Details of the Target

General Information of Target

Target ID LDTP10255
Target Name Protein Hook homolog 2 (HOOK2)
Gene Name HOOK2
Gene ID 29911
Synonyms
Protein Hook homolog 2; h-hook2; hHK2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEAEESPGDPGTASPRPLFAGLSDISISQDIPVEGEITIPMRSRIREFDSSTLNESVRN
TIMRDLKAVGKKFMHVLYPRKSNTLLRDWDLWGPLILCVTLALMLQRDSADSEKDGGPQF
AEVFVIVWFGAVTITLNSKLLGGNISFFQSLCVLGYCILPLTVAMLICRLVLLADPGPVN
FMVRLFVVIVMFAWSIVASTAFLADSQPPNRRALAVYPVFLFYFVISWMILTFTPQ
Target Bioclass
Other
Family
Hook family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell.
Uniprot ID
Q96ED9
Ensemble ID
ENST00000264827.9
HGNC ID
HGNC:19885

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.E371NfsTer11 .
CAMA1 SNV: p.E660Q .
CHL1 SNV: p.G120C .
HCT15 SNV: p.A274T DBIA    Probe Info 
HEC1 SNV: p.R193H DBIA    Probe Info 
HEC1B SNV: p.R193H .
JURKAT SNV: p.Q29Ter .
KMCH1 SNV: p.D554H DBIA    Probe Info 
KURAMOCHI SNV: p.I537V .
LN229 SNV: p.C25F .
MCC26 SNV: p.E182K .
MDAMB231 SNV: p.P108R .
P31FUJ SNV: p.Q43L .
RCC10RGB SNV: p.F179I .
SKMM2 SNV: p.E483G .
SNU1079 SNV: p.V610G DBIA    Probe Info 
SW1783 SNV: p.R221W .
SW620 SNV: p.E246D .
UACC62 SNV: p.P225L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K128(10.00)  LDD0277  [1]
Probe 1
 Probe Info  		Y167(11.77); Y563(7.67)  LDD3495  [2]
HPAP
 Probe Info  		3.38  LDD0062  [3]
DBIA
 Probe Info  		C121(0.90); C125(0.90); C423(1.00)  LDD0531  [4]
IA-alkyne
 Probe Info  		C194(0.00); C317(0.00); C390(0.00)  LDD0162  [5]
IPM
 Probe Info  		C317(0.00); C423(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C317(0.00); C423(0.00)  LDD0148  [6]
AOyne
 Probe Info  		13.40  LDD0443  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		15.03  LDD1760  [9]
C106
 Probe Info  		18.25  LDD1793  [9]
C158
 Probe Info  		9.13  LDD1838  [9]
C173
 Probe Info  		5.50  LDD1853  [9]
C201
 Probe Info  		97.68  LDD1877  [9]
C205
 Probe Info  		7.52  LDD1880  [9]
C206
 Probe Info  		21.56  LDD1881  [9]
C207
 Probe Info  		21.86  LDD1882  [9]
C313
 Probe Info  		28.05  LDD1980  [9]
C356
 Probe Info  		14.83  LDD2017  [9]
C361
 Probe Info  		17.15  LDD2022  [9]
C362
 Probe Info  		31.78  LDD2023  [9]
C363
 Probe Info  		27.47  LDD2024  [9]
C364
 Probe Info  		20.11  LDD2025  [9]
C388
 Probe Info  		37.27  LDD2047  [9]
C403
 Probe Info  		19.97  LDD2061  [9]
C413
 Probe Info  		23.10  LDD2069  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C121(0.90); C125(0.90); C423(1.00)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C423(1.29)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C121(0.84); C125(0.84)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C121(0.79); C125(0.79)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C121(0.75); C125(0.75)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C121(0.89); C125(0.89)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C121(0.84); C125(0.84)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C121(0.87); C125(0.87)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C121(0.89); C125(0.89)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C121(1.12); C125(1.12)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C121(0.60); C125(0.60)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C121(0.71); C125(0.71)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C423(1.11)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C121(0.76); C125(0.76)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C121(0.76); C125(0.76)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C121(0.93); C125(0.93)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C423(1.10)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C423(1.07)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C423(1.13)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C423(0.99)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C423(1.22)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C423(1.19)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C423(1.11)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C423(0.72)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C423(1.09)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C423(1.04)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C423(1.01)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C423(1.21)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C423(1.04)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C423(0.96)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C423(1.08)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C423(1.16)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C423(1.71)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C423(1.28)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C423(2.14)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C423(1.14)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C423(1.27)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C423(1.49)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C423(1.62)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C423(1.82)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C423(1.02)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C423(0.92)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C423(1.99)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C423(1.87)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C423(0.74)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C423(1.63)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C423(1.49)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C423(1.14)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C423(1.34)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C423(0.95)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C423(0.98)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C423(1.13)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C423(0.90)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C423(1.03)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C423(1.09)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C423(0.82)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C423(0.85)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C423(1.04)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C423(1.09)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C423(1.60)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C423(1.19)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C423(1.06)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C423(1.19)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C423(1.36)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C423(0.60)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C423(0.97)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C423(0.77)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C121(0.99); C125(0.99); C423(1.15)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C423(0.45)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C423(0.52)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C423(0.55)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C423(0.56)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C423(0.58)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C423(1.67)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C423(1.83)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C423(1.92)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C423(1.46)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C423(1.78)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C423(1.02); C121(1.06); C125(1.06)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C423(1.55)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C423(1.32)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C423(1.51)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C423(1.70)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C423(1.58)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C423(1.13)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C423(0.73)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C423(0.67)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C423(0.71)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C423(0.82)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C121(1.28); C125(1.28); C423(1.71)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C423(0.75)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C423(0.79)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C423(0.85)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C423(0.77)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C423(0.59)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C423(0.70)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C423(1.17)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C423(0.75)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C423(1.23)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C423(1.26)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C121(1.26); C125(1.26); C423(1.44)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C423(1.31)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C423(0.94)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C423(0.98)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C423(0.85)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C423(1.64)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C423(0.95)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C423(1.16)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C423(1.11)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C423(0.88)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C423(1.02)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C423(0.80)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C423(1.21)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C423(0.95)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C423(1.11)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C423(0.93)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C423(1.23)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C423(1.08)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C423(0.90)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C423(1.01)  LDD0648  [4]
 LDCM0334  AC7 HCT 116 C423(0.59)  LDD0651  [4]
 LDCM0345  AC8 HCT 116 C423(0.98)  LDD0662  [4]
 LDCM0349  AC83 HCT 116 C121(1.15); C125(1.15)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C121(1.47); C125(1.47)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C121(1.45); C125(1.45)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C121(1.27); C125(1.27)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C121(0.98); C125(0.98)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C121(0.93); C125(0.93)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C121(1.84); C125(1.84)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C121(1.22); C125(1.22)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C121(1.37); C125(1.37)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C121(1.81); C125(1.81)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C121(1.18); C125(1.18)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C121(1.06); C125(1.06)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C121(1.39); C125(1.39)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C121(1.28); C125(1.28)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C121(1.33); C125(1.33)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C121(0.87); C125(0.87)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C121(0.79); C125(0.79)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C423(1.06)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C423(1.76)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C423(1.09)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C317(1.04)  LDD2171  [4]
 LDCM0632  CL-Sc Hep-G2 C317(0.99)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C423(1.36)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C423(1.49)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C423(1.02); C121(1.08); C125(1.08)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C423(1.04)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C423(0.65)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C423(0.90)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C423(0.84)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C423(0.46)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C423(0.78)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C423(0.88)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C423(0.61)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C423(0.82)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C423(1.08)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C423(0.70)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C423(0.84)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C423(0.94)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C423(1.71)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C423(1.48)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C423(1.36)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C423(2.04)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C423(0.62)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C423(0.86)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C423(0.77)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C423(1.47)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C423(0.76)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C423(0.76)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C423(0.68)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C423(0.66)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C423(1.01)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C423(0.95)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C423(0.66)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C423(0.90)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C423(0.87)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C423(1.25)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C423(1.31)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C423(1.15)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C423(1.54)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C423(0.81)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C423(0.80)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C423(0.89)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C423(1.11)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C423(1.08)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C423(0.84)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C423(0.83)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C423(1.06)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C423(1.03)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C423(0.87)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C423(1.32)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C423(1.01)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C423(1.00)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C423(0.94)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C423(1.06)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C423(1.15)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C121(1.19); C125(1.19)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C121(0.98); C125(0.98)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C121(1.03); C125(1.03)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C121(1.06); C125(1.06)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C121(1.06); C125(1.06)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C121(1.30); C125(1.30)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C121(1.24); C125(1.24)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C121(0.95); C125(0.95)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C423(1.13)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C121(0.78); C125(0.78)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C121(1.19); C125(1.19)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C121(1.23); C125(1.23)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C121(1.32); C125(1.32)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C121(1.17); C125(1.17)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C121(1.12); C125(1.12)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C125(1.26)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C125(1.14)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C125(0.93)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C125(1.13)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C423(1.02)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C125(1.37)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C125(1.31)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C125(0.99)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C125(1.15)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C125(1.32)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C125(1.16)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C125(0.93)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C125(1.37)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C125(1.05)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C125(1.22)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C423(1.20)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C125(1.37)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C423(0.81)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C423(0.94)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C423(1.26)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C423(0.71)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C423(1.05)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C423(1.20)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C423(0.89)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C423(0.73)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C423(1.56)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C423(1.16)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C423(1.05)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C423(0.95)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C423(0.92)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C423(0.87)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C423(1.24)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C121(1.09); C125(1.09); C423(1.13)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C121(0.84); C125(0.84); C423(0.79)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C121(1.09); C125(1.09); C423(0.72)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C121(1.21); C125(1.21); C423(1.19)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C423(1.25)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C121(0.84); C125(0.84); C423(0.79)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C121(1.14); C125(1.14); C423(0.91)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C121(1.56); C125(1.56); C423(1.10)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C121(1.26); C125(1.26); C423(0.92)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C121(1.47); C125(1.47); C423(0.99)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C121(1.05); C125(1.05); C423(1.40)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C121(1.12); C125(1.12); C423(1.23)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C121(1.12); C125(1.12); C423(0.91)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C121(1.46); C125(1.46); C423(1.21)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C121(1.97); C125(1.97); C423(1.02)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C423(1.16)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C121(0.92); C125(0.92); C423(1.50)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C121(1.00); C125(1.00); C423(1.15)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C121(0.76); C125(0.76); C423(0.74)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C121(0.77); C125(0.77); C423(0.98)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C121(0.82); C125(0.82); C423(1.48)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C121(0.87); C125(0.87); C423(0.98)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C121(1.08); C125(1.08); C423(0.94)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C121(0.99); C125(0.99); C423(1.04)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C121(0.98); C125(0.98); C423(1.20)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C121(1.06); C125(1.06); C423(1.20)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C423(1.01); C317(1.04); C125(1.01)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C423(1.09)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C121(1.24); C125(1.24)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C423(0.89); C317(0.98)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C423(0.95); C317(1.05)  LDD1497  [10]
 LDCM0024  KB05 G361 C423(2.22)  LDD3311  [11]
 LDCM0014  Panhematin HEK-293T 3.38  LDD0062  [3]
 LDCM0021  THZ1 HCT 116 C317(1.04)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Cyclin-dependent kinase 18 (CDK18) CMGC Ser/Thr protein kinase family Q07002
Dual specificity protein phosphatase 13B (DUSP13B) Protein-tyrosine phosphatase family Q9UII6
E3 ubiquitin-protein ligase RNF169 (RNF169) RNF169 family Q8NCN4
GTP-binding protein GEM (GEM) RGK family P55040
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
AKT-interacting protein (AKTIP) Ubiquitin-conjugating enzyme family Q9H8T0
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
Leucine-rich repeat and guanylate kinase domain-containing protein (LRGUK) . Q96M69
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Zinc finger and BTB domain-containing protein 47 (ZBTB47) Krueppel C2H2-type zinc-finger protein family Q9UFB7
Zinc finger protein 1 homolog (ZFP1) Krueppel C2H2-type zinc-finger protein family Q6P2D0
Zinc finger protein 107 (ZNF107) Krueppel C2H2-type zinc-finger protein family Q9UII5
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Zinc finger protein 497 (ZNF497) Krueppel C2H2-type zinc-finger protein family Q6ZNH5
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Zinc finger protein 587 (ZNF587) Krueppel C2H2-type zinc-finger protein family Q96SQ5
Zinc finger protein 648 (ZNF648) Krueppel C2H2-type zinc-finger protein family Q5T619
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein 844 (ZNF844) Krueppel C2H2-type zinc-finger protein family Q08AG5
Other
Click To Hide/Show 45 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Bystin (BYSL) Bystin family Q13895
Cyclin-dependent kinase inhibitor 1 (CDKN1A) CDI family P38936
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Eukaryotic translation initiation factor 3 subunit D (EIF3D) EIF-3 subunit D family O15371
Protein FAM110A (FAM110A) FAM110 family Q9BQ89
Protein FAM161A (FAM161A) FAM161 family Q3B820
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Protein FAM50B (FAM50B) FAM50 family Q9Y247
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
FHF complex subunit HOOK interacting protein 2A (FHIP2A) FHIP family Q5W0V3
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Fibroblast growth factor 16 (FGF16) Heparin-binding growth factors family O43320
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
G-patch domain and KOW motifs-containing protein (GPKOW) MOS2 family Q92917
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
SNW domain-containing protein 1 (SNW1) SNW family Q13573
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Trichoplein keratin filament-binding protein (TCHP) TCHP family Q9BT92
U3 small nucleolar RNA-associated protein 14 homolog C (UTP14C) UTP14 family Q5TAP6
Zinc finger C2HC domain-containing protein 1C (ZC2HC1C) ZC2HC1 family Q53FD0
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Calcium-binding protein 2 (CABP2) . Q9NPB3
Centrosomal protein of 95 kDa (CEP95) . Q96GE4
Chromobox protein homolog 8 (CBX8) . Q9HC52
Coiled-coil domain-containing protein 33 (CCDC33) . Q8N5R6
Cytohesin-4 (CYTH4) . Q9UIA0
Enkurin domain-containing protein 1 (ENKD1) . Q9H0I2
FLYWCH-type zinc finger-containing protein 1 (FLYWCH1) . Q4VC44
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3
Leukocyte receptor cluster member 1 (LENG1) . Q96BZ8
Microspherule protein 1 (MCRS1) . Q96EZ8
MORN repeat-containing protein 3 (MORN3) . Q6PF18
Phostensin (PPP1R18) . Q6NYC8
Proline-rich protein 35 (PRR35) . P0CG20
Protein phosphatase 1 regulatory subunit 26 (PPP1R26) . Q5T8A7
Protein PIMREG (PIMREG) . Q9BSJ6
Putative ankyrin repeat domain-containing protein 26-like 1 (ANKRD36BP1) . Q96IX9
RNA-binding protein 41 (RBM41) . Q96IZ5
SH2 domain-containing protein 4A (SH2D4A) . Q9H788
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840