Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C413  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 93 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 99.7
 LDTP00697  Cytochrome b5 type B (CYB5B) 91.8
 LDTP03145  Catechol O-methyltransferase (COMT) 69.6
 LDTP03540  Heme oxygenase 2 (HMOX2) 69.6
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 66.7
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 59.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 56.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 45.6
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 44.9
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 41.4
 LDTP14276  NADH dehydrogenase 1 beta subcomplex subunit 9 (NDUFB9) 41.4
 LDTP06617  Ceramide glucosyltransferase (UGCG) 39.7
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 38.6
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 38.1
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 36.8
 LDTP03671  Multidrug resistance-associated protein 1 (ABCC1) 36.3
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 35.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 34.1
 LDTP02223  Cathepsin B (CTSB) 31.1
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 30.1
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 29.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 29.0
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 27.7
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 27.1
 LDTP07966  COP9 signalosome complex subunit 6 (COPS6) 26.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 26.2
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 25.1
 LDTP00544  Sphingolipid delta(4)-desaturase DES1 (DEGS1) 24.6
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 24.4
 LDTP05905  Acid ceramidase (ASAH1) 23.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 23.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 23.3
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 23.1
 LDTP02837  Beta-galactosidase (GLB1) 22.3
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 22.2
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 22.0
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 21.9
 LDTP02505  Lysosomal protective protein (CTSA) 21.7
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 21.6
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 19.7
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 19.3
 LDTP01773  Cytochrome c oxidase subunit 2 (MT-CO2) 19.2
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 18.8
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 18.5
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 18.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 17.5
 LDTP05396  Histone-lysine N-methyltransferase 2A (KMT2A) 17.3
 LDTP04689  Adenosine kinase (ADK) 17.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 16.8
 LDTP03680  DNA replication licensing factor MCM4 (MCM4) 16.7
 LDTP01803  Adenosine deaminase (ADA) 15.9
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 15.5
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 15.5
 LDTP03139  Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) 15.5
 LDTP02359  Heme oxygenase 1 (HMOX1) 15.2
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 15.1
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 14.8
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 14.8
 LDTP12003  Ribosomal oxygenase 1 (RIOX1) 14.8
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.8
 LDTP11127  ADP-dependent glucokinase (ADPGK) 14.7
 LDTP02141  Alpha-galactosidase A (GLA) 14.5
 LDTP00316  Ribonuclease T2 (RNASET2) 14.5
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 14.3
 LDTP19851  Isochorismatase domain-containing protein 1 (ISOC1) 14.1
 LDTP07990  Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) 14.0
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 13.9
 LDTP01743  NADH dehydrogenase 1 beta subcomplex subunit 10 (NDUFB10) 13.8
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 13.6
 LDTP11225  Deoxyhypusine hydroxylase (DOHH) 13.5
 LDTP00988  Protein O-GlcNAcase (OGA) 13.3
 LDTP03779  Copper-transporting ATPase 2 (ATP7B) 13.2
 LDTP02539  Lysosomal acid phosphatase (ACP2) 13.2
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 12.9
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 12.9
 LDTP01462  Endonuclease domain-containing 1 protein (ENDOD1) 12.8
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 12.7
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 12.6
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.6
 LDTP01515  NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) 12.5
 LDTP06307  Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) 12.4
 LDTP03842  Squalene synthase (FDFT1) 12.4
 LDTP03419  Proteasome subunit beta type-5 (PSMB5) 12.3
 LDTP13409  Anaphase-promoting complex subunit 7 (ANAPC7) 12.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) 12.0
 LDTP10329  Ceramide synthase 2 (CERS2) 11.9
 LDTP13056  Leucine--tRNA ligase, cytoplasmic (LARS1) 11.8
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 11.7
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 11.6
 LDTP01300  Cartilage-associated protein (CRTAP) 11.6
 LDTP04333  GMP synthase [glutamine-hydrolyzing] (GMPS) 11.3
 LDTP02486  Lysosomal alpha-glucosidase (GAA) 11.0
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 11.0
Transporter and channel
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 99.7
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 93.7
 LDTP03546  Translocator protein (TSPO) 83.3
 LDTP02215  Prosaposin (PSAP) 73.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 65.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 55.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 55.7
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 55.7
 LDTP11615  Protein tweety homolog 3 (TTYH3) 49.5
 LDTP16813  Tetraspanin-3 (TSPAN3) 49.5
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 47.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 46.5
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 45.9
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 44.9
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 44.3
 LDTP08881  Transmembrane protein 199 (TMEM199) 42.2
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 38.9
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 33.1
 LDTP05900  Metaxin-1 (MTX1) 32.2
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 31.3
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 30.5
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 29.7
 LDTP07531  Sideroflexin-4 (SFXN4) 29.2
 LDTP16190  Protein FAM8A1 (FAM8A1) 25.1
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 23.6
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 21.7
 LDTP10036  BOS complex subunit NCLN (NCLN) 21.4
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) 21.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.7
 LDTP08016  Proton-coupled amino acid transporter 1 (SLC36A1) 20.5
 LDTP09328  Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2) 19.8
 LDTP09203  Nucleoporin Nup37 (NUP37) 18.9
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 18.8
 LDTP14002  Transmembrane emp24 domain-containing protein 3 (TMED3) 17.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 17.5
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 17.3
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 16.7
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 15.9
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 15.5
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 15.2
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 15.0
 LDTP01200  Peroxisomal membrane protein PEX14 (PEX14) 14.1
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 14.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 14.0
 LDTP01601  Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1) 13.7
 LDTP00547  Secretory carrier-associated membrane protein 2 (SCAMP2) 13.7
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 13.7
 LDTP04237  Protein ERGIC-53 (LMAN1) 13.5
 LDTP11213  Nucleoporin NDC1 (NDC1) 13.3
 LDTP12207  Putative divalent cation/proton antiporter TMEM165 (TMEM165) 12.7
 LDTP04597  Methylosome subunit pICln (CLNS1A) 12.4
 LDTP10343  Vacuole membrane protein 1 (VMP1) 12.3
 LDTP01043  Sorting nexin-2 (SNX2) 12.2
 LDTP11245  Derlin-1 (DERL1) 12.0
 LDTP11869  Growth hormone-inducible transmembrane protein (GHITM) 12.0
 LDTP10059  PAT complex subunit CCDC47 (CCDC47) 12.0
 LDTP02061  Anion exchange protein 2 (SLC4A2) 11.9
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 11.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 11.6
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 11.2
 LDTP15845  Transmembrane 9 superfamily member 2 (TM9SF2) 11.2
 LDTP10317  THO complex subunit 1 (THOC1) 11.1
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 12.4
Other
Click to Show/Hide to Show 70 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 89.9
 LDTP15269  Large ribosomal subunit protein mL55 (MRPL55) 59.3
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 49.9
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 48.5
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 44.0
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 37.3
 LDTP00105  Protein unc-119 homolog B (UNC119B) 36.3
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 34.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 34.3
 LDTP01522  Reticulon-3 (RTN3) 30.7
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 29.0
 LDTP13797  HIG1 domain family member 1A, mitochondrial (HIGD1A) 27.1
 LDTP14458  Tetraspanin-6 (TSPAN6) 25.5
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 24.8
 LDTP15253  HEAT repeat-containing protein 3 (HEATR3) 24.3
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 23.6
 LDTP10255  Protein Hook homolog 2 (HOOK2) 23.1
 LDTP00859  Synaptogyrin-2 (SYNGR2) 23.1
 LDTP05160  Nucleobindin-2 (NUCB2) 21.1
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 20.8
 LDTP06097  Reticulocalbin-2 (RCN2) 20.5
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) 20.3
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 20.1
 LDTP08154  Large ribosomal subunit protein uL10m (MRPL10) 19.7
 LDTP01359  Dynactin subunit 3 (DCTN3) 19.3
 LDTP12412  Reticulon-4 (RTN4) 19.2
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 18.8
 LDTP05076  Tubulin beta-4B chain (TUBB4B) 18.8
 LDTP02297  Vimentin (VIM) 18.5
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 18.4
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 17.8
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 17.8
 LDTP02205  Tubulin beta chain (TUBB) 17.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 17.5
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 17.3
 LDTP16285  Transducin beta-like protein 2 (TBL2) 17.3
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 16.8
 LDTP05277  Protein SET (SET) 16.6
 LDTP13086  Syntaxin-18 (STX18) 16.6
 LDTP10965  Nucleosome assembly protein 1-like 4 (NAP1L4) 16.3
 LDTP11525  Kinetochore protein Nuf2 (NUF2) 16.0
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 15.2
 LDTP01652  Centrosomal protein 43 (CEP43) 14.3
 LDTP08689  Dyslexia-associated protein KIAA0319-like protein (KIAA0319L) 14.2
 LDTP05998  Tubulin beta-2A chain (TUBB2A) 14.2
 LDTP12755  OCIA domain-containing protein 1 (OCIAD1) 14.1
 LDTP12476  Translation initiation factor eIF2B subunit gamma (EIF2B3) 14.0
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 13.8
 LDTP11233  Tubulin beta-6 chain (TUBB6) 13.5
 LDTP11277  Tubulin beta-2B chain (TUBB2B) 13.2
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 13.0
 LDTP03926  Centrin-2 (CETN2) 12.7
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 12.7
 LDTP01932  Prelamin-A/C (LMNA) 12.6
 LDTP04207  Heat shock 70 kDa protein 13 (HSPA13) 12.5
 LDTP13519  Proteasome activator complex subunit 2 (PSME2) 12.3
 LDTP19963  TraB domain-containing protein (TRABD) 12.3
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 12.2
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 12.2
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 12.0
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 11.8
 LDTP02037  Tubulin beta-4A chain (TUBB4A) 11.7
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 11.6
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 11.3
 LDTP05068  Tropomyosin alpha-4 chain (TPM4) 11.2
 LDTP08224  Protein LYRIC (MTDH) 11.2
 LDTP00887  Calumenin (CALU) 11.1
 LDTP19924  Protein PBDC1 (PBDC1) 11.1
 LDTP18272  Transmembrane protein 209 (TMEM209) 11.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587