Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C244  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 64 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01561  NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10) 66.3
 LDTP02359  Heme oxygenase 1 (HMOX1) 59.7
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 50.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 49.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 41.6
 LDTP01803  Adenosine deaminase (ADA) 39.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 39.7
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 39.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 38.3
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 36.3
 LDTP15422  Prostaglandin reductase 3 (PTGR3) 32.2
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 30.7
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 30.3
 LDTP03331  Proteasome subunit alpha type-2 (PSMA2) 30.1
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 29.2
 LDTP01300  Cartilage-associated protein (CRTAP) 28.4
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 27.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 27.1
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 26.5
 LDTP00697  Cytochrome b5 type B (CYB5B) 26.2
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 26.0
 LDTP10215  Carboxymethylenebutenolidase homolog (CMBL) 25.8
 LDTP13352  GTP:AMP phosphotransferase AK3, mitochondrial (AK3) 25.6
 LDTP08598  NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 25.5
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 25.3
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 24.9
 LDTP02783  Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) 24.3
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 24.1
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 23.6
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 23.4
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 22.6
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 21.9
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 21.3
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 20.8
 LDTP12868  Endoplasmic reticulum aminopeptidase 1 (ERAP1) 20.5
 LDTP11437  Peroxisomal trans-2-enoyl-CoA reductase (PECR) 20.5
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 20.5
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 19.2
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 18.6
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 18.6
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 18.5
 LDTP12105  L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) 18.5
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 18.3
 LDTP11321  Acetyl-CoA acetyltransferase, cytosolic (ACAT2) 17.9
 LDTP09874  Endoplasmic reticulum protein SC65 (P3H4) 17.9
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 17.5
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 17.1
 LDTP05408  Antigen peptide transporter 1 (TAP1) 16.9
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 16.9
 LDTP06750  Prolyl 3-hydroxylase 1 (P3H1) 16.9
 LDTP07868  Protein O-mannosyl-transferase TMTC3 (TMTC3) 16.9
 LDTP05446  Ubiquitin-protein ligase E3A (UBE3A) 16.7
 LDTP04374  Dynamin-2 (DNM2) 16.4
 LDTP12610  Obg-like ATPase 1 (OLA1) 16.4
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 15.7
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 15.7
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 15.6
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 15.2
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 15.2
 LDTP12588  Isoleucine--tRNA ligase, mitochondrial (IARS2) 14.9
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 14.7
 LDTP04581  Holocytochrome c-type synthase (HCCS) 14.6
 LDTP03817  Lon protease homolog, mitochondrial (LONP1) 13.9
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 13.8
Transporter and channel
Click to Show/Hide to Show 51 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 58.1
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 57.3
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 45.3
 LDTP11095  Mitochondrial 2-oxodicarboxylate carrier (SLC25A21) 42.5
 LDTP07156  Protein wntless homolog (WLS) 39.7
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 38.9
 LDTP15948  Transmembrane protein 126A (TMEM126A) 37.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 36.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 36.3
 LDTP01804  ATP synthase subunit a (MT-ATP6) 33.6
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 32.0
 LDTP07236  Protein GPR107 (GPR107) 31.8
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 31.1
 LDTP10663  Importin-9 (IPO9) 30.5
 LDTP03546  Translocator protein (TSPO) 30.5
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 29.7
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 28.8
 LDTP08881  Transmembrane protein 199 (TMEM199) 27.9
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 26.7
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 24.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 24.6
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 23.6
 LDTP20002  Transmembrane protein 160 (TMEM160) 22.5
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 22.2
 LDTP05900  Metaxin-1 (MTX1) 22.2
 LDTP11116  45 kDa calcium-binding protein (SDF4) 20.5
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 19.6
 LDTP06308  Mitochondrial inner membrane protein OXA1L (OXA1L) 19.3
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 18.6
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 18.4
 LDTP03811  V-type proton ATPase subunit E 1 (ATP6V1E1) 17.8
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 17.6
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 17.5
 LDTP09203  Nucleoporin Nup37 (NUP37) 16.3
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 16.2
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 16.1
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 16.0
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 15.9
 LDTP05667  Syntaxin-4 (STX4) 15.6
 LDTP15648  BRI3-binding protein (BRI3BP) 15.5
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 15.5
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 15.5
 LDTP13164  Protein sel-1 homolog 1 (SEL1L) 14.5
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 14.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 14.3
 LDTP00477  Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23) 14.3
 LDTP16190  Protein FAM8A1 (FAM8A1) 14.3
 LDTP13833  Integral membrane protein 2B (ITM2B) 14.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 14.0
 LDTP02645  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1) 13.9
 LDTP04237  Protein ERGIC-53 (LMAN1) 13.9
Other
Click to Show/Hide to Show 75 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 99.7
 LDTP08594  Negative elongation factor C/D (NELFCD) 45.3
 LDTP05160  Nucleobindin-2 (NUCB2) 43.4
 LDTP14939  Membralin (TMEM259) 36.8
 LDTP16192  Mitochondrial fission process protein 1 (MTFP1) 36.8
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 31.6
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 31.3
 LDTP14792  Small ribosomal subunit protein uS9m (MRPS9) 30.5
 LDTP00986  Syntaxin-10 (STX10) 29.2
 LDTP16078  Heme-binding protein 1 (HEBP1) 27.5
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 27.3
 LDTP16006  Optic atrophy 3 protein (OPA3) 25.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 24.8
 LDTP06097  Reticulocalbin-2 (RCN2) 24.8
 LDTP10056  Protein FAM162A (FAM162A) 24.4
 LDTP19785  Transmembrane protein 35B (TMEM35B) 23.9
 LDTP01359  Dynactin subunit 3 (DCTN3) 23.8
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 23.4
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 23.3
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 22.9
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 22.8
 LDTP09870  Signal transducing adapter molecule 1 (STAM) 22.3
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 21.9
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 21.7
 LDTP05375  Nucleobindin-1 (NUCB1) 21.7
 LDTP07891  Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP) 21.1
 LDTP12287  Ran guanine nucleotide release factor (RANGRF) 20.5
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 20.4
 LDTP02297  Vimentin (VIM) 20.1
 LDTP08796  Protein SYS1 homolog (SYS1) 20.0
 LDTP02180  Neurofilament light polypeptide (NEFL) 19.3
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 18.9
 LDTP06292  Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) 18.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 18.1
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 18.0
 LDTP11911  Golgi phosphoprotein 3 (GOLPH3) 18.0
 LDTP19963  TraB domain-containing protein (TRABD) 18.0
 LDTP14126  Mitochondrial import inner membrane translocase subunit Tim9 (TIMM9) 17.8
 LDTP05277  Protein SET (SET) 17.8
 LDTP18883  Protein CEBPZOS (CEBPZOS) 17.5
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 17.3
 LDTP10775  Endoplasmic reticulum-Golgi intermediate compartment protein 2 (ERGIC2) 17.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 17.0
 LDTP19912  Protein NipSnap homolog 1 (NIPSNAP1) 16.9
 LDTP00859  Synaptogyrin-2 (SYNGR2) 16.9
 LDTP13086  Syntaxin-18 (STX18) 16.7
 LDTP10213  Anaphase-promoting complex subunit 16 (ANAPC16) 16.4
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 16.4
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 16.4
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 16.1
 LDTP15623  Neuferricin (CYB5D2) 16.1
 LDTP01075  Protein CutA (CUTA) 16.1
 LDTP00887  Calumenin (CALU) 16.0
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 15.8
 LDTP11113  Receptor expression-enhancing protein 2 (REEP2) 15.8
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 15.5
 LDTP09069  Kinetochore protein Spc24 (SPC24) 15.2
 LDTP03775  RNA-binding protein FUS (FUS) 15.1
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 15.0
 LDTP10927  COP9 signalosome complex subunit 8 (COPS8) 14.9
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 14.8
 LDTP02535  Laminin subunit gamma-1 (LAMC1) 14.8
 LDTP09589  Charged multivesicular body protein 7 (CHMP7) 14.7
 LDTP17003  Matrix-remodeling-associated protein 7 (MXRA7) 14.7
 LDTP06121  Caprin-1 (CAPRIN1) 14.6
 LDTP01652  Centrosomal protein 43 (CEP43) 14.6
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 14.6
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 14.3
 LDTP04206  Nestin (NES) 14.3
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) 14.3
 LDTP12412  Reticulon-4 (RTN4) 14.3
 LDTP04111  Small ribosomal subunit protein eS10 (RPS10) 14.2
 LDTP09671  U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) 14.2
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 13.8
 LDTP05418  UBX domain-containing protein 1 (UBXN1) 13.8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587