Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C205  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 37.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 27.7
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 15.2
 LDTP08933  Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2) 13.7
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 11.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.5
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 11.2
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 11.1
 LDTP00988  Protein O-GlcNAcase (OGA) 9.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 9.5
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 9.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.8
 LDTP14030  V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2) 8.0
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 7.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 7.8
 LDTP03787  Choline kinase alpha (CHKA) 7.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 7.6
 LDTP13751  Exonuclease 1 (EXO1) 7.5
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 7.5
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 7.4
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 6.5
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 5.9
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.8
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 5.5
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 5.5
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) 5.4
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 5.4
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 5.4
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 5.3
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 5.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 5.0
Transporter and channel
Click to Show/Hide to Show 23 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 11.6
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 11.2
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 10.3
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 9.7
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 9.3
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 9.3
 LDTP07236  Protein GPR107 (GPR107) 8.8
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 8.6
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 8.1
 LDTP05900  Metaxin-1 (MTX1) 7.9
 LDTP02215  Prosaposin (PSAP) 7.7
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 7.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 7.5
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 6.7
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 6.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 5.8
 LDTP01969  Transferrin receptor protein 1 (TFRC) 5.8
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 5.4
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 5.3
 LDTP17641  Solute carrier family 35 member F2 (SLC35F2) 5.2
 LDTP11615  Protein tweety homolog 3 (TTYH3) 5.2
 LDTP02071  Amyloid-beta precursor protein (APP) 5.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13718  Zinc finger CCCH domain-containing protein 4 (ZC3H4) 5.1
Other
Click to Show/Hide to Show 19 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 13.5
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 13.5
 LDTP01652  Centrosomal protein 43 (CEP43) 11.5
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 11.1
 LDTP05160  Nucleobindin-2 (NUCB2) 10.9
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 8.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 8.7
 LDTP10255  Protein Hook homolog 2 (HOOK2) 7.5
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 7.1
 LDTP13630  Neudesin (NENF) 6.8
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.6
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 5.8
 LDTP09920  Golgi apparatus protein 1 (GLG1) 5.6
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 5.5
 LDTP13086  Syntaxin-18 (STX18) 5.4
 LDTP05375  Nucleobindin-1 (NUCB1) 5.2
 LDTP04396  RNA-binding protein FXR2 (FXR2) 5.2
 LDTP01359  Dynactin subunit 3 (DCTN3) 5.1
 LDTP12412  Reticulon-4 (RTN4) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587