSNA1 (SSNA1) | 5.9 | ||||
| LDTP02124 | Keratin, type I cytoskeletal 18 (KRT18) | 5.8 | ||||
| LDTP02345 | Retinol-binding protein 1 (RBP1) | 5.8 | ||||
| LDTP02297 | Vimentin (VIM) | 5.7 | ||||
| LDTP08707 | Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) | 5.5 | ||||
| LDTP08689 | Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) | 5.5 | ||||
| LDTP11076 | Apolipoprotein L2 (APOL2) | 5.3 | ||||
| LDTP01359 | Dynactin subunit 3 (DCTN3) | 5.3 | ||||
| LDTP01652 | Centrosomal protein 43 (CEP43) | 5.2 | ||||
| LDTP00281 | Golgi integral membrane protein 4 (GOLIM4) | 5.2 | ||||
| LDTP08364 | Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) | 5.1 | ||||
| LDTP05160 | Nucleobindin-2 (NUCB2) | 5.1 | ||||
| LDTP06097 | Reticulocalbin-2 (RCN2) | 5.1 | ||||
| LDTP12642 | CYFIP-related Rac1 interactor B (CYRIB) | 5.0 | ||||
| LDTP08766 | Vacuolar protein sorting-associated protein 52 homolog (VPS52) | 4.9 | ||||