Details of the Target

General Information of Target

Target ID LDTP04237
Target Name Protein ERGIC-53 (LMAN1)
Gene Name LMAN1
Gene ID 3998
Synonyms
ERGIC53; F5F8D; Protein ERGIC-53; ER-Golgi intermediate compartment 53 kDa protein; Gp58; Intracellular mannose-specific lectin MR60; Lectin mannose-binding 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQS
DGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGA
DGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQN
DGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPA
QGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQEL
DKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQR
RYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGM
QHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVH
FIIFVVVQTVLFIGYIMYRSQQEAAAKKFF
Target Bioclass
Transporter and channel
Subcellular location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Function
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Uniprot ID
P49257
Ensemble ID
ENST00000251047.6
HGNC ID
HGNC:6631

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		8.87  LDD0066  [1]
YN-4
 Probe Info  		100.00  LDD0445  [2]
ONAyne
 Probe Info  		K346(10.00)  LDD0274  [3]
OPA-S-S-alkyne
 Probe Info  		K372(2.72); K407(3.11); K87(3.85); K346(9.39)  LDD3494  [4]
Probe 1
 Probe Info  		Y362(75.59)  LDD3495  [5]
BTD
 Probe Info  		C230(1.16)  LDD2099  [6]
IPM
 Probe Info  		C190(2.31)  LDD1702  [6]
DBIA
 Probe Info  		C230(1.23)  LDD0080  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		K346(0.00); K372(0.00)  LDD0199  [9]
m-APA
 Probe Info  		H381(0.00); H56(0.00); H175(0.00); H69(0.00)  LDD2231  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C230(0.00); C190(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
STPyne
 Probe Info  		N.A.  LDD0009  [14]
Acrolein
 Probe Info  		H422(0.00); H435(0.00); H444(0.00); H442(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		H444(0.00); H381(0.00); H397(0.00); H311(0.00)  LDD0219  [15]
AOyne
 Probe Info  		11.60  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C053
 Probe Info  		7.57  LDD1751  [18]
C092
 Probe Info  		17.03  LDD1783  [18]
C094
 Probe Info  		23.26  LDD1785  [18]
C134
 Probe Info  		38.05  LDD1816  [18]
C143
 Probe Info  		13.93  LDD1825  [18]
C187
 Probe Info  		74.03  LDD1865  [18]
C190
 Probe Info  		6.54  LDD1867  [18]
C191
 Probe Info  		44.32  LDD1868  [18]
C193
 Probe Info  		18.77  LDD1869  [18]
C244
 Probe Info  		13.93  LDD1917  [18]
C246
 Probe Info  		17.15  LDD1919  [18]
C349
 Probe Info  		9.58  LDD2010  [18]
C350
 Probe Info  		25.99  LDD2011  [18]
C362
 Probe Info  		34.54  LDD2023  [18]
C388
 Probe Info  		49.52  LDD2047  [18]
C403
 Probe Info  		14.52  LDD2061  [18]
C413
 Probe Info  		13.55  LDD2069  [18]
C431
 Probe Info  		19.97  LDD2086  [18]
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe12
 Probe Info  		20.00  LDD0473  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe14
 Probe Info  		20.00  LDD0477  [19]
FFF probe2
 Probe Info  		20.00  LDD0463  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
STS-1
 Probe Info  		N.A.  LDD0136  [20]
STS-2
 Probe Info  		N.A.  LDD0138  [20]
Staurosporine capture compound
 Probe Info  		4.00  LDD0083  [21]
DA-2
 Probe Info  		N.A.  LDD0072  [22]
OEA-DA
 Probe Info  		16.70  LDD0046  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C230(0.98)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C230(1.16)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C230(2.04)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C230(0.72)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C230(0.59)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C230(0.49)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C230(0.47)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C230(0.58)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C230(0.61)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C230(0.43)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C230(0.83)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C230(1.27)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C230(0.85)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C230(0.73)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C230(0.59)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C230(0.59)  LDD0546  [7]
 LDCM0230  AC113 PaTu 8988t C230(1.35)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C230(1.92)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C230(0.56)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C230(0.65)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C230(0.59)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C230(1.00)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C230(0.49)  LDD1115  [7]
 LDCM0237  AC12 HCT 116 C230(1.12)  LDD0554  [7]
 LDCM0238  AC120 PaTu 8988t C230(0.76)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C230(0.32)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C230(1.38)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C230(0.53)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C230(0.35)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C230(0.82)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C230(0.89)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C230(0.47)  LDD1124  [7]
 LDCM0246  AC128 HCT 116 C230(0.59)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C230(1.32)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C230(1.28)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C230(2.05)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C230(1.32)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C230(1.43)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C230(1.09)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C230(1.24)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C230(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C230(1.12)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C230(1.33)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C230(1.40)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C230(1.29)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C230(1.13)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C230(1.20)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C230(2.12)  LDD0579  [7]
 LDCM0263  AC143 PaTu 8988t C230(1.11)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C230(0.89)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C230(1.35)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C230(1.52)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C230(1.17)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C230(0.77)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C230(0.93)  LDD1148  [7]
 LDCM0270  AC15 HCT 116 C230(0.96)  LDD0587  [7]
 LDCM0271  AC150 PaTu 8988t C230(0.88)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C230(0.31)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C230(0.95)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C230(0.50)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C230(0.38)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C230(0.63)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C230(1.19)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C230(0.67)  LDD2169  [7]
 LDCM0276  AC17 HCT 116 C230(0.94)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C230(0.49)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C230(0.84)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C230(1.36)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C230(0.93)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C230(0.79)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C230(1.36)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C230(0.95)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C230(0.97)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C230(0.95)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C230(0.95)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C230(0.85)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C230(0.69)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C230(1.17)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C230(1.19)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C230(0.81)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C230(0.81)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C230(0.74)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C230(0.75)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C230(0.56)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C230(0.99)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C230(1.30)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C230(1.61)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C230(1.42)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C230(0.97)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C230(0.76)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C230(0.66)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C230(1.26)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C230(0.91)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C230(1.25)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C230(0.91)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C230(0.68)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C230(1.16)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C230(1.15)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C230(2.38)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C230(0.37)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C230(0.96)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C230(0.57)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C230(1.97)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C230(1.13)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C230(0.71)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C230(0.72)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C230(0.50)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C230(0.32)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C230(0.80)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C230(1.14)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C230(0.57)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C230(1.08)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C230(0.94)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C230(1.53)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C230(0.47)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C230(1.18)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C230(0.57)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C230(0.99)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C230(1.16)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C230(0.29)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C230(1.39)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C230(1.10)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C230(1.14)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C230(0.66)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C230(1.41)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C230(1.16)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C230(0.48)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C230(0.55)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C230(0.41)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C230(0.97)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C230(1.03)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C230(1.77)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C230(1.20)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C230(0.83)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C230(1.05)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C230(1.01)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C230(0.35)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C230(0.40)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C230(0.34)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C230(0.63)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C230(0.83)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C230(1.36)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C230(0.74)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C230(0.61)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C230(1.79)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C230(0.32)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C230(0.39)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C230(0.61)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C230(0.67)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C230(1.49)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C230(0.80)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C230(0.41)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C230(0.11)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C230(0.63)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C230(1.96)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C230(1.21)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C230(0.49)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa H444(0.00); C190(0.00); H442(0.00); H422(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C230(1.18)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C230(0.81)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C230(0.85)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C230(1.04)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C230(1.42)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C230(1.68)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C230(1.52)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C230(0.93)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C230(0.71)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C230(0.74)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C230(0.42)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C230(0.83)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C230(0.53)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C230(0.77)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C230(0.80)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C230(0.83)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C230(0.63)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C230(0.94)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C230(0.64)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C230(0.94)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C230(0.33)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C230(0.79)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C230(0.76)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C230(0.45)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C230(1.28)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C230(0.72)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C230(1.30)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C230(0.67)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C230(0.55)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C230(1.27)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C230(0.95)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C230(0.88)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C230(0.58)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C230(1.17)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C230(1.41)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C230(0.64)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C230(0.68)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C230(1.04)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C230(1.79)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C230(0.92)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C230(0.93)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C230(0.46)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C230(0.45)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C230(0.20)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C230(0.67)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C230(0.37)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C230(0.44)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C230(0.68)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C230(0.95)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C230(0.56)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C230(0.64)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C230(0.82)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C230(0.75)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C230(0.91)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C230(2.81)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C230(0.91)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C230(0.65)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C230(0.53)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C230(1.07)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C230(0.60)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C230(0.60)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C230(0.95)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C230(0.70)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C230(0.78)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C230(0.33)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C230(0.50)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C230(0.69)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C230(0.70)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C230(1.13)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C230(0.77)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C230(1.07)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C230(1.01)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C230(0.97)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C230(1.52)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C230(1.16)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C230(1.34)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C230(1.54)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C230(2.05)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C230(1.25)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C230(0.80)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C230(1.40)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C230(1.23)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C230(0.98)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C230(1.17)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C230(0.89)  LDD0769  [7]
 LDCM0453  CL61 HEK-293T C230(0.77)  LDD1051  [7]
 LDCM0454  CL62 HEK-293T C230(0.91)  LDD1052  [7]
 LDCM0455  CL63 HEK-293T C230(0.72)  LDD1053  [7]
 LDCM0456  CL64 HEK-293T C230(0.79)  LDD1054  [7]
 LDCM0457  CL65 HEK-293T C230(0.79)  LDD1055  [7]
 LDCM0458  CL66 HEK-293T C230(0.91)  LDD1056  [7]
 LDCM0459  CL67 HEK-293T C230(1.00)  LDD1057  [7]
 LDCM0460  CL68 HEK-293T C230(1.03)  LDD1058  [7]
 LDCM0461  CL69 HEK-293T C230(0.94)  LDD1059  [7]
 LDCM0462  CL7 HCT 116 C230(0.67)  LDD0779  [7]
 LDCM0463  CL70 HEK-293T C230(1.07)  LDD1061  [7]
 LDCM0464  CL71 HEK-293T C230(0.89)  LDD1062  [7]
 LDCM0465  CL72 HEK-293T C230(0.94)  LDD1063  [7]
 LDCM0466  CL73 HEK-293T C230(1.28)  LDD1064  [7]
 LDCM0467  CL74 HEK-293T C230(1.04)  LDD1065  [7]
 LDCM0469  CL76 HCT 116 C230(0.72)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C230(0.63)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C230(0.82)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C230(0.57)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C230(0.40)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C230(0.90)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C230(0.97)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C230(0.47)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C230(0.49)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C230(0.37)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C230(1.38)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C230(1.33)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C230(0.68)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C230(0.59)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C230(0.22)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C230(0.76)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C230(0.90)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C230(0.72)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C230(0.68)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C230(0.63)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C230(1.00)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C230(0.82)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C230(0.74)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C230(0.82)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C230(0.63)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C230(1.10)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C230(1.05); C190(1.08); C18(0.76)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C190(2.31)  LDD1702  [6]
 LDCM0468  Fragment33 HEK-293T C230(0.59)  LDD1066  [7]
 LDCM0427  Fragment51 HCT 116 C230(0.35)  LDD0744  [7]
 LDCM0107  IAA HeLa H435(0.00); H311(0.00); H295(0.00); H442(0.00)  LDD0221  [15]
 LDCM0022  KB02 HCT 116 C230(1.23)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C230(1.60)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C230(1.41)  LDD0082  [7]
 LDCM0109  NEM HeLa H435(0.00); H295(0.00); H422(0.00); H311(0.00)  LDD0223  [15]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C230(1.16)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C230(1.20)  LDD2107  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C230(1.18)  LDD2125  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C230(1.42)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C230(1.08)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C230(1.02)  LDD2140  [6]
 LDCM0019  Staurosporine Hep-G2 4.00  LDD0083  [21]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Surfeit locus protein 4 (SURF4) SURF4 family O15260
Multiple coagulation factor deficiency protein 2 (MCFD2) . Q8NI22
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum resident protein 44 (ERP44) . Q9BS26

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Antihemophilic Factor Human Recombinant BiotechDrug DB00025
Lonoctocog Alfa . DB13998
Moroctocog Alfa . DB13999

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402