Details of the Target

General Information of Target

Target ID LDTP04253
Target Name Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)
Gene Name ALDH7A1
Gene ID 501
Synonyms
ATQ1; Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; EC 1.2.1.31; Aldehyde dehydrogenase family 7 member A1; EC 1.2.1.3; Antiquitin-1; Betaine aldehyde dehydrogenase; EC 1.2.1.8; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWG
GRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDA
LREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIE
QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED
NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN
NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVG
NPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHD
ASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGI
VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
Target Bioclass
Enzyme
Family
Aldehyde dehydrogenase family
Subcellular location
Cytoplasm, cytosol; Mitochondrion
Function
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Uniprot ID
P49419
Ensemble ID
ENST00000409134.8
HGNC ID
HGNC:877

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.T415I DBIA    Probe Info 
HEC1B SNV: p.T415I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 34 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		1.70  LDD0197  [2]
W1
 Probe Info  		19.37  LDD0235  [3]
TH211
 Probe Info  		Y526(13.21)  LDD0257  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K100(7.04); K352(7.64)  LDD0277  [6]
BTD
 Probe Info  		C70(4.95)  LDD1699  [7]
Probe 1
 Probe Info  		Y69(10.58); Y88(8.47)  LDD3495  [8]
JZ128-DTB
 Probe Info  		C478(0.00); C70(0.00)  LDD0462  [9]
THZ1-DTB
 Probe Info  		C478(1.05)  LDD0460  [9]
DBIA
 Probe Info  		C522(1.22)  LDD0078  [10]
5E-2FA
 Probe Info  		N.A.  LDD2235  [11]
ATP probe
 Probe Info  		N.A.  LDD0199  [12]
IA-alkyne
 Probe Info  		C70(0.00); C248(0.00); C522(0.00)  LDD0032  [13]
IPM
 Probe Info  		C522(0.00); C478(0.00); C70(0.00)  LDD0025  [14]
JW-RF-010
 Probe Info  		C70(0.00); C478(0.00); C522(0.00)  LDD0026  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
TFBX
 Probe Info  		C70(0.00); C522(0.00); C478(0.00)  LDD0027  [14]
WYneN
 Probe Info  		C70(0.00); C522(0.00); C478(0.00)  LDD0021  [16]
WYneO
 Probe Info  		C522(0.00); C70(0.00)  LDD0022  [16]
NHS
 Probe Info  		N.A.  LDD0010  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C9(0.00); C478(0.00); C522(0.00)  LDD0018  [17]
Ox-W18
 Probe Info  		W447(0.00); W363(0.00)  LDD2175  [18]
1c-yne
 Probe Info  		K528(0.00); K500(0.00); K100(0.00); K474(0.00)  LDD0228  [19]
1d-yne
 Probe Info  		N.A.  LDD0357  [19]
Acrolein
 Probe Info  		C478(0.00); C70(0.00); C522(0.00)  LDD0217  [20]
Crotonaldehyde
 Probe Info  		C70(0.00); C522(0.00)  LDD0219  [20]
Methacrolein
 Probe Info  		C70(0.00); C522(0.00); C478(0.00)  LDD0218  [20]
AOyne
 Probe Info  		11.60  LDD0443  [21]
MPP-AC
 Probe Info  		N.A.  LDD0428  [22]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
HHS-465
 Probe Info  		N.A.  LDD2240  [23]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C180
 Probe Info  		7.36  LDD1859  [24]
C183
 Probe Info  		7.62  LDD1861  [24]
C216
 Probe Info  		7.94  LDD1890  [24]
C290
 Probe Info  		5.43  LDD1960  [24]
C292
 Probe Info  		7.16  LDD1962  [24]
C333
 Probe Info  		8.88  LDD1996  [24]
C360
 Probe Info  		5.66  LDD2021  [24]
FFF probe13
 Probe Info  		17.68  LDD0475  [25]
FFF probe7
 Probe Info  		8.86  LDD0483  [25]
JN0003
 Probe Info  		12.27  LDD0469  [25]
STS-1
 Probe Info  		3.80  LDD0137  [26]
STS-2
 Probe Info  		N.A.  LDD0138  [26]
DA-2
 Probe Info  		N.A.  LDD0072  [27]
OEA-DA
 Probe Info  		4.60  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C70(0.76); C522(0.94)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C522(1.24)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C70(0.72)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C522(0.53)  LDD2130  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C522(1.25)  LDD2152  [7]
 LDCM0214  AC1 HCT 116 C248(0.48); C252(0.48); C478(1.23); C522(0.90)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C522(0.95)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C522(1.26)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C522(1.08)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C522(1.07)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C522(0.77)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C522(0.92)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C522(0.73)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C522(0.89)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C522(0.76)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C522(1.08)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C522(1.92)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C522(0.76)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C522(1.59)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C522(1.16)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C522(1.01)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C522(1.20)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C522(1.19)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C522(1.11)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C522(1.05)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C522(1.16)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C522(1.04)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C522(1.20)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C522(0.74)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C522(1.37)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C522(1.09)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C522(1.20)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C522(1.38)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C522(1.27)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C522(1.21)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C522(1.16)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C522(1.14)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C478(0.56); C522(0.50)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C478(1.17); C522(0.56)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C478(0.72); C522(0.53)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C478(1.22); C522(0.64)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C478(1.26); C522(0.61)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C478(0.80); C522(0.55)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C478(0.70); C522(0.51)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C478(0.76); C522(0.58)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C478(0.82); C522(0.65)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C478(1.05); C522(0.55)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C478(0.80); C522(0.46)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C478(0.96); C522(0.67)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C522(0.77)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C478(0.73); C522(0.51)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C478(0.97); C522(0.40)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C478(1.54); C522(0.64)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C478(0.86); C522(1.32)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C478(0.42); C522(1.27)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C478(0.71); C522(1.06)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C478(0.77); C522(1.04)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C478(0.51); C522(0.95)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C478(0.31); C522(1.00)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C478(0.45); C522(0.98)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C522(0.92)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C478(0.94); C522(0.99)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C478(0.70); C522(1.09)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C478(0.37); C522(1.12)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C478(0.30); C522(1.19)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C478(0.55); C522(1.17)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C478(0.50); C522(1.16)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C478(0.81); C522(1.22)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C478(1.03); C522(1.26)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C522(1.27)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C522(1.09)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C522(0.92)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C248(0.69); C252(0.69); C522(0.76); C478(0.93)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C522(1.16)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C522(1.02)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C522(1.33)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C522(1.01)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C522(1.25)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C522(0.76); C478(0.80)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C478(0.86); C522(0.91)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C478(0.78); C522(1.39)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C478(0.76); C522(1.25)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C478(0.83); C522(1.71)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C248(0.74); C252(0.74); C522(0.79); C478(1.07)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C478(0.71); C522(1.66)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C478(1.00); C522(1.41)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C478(0.53); C522(1.44)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C478(0.59); C522(1.05)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C478(0.57); C522(1.22)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C522(0.73); C478(1.51)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C522(0.78); C478(1.25)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C522(0.75); C478(1.17)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C522(1.09); C478(1.23)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C522(0.77); C478(1.12)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C248(0.65); C252(0.65); C522(0.67); C478(1.53)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C478(0.78); C522(0.83)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C522(0.85); C478(1.08)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C522(1.03); C478(1.09)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C522(1.03); C478(1.34)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C478(0.93); C522(1.04)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C522(0.90); C478(0.90)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C522(0.92); C478(1.62)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C522(0.82); C478(1.09)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C522(0.77); C478(1.94)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C522(0.99); C478(1.06)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C522(0.62); C248(0.62); C252(0.62); C478(1.39)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C522(0.93); C478(1.05)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C522(0.86); C478(1.66)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C522(0.94); C478(1.17)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C478(0.87); C522(0.89)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C522(0.74); C478(1.11)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C478(1.06); C522(1.28)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C478(0.95); C522(1.01)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C478(0.55); C248(0.62); C252(0.62); C522(1.08)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C248(0.61); C252(0.61); C478(0.66); C522(1.02)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C478(0.47); C248(0.68); C252(0.68); C522(1.17)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C522(1.06)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C248(0.56); C252(0.56); C478(0.79); C522(1.16)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C248(0.47); C252(0.47); C522(1.07); C478(1.41)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C478(0.47); C248(0.58); C252(0.58); C522(1.04)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C478(0.58); C248(0.58); C252(0.58); C522(1.12)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C478(0.59); C248(0.68); C252(0.68); C522(1.15)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C248(0.73); C252(0.73); C478(0.95); C522(1.19)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C248(0.64); C252(0.64); C522(1.08); C478(1.18)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C248(0.17); C252(0.17); C478(0.56); C522(1.17)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C248(0.87); C252(0.87); C478(0.94); C522(1.04)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C248(0.72); C252(0.72); C478(0.86); C522(1.19)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C522(0.88)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C478(0.49); C248(0.69); C252(0.69); C522(0.80)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C248(0.93); C252(0.93); C478(0.94); C522(1.09)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C478(0.84); C248(0.95); C252(0.95); C522(1.07)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C248(0.24); C252(0.24); C478(0.45); C522(0.74)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C248(0.26); C252(0.26); C478(0.47); C522(0.67)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C248(0.10); C252(0.10); C478(0.43); C522(1.05)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C478(0.71); C522(0.92); C248(0.99); C252(0.99)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C478(0.61); C522(0.87); C248(1.24); C252(1.24)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C248(0.69); C252(0.69); C478(1.18); C522(2.29)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C248(0.95); C252(0.95); C478(1.05); C522(1.33)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C522(0.68)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C478(0.72); C522(0.75); C248(0.86); C252(0.86)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C248(0.47); C252(0.47); C522(1.06); C478(1.25)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C248(0.05); C252(0.05); C478(0.40); C522(0.77)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C478(0.34); C522(1.23)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C478(0.41); C522(1.15)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C478(0.90); C522(1.13)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C478(0.64); C522(1.03)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C478(0.82); C522(1.12)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C478(0.57); C522(0.99)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C478(0.44); C522(1.17)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C522(1.17); C478(1.32)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C478(0.31); C522(0.94)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C478(0.33); C522(1.03)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C478(0.57); C522(1.17)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C478(0.88); C522(0.95)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C478(0.82); C522(0.99)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C478(0.59); C522(0.96)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C478(0.36); C522(1.05)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C522(0.73)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C522(1.17)  LDD0683  [10]
 LDCM0545  Acetamide MDA-MB-231 C70(0.57); C522(1.19)  LDD2138  [7]
 LDCM0248  AKOS034007472 HCT 116 C522(0.91)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C522(0.93)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C522(1.10)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 11.47  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C522(1.22)  LDD0078  [10]
 LDCM0498  BS-3668 MDA-MB-231 C522(0.59)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C478(1.72)  LDD2214  [29]
 LDCM0108  Chloroacetamide HeLa C478(0.00); C70(0.00); C522(0.00)  LDD0222  [20]
 LDCM0367  CL1 HCT 116 C248(0.99); C252(0.99); C478(1.22)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C248(0.68); C252(0.68); C478(0.83)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C522(0.61); C248(0.63); C252(0.63); C478(1.13)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C522(0.88)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C522(0.92)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C522(0.74)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C522(0.93)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C522(1.18)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C522(0.91)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C522(1.07)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C522(1.08)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C522(1.00)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C248(0.60); C252(0.60); C478(1.11)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C522(0.74)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C522(0.70)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C478(0.74); C522(0.77)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C478(0.54); C522(1.34)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C478(0.81); C522(1.26)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C478(0.76); C522(1.03)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C478(0.86); C522(1.08)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C522(0.77); C478(0.81)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C522(0.89); C478(1.00)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C522(0.82); C478(1.05)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C248(0.49); C252(0.49); C478(0.89)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C522(0.82); C478(1.28)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C522(1.09); C478(1.55)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C522(0.73); C478(1.30)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C522(0.83); C478(1.07)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C522(0.86); C478(1.24)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C478(0.87); C248(1.20); C252(1.20); C522(1.26)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C478(0.68); C522(1.19); C248(1.33); C252(1.33)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C248(0.72); C252(0.72); C478(0.80); C522(1.08)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C478(0.46); C248(0.75); C252(0.75); C522(1.09)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C248(0.78); C252(0.78); C478(1.51)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C248(0.75); C252(0.75); C478(0.92)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C248(0.51); C252(0.51); C478(1.13)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C478(0.82); C248(0.85); C252(0.85); C522(1.11)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C248(0.61); C252(0.61); C522(0.75); C478(0.91)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C248(0.39); C252(0.39); C522(0.90); C478(1.76)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C248(0.70); C252(0.70); C522(0.88); C478(1.08)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C478(0.88); C248(0.99); C252(0.99)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C478(0.53); C248(0.92); C252(0.92); C522(1.02)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C248(0.44); C252(0.44); C478(0.52); C522(0.89)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C248(0.10); C252(0.10); C478(0.51); C522(1.06)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C478(0.62); C248(0.83); C252(0.83); C522(1.08)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C478(0.61); C248(0.62); C252(0.62); C522(0.99)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C248(0.63); C252(0.63); C478(0.51); C522(0.95)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C248(0.72); C252(0.72); C478(0.61); C522(0.76)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C248(0.88); C252(0.88); C478(0.65); C522(0.98)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C248(0.65); C252(0.65); C478(0.64); C522(1.00)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C248(0.65); C252(0.65); C478(0.65); C522(1.02)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C248(0.95); C252(0.95); C478(1.02)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C248(0.77); C252(0.77); C478(0.89); C522(0.99)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C248(0.94); C252(0.94); C478(0.61); C522(1.04)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C248(0.60); C252(0.60); C478(1.05)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C248(0.78); C252(0.78); C478(1.02)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C248(0.83); C252(0.83); C478(0.39)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C248(0.77); C252(0.77); C478(0.44)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C248(0.93); C252(0.93); C478(0.41)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C248(0.78); C252(0.78); C478(0.49)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C248(0.78); C252(0.78); C478(0.43)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C248(0.98); C252(0.98); C478(0.88)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C248(0.92); C252(0.92); C478(0.45)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C248(0.89); C252(0.89); C478(0.44)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C248(0.14); C252(0.14); C478(0.44)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C248(0.50); C252(0.50); C478(0.41)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C248(0.70); C252(0.70); C478(0.56)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C248(0.68); C252(0.68); C478(0.69)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C248(1.66); C252(1.66); C478(1.27); C522(1.31)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C248(1.47); C252(1.47); C478(1.22); C522(1.16)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C248(1.48); C252(1.48); C478(1.68); C522(1.14)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C248(1.55); C252(1.55); C478(0.97); C522(1.03)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C248(1.06); C252(1.06); C478(0.87)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C248(1.27); C252(1.27); C478(0.97); C522(1.11)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C248(1.48); C252(1.48); C478(1.22); C522(1.08)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C248(1.35); C252(1.35); C478(1.20); C522(0.98)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C248(1.57); C252(1.57); C478(1.26); C522(1.07)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C248(1.81); C252(1.81); C478(1.44); C522(0.99)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C248(1.44); C252(1.44); C478(1.26); C522(1.05)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C248(1.29); C252(1.29); C478(1.22); C522(1.30)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C248(1.17); C252(1.17); C478(1.28); C522(0.98)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C248(1.53); C252(1.53); C478(1.56); C522(1.03)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C248(1.31); C252(1.31); C478(1.50); C522(1.19)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C248(0.60); C252(0.60); C478(1.16)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C248(1.48); C252(1.48); C478(1.09); C522(1.17)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C248(0.80); C252(0.80); C522(1.00)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C248(0.77); C252(0.77); C522(0.92)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C248(0.67); C252(0.67); C522(0.87)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C248(0.56); C252(0.56); C522(1.01)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C248(0.73); C252(0.73); C522(0.93)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C248(0.57); C252(0.57); C522(1.16)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C248(0.56); C252(0.56); C522(1.06)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C248(0.46); C252(0.46); C522(1.05)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C248(0.43); C252(0.43); C522(1.04)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C248(0.73); C252(0.73); C478(0.92)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C248(0.53); C252(0.53); C522(1.09)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C248(0.56); C252(0.56); C522(1.15)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C248(0.71); C252(0.71); C522(1.10)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C248(0.58); C252(0.58); C522(0.89)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C248(0.59); C252(0.59); C522(0.87)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C248(0.73); C252(0.73); C478(1.16); C522(0.69)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C248(0.88); C252(0.88); C478(0.80); C522(0.85)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C248(0.99); C252(0.99); C478(0.53); C522(0.47)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C248(0.83); C252(0.83); C478(0.47); C522(0.33)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C248(0.47); C252(0.47); C478(0.64)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C248(0.61); C252(0.61); C478(1.44); C522(1.26)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C248(1.06); C252(1.06); C478(0.52); C522(0.36)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C248(0.47); C252(0.47); C478(0.41); C522(0.33)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C248(0.77); C252(0.77); C478(0.44); C522(0.31)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C248(0.21); C252(0.21); C478(0.37); C522(0.42)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C248(1.10); C252(1.10); C478(0.67); C522(0.41)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C248(1.01); C252(1.01); C478(0.93); C522(0.62)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C248(1.01); C252(1.01); C478(0.59); C522(0.33)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C248(0.73); C252(0.73); C478(0.43); C522(0.26)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C248(0.11); C252(0.11); C478(0.44); C522(0.71)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C248(0.92); C252(0.92); C478(0.79)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C248(0.99); C252(0.99); C478(1.08); C522(0.77)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C248(0.62); C252(0.62); C478(1.38); C522(0.72)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C248(0.68); C252(0.68); C478(0.89); C522(0.66)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C248(0.66); C252(0.66); C478(1.25); C522(0.72)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C248(0.64); C252(0.64); C478(1.00); C522(0.56)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C248(0.58); C252(0.58); C478(0.76); C522(0.55)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C248(0.71); C252(0.71); C478(0.59); C522(0.56)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C248(0.63); C252(0.63); C478(1.20); C522(0.63)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C248(0.63); C252(0.63); C478(0.97); C522(0.57)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C248(0.58); C252(0.58); C478(0.98); C522(0.62)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C9(1.12); C522(1.66); C70(1.05); C478(1.21)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C252(7.35); C70(2.26); C478(1.79); C522(1.50)  LDD1702  [7]
 LDCM0574  Fragment12 MDA-MB-231 C522(1.35)  LDD1393  [31]
 LDCM0575  Fragment13 MDA-MB-231 C522(0.72)  LDD1395  [31]
 LDCM0579  Fragment20 MDA-MB-231 C522(1.02)  LDD1402  [31]
 LDCM0580  Fragment21 MDA-MB-231 C522(1.01)  LDD1404  [31]
 LDCM0578  Fragment27 MDA-MB-231 C522(0.64)  LDD1401  [31]
 LDCM0589  Fragment31 MDA-MB-231 C522(0.95)  LDD1421  [31]
 LDCM0468  Fragment33 HCT 116 C248(0.59); C252(0.59); C522(0.90)  LDD0785  [10]
 LDCM0596  Fragment38 MDA-MB-231 C522(20.00)  LDD1433  [31]
 LDCM0566  Fragment4 MDA-MB-231 C522(0.73)  LDD1378  [31]
 LDCM0607  Fragment49 MDA-MB-231 C522(0.27)  LDD1448  [31]
 LDCM0427  Fragment51 HCT 116 C248(0.25); C252(0.25); C478(0.37)  LDD0744  [10]
 LDCM0570  Fragment8 MDA-MB-231 C522(0.89)  LDD1385  [31]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0179  JZ128 PC-3 C478(0.00); C70(0.00)  LDD0462  [9]
 LDCM0022  KB02 HCT 116 C478(4.27); C522(4.88)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C478(2.32); C522(1.95)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C478(1.49); C522(1.42)  LDD0082  [10]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C70(0.53); C522(0.76)  LDD2121  [7]
 LDCM0109  NEM HeLa H373(0.00); H339(0.00)  LDD0223  [20]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C70(0.58); C522(0.66)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C70(1.07)  LDD2090  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C522(1.00)  LDD2093  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C522(0.77)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C522(1.02)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C522(0.92)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C522(1.00)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C522(0.82)  LDD2101  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C70(1.24)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C522(0.84)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C70(0.76); C522(0.93)  LDD2108  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C70(1.45)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C522(1.26)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C522(0.83)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C522(0.77)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C522(1.09)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C522(2.10)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C522(0.90)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C522(0.91)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C522(0.73)  LDD2124  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C522(0.71)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C522(0.78)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C522(1.17)  LDD2128  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C522(0.53)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C522(1.00)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C522(1.18)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C522(0.82)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C522(1.65)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C522(0.66)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C70(0.84); C522(0.89)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C522(0.89)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C522(1.38)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C522(2.94)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C522(0.95)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C522(2.60)  LDD2147  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C522(0.46)  LDD2150  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C478(0.84)  LDD2206  [32]
 LDCM0021  THZ1 HeLa S3 C478(1.05)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157
Artenimol . DB11638

References

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2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
18 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
25 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
26 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
27 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
28 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
29 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
31 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.