Details of the Target

General Information of Target

Target ID LDTP19372
Target Name Tetratricopeptide repeat protein 38 (TTC38)
Gene Name TTC38
Gene ID 55020
Synonyms
Tetratricopeptide repeat protein 38; TPR repeat protein 38
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQLLRNVLCVIETFHKYASEDSNGATLTGRELKQLIQGEFGDFFQPCVLHAVEKNSNLL
NIDSNGIISFDEFVLAIFNLLNLCYLDIKSLLSSELRQVTKPEKEKLDDVDVQATTGDGQ
WTVGTSPTQEKRMLPSGMASSSQLIPEESGAVGNNRVDPWREAKTHNFPGEASEHNDPKN
KHLEGDEQSQEVAQDIQTTEDNEGQLKTNKPMAGSKKTSSPTERKGQDKEISQEGDEPAR
EQSVSKIRDQFGEQEGNLATQSSPPKEATQRPCEDQEVRTEKEKHSNIQEPPLQREDEPS
SQHADLPEQAAARSPSQTQKSTDSKDVCRMFDTQEPGKDADQTPAKTKNLGEPEDYGRTS
ETQEKECETKDLPVQYGSRNGSETSDMRDERKERRGPEAHGTAGQKERDRKTRPLVLETQ
TQDGKYQELQGLSKSKDAEKGSETQYLSSEGGDQTHPELEGTAVSGEEAEHTKEGTAEAF
VNSKNAPAAERTLGARERTQDLAPLEKQSVGENTRVTKTHDQPVEEEDGYQGEDPESPFT
QSDEGSSETPNSLASEEGNSSSETGELPVQGDSQSQGDQHGESVQGGHNNNPDTQRQGTP
GEKNRALEAVVPAVRGEDVQLTEDQEQPARGEHKNQGPGTKGPGAAVEPNGHPEAQESTA
GDENRKSLEIEITGALDEDFTDQLSLMQLPGKGDSRNELKVQGPSSKEEKGRATEAQNTL
LESLDEDNSASLKIQLETKEPVTSEEEDESPQELAGEGGDQKSPAKKEHNSSVPWSSLEK
QMQRDQEPCSVERGAVYSSPLYQYLQEKILQQTNVTQEEHQKQVQIAQASGPELCSVSLT
SEISDCSVFFNYSQASQPYTRGLPLDESPAGAQETPAPQALEDKQGHPQRERLVLQREAS
TTKQ
Target Bioclass
Other
Family
TTC38 family
Uniprot ID
Q5R3I4
Ensemble ID
ENST00000381031.8
HGNC ID
HGNC:26082

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 2
 Probe Info  		14.00  LDD0389  [1]
AZ-9
 Probe Info  		E51(10.00); C53(10.00)  LDD2208  [2]
P11
 Probe Info  		20.00  LDD0201  [3]
Alkylaryl probe 1
 Probe Info  		4.00  LDD0386  [1]
SAHA-CA-4PAP
 Probe Info  		20.00  LDD0269  [4]
BTD
 Probe Info  		C28(0.75)  LDD2118  [5]
DBIA
 Probe Info  		C53(1.01)  LDD0547  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [8]
NAIA_4
 Probe Info  		C28(0.00); C128(0.00); C367(0.00); C380(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
IPM
 Probe Info  		C28(0.00); C53(0.00)  LDD2156  [11]
Acrolein
 Probe Info  		C380(0.00); C367(0.00)  LDD0217  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		C128(0.00); C10(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 55 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C021
 Probe Info  		14.42  LDD1727  [14]
C024
 Probe Info  		13.36  LDD1730  [14]
C026
 Probe Info  		10.78  LDD1732  [14]
C056
 Probe Info  		23.92  LDD1753  [14]
C059
 Probe Info  		10.20  LDD1756  [14]
C061
 Probe Info  		5.70  LDD1758  [14]
C064
 Probe Info  		8.51  LDD1761  [14]
C070
 Probe Info  		20.53  LDD1766  [14]
C140
 Probe Info  		8.63  LDD1822  [14]
C145
 Probe Info  		41.93  LDD1827  [14]
C166
 Probe Info  		7.67  LDD1846  [14]
C173
 Probe Info  		6.15  LDD1853  [14]
C193
 Probe Info  		5.70  LDD1869  [14]
C196
 Probe Info  		11.00  LDD1872  [14]
C204
 Probe Info  		4.99  LDD1879  [14]
C205
 Probe Info  		13.55  LDD1880  [14]
C212
 Probe Info  		7.11  LDD1886  [14]
C229
 Probe Info  		11.39  LDD1902  [14]
C233
 Probe Info  		16.00  LDD1906  [14]
C240
 Probe Info  		9.71  LDD1913  [14]
C241
 Probe Info  		4.92  LDD1914  [14]
C244
 Probe Info  		16.45  LDD1917  [14]
C249
 Probe Info  		16.22  LDD1922  [14]
C255
 Probe Info  		7.78  LDD1928  [14]
C266
 Probe Info  		22.47  LDD1937  [14]
C269
 Probe Info  		9.78  LDD1939  [14]
C301
 Probe Info  		5.39  LDD1970  [14]
C305
 Probe Info  		18.64  LDD1974  [14]
C320
 Probe Info  		5.82  LDD1986  [14]
C326
 Probe Info  		9.58  LDD1990  [14]
C337
 Probe Info  		5.66  LDD2000  [14]
C339
 Probe Info  		8.34  LDD2002  [14]
C349
 Probe Info  		11.71  LDD2010  [14]
C354
 Probe Info  		26.17  LDD2015  [14]
C355
 Probe Info  		23.75  LDD2016  [14]
C373
 Probe Info  		34.54  LDD2033  [14]
C374
 Probe Info  		5.13  LDD2034  [14]
C380
 Probe Info  		19.03  LDD2039  [14]
C382
 Probe Info  		11.24  LDD2041  [14]
C391
 Probe Info  		13.55  LDD2050  [14]
C399
 Probe Info  		8.51  LDD2058  [14]
C405
 Probe Info  		7.01  LDD2063  [14]
C407
 Probe Info  		14.32  LDD2064  [14]
C418
 Probe Info  		12.47  LDD2073  [14]
C419
 Probe Info  		9.00  LDD2074  [14]
C433
 Probe Info  		6.32  LDD2088  [14]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe15
 Probe Info  		20.00  LDD0478  [15]
FFF probe3
 Probe Info  		20.00  LDD0480  [15]
FFF probe6
 Probe Info  		20.00  LDD0482  [15]
FFF probe7
 Probe Info  		20.00  LDD0483  [15]
SAHA-CA-3PAP
 Probe Info  		N.A.  LDD0363  [4]
SAHA-CA-8PAP
 Probe Info  		N.A.  LDD0362  [4]
Alk-rapa
 Probe Info  		13.40  LDD0213  [16]
OEA-DA
 Probe Info  		20.00  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C28(1.08)  LDD0812  [6]
 LDCM0215  AC10 HEK-293T C28(1.40); C53(0.77)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C28(1.90); C53(0.81)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C28(1.96); C53(0.91)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C28(1.98); C53(0.89)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C28(2.19); C53(0.85)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C28(1.31); C53(0.93)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C28(1.63); C53(1.01)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C28(1.06); C53(1.09)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C28(1.36); C53(0.80)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C28(1.14); C53(0.88)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C28(1.58); C53(0.98)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C28(1.12); C53(0.94)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C28(1.77); C53(0.54)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C28(1.70); C53(0.45)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C28(2.30); C53(0.47)  LDD0827  [6]
 LDCM0230  AC113 HCT 116 C53(1.01)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C53(0.94)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C53(0.93)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C53(1.03)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C53(1.00)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C53(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C53(0.88)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C28(1.11); C53(1.17)  LDD0835  [6]
 LDCM0238  AC120 HCT 116 C53(0.96)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C53(1.05)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C53(1.01)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C53(1.17)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C53(0.97)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C53(1.02)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C53(1.03)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C53(1.06)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C28(0.79)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C28(0.82)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C28(1.04)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C28(0.80)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C28(1.14)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C28(1.19)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C28(1.26)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C28(1.05)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C28(1.01)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C28(1.14)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C28(1.06)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C28(0.88)  LDD0856  [6]
 LDCM0259  AC14 HEK-293T C28(1.47); C53(1.08)  LDD0857  [6]
 LDCM0260  AC140 HEK-293T C28(1.30)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C28(1.40)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C28(1.13)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C53(1.12)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C53(1.11)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C53(1.19)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C53(1.26)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C53(1.07)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C53(1.45)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C53(1.35)  LDD0586  [6]
 LDCM0270  AC15 HEK-293T C28(1.58); C53(0.86)  LDD0868  [6]
 LDCM0271  AC150 HCT 116 C53(1.30)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C53(1.41)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C53(1.25)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C53(1.92)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C53(1.32)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C53(1.37)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C53(1.43)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C53(1.53)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C53(1.12)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C53(0.99)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C53(1.12)  LDD0595  [6]
 LDCM0279  AC2 HEK-293T C28(1.60)  LDD0877  [6]
 LDCM0280  AC20 HCT 116 C53(1.03)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C53(1.05)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C53(1.02)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C53(1.06)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C53(1.12)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C28(0.99)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C28(0.79)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C28(0.95)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C28(1.90)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C28(0.77)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C28(1.08)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C28(0.72)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C28(0.70)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C28(0.70)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C28(0.69)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C28(0.61)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C53(0.92); C367(1.00); C380(1.22); C128(1.41)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C53(1.00)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C53(1.03); C367(1.12)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C53(0.87); C367(1.12); C429(1.15); C128(1.25)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C53(0.86); C367(1.06)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C28(1.20)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C367(0.99); C429(1.10); C128(1.06)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C53(1.03)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C53(1.09); C367(1.00); C28(1.13)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C53(0.97); C367(0.97); C380(1.09); C128(0.94)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C53(0.90)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C53(1.08); C367(0.93)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C28(1.43)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C28(1.59)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C28(1.31)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C28(1.22)  LDD0909  [6]
 LDCM0312  AC5 HEK-293T C28(1.35)  LDD0910  [6]
 LDCM0313  AC50 HEK-293T C28(0.94)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C28(1.01)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C28(1.24)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C28(1.34)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C28(1.17)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C28(2.09)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C28(1.95)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C28(0.79)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C28(0.78)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C28(0.50)  LDD0920  [6]
 LDCM0323  AC6 HEK-293T C28(0.87); C53(0.76)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C28(1.15)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C28(0.73)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C28(0.65)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C28(0.74)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C28(0.74)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C28(0.96)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C28(0.79)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C28(0.83)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C53(1.06)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C53(0.93)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C28(1.19); C53(0.88)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C53(1.01)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C53(0.96)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C53(1.04)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C53(1.05)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C53(0.94)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C53(1.01)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C53(0.89)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C53(0.78)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C53(0.96)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C53(0.97)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C28(1.16); C53(0.99)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C53(1.00)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C53(0.88)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C53(0.83)  LDD0665  [6]
 LDCM0349  AC83 HEK-293T C28(0.69); C53(0.83)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C28(0.99); C53(0.78)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C28(0.94); C53(0.72)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C28(0.97); C53(0.80)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C28(1.17); C53(0.75)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C28(1.06); C53(0.83)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C28(1.16); C53(0.90)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C28(0.88); C53(0.77)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C28(0.77); C53(0.74)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C28(0.72); C53(0.74)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C28(0.82); C53(0.88)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C28(1.28); C53(0.75)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C28(1.09); C53(0.87)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C28(1.03); C53(0.84)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C28(1.47); C53(0.39)  LDD0962  [6]
 LDCM0365  AC98 HEK-293T C28(1.55); C53(1.03)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C28(1.36); C53(0.87)  LDD0964  [6]
 LDCM0248  AKOS034007472 HEK-293T C28(1.47); C53(1.06)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C28(1.88); C53(1.02)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C28(1.27); C53(1.22)  LDD0873  [6]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [3]
 LDCM0108  Chloroacetamide HeLa C367(0.00); C53(0.00)  LDD0222  [12]
 LDCM0367  CL1 HEK-293T C53(1.04); C367(1.30); C28(1.19); C429(0.92)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C53(1.07); C367(0.95); C429(1.55); C128(1.12)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C28(1.17)  LDD0967  [6]
 LDCM0370  CL101 HEK-293T C28(1.04); C53(1.06)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C28(1.15); C53(1.16)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C28(1.19); C53(1.13)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C28(1.29); C53(0.95)  LDD0971  [6]
 LDCM0374  CL105 HCT 116 C53(1.17)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C53(1.08)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C53(1.04)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C53(1.10)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C53(1.22)  LDD0695  [6]
 LDCM0379  CL11 HEK-293T C53(1.14); C367(1.08)  LDD1583  [18]
 LDCM0380  CL110 HCT 116 C53(1.38)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C53(1.27)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C28(0.69)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C28(0.65)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C28(0.77)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C28(1.00)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C28(0.90)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C53(0.87); C367(1.00); C28(1.13); C429(0.90)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C53(1.04); C367(1.13); C429(0.90)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C53(0.99); C367(1.01); C28(1.03)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C367(1.14); C429(0.99); C128(1.26)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C53(0.99); C28(1.15)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C28(1.60)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C28(1.62)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C28(1.60)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C28(1.90)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C28(0.78)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C28(0.68)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C28(0.90)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C28(0.87)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C53(1.00); C367(0.93); C28(0.93); C429(0.91)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C53(0.91); C367(1.11); C429(0.93)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C53(0.95); C367(1.01); C28(1.05)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C28(0.54); C53(0.78)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C28(0.79); C53(0.92)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C28(0.69); C53(1.10)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C28(1.02); C53(0.91)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C53(1.15); C367(0.92); C429(1.05)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C28(1.09); C53(1.10)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C28(1.76); C53(1.27)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C28(0.58); C53(1.39)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C28(0.73); C53(1.06)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C28(0.83); C53(1.40)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C28(0.72); C53(0.84)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C28(0.69); C53(1.24)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C28(1.28); C53(1.09)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C28(1.00); C53(0.99)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C28(0.94); C53(1.26)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C53(0.95); C367(0.98); C28(1.19)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C28(0.70); C53(1.48)  LDD1017  [6]
 LDCM0420  CL31 PaTu 8988t C53(1.26)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C53(1.29)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C53(1.32)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C53(1.58)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C53(1.17)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C53(1.16)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C53(1.12)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C53(1.21)  LDD1307  [6]
 LDCM0429  CL4 HEK-293T C53(0.98); C28(1.19)  LDD1633  [18]
 LDCM0430  CL40 PaTu 8988t C53(1.10)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C53(1.35)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C53(0.92)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C53(0.57)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C53(1.15)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C53(1.84)  LDD1314  [6]
 LDCM0436  CL46 HCT 116 C53(0.68)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C53(0.93)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C53(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C53(0.90)  LDD0756  [6]
 LDCM0440  CL5 HEK-293T C53(1.10)  LDD1644  [18]
 LDCM0441  CL50 HCT 116 C53(0.96)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C53(1.19)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C53(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C53(0.92)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C53(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C53(0.94)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C53(0.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C53(1.21)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C53(0.97)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C53(0.87)  LDD0767  [6]
 LDCM0451  CL6 HEK-293T C53(1.04); C367(1.11); C28(1.15)  LDD1654  [18]
 LDCM0452  CL60 HCT 116 C53(0.99)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C53(1.14)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C53(1.05)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C53(0.95)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C53(1.11)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C53(0.88)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C53(1.25)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C53(0.94)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C53(1.37)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C53(1.15)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C53(1.00); C367(1.14); C380(0.97); C128(0.97)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C53(1.39)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C53(1.30)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C53(1.47)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C53(1.39)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C53(1.57)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C53(0.93); C28(1.22)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C53(1.00)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C53(0.98); C367(1.05); C28(1.21)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C53(1.11); C367(1.12); C380(1.15); C128(1.15)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C53(1.01)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C53(1.13)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C53(1.09); C367(1.11)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C53(0.98); C367(0.99); C429(1.13); C128(1.20)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C53(1.19); C367(1.02)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C367(1.20); C429(0.83); C128(1.16)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C53(1.04); C367(1.21); C28(1.14); C429(0.90)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C53(1.14); C367(1.03); C429(0.77)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C53(0.96); C367(1.15); C28(1.06)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C53(1.02); C28(1.14)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C53(0.98)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C53(1.13); C367(1.19)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C53(1.08); C367(1.19); C28(1.04)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C28(0.80)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C28(1.05)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C28(0.79)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C28(0.89)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C28(1.10)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C28(1.12)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C28(1.27)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C28(1.28)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C28(1.06)  LDD1092  [6]
 LDCM0189  Compound 16 HEK-293T 74.07  LDD0492  [15]
 LDCM0190  Compound 34 HEK-293T 12.35  LDD0497  [15]
 LDCM0192  Compound 35 HEK-293T 5.26  LDD0491  [15]
 LDCM0196  Compound 39 HEK-293T 14.08  LDD0496  [15]
 LDCM0495  E2913 HEK-293T C53(0.89); C367(0.86); C28(0.92)  LDD1698  [18]
 LDCM0468  Fragment33 HEK-293T C53(1.37)  LDD1066  [6]
 LDCM0427  Fragment51 PaTu 8988t C53(1.00)  LDD1306  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C367(0.79); C128(1.00); C53(0.89); C429(1.07)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C367(1.04); C128(1.00); C53(1.00); C429(1.03)  LDD1497  [18]
 LDCM0024  KB05 MOLM-13 C53(2.51)  LDD3333  [19]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C28(0.75)  LDD2118  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C367(0.74)  LDD2134  [5]
 LDCM0099  Phenelzine HEK-293T 4.00  LDD0386  [1]
 LDCM0090  Rapamycin JHH-7 13.40  LDD0213  [16]
 LDCM0096  SAHA K562 20.00  LDD0269  [4]

References

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2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840