Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C180  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 34.8
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) 10.9
 LDTP09043  Lysine-specific histone demethylase 2 (KDM1B) 8.1
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.9
 LDTP04253  Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) 7.4
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 6.4
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 5.0
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 15.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.4
 LDTP05900  Metaxin-1 (MTX1) 5.1
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15623  Neuferricin (CYB5D2) 6.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587