Details of the Target

General Information of Target

Target ID	LDTP05900
Target Name	Metaxin-1 (MTX1)
Gene Name	MTX1
Gene ID	4580
Synonyms	MTX; MTXN; Metaxin-1; Mitochondrial outer membrane import complex protein 1
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MLLGGPPRSPRSGTSPKGPWSSTGHVQFGKSPQTWPRRTRPRSPEPAAPSGVRGSTWTRR RDSPRRAGPTALSRYVGHLWMGRRPPSPEARGPVPRSSAASRARRSLASPGISPGPLTAT IGGAVAGGGPRQGRAEAHKEVFPGQRVGKMAAPMELFCWSGGWGLPSVDLDSLAVLTYAR FTGAPLKVHKISNPWQSPSGTLPALRTSHGEVISVPHKIITHLRKEKYNADYDLSARQGA DTLAFMSLLEEKLLPVLVHTFWIDTKNYVEVTRKWYAEAMPFPLNFFLPGRMQRQYMERL QLLTGEHRPEDEEELEKELYREARECLTLLSQRLGSQKFFFGDAPASLDAFVFSYLALLL QAKLPSGKLQVHLRGLHNLCAYCTHILSLYFPWDGAEVPPQRQTPAGPETEEEPYRRRNQ ILSVLAGLAAMVGYALLSGIVSIQRATPARAPGTRTLGMAEEDEEE
Target Bioclass	Transporter and channel
Family	Metaxin family
Subcellular location	Membrane
Function	Involved in transport of proteins into the mitochondrion. Essential for embryonic development.
Uniprot ID	Q13505
Ensemble ID	ENST00000316721.8
HGNC ID	HGNC:7504

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 14 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
TH211 Probe Info	Y415(20.00)	LDD0260	[1]
IPM Probe Info	N.A.	LDD0241	[2]
Probe 1 Probe Info	Y228(14.23)	LDD3495	[3]
m-APA Probe Info	14.62	LDD0403	[4]
DBIA Probe Info	C326(2.20)	LDD3310	[5]
BTD Probe Info	C326(1.22)	LDD2097	[6]
IA-alkyne Probe Info	N.A.	LDD0162	[7]
Lodoacetamide azide Probe Info	N.A.	LDD0037	[8]
TFBX Probe Info	N.A.	LDD0027	[9]
NHS Probe Info	K227(0.00); K190(0.00)	LDD0010	[10]
STPyne Probe Info	N.A.	LDD0009	[10]
1c-yne Probe Info	N.A.	LDD0228	[11]
Acrolein Probe Info	H209(0.00); H217(0.00)	LDD0217	[12]
AOyne Probe Info	15.00	LDD0443	[13]

PAL-AfBPP Probe

Click To Hide/Show 170 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
C004 Probe Info	11.00	LDD1714	[14]
C007 Probe Info	5.62	LDD1716	[14]
C010 Probe Info	5.24	LDD1719	[14]
C022 Probe Info	27.28	LDD1728	[14]
C026 Probe Info	8.94	LDD1732	[14]
C040 Probe Info	14.62	LDD1740	[14]
C041 Probe Info	21.56	LDD1741	[14]
C055 Probe Info	48.17	LDD1752	[14]
C056 Probe Info	71.01	LDD1753	[14]
C063 Probe Info	23.10	LDD1760	[14]
C064 Probe Info	8.57	LDD1761	[14]
C067 Probe Info	5.10	LDD1763	[14]
C070 Probe Info	39.12	LDD1766	[14]
C071 Probe Info	10.93	LDD1767	[14]
C072 Probe Info	13.55	LDD1768	[14]
C082 Probe Info	6.28	LDD1774	[14]
C087 Probe Info	8.17	LDD1779	[14]
C089 Probe Info	5.86	LDD1781	[14]
C091 Probe Info	32.90	LDD1782	[14]
C092 Probe Info	40.79	LDD1783	[14]
C094 Probe Info	53.08	LDD1785	[14]
C095 Probe Info	14.52	LDD1786	[14]
C100 Probe Info	8.88	LDD1789	[14]
C102 Probe Info	6.11	LDD1790	[14]
C106 Probe Info	28.44	LDD1793	[14]
C107 Probe Info	16.34	LDD1794	[14]
C108 Probe Info	9.65	LDD1795	[14]
C112 Probe Info	47.84	LDD1799	[14]
C129 Probe Info	5.94	LDD1811	[14]
C130 Probe Info	10.20	LDD1812	[14]
C133 Probe Info	10.13	LDD1815	[14]
C134 Probe Info	87.43	LDD1816	[14]
C135 Probe Info	64.89	LDD1817	[14]
C138 Probe Info	7.36	LDD1820	[14]
C139 Probe Info	13.36	LDD1821	[14]
C140 Probe Info	12.38	LDD1822	[14]
C141 Probe Info	13.36	LDD1823	[14]
C153 Probe Info	26.72	LDD1834	[14]
C158 Probe Info	9.25	LDD1838	[14]
C159 Probe Info	8.00	LDD1839	[14]
C160 Probe Info	15.45	LDD1840	[14]
C161 Probe Info	23.92	LDD1841	[14]
C163 Probe Info	17.88	LDD1843	[14]
C165 Probe Info	18.25	LDD1845	[14]
C166 Probe Info	14.03	LDD1846	[14]
C169 Probe Info	63.56	LDD1849	[14]
C173 Probe Info	8.51	LDD1853	[14]
C174 Probe Info	8.34	LDD1854	[14]
C177 Probe Info	11.55	LDD1856	[14]
C178 Probe Info	15.35	LDD1857	[14]
C180 Probe Info	5.10	LDD1859	[14]
C183 Probe Info	5.31	LDD1861	[14]
C187 Probe Info	36.76	LDD1865	[14]
C194 Probe Info	26.54	LDD1870	[14]
C196 Probe Info	16.80	LDD1872	[14]
C197 Probe Info	5.31	LDD1873	[14]
C198 Probe Info	40.22	LDD1874	[14]
C201 Probe Info	98.36	LDD1877	[14]
C205 Probe Info	7.89	LDD1880	[14]
C206 Probe Info	51.98	LDD1881	[14]
C210 Probe Info	99.73	LDD1884	[14]
C211 Probe Info	8.75	LDD1885	[14]
C214 Probe Info	5.62	LDD1888	[14]
C216 Probe Info	13.00	LDD1890	[14]
C218 Probe Info	38.85	LDD1892	[14]
C219 Probe Info	21.11	LDD1893	[14]
C220 Probe Info	38.32	LDD1894	[14]
C225 Probe Info	6.96	LDD1898	[14]
C226 Probe Info	12.30	LDD1899	[14]
C228 Probe Info	25.99	LDD1901	[14]
C229 Probe Info	17.03	LDD1902	[14]
C231 Probe Info	21.11	LDD1904	[14]
C232 Probe Info	99.73	LDD1905	[14]
C233 Probe Info	19.43	LDD1906	[14]
C234 Probe Info	13.45	LDD1907	[14]
C235 Probe Info	24.76	LDD1908	[14]
C238 Probe Info	19.84	LDD1911	[14]
C240 Probe Info	12.38	LDD1913	[14]
C242 Probe Info	7.11	LDD1915	[14]
C243 Probe Info	33.36	LDD1916	[14]
C244 Probe Info	22.16	LDD1917	[14]
C246 Probe Info	39.40	LDD1919	[14]
C249 Probe Info	37.27	LDD1922	[14]
C252 Probe Info	16.34	LDD1925	[14]
C256 Probe Info	14.52	LDD1929	[14]
C258 Probe Info	6.45	LDD1931	[14]
C260 Probe Info	11.39	LDD1932	[14]
C264 Probe Info	42.81	LDD1935	[14]
C265 Probe Info	17.63	LDD1936	[14]
C266 Probe Info	7.62	LDD1937	[14]
C269 Probe Info	20.82	LDD1939	[14]
C270 Probe Info	14.42	LDD1940	[14]
C271 Probe Info	12.47	LDD1941	[14]
C272 Probe Info	6.92	LDD1942	[14]
C273 Probe Info	9.45	LDD1943	[14]
C277 Probe Info	14.03	LDD1947	[14]
C278 Probe Info	99.73	LDD1948	[14]
C280 Probe Info	11.55	LDD1950	[14]
C282 Probe Info	23.26	LDD1952	[14]
C284 Probe Info	58.08	LDD1954	[14]
C285 Probe Info	50.21	LDD1955	[14]
C287 Probe Info	22.01	LDD1957	[14]
C288 Probe Info	10.20	LDD1958	[14]
C289 Probe Info	95.01	LDD1959	[14]
C290 Probe Info	11.55	LDD1960	[14]
C292 Probe Info	22.16	LDD1962	[14]
C293 Probe Info	34.78	LDD1963	[14]
C296 Probe Info	35.02	LDD1966	[14]
C299 Probe Info	9.78	LDD1968	[14]
C300 Probe Info	5.10	LDD1969	[14]
C301 Probe Info	10.48	LDD1970	[14]
C305 Probe Info	32.00	LDD1974	[14]
C310 Probe Info	36.25	LDD1977	[14]
C313 Probe Info	24.25	LDD1980	[14]
C314 Probe Info	15.45	LDD1981	[14]
C317 Probe Info	14.03	LDD1983	[14]
C321 Probe Info	6.82	LDD1987	[14]
C322 Probe Info	18.90	LDD1988	[14]
C326 Probe Info	18.77	LDD1990	[14]
C333 Probe Info	5.43	LDD1996	[14]
C338 Probe Info	36.00	LDD2001	[14]
C339 Probe Info	8.57	LDD2002	[14]
C343 Probe Info	28.84	LDD2005	[14]
C346 Probe Info	19.70	LDD2007	[14]
C347 Probe Info	5.10	LDD2008	[14]
C348 Probe Info	12.47	LDD2009	[14]
C349 Probe Info	20.25	LDD2010	[14]
C350 Probe Info	45.89	LDD2011	[14]
C354 Probe Info	11.08	LDD2015	[14]
C355 Probe Info	49.18	LDD2016	[14]
C362 Probe Info	85.04	LDD2023	[14]
C363 Probe Info	35.75	LDD2024	[14]
C364 Probe Info	27.10	LDD2025	[14]
C366 Probe Info	8.88	LDD2027	[14]
C367 Probe Info	11.47	LDD2028	[14]
C378 Probe Info	6.19	LDD2037	[14]
C380 Probe Info	11.16	LDD2039	[14]
C382 Probe Info	26.35	LDD2041	[14]
C383 Probe Info	13.45	LDD2042	[14]
C386 Probe Info	11.55	LDD2045	[14]
C388 Probe Info	99.73	LDD2047	[14]
C390 Probe Info	93.05	LDD2049	[14]
C391 Probe Info	26.35	LDD2050	[14]
C397 Probe Info	10.70	LDD2056	[14]
C399 Probe Info	12.91	LDD2058	[14]
C400 Probe Info	5.98	LDD2059	[14]
C403 Probe Info	33.13	LDD2061	[14]
C407 Probe Info	20.25	LDD2064	[14]
C413 Probe Info	32.22	LDD2069	[14]
C419 Probe Info	23.75	LDD2074	[14]
C420 Probe Info	13.27	LDD2075	[14]
C424 Probe Info	11.47	LDD2079	[14]
C426 Probe Info	18.64	LDD2081	[14]
C429 Probe Info	21.41	LDD2084	[14]
C430 Probe Info	8.34	LDD2085	[14]
C431 Probe Info	14.72	LDD2086	[14]
C433 Probe Info	6.36	LDD2088	[14]
FFF probe11 Probe Info	20.00	LDD0471	[15]
FFF probe12 Probe Info	5.04	LDD0473	[15]
FFF probe13 Probe Info	20.00	LDD0475	[15]
FFF probe14 Probe Info	20.00	LDD0477	[15]
FFF probe15 Probe Info	20.00	LDD0478	[15]
FFF probe2 Probe Info	20.00	LDD0463	[15]
FFF probe3 Probe Info	20.00	LDD0464	[15]
FFF probe4 Probe Info	20.00	LDD0466	[15]
FFF probe6 Probe Info	20.00	LDD0467	[15]
FFF probe7 Probe Info	20.00	LDD0483	[15]
JN0003 Probe Info	20.00	LDD0469	[15]
Alk-rapa Probe Info	6.89	LDD0213	[16]
OEA-DA Probe Info	17.27	LDD0046	[17]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0519	1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one	MDA-MB-231	C326(0.56)	LDD2112	[6]
LDCM0214	AC1	HEK-293T	C326(1.40)	LDD0812	[18]
LDCM0215	AC10	HEK-293T	C326(0.97); C380(0.94)	LDD1508	[19]
LDCM0226	AC11	HEK-293T	C326(0.96); C380(0.97)	LDD1509	[19]
LDCM0230	AC113	HEK-293T	C326(2.12)	LDD0828	[18]
LDCM0231	AC114	HEK-293T	C326(1.96)	LDD0829	[18]
LDCM0232	AC115	HEK-293T	C326(1.36)	LDD0830	[18]
LDCM0233	AC116	HEK-293T	C326(1.59)	LDD0831	[18]
LDCM0234	AC117	HEK-293T	C326(2.04)	LDD0832	[18]
LDCM0235	AC118	HEK-293T	C326(1.58)	LDD0833	[18]
LDCM0236	AC119	HEK-293T	C326(2.21)	LDD0834	[18]
LDCM0237	AC12	HEK-293T	C326(0.98); C380(1.44)	LDD1510	[19]
LDCM0238	AC120	HEK-293T	C326(1.12)	LDD0836	[18]
LDCM0239	AC121	HEK-293T	C326(2.18)	LDD0837	[18]
LDCM0240	AC122	HEK-293T	C326(3.36)	LDD0838	[18]
LDCM0241	AC123	HEK-293T	C326(2.34)	LDD0839	[18]
LDCM0242	AC124	HEK-293T	C326(1.76)	LDD0840	[18]
LDCM0243	AC125	HEK-293T	C326(1.70)	LDD0841	[18]
LDCM0244	AC126	HEK-293T	C326(2.06)	LDD0842	[18]
LDCM0245	AC127	HEK-293T	C326(2.26)	LDD0843	[18]
LDCM0259	AC14	HEK-293T	C326(0.93); C380(0.97)	LDD1512	[19]
LDCM0270	AC15	HEK-293T	C326(1.00); C380(1.07)	LDD1513	[19]
LDCM0276	AC17	HEK-293T	C326(0.91)	LDD1515	[19]
LDCM0277	AC18	HEK-293T	C326(0.90); C380(0.95)	LDD1516	[19]
LDCM0278	AC19	HEK-293T	C326(1.04); C380(1.20)	LDD1517	[19]
LDCM0279	AC2	HEK-293T	C326(0.91)	LDD0877	[18]
LDCM0280	AC20	HEK-293T	C326(0.95); C380(1.10)	LDD1519	[19]
LDCM0281	AC21	HEK-293T	C326(0.97)	LDD1520	[19]
LDCM0282	AC22	HEK-293T	C326(0.94); C380(1.19)	LDD1521	[19]
LDCM0283	AC23	HEK-293T	C326(1.04); C380(1.11)	LDD1522	[19]
LDCM0284	AC24	HEK-293T	C326(1.00); C380(1.03)	LDD1523	[19]
LDCM0285	AC25	HEK-293T	C326(0.69)	LDD0883	[18]
LDCM0286	AC26	HEK-293T	C326(0.70)	LDD0884	[18]
LDCM0287	AC27	HEK-293T	C326(3.28)	LDD0885	[18]
LDCM0288	AC28	HEK-293T	C326(1.31)	LDD0886	[18]
LDCM0289	AC29	HEK-293T	C326(0.81)	LDD0887	[18]
LDCM0290	AC3	HEK-293T	C326(1.04)	LDD0888	[18]
LDCM0291	AC30	HEK-293T	C326(1.07)	LDD0889	[18]
LDCM0292	AC31	HEK-293T	C326(0.99)	LDD0890	[18]
LDCM0293	AC32	HEK-293T	C326(0.90)	LDD0891	[18]
LDCM0294	AC33	HEK-293T	C326(1.07)	LDD0892	[18]
LDCM0295	AC34	HEK-293T	C326(1.00)	LDD0893	[18]
LDCM0296	AC35	HEK-293T	C326(0.96); C380(0.91)	LDD1535	[19]
LDCM0297	AC36	HEK-293T	C326(0.94); C380(1.28)	LDD1536	[19]
LDCM0298	AC37	HEK-293T	C326(1.01)	LDD1537	[19]
LDCM0299	AC38	HEK-293T	C326(0.94); C380(1.31)	LDD1538	[19]
LDCM0300	AC39	HEK-293T	C326(1.03); C380(1.07)	LDD1539	[19]
LDCM0301	AC4	HEK-293T	C326(1.01)	LDD0899	[18]
LDCM0302	AC40	HEK-293T	C326(1.01); C380(1.09)	LDD1541	[19]
LDCM0303	AC41	HEK-293T	C326(0.89)	LDD1542	[19]
LDCM0304	AC42	HEK-293T	C326(1.01); C380(1.13)	LDD1543	[19]
LDCM0305	AC43	HEK-293T	C326(0.90); C380(0.97)	LDD1544	[19]
LDCM0306	AC44	HEK-293T	C326(0.95); C380(1.37)	LDD1545	[19]
LDCM0307	AC45	HEK-293T	C326(0.99)	LDD1546	[19]
LDCM0308	AC46	HEK-293T	C326(0.90)	LDD0906	[18]
LDCM0309	AC47	HEK-293T	C326(0.89)	LDD0907	[18]
LDCM0310	AC48	HEK-293T	C326(0.94)	LDD0908	[18]
LDCM0311	AC49	HEK-293T	C326(1.71)	LDD0909	[18]
LDCM0312	AC5	HEK-293T	C326(1.16)	LDD0910	[18]
LDCM0313	AC50	HEK-293T	C326(1.30)	LDD0911	[18]
LDCM0314	AC51	HEK-293T	C326(1.55)	LDD0912	[18]
LDCM0315	AC52	HEK-293T	C326(2.22)	LDD0913	[18]
LDCM0316	AC53	HEK-293T	C326(1.26)	LDD0914	[18]
LDCM0317	AC54	HEK-293T	C326(1.18)	LDD0915	[18]
LDCM0318	AC55	HEK-293T	C326(1.29)	LDD0916	[18]
LDCM0319	AC56	HEK-293T	C326(1.10)	LDD0917	[18]
LDCM0320	AC57	HEK-293T	C326(1.11)	LDD0918	[18]
LDCM0321	AC58	HEK-293T	C326(1.15)	LDD0919	[18]
LDCM0322	AC59	HEK-293T	C326(0.95)	LDD0920	[18]
LDCM0323	AC6	HEK-293T	C326(0.91); C380(1.23)	LDD1562	[19]
LDCM0324	AC60	HEK-293T	C326(0.96)	LDD0922	[18]
LDCM0325	AC61	HEK-293T	C326(1.11)	LDD0923	[18]
LDCM0326	AC62	HEK-293T	C326(1.01)	LDD0924	[18]
LDCM0327	AC63	HEK-293T	C326(1.25)	LDD0925	[18]
LDCM0328	AC64	HEK-293T	C326(0.90)	LDD0926	[18]
LDCM0329	AC65	HEK-293T	C326(1.49)	LDD0927	[18]
LDCM0330	AC66	HEK-293T	C326(1.18)	LDD0928	[18]
LDCM0331	AC67	HEK-293T	C326(1.20)	LDD0929	[18]
LDCM0334	AC7	HEK-293T	C326(1.01); C380(1.06)	LDD1568	[19]
LDCM0345	AC8	HEK-293T	C326(1.03); C380(0.95)	LDD1569	[19]
LDCM0349	AC83	HEK-293T	C326(1.32)	LDD0947	[18]
LDCM0350	AC84	HEK-293T	C326(1.90)	LDD0948	[18]
LDCM0351	AC85	HEK-293T	C326(1.07)	LDD0949	[18]
LDCM0352	AC86	HEK-293T	C326(2.07)	LDD0950	[18]
LDCM0353	AC87	HEK-293T	C326(2.55)	LDD0951	[18]
LDCM0354	AC88	HEK-293T	C326(1.41)	LDD0952	[18]
LDCM0355	AC89	HEK-293T	C326(4.42)	LDD0953	[18]
LDCM0357	AC90	HEK-293T	C326(3.78)	LDD0955	[18]
LDCM0358	AC91	HEK-293T	C326(3.36)	LDD0956	[18]
LDCM0359	AC92	HEK-293T	C326(1.39)	LDD0957	[18]
LDCM0360	AC93	HEK-293T	C326(1.99)	LDD0958	[18]
LDCM0361	AC94	HEK-293T	C326(1.95)	LDD0959	[18]
LDCM0362	AC95	HEK-293T	C326(1.40)	LDD0960	[18]
LDCM0363	AC96	HEK-293T	C326(1.43)	LDD0961	[18]
LDCM0364	AC97	HEK-293T	C326(2.77)	LDD0962	[18]
LDCM0520	AKOS000195272	MDA-MB-231	C326(0.88)	LDD2113	[6]
LDCM0248	AKOS034007472	HEK-293T	C326(1.03)	LDD1511	[19]
LDCM0356	AKOS034007680	HEK-293T	C326(0.92)	LDD1570	[19]
LDCM0275	AKOS034007705	HEK-293T	C326(0.99); C380(1.14)	LDD1514	[19]
LDCM0156	Aniline	NCI-H1299	14.62	LDD0403	[4]
LDCM0108	Chloroacetamide	HeLa	N.A.	LDD0222	[12]
LDCM0367	CL1	HEK-293T	C326(1.04); C380(1.02)	LDD1571	[19]
LDCM0368	CL10	HEK-293T	C326(0.85); C380(0.91)	LDD1572	[19]
LDCM0369	CL100	HEK-293T	C326(1.33)	LDD0967	[18]
LDCM0370	CL101	HEK-293T	C326(1.03); C380(1.03)	LDD1574	[19]
LDCM0371	CL102	HEK-293T	C326(1.09); C380(1.27)	LDD1575	[19]
LDCM0372	CL103	HEK-293T	C326(0.97); C380(1.32)	LDD1576	[19]
LDCM0373	CL104	HEK-293T	C326(1.01); C380(1.07)	LDD1577	[19]
LDCM0374	CL105	HEK-293T	C326(1.12); C380(1.14)	LDD1578	[19]
LDCM0375	CL106	HEK-293T	C326(1.00); C380(1.38)	LDD1579	[19]
LDCM0376	CL107	HEK-293T	C326(1.02); C380(0.92)	LDD1580	[19]
LDCM0377	CL108	HEK-293T	C326(0.98); C380(0.94)	LDD1581	[19]
LDCM0378	CL109	HEK-293T	C326(1.06); C380(1.02)	LDD1582	[19]
LDCM0379	CL11	HEK-293T	C326(0.97); C380(1.00)	LDD1583	[19]
LDCM0380	CL110	HEK-293T	C326(1.14); C380(1.22)	LDD1584	[19]
LDCM0381	CL111	HEK-293T	C326(1.00); C380(1.33)	LDD1585	[19]
LDCM0382	CL112	HEK-293T	C326(1.44)	LDD0980	[18]
LDCM0383	CL113	HEK-293T	C326(1.10)	LDD0981	[18]
LDCM0384	CL114	HEK-293T	C326(1.25)	LDD0982	[18]
LDCM0385	CL115	HEK-293T	C326(1.32)	LDD0983	[18]
LDCM0386	CL116	HEK-293T	C326(1.04)	LDD0984	[18]
LDCM0387	CL117	HEK-293T	C326(1.06); C380(1.14)	LDD1591	[19]
LDCM0388	CL118	HEK-293T	C326(0.96); C380(1.17)	LDD1592	[19]
LDCM0389	CL119	HEK-293T	C326(1.02); C380(1.06)	LDD1593	[19]
LDCM0390	CL12	HEK-293T	C326(1.06); C380(0.82)	LDD1594	[19]
LDCM0391	CL120	HEK-293T	C326(1.08); C380(0.86)	LDD1595	[19]
LDCM0392	CL121	HEK-293T	C326(1.45)	LDD0990	[18]
LDCM0393	CL122	HEK-293T	C326(1.40)	LDD0991	[18]
LDCM0394	CL123	HEK-293T	C326(1.82)	LDD0992	[18]
LDCM0395	CL124	HEK-293T	C326(1.58)	LDD0993	[18]
LDCM0396	CL125	HEK-293T	C326(1.29)	LDD0994	[18]
LDCM0397	CL126	HEK-293T	C326(1.00)	LDD0995	[18]
LDCM0398	CL127	HEK-293T	C326(1.18)	LDD0996	[18]
LDCM0399	CL128	HEK-293T	C326(1.20)	LDD0997	[18]
LDCM0400	CL13	HEK-293T	C326(1.11); C380(1.20)	LDD1604	[19]
LDCM0401	CL14	HEK-293T	C326(0.99); C380(1.24)	LDD1605	[19]
LDCM0402	CL15	HEK-293T	C326(1.05); C380(0.92)	LDD1606	[19]
LDCM0403	CL16	HEK-293T	C326(1.01); C380(0.88)	LDD1607	[19]
LDCM0404	CL17	HEK-293T	C326(0.93)	LDD1608	[19]
LDCM0405	CL18	HEK-293T	C326(0.97); C380(0.88)	LDD1609	[19]
LDCM0406	CL19	HEK-293T	C326(0.92); C380(0.67)	LDD1610	[19]
LDCM0407	CL2	HEK-293T	C326(1.04); C380(1.17)	LDD1611	[19]
LDCM0408	CL20	HEK-293T	C326(1.01); C380(1.43)	LDD1612	[19]
LDCM0409	CL21	HEK-293T	C326(0.97)	LDD1613	[19]
LDCM0410	CL22	HEK-293T	C326(0.84); C380(0.68)	LDD1614	[19]
LDCM0411	CL23	HEK-293T	C326(1.04); C380(0.96)	LDD1615	[19]
LDCM0412	CL24	HEK-293T	C326(1.00); C380(0.93)	LDD1616	[19]
LDCM0413	CL25	HEK-293T	C326(1.03); C380(1.05)	LDD1617	[19]
LDCM0414	CL26	HEK-293T	C326(1.08); C380(0.92)	LDD1618	[19]
LDCM0415	CL27	HEK-293T	C326(0.99); C380(0.68)	LDD1619	[19]
LDCM0416	CL28	HEK-293T	C326(1.02); C380(1.07)	LDD1620	[19]
LDCM0417	CL29	HEK-293T	C326(0.91)	LDD1621	[19]
LDCM0418	CL3	HEK-293T	C326(1.05); C380(1.19)	LDD1622	[19]
LDCM0419	CL30	HEK-293T	C326(1.08); C380(1.10)	LDD1623	[19]
LDCM0420	CL31	HEK-293T	C326(1.38)	LDD1018	[18]
LDCM0421	CL32	HEK-293T	C326(1.03)	LDD1019	[18]
LDCM0422	CL33	HEK-293T	C326(2.38)	LDD1020	[18]
LDCM0423	CL34	HEK-293T	C326(1.22)	LDD1021	[18]
LDCM0424	CL35	HEK-293T	C326(1.33)	LDD1022	[18]
LDCM0425	CL36	HEK-293T	C326(1.05)	LDD1023	[18]
LDCM0426	CL37	HEK-293T	C326(1.30)	LDD1024	[18]
LDCM0428	CL39	HEK-293T	C326(1.48)	LDD1026	[18]
LDCM0429	CL4	HEK-293T	C326(1.03); C380(0.86)	LDD1633	[19]
LDCM0430	CL40	HEK-293T	C326(1.06)	LDD1028	[18]
LDCM0431	CL41	HEK-293T	C326(1.46)	LDD1029	[18]
LDCM0432	CL42	HEK-293T	C326(1.31)	LDD1030	[18]
LDCM0433	CL43	HEK-293T	C326(1.48)	LDD1031	[18]
LDCM0434	CL44	HEK-293T	C326(0.96)	LDD1032	[18]
LDCM0435	CL45	HEK-293T	C326(1.60)	LDD1033	[18]
LDCM0436	CL46	HEK-293T	C326(1.14)	LDD1034	[18]
LDCM0437	CL47	HEK-293T	C326(1.22)	LDD1035	[18]
LDCM0438	CL48	HEK-293T	C326(0.89)	LDD1036	[18]
LDCM0439	CL49	HEK-293T	C326(1.11)	LDD1037	[18]
LDCM0440	CL5	HEK-293T	C326(0.89)	LDD1644	[19]
LDCM0441	CL50	HEK-293T	C326(1.21)	LDD1039	[18]
LDCM0442	CL51	HEK-293T	C326(1.41)	LDD1040	[18]
LDCM0443	CL52	HEK-293T	C326(0.72)	LDD1041	[18]
LDCM0444	CL53	HEK-293T	C326(1.19)	LDD1042	[18]
LDCM0445	CL54	HEK-293T	C326(0.84)	LDD1043	[18]
LDCM0446	CL55	HEK-293T	C326(1.10)	LDD1044	[18]
LDCM0447	CL56	HEK-293T	C326(0.90)	LDD1045	[18]
LDCM0448	CL57	HEK-293T	C326(1.46)	LDD1046	[18]
LDCM0449	CL58	HEK-293T	C326(0.94)	LDD1047	[18]
LDCM0450	CL59	HEK-293T	C326(1.41)	LDD1048	[18]
LDCM0451	CL6	HEK-293T	C326(0.95); C380(1.03)	LDD1654	[19]
LDCM0452	CL60	HEK-293T	C326(0.95)	LDD1050	[18]
LDCM0453	CL61	HEK-293T	C326(1.13); C380(1.24)	LDD1656	[19]
LDCM0454	CL62	HEK-293T	C326(1.12); C380(1.05)	LDD1657	[19]
LDCM0455	CL63	HEK-293T	C326(1.03); C380(0.90)	LDD1658	[19]
LDCM0456	CL64	HEK-293T	C326(1.06); C380(0.90)	LDD1659	[19]
LDCM0457	CL65	HEK-293T	C326(1.00)	LDD1660	[19]
LDCM0458	CL66	HEK-293T	C326(0.92); C380(1.03)	LDD1661	[19]
LDCM0459	CL67	HEK-293T	C326(1.00); C380(0.89)	LDD1662	[19]
LDCM0460	CL68	HEK-293T	C326(1.03); C380(0.84)	LDD1663	[19]
LDCM0461	CL69	HEK-293T	C326(0.95)	LDD1664	[19]
LDCM0462	CL7	HEK-293T	C326(0.92); C380(0.78)	LDD1665	[19]
LDCM0463	CL70	HEK-293T	C326(0.92); C380(0.83)	LDD1666	[19]
LDCM0464	CL71	HEK-293T	C326(1.06); C380(0.88)	LDD1667	[19]
LDCM0465	CL72	HEK-293T	C326(1.03); C380(0.94)	LDD1668	[19]
LDCM0466	CL73	HEK-293T	C326(1.07); C380(1.12)	LDD1669	[19]
LDCM0467	CL74	HEK-293T	C326(1.00); C380(1.11)	LDD1670	[19]
LDCM0469	CL76	HEK-293T	C326(1.15)	LDD1067	[18]
LDCM0470	CL77	HEK-293T	C326(1.19)	LDD1068	[18]
LDCM0471	CL78	HEK-293T	C326(0.71)	LDD1069	[18]
LDCM0472	CL79	HEK-293T	C326(0.89)	LDD1070	[18]
LDCM0473	CL8	HEK-293T	C326(1.20); C380(1.48)	LDD1676	[19]
LDCM0474	CL80	HEK-293T	C326(1.07)	LDD1072	[18]
LDCM0475	CL81	HEK-293T	C326(0.85)	LDD1073	[18]
LDCM0476	CL82	HEK-293T	C326(1.18)	LDD1074	[18]
LDCM0477	CL83	HEK-293T	C326(1.67)	LDD1075	[18]
LDCM0478	CL84	HEK-293T	C326(1.00)	LDD1076	[18]
LDCM0479	CL85	HEK-293T	C326(0.87)	LDD1077	[18]
LDCM0480	CL86	HEK-293T	C326(0.69)	LDD1078	[18]
LDCM0481	CL87	HEK-293T	C326(1.72)	LDD1079	[18]
LDCM0482	CL88	HEK-293T	C326(1.06)	LDD1080	[18]
LDCM0483	CL89	HEK-293T	C326(0.78)	LDD1081	[18]
LDCM0484	CL9	HEK-293T	C326(1.00)	LDD1687	[19]
LDCM0485	CL90	HEK-293T	C326(1.55)	LDD1083	[18]
LDCM0486	CL91	HEK-293T	C326(0.91)	LDD1084	[18]
LDCM0487	CL92	HEK-293T	C326(1.75)	LDD1085	[18]
LDCM0488	CL93	HEK-293T	C326(1.10)	LDD1086	[18]
LDCM0489	CL94	HEK-293T	C326(0.96)	LDD1087	[18]
LDCM0490	CL95	HEK-293T	C326(1.42)	LDD1088	[18]
LDCM0491	CL96	HEK-293T	C326(1.64)	LDD1089	[18]
LDCM0492	CL97	HEK-293T	C326(1.40)	LDD1090	[18]
LDCM0493	CL98	HEK-293T	C326(1.17)	LDD1091	[18]
LDCM0494	CL99	HEK-293T	C326(0.95)	LDD1092	[18]
LDCM0495	E2913	HEK-293T	C326(1.09); C380(0.75)	LDD1698	[19]
LDCM0625	F8	Ramos	C326(0.89)	LDD2187	[20]
LDCM0572	Fragment10	Ramos	C326(1.81)	LDD2189	[20]
LDCM0573	Fragment11	Ramos	C326(20.00)	LDD2190	[20]
LDCM0574	Fragment12	Ramos	C326(3.27)	LDD2191	[20]
LDCM0575	Fragment13	Ramos	C326(0.93)	LDD2192	[20]
LDCM0576	Fragment14	Ramos	C326(6.11)	LDD2193	[20]
LDCM0579	Fragment20	Ramos	C326(6.28)	LDD2194	[20]
LDCM0580	Fragment21	Ramos	C326(1.01)	LDD2195	[20]
LDCM0582	Fragment23	Ramos	C326(2.10)	LDD2196	[20]
LDCM0578	Fragment27	Ramos	C326(0.92)	LDD2197	[20]
LDCM0586	Fragment28	Ramos	C326(0.84)	LDD2198	[20]
LDCM0588	Fragment30	Ramos	C326(1.09)	LDD2199	[20]
LDCM0589	Fragment31	Ramos	C326(1.38)	LDD2200	[20]
LDCM0590	Fragment32	Ramos	C326(1.32)	LDD2201	[20]
LDCM0468	Fragment33	HEK-293T	C326(0.98); C380(0.90)	LDD1671	[19]
LDCM0596	Fragment38	Ramos	C326(1.02)	LDD2203	[20]
LDCM0566	Fragment4	Ramos	C326(1.71)	LDD2184	[20]
LDCM0427	Fragment51	HEK-293T	C326(1.07)	LDD1025	[18]
LDCM0610	Fragment52	Ramos	C326(0.99)	LDD2204	[20]
LDCM0614	Fragment56	Ramos	C326(1.00)	LDD2205	[20]
LDCM0569	Fragment7	Ramos	C326(1.78)	LDD2186	[20]
LDCM0571	Fragment9	Ramos	C326(7.24)	LDD2188	[20]
LDCM0015	HNE	MDA-MB-231	C326(0.99)	LDD0346	[20]
LDCM0022	KB02	HEK-293T	C326(0.93); C380(0.94)	LDD1492	[19]
LDCM0023	KB03	HEK-293T	C326(0.98); C380(0.99)	LDD1497	[19]
LDCM0024	KB05	COLO792	C326(2.20)	LDD3310	[5]
LDCM0109	NEM	HeLa	N.A.	LDD0223	[12]
LDCM0504	Nucleophilic fragment 15a	MDA-MB-231	C326(1.22)	LDD2097	[6]
LDCM0508	Nucleophilic fragment 17a	MDA-MB-231	C326(0.59)	LDD2101	[6]
LDCM0515	Nucleophilic fragment 20b	MDA-MB-231	C326(0.61)	LDD2108	[6]
LDCM0522	Nucleophilic fragment 24a	MDA-MB-231	C326(0.51)	LDD2115	[6]
LDCM0541	Nucleophilic fragment 36	MDA-MB-231	C326(0.49)	LDD2134	[6]
LDCM0542	Nucleophilic fragment 37	MDA-MB-231	C326(1.69)	LDD2135	[6]
LDCM0546	Nucleophilic fragment 40	MDA-MB-231	C326(1.03)	LDD2140	[6]
LDCM0628	OTUB2-COV-1	HEK-293T	C326(1.07)	LDD2207	[21]
LDCM0090	Rapamycin	JHH-7	6.89	LDD0213	[16]

References

1	Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3	An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4	Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
6	Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29. Mass spectrometry data entry: PXD039908 , PXD029761
7	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8	Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23. Mass spectrometry data entry: PXD028853
9	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
10	A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21. Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11	Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13	Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
15	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16	Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
17	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
18	Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
20	Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7. Mass spectrometry data entry: PXD027578
21	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

Details of the Target

Citation

Visitor Map

Correspondence

Prof. Feng Zhu

Prof. Feng Ni