Details of the Probe

General Information of Probe

Probe ID
LDPC0413
Probe Name
C173
Synonyms
Z3433405276
Probe Type
PAL-AfBPP Probe
Structure
3D MOL 2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 329.38
Lipid-water partition coefficient (xlogp) 1.6
Rotatable Bond Count (rotbonds) 8
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 7
Chemical Identifiers
Formula
C14H15N7OS
IUPAC Name
N-[2-(3-but-3-ynyldiazirin-3-yl)ethyl]-2-(5-thiophen-3-yltetrazol-1-yl)acetamide
Canonical SMILES
C#CCCC1(N=N1)CCNC(=O)CN2C(=NN=N2)C3=CSC=C3
InChI
InChI=1S/C14H15N7OS/c1-2-3-5-14(17-18-14)6-7-15-12(22)9-21-13(16-19-20-21)11-4-8-23-10-11/h1,4,8,10H,3,5-7,9H2,(H,15,22)
InChIKey
LWVOQVXIKJLTCI-UHFFFAOYSA-N

The Probe Interaction Atlas

Target(s) List of this Probe

59 Enzyme Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5) LDTP12639 6.19  LDD1853 
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) LDTP11321 5.94  LDD1853 
Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) LDTP03560 5.74  LDD1853 
Beta-1,4-galactosyltransferase 3 (B4GALT3) LDTP00994 5.70  LDD1853 
BRCA1-associated protein (BRAP) LDTP08084 5.54  LDD1853 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 6.68  LDD1853 
Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) LDTP03257 11.24  LDD1853 
Ceramide glucosyltransferase (UGCG) LDTP06617 5.46  LDD1853 
Choline kinase alpha (CHKA) LDTP03787 12.04  LDD1853 
Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) LDTP08933 9.78  LDD1853 
COP9 signalosome complex subunit 4 (COPS4) LDTP11187 6.32  LDD1853 
Cytochrome b5 type B (CYB5B) LDTP00697 17.75  LDD1853 
Cytochrome P450 20A1 (CYP20A1) LDTP17410 5.58  LDD1853 
Delta(24)-sterol reductase (DHCR24) LDTP06375 13.74  LDD1853 
Dihydrofolate reductase (DHFR) LDTP01769 5.24  LDD1853 
E3 ubiquitin-protein ligase SHPRH (SHPRH) LDTP06253 5.66  LDD1853 
eEF1A lysine and N-terminal methyltransferase (METTL13) LDTP08947 5.24  LDD1853 
Endoplasmic reticulum transmembrane helix translocase (ATP13A1) LDTP12279 7.06  LDD1853 
Epoxide hydrolase 1 (EPHX1) LDTP02175 17.39  LDD1853 
Exonuclease 1 (EXO1) LDTP13751 10.20  LDD1853 
Heme oxygenase 1 (HMOX1) LDTP02359 7.89  LDD1853 
Heme oxygenase 2 (HMOX2) LDTP03540 29.24  LDD1853 
Histone-lysine N-methyltransferase 2A (KMT2A) LDTP05396 6.73  LDD1853 
Holocytochrome c-type synthase (HCCS) LDTP04581 5.43  LDD1853 
Hydroxysteroid dehydrogenase-like protein 2 (HSDL2) LDTP07762 6.36  LDD1853 
Isochorismatase domain-containing protein 1 (ISOC1) LDTP19851 9.58  LDD1853 
Kinesin-like protein KIF11 (KIF11) LDTP04519 5.43  LDD1853 
L-2-hydroxyglutarate dehydrogenase, mitochondrial (L2HGDH) LDTP12105 10.34  LDD1853 
Lanosterol 14-alpha demethylase (CYP51A1) LDTP06648 7.89  LDD1853 
Lysophosphatidic acid phosphatase type 6 (ACP6) LDTP12363 5.94  LDD1853 
Lysosomal Pro-X carboxypeptidase (PRCP) LDTP04004 8.57  LDD1853 
Methionine aminopeptidase 2 (METAP2) LDTP04375 12.73  LDD1853 
N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) LDTP11273 6.23  LDD1853 
NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) LDTP00832 7.57  LDD1853 
Nicotinamide phosphoribosyltransferase (NAMPT) LDTP04051 19.43  LDD1853 
Palmitoyltransferase ZDHHC13 (ZDHHC13) LDTP08455 6.36  LDD1853 
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) LDTP10101 5.31  LDD1853 
Peroxisomal leader peptide-processing protease (TYSND1) LDTP06720 5.43  LDD1853 
Phospholipase A2 group XV (PLA2G15) LDTP09088 6.28  LDD1853 
Poly [ADP-ribose] polymerase 2 (PARP2) LDTP13240 15.24  LDD1853 
Prenylcysteine oxidase 1 (PCYOX1) LDTP13282 6.87  LDD1853 
Proteasome subunit beta type-2 (PSMB2) LDTP04285 6.06  LDD1853 
Protein O-GlcNAcase (OGA) LDTP00988 17.51  LDD1853 
Protein SCO1 homolog, mitochondrial (SCO1) LDTP01335 5.58  LDD1853 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 14.93  LDD1853 
RAC-beta serine/threonine-protein kinase (AKT2) LDTP03608 6.45  LDD1853 
Serum paraoxonase/arylesterase 2 (PON2) LDTP06333 10.06  LDD1853 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 6.19  LDD1853 
Sphingosine kinase 2 (SPHK2) LDTP12490 7.01  LDD1853 
Spliceosome-associated protein CWC27 homolog (CWC27) LDTP07688 7.78  LDD1853 
Squalene synthase (FDFT1) LDTP03842 8.51  LDD1853 
TLC domain-containing protein 1 (TLCD1) LDTP10182 8.88  LDD1853 
Trimethyllysine dioxygenase, mitochondrial (TMLHE) LDTP12679 5.86  LDD1853 
Ubiquitin carboxyl-terminal hydrolase 24 (USP24) LDTP13720 5.17  LDD1853 
UDP-glucuronic acid decarboxylase 1 (UXS1) LDTP09074 5.66  LDD1853 
Uracil-DNA glycosylase (UNG) LDTP02643 5.54  LDD1853 
V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) LDTP14030 5.94  LDD1853 
Valacyclovir hydrolase (BPHL) LDTP08322 10.41  LDD1853 
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL) LDTP04289 12.47  LDD1853 
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⏷ Show the Full List of 59 Enzyme
27 Transporter and channel Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
ER lumen protein-retaining receptor 1 (KDELR1) LDTP03277 5.28  LDD1853 
Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) LDTP01100 16.00  LDD1853 
Magnesium transporter NIPA3 (NIPAL1) LDTP17362 10.48  LDD1853 
Major facilitator superfamily domain-containing protein 3 (MFSD3) LDTP18153 5.98  LDD1853 
Membrane-associated progesterone receptor component 2 (PGRMC2) LDTP00562 7.01  LDD1853 
Metaxin-1 (MTX1) LDTP05900 8.51  LDD1853 
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) LDTP10913 9.65  LDD1853 
Mitochondrial ornithine transporter 1 (SLC25A15) LDTP14200 7.36  LDD1853 
Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) LDTP07885 7.67  LDD1853 
Mpv17-like protein 2 (MPV17L2) LDTP14952 10.56  LDD1853 
Protein ARV1 (ARV1) LDTP11812 7.73  LDD1853 
Protein GPR107 (GPR107) LDTP07236 5.43  LDD1853 
Reduced folate transporter (SLC19A1) LDTP03952 6.87  LDD1853 
Scavenger receptor class B member 1 (SCARB1) LDTP09547 5.54  LDD1853 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 9.19  LDD1853 
Solute carrier family 35 member F2 (SLC35F2) LDTP17641 6.15  LDD1853 
Sorting and assembly machinery component 50 homolog (SAMM50) LDTP14084 13.64  LDD1853 
STARD3 N-terminal-like protein (STARD3NL) LDTP01671 5.50  LDD1853 
Syntaxin-6 (STX6) LDTP00857 5.82  LDD1853 
Translocating chain-associated membrane protein 1 (TRAM1) LDTP06426 12.04  LDD1853 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 8.57  LDD1853 
Transmembrane 9 superfamily member 3 (TM9SF3) LDTP18448 5.28  LDD1853 
Transmembrane protein 199 (TMEM199) LDTP08881 5.98  LDD1853 
Transmembrane protein 59 (TMEM59) LDTP11406 9.38  LDD1853 
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) LDTP09968 5.94  LDD1853 
Voltage-dependent anion-selective channel protein 1 (VDAC1) LDTP03132 5.50  LDD1853 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 6.28  LDD1853 
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⏷ Show the Full List of 27 Transporter and channel
37 Other Labeled by This Probe
Target Name Target ID Binding Site(Ratio) Interaction ID
Apolipoprotein L2 (APOL2) LDTP11076 10.06  LDD1853 
Beta-2-syntrophin (SNTB2) LDTP05864 5.17  LDD1853 
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) LDTP13755 9.78  LDD1853 
Centrosomal protein 43 (CEP43) LDTP01652 7.73  LDD1853 
Clustered mitochondria protein homolog (CLUH) LDTP14486 6.92  LDD1853 
Coiled-coil domain-containing protein 97 (CCDC97) LDTP19860 5.98  LDD1853 
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) LDTP13902 11.96  LDD1853 
Dymeclin (DYM) LDTP08000 14.72  LDD1853 
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) LDTP13828 8.82  LDD1853 
ER lumen protein-retaining receptor 2 (KDELR2) LDTP03678 8.11  LDD1853 
Large proline-rich protein BAG6 (BAG6) LDTP04094 5.90  LDD1853 
Mitochondrial fission process protein 1 (MTFP1) LDTP16192 5.62  LDD1853 
Mitochondrial import receptor subunit TOM22 homolog (TOMM22) LDTP12565 18.38  LDD1853 
Mitochondrial import receptor subunit TOM5 homolog (TOMM5) LDTP15420 14.22  LDD1853 
Neudesin (NENF) LDTP13630 7.16  LDD1853 
Neuferricin (CYB5D2) LDTP15623 7.41  LDD1853 
Nidogen-1 (NID1) LDTP02728 7.06  LDD1853 
Nucleobindin-2 (NUCB2) LDTP05160 9.99  LDD1853 
Nucleosome assembly protein 1-like 1 (NAP1L1) LDTP04684 6.11  LDD1853 
Nucleosome assembly protein 1-like 4 (NAP1L4) LDTP10965 7.46  LDD1853 
Optic atrophy 3 protein (OPA3) LDTP16006 8.63  LDD1853 
Oxysterol-binding protein-related protein 6 (OSBPL6) LDTP11533 7.01  LDD1853 
Phosphatidylethanolamine-binding protein 1 (PEBP1) LDTP03520 12.91  LDD1853 
Poly(U)-binding-splicing factor PUF60 (PUF60) LDTP13311 6.87  LDD1853 
Protein CUSTOS (CUSTOS) LDTP18134 5.17  LDD1853 
Protein CutA (CUTA) LDTP01075 13.64  LDD1853 
Protein Hook homolog 2 (HOOK2) LDTP10255 5.50  LDD1853 
Protein unc-119 homolog B (UNC119B) LDTP00105 8.75  LDD1853 
Rap guanine nucleotide exchange factor 2 (RAPGEF2) LDTP14058 9.65  LDD1853 
Reticulon-3 (RTN3) LDTP01522 5.17  LDD1853 
RNA-binding protein 3 (RBM3) LDTP05226 5.94  LDD1853 
Syntaxin-18 (STX18) LDTP13086 9.06  LDD1853 
Syntaxin-binding protein 2 (STXBP2) LDTP06487 6.02  LDD1853 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 6.15  LDD1853 
U6 snRNA-associated Sm-like protein LSm3 (LSM3) LDTP04979 5.58  LDD1853 
Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) LDTP15067 37.27  LDD1853 
WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) LDTP07037 5.62  LDD1853 
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⏷ Show the Full List of 37 Other

Full Information of The Labelling Profiles of This Probe

Quantification: AfBPP Probe vs Negative Probe
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration
Probe:50uM; negative probe:50uM
Quantitative Method
TMT
In Vitro Experiment Model
Model Type
Living cell
Derived Tissue
Peripheral blood
Disease Model
Normal
Model Name
Human normal cells (HEK-293T)
Note
Negative probe:C#CCCC1(CCC(NC)=O)N=N1
Interaction Atlas ID
 LDD1853 
Download The Altas

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587