Details of the Target

General Information of Target

Target ID LDTP01043
Target Name Sorting nexin-2 (SNX2)
Gene Name SNX2
Gene ID 6643
Synonyms
Sorting nexin-2; Transformation-related gene 9 protein; TRG-9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEREPPPLGDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAEDISANSNGPK
PTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTLIAPRIESKSMSA
PVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTKTSLSMFSKSEFSV
KRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSSSTEFVEKRRAALE
RYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNKAADAVNKMTIKMN
ESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKSAAMLGNSEDHTAL
SRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVFDHRMKCWQKWEDA
QITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQISKTIRKEVGRFEK
ERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Early endosome membrane
Function
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.
Uniprot ID
O60749
Ensemble ID
ENST00000379516.7
HGNC ID
HGNC:11173

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R482Ter DBIA    Probe Info 
CAL27 SNV: p.S338L .
HT115 SNV: p.K442Q .
HUH1 SNV: p.P206L .
MDAMB453 SNV: p.I491M .
SW1783 SNV: p.D186N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
DBIA
 Probe Info  		C332(2.17)  LDD3314  [3]
BTD
 Probe Info  		C413(0.90)  LDD2093  [4]
HHS-482
 Probe Info  		Y203(0.25)  LDD0287  [5]
HHS-475
 Probe Info  		Y203(0.77)  LDD0264  [6]
HHS-465
 Probe Info  		Y203(8.86)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K469(0.00); K211(0.00); K218(0.00); K220(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		C413(0.00); C332(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C413(0.00); C332(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD2156  [12]
NHS
 Probe Info  		K234(0.00); K335(0.00); K223(0.00)  LDD0010  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Ox-W18
 Probe Info  		W305(0.00); W508(0.00)  LDD2175  [16]
AOyne
 Probe Info  		11.30  LDD0443  [17]
NAIA_5
 Probe Info  		N.A.  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C201
 Probe Info  		27.67  LDD1877  [19]
C214
 Probe Info  		7.84  LDD1888  [19]
C296
 Probe Info  		11.39  LDD1966  [19]
C314
 Probe Info  		14.83  LDD1981  [19]
C353
 Probe Info  		13.36  LDD2014  [19]
C364
 Probe Info  		28.44  LDD2025  [19]
C390
 Probe Info  		33.36  LDD2049  [19]
C413
 Probe Info  		12.21  LDD2069  [19]
FFF probe11
 Probe Info  		7.08  LDD0471  [20]
FFF probe13
 Probe Info  		20.00  LDD0475  [20]
FFF probe14
 Probe Info  		12.59  LDD0477  [20]
FFF probe2
 Probe Info  		15.68  LDD0463  [20]
FFF probe3
 Probe Info  		16.65  LDD0464  [20]
FFF probe6
 Probe Info  		9.38  LDD0467  [20]
JN0003
 Probe Info  		14.17  LDD0469  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]
OEA-DA
 Probe Info  		7.16  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C413(0.57)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C413(1.14)  LDD2152  [4]
 LDCM0214  AC1 HEK-293T C332(1.04)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C332(0.99)  LDD1508  [23]
 LDCM0216  AC100 PaTu 8988t C332(0.92)  LDD1095  [24]
 LDCM0217  AC101 PaTu 8988t C332(0.89)  LDD1096  [24]
 LDCM0218  AC102 PaTu 8988t C332(0.85)  LDD1097  [24]
 LDCM0219  AC103 PaTu 8988t C332(1.15)  LDD1098  [24]
 LDCM0220  AC104 PaTu 8988t C332(0.91)  LDD1099  [24]
 LDCM0221  AC105 PaTu 8988t C332(0.94)  LDD1100  [24]
 LDCM0222  AC106 PaTu 8988t C332(1.20)  LDD1101  [24]
 LDCM0223  AC107 PaTu 8988t C332(0.84)  LDD1102  [24]
 LDCM0224  AC108 PaTu 8988t C332(1.09)  LDD1103  [24]
 LDCM0225  AC109 PaTu 8988t C332(0.96)  LDD1104  [24]
 LDCM0226  AC11 HEK-293T C332(0.92)  LDD1509  [23]
 LDCM0227  AC110 PaTu 8988t C332(1.06)  LDD1106  [24]
 LDCM0228  AC111 PaTu 8988t C332(1.07)  LDD1107  [24]
 LDCM0229  AC112 PaTu 8988t C332(1.20)  LDD1108  [24]
 LDCM0237  AC12 HEK-293T C332(1.05)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C332(1.03)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C332(0.92)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C332(1.16)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C332(1.02)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C332(0.82)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C332(0.98)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C332(1.06)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C332(0.96)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C332(1.10)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C332(1.01)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C332(1.04)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C332(1.09)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C332(1.06)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C332(0.99)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C332(1.17)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C332(0.93)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C332(1.13)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C332(1.02)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C332(0.96)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C332(1.02)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C332(1.02)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C332(1.06)  LDD1534  [23]
 LDCM0296  AC35 PaTu 8988t C332(1.39)  LDD1175  [24]
 LDCM0297  AC36 PaTu 8988t C332(1.59)  LDD1176  [24]
 LDCM0298  AC37 PaTu 8988t C332(1.16)  LDD1177  [24]
 LDCM0299  AC38 PaTu 8988t C332(1.12)  LDD1178  [24]
 LDCM0300  AC39 PaTu 8988t C332(1.90)  LDD1179  [24]
 LDCM0301  AC4 HEK-293T C332(1.00)  LDD1540  [23]
 LDCM0302  AC40 PaTu 8988t C332(1.43)  LDD1181  [24]
 LDCM0303  AC41 PaTu 8988t C332(1.44)  LDD1182  [24]
 LDCM0304  AC42 PaTu 8988t C332(1.14)  LDD1183  [24]
 LDCM0305  AC43 PaTu 8988t C332(1.12)  LDD1184  [24]
 LDCM0306  AC44 PaTu 8988t C332(1.36)  LDD1185  [24]
 LDCM0307  AC45 PaTu 8988t C332(1.21)  LDD1186  [24]
 LDCM0308  AC46 PaTu 8988t C332(1.22)  LDD1187  [24]
 LDCM0309  AC47 PaTu 8988t C332(0.99)  LDD1188  [24]
 LDCM0310  AC48 PaTu 8988t C332(1.02)  LDD1189  [24]
 LDCM0311  AC49 PaTu 8988t C332(1.25)  LDD1190  [24]
 LDCM0312  AC5 HEK-293T C332(0.88)  LDD1551  [23]
 LDCM0313  AC50 PaTu 8988t C332(1.44)  LDD1192  [24]
 LDCM0314  AC51 PaTu 8988t C332(1.23)  LDD1193  [24]
 LDCM0315  AC52 PaTu 8988t C332(1.81)  LDD1194  [24]
 LDCM0316  AC53 PaTu 8988t C332(1.38)  LDD1195  [24]
 LDCM0317  AC54 PaTu 8988t C332(1.95)  LDD1196  [24]
 LDCM0318  AC55 PaTu 8988t C332(1.00)  LDD1197  [24]
 LDCM0319  AC56 PaTu 8988t C332(1.59)  LDD1198  [24]
 LDCM0320  AC57 HEK-293T C332(0.96)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C332(0.98)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C332(0.92)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C332(0.99)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C332(1.03)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C332(0.89)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C332(0.96)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C332(0.93)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C332(0.97)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C332(0.98)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C332(1.08)  LDD1569  [23]
 LDCM0349  AC83 PaTu 8988t C332(0.72)  LDD1228  [24]
 LDCM0350  AC84 PaTu 8988t C332(0.75)  LDD1229  [24]
 LDCM0351  AC85 PaTu 8988t C332(0.67)  LDD1230  [24]
 LDCM0352  AC86 PaTu 8988t C332(0.73)  LDD1231  [24]
 LDCM0353  AC87 PaTu 8988t C332(0.63)  LDD1232  [24]
 LDCM0354  AC88 PaTu 8988t C332(0.75)  LDD1233  [24]
 LDCM0355  AC89 PaTu 8988t C332(0.86)  LDD1234  [24]
 LDCM0357  AC90 PaTu 8988t C332(0.59)  LDD1236  [24]
 LDCM0358  AC91 PaTu 8988t C332(0.61)  LDD1237  [24]
 LDCM0359  AC92 PaTu 8988t C332(0.67)  LDD1238  [24]
 LDCM0360  AC93 PaTu 8988t C332(0.71)  LDD1239  [24]
 LDCM0361  AC94 PaTu 8988t C332(0.64)  LDD1240  [24]
 LDCM0362  AC95 PaTu 8988t C332(0.64)  LDD1241  [24]
 LDCM0363  AC96 PaTu 8988t C332(0.59)  LDD1242  [24]
 LDCM0364  AC97 PaTu 8988t C332(0.59)  LDD1243  [24]
 LDCM0365  AC98 PaTu 8988t C332(0.96)  LDD1244  [24]
 LDCM0366  AC99 PaTu 8988t C332(0.74)  LDD1245  [24]
 LDCM0248  AKOS034007472 HEK-293T C332(0.89)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C332(1.04)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C332(1.03)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C332(1.97); C332(1.06); C332(0.95); C332(0.62)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C332(0.89)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C332(1.12)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C332(0.99)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C332(0.95)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C332(0.95)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C332(0.89)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C332(0.96)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C332(1.04)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C332(1.04)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C332(1.05)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C332(1.00)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C332(0.95)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C332(1.00)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C332(0.93)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C332(0.97)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C332(0.96)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C332(1.07)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C332(0.92)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C332(0.86)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C332(1.08)  LDD1590  [23]
 LDCM0387  CL117 PaTu 8988t C332(1.06)  LDD1266  [24]
 LDCM0388  CL118 PaTu 8988t C332(0.82)  LDD1267  [24]
 LDCM0389  CL119 PaTu 8988t C332(1.53)  LDD1268  [24]
 LDCM0390  CL12 HEK-293T C332(1.05)  LDD1594  [23]
 LDCM0391  CL120 PaTu 8988t C332(1.94)  LDD1270  [24]
 LDCM0392  CL121 PaTu 8988t C332(1.02)  LDD1271  [24]
 LDCM0393  CL122 PaTu 8988t C332(1.27)  LDD1272  [24]
 LDCM0394  CL123 PaTu 8988t C332(1.36)  LDD1273  [24]
 LDCM0395  CL124 PaTu 8988t C332(1.60)  LDD1274  [24]
 LDCM0396  CL125 HEK-293T C332(0.88)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C332(0.85)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C332(0.85)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C332(0.85)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C332(0.87)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C332(1.02)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C332(0.84)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C332(0.99)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C332(0.96)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C332(1.00)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C332(1.00)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C332(0.99)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C332(1.11)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C332(0.88)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C332(1.07)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C332(1.10)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C332(1.13)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C332(0.88)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C332(1.01)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C332(0.97)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C332(0.95)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C332(0.97)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C332(0.92)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C332(1.02)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C332(0.92)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C332(1.03)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C332(0.90)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C332(1.01)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C332(1.13)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C332(1.13)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C332(0.90)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C332(0.95)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C332(0.86)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C332(1.00)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C332(1.00)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C332(0.99)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C332(1.00)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C332(1.14)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C332(0.96)  LDD1639  [23]
 LDCM0436  CL46 PaTu 8988t C332(1.14)  LDD1315  [24]
 LDCM0437  CL47 PaTu 8988t C332(1.11)  LDD1316  [24]
 LDCM0438  CL48 PaTu 8988t C332(1.41)  LDD1317  [24]
 LDCM0439  CL49 PaTu 8988t C332(1.38)  LDD1318  [24]
 LDCM0440  CL5 HEK-293T C332(0.89)  LDD1644  [23]
 LDCM0441  CL50 PaTu 8988t C332(2.13)  LDD1320  [24]
 LDCM0442  CL51 PaTu 8988t C332(0.95)  LDD1321  [24]
 LDCM0443  CL52 PaTu 8988t C332(1.43)  LDD1322  [24]
 LDCM0444  CL53 PaTu 8988t C332(1.46)  LDD1323  [24]
 LDCM0445  CL54 PaTu 8988t C332(1.42)  LDD1324  [24]
 LDCM0446  CL55 PaTu 8988t C332(1.32)  LDD1325  [24]
 LDCM0447  CL56 PaTu 8988t C332(0.36)  LDD1326  [24]
 LDCM0448  CL57 PaTu 8988t C332(3.56)  LDD1327  [24]
 LDCM0449  CL58 PaTu 8988t C332(1.92)  LDD1328  [24]
 LDCM0450  CL59 PaTu 8988t C332(3.80)  LDD1329  [24]
 LDCM0451  CL6 HEK-293T C332(0.88)  LDD1654  [23]
 LDCM0452  CL60 PaTu 8988t C332(2.92)  LDD1331  [24]
 LDCM0453  CL61 HEK-293T C332(0.84)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C332(1.02)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C332(0.89)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C332(0.98)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C332(1.04)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C332(1.04)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C332(0.99)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C332(0.94)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C332(0.91)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C332(0.93)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C332(1.07)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C332(0.99)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C332(1.07)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C332(0.95)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C332(0.99)  LDD1670  [23]
 LDCM0469  CL76 PaTu 8988t C332(1.08)  LDD1348  [24]
 LDCM0470  CL77 PaTu 8988t C332(1.16)  LDD1349  [24]
 LDCM0471  CL78 PaTu 8988t C332(1.13)  LDD1350  [24]
 LDCM0472  CL79 PaTu 8988t C332(1.03)  LDD1351  [24]
 LDCM0473  CL8 HEK-293T C332(0.79)  LDD1676  [23]
 LDCM0474  CL80 PaTu 8988t C332(1.31)  LDD1353  [24]
 LDCM0475  CL81 PaTu 8988t C332(1.51)  LDD1354  [24]
 LDCM0476  CL82 PaTu 8988t C332(1.34)  LDD1355  [24]
 LDCM0477  CL83 PaTu 8988t C332(1.07)  LDD1356  [24]
 LDCM0478  CL84 PaTu 8988t C332(1.75)  LDD1357  [24]
 LDCM0479  CL85 PaTu 8988t C332(1.07)  LDD1358  [24]
 LDCM0480  CL86 PaTu 8988t C332(1.68)  LDD1359  [24]
 LDCM0481  CL87 PaTu 8988t C332(1.97)  LDD1360  [24]
 LDCM0482  CL88 PaTu 8988t C332(1.83)  LDD1361  [24]
 LDCM0483  CL89 PaTu 8988t C332(1.97)  LDD1362  [24]
 LDCM0484  CL9 HEK-293T C332(0.94)  LDD1687  [23]
 LDCM0485  CL90 PaTu 8988t C332(1.89)  LDD1364  [24]
 LDCM0486  CL91 HEK-293T C332(0.72)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C332(0.87)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C332(0.93)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C332(1.07)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C332(0.87)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C332(0.77)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C332(0.91)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C332(0.97)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C332(0.94)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C332(0.91)  LDD1698  [23]
 LDCM0468  Fragment33 HEK-293T C332(0.96)  LDD1671  [23]
 LDCM0427  Fragment51 HEK-293T C332(0.93)  LDD1631  [23]
 LDCM0116  HHS-0101 DM93 Y203(0.77)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y203(0.74)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y203(0.51)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y203(0.91)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y203(0.99)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0125  JWB146 DM93 Y203(0.25)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y203(0.76)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y203(0.67)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y203(0.85)  LDD0290  [5]
 LDCM0130  JWB211 DM93 Y203(0.21)  LDD0292  [5]
 LDCM0022  KB02 HEK-293T C332(1.01)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C332(0.89)  LDD1497  [23]
 LDCM0024  KB05 IGR37 C332(2.17)  LDD3314  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C413(0.90)  LDD2093  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C413(1.02)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C413(0.89)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C413(1.14)  LDD2111  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C413(1.74)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C413(1.14)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C413(0.85)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C413(1.02)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C413(1.51)  LDD2135  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C413(1.04)  LDD2137  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C413(0.99)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bifunctional polynucleotide phosphatase/kinase (PNKP) DNA 3' phosphatase family Q96T60
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-1 (SNX1) Sorting nexin family Q13596
Sorting nexin-32 (SNX32) Sorting nexin family Q86XE0
Sorting nexin-6 (SNX6) Sorting nexin family Q9UNH7
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Centromere protein Q (CENPQ) CENP-Q/OKP1 family Q7L2Z9
Formin-binding protein 1 (FNBP1) FNBP1 family Q96RU3
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Perilipin-3 (PLIN3) Perilipin family O60664
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637
Protein YIF1A (YIF1A) YIF1 family O95070

References

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2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.