Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C214  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 76.1
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 48.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 39.9
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 21.9
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 11.3
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 11.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.6
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 10.1
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 9.1
 LDTP00575  Glutathione S-transferase A4 (GSTA4) 8.2
 LDTP09095  Diacylglycerol lipase-beta (DAGLB) 7.6
 LDTP00645  Prolyl 4-hydroxylase subunit alpha-2 (P4HA2) 6.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 6.8
 LDTP01518  NADH dehydrogenase 1 alpha subcomplex subunit 7 (NDUFA7) 6.8
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) 6.6
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 6.5
 LDTP03540  Heme oxygenase 2 (HMOX2) 6.3
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 6.3
 LDTP01640  CCR4-NOT transcription complex subunit 4 (CNOT4) 5.9
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 5.7
 LDTP06721  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11) 5.7
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 5.7
 LDTP11617  Myotubularin-related protein 12 (MTMR12) 5.7
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 5.7
 LDTP11127  ADP-dependent glucokinase (ADPGK) 5.5
 LDTP13200  tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase (FTSJ1) 5.5
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.4
Transporter and channel
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 28.8
 LDTP05662  Cell division cycle protein 20 homolog (CDC20) 21.3
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 20.4
 LDTP13256  SUN domain-containing protein 2 (SUN2) 12.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 11.6
 LDTP16190  Protein FAM8A1 (FAM8A1) 10.9
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 8.8
 LDTP04789  Synaptojanin-2-binding protein (SYNJ2BP) 8.5
 LDTP20002  Transmembrane protein 160 (TMEM160) 8.1
 LDTP01043  Sorting nexin-2 (SNX2) 7.8
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 7.7
 LDTP00592  Surfeit locus protein 4 (SURF4) 7.7
 LDTP15948  Transmembrane protein 126A (TMEM126A) 7.6
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 6.7
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) 6.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 6.6
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 6.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.5
 LDTP05236  Phosphatidylinositol transfer protein alpha isoform (PITPNA) 6.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 6.0
 LDTP05900  Metaxin-1 (MTX1) 5.6
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 6.5
Other
Click to Show/Hide to Show 31 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 12.0
 LDTP05160  Nucleobindin-2 (NUCB2) 11.9
 LDTP11076  Apolipoprotein L2 (APOL2) 11.2
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 9.8
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 8.7
 LDTP00620  Eukaryotic translation initiation factor 3 subunit H (EIF3H) 8.5
 LDTP11995  WD repeat and coiled-coil-containing protein (WDCP) 8.5
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 8.4
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 8.2
 LDTP00887  Calumenin (CALU) 8.0
 LDTP05375  Nucleobindin-1 (NUCB1) 7.0
 LDTP13152  DnaJ homolog subfamily B member 11 (DNAJB11) 6.8
 LDTP11327  RNA polymerase II-associated protein 1 (RPAP1) 6.8
 LDTP05226  RNA-binding protein 3 (RBM3) 6.6
 LDTP10281  Cytoplasmic dynein 2 intermediate chain 2 (DYNC2I2) 6.5
 LDTP01652  Centrosomal protein 43 (CEP43) 6.5
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 6.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.1
 LDTP13630  Neudesin (NENF) 6.1
 LDTP01494  Protein YIF1A (YIF1A) 6.1
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 6.1
 LDTP15623  Neuferricin (CYB5D2) 5.9
 LDTP05277  Protein SET (SET) 5.9
 LDTP02443  Calmodulin-3 (CALM3) 5.9
 LDTP18883  Protein CEBPZOS (CEBPZOS) 5.9
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.7
 LDTP02181  Neurofilament medium polypeptide (NEFM) 5.6
 LDTP01359  Dynactin subunit 3 (DCTN3) 5.6
 LDTP10056  Protein FAM162A (FAM162A) 5.5
 LDTP12073  Golgi reassembly-stacking protein 2 (GORASP2) 5.4
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 5.4

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587