Details of the Target

General Information of Target

Target ID LDTP04396
Target Name RNA-binding protein FXR2 (FXR2)
Gene Name FXR2
Gene ID 9513
Synonyms
FMR1L2; RNA-binding protein FXR2; FXR2P; FMR1 autosomal homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGLASGGDVEPGLPVEVRGSNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLP
PPADYNKEITEGDEVEVYSRANEQEPCGWWLARVRMMKGDFYVIEYAACDATYNEIVTLE
RLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKEFKKALGANCIFLNITNSELFI
LSTTEAPVKRASLLGDMHFRSLRTKLLLMSRNEEATKHLETSKQLAAAFQEEFTVREDLM
GLAIGTHGANIQQARKVPGVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPR
NLVGKVIGKNGKVIQEIVDKSGVVRVRVEGDNDKKNPREEGMVPFIFVGTRENISNAQAL
LEYHLSYLQEVEQLRLERLQIDEQLRQIGLGFRPPGSGRGSGGSDKAGYSTDESSSSSLH
ATRTYGGSYGGRGRGRRTGGPAYGPSSDVSTASETESEKREEPNRAGPGDRDPPTRGEES
RRRPTGGRGRGPPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEPPVDSEPGEPPP
ASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDESRPQRRNRSRRRRNRGNRTDG
SISGDRQPVTVADYISRAESQSRQRPPLERTKPSEDSLSGQKGDSVSKLPKGPSENGELS
APLELGSMVNGVS
Target Bioclass
Other
Family
FMR1 family
Subcellular location
Cytoplasm, Cytoplasmic ribonucleoprotein granule
Function
mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability. Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus.
Uniprot ID
P51116
Ensemble ID
ENST00000250113.12
HGNC ID
HGNC:4024
ChEMBL ID
CHEMBL5169136

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K205(5.10)  LDD0277  [3]
Probe 1
 Probe Info  		Y78(13.73); Y288(10.72); Y443(9.76)  LDD3495  [4]
BTD
 Probe Info  		C151(1.48)  LDD1700  [5]
Sulforaphane-probe2
 Probe Info  		4.14  LDD0042  [6]
DA-P3
 Probe Info  		13.92  LDD0180  [7]
AHL-Pu-1
 Probe Info  		C270(2.89)  LDD0169  [8]
DBIA
 Probe Info  		C87(1.09); C151(1.00)  LDD0078  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C87(0.00); C282(0.00); C151(0.00); C270(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C151(0.00); C270(0.00)  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C87(0.00); C282(0.00); C168(0.00); C151(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C87(0.00); C270(0.00); C282(0.00)  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
WYneN
 Probe Info  		C282(0.00); C270(0.00)  LDD0021  [16]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
IPM
 Probe Info  		C282(0.00); C270(0.00)  LDD0147  [15]
SF
 Probe Info  		N.A.  LDD0028  [17]
Phosphinate-6
 Probe Info  		C168(0.00); C87(0.00)  LDD0018  [18]
Acrolein
 Probe Info  		C151(0.00); C282(0.00); C270(0.00)  LDD0217  [19]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [19]
Methacrolein
 Probe Info  		C151(0.00); C282(0.00)  LDD0218  [19]
W1
 Probe Info  		C282(0.00); C151(0.00)  LDD0236  [20]
NAIA_5
 Probe Info  		C168(0.00); C151(0.00); C282(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y409(0.70)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		8.82  LDD1714  [22]
C205
 Probe Info  		5.17  LDD1880  [22]
C280
 Probe Info  		9.92  LDD1950  [22]
C364
 Probe Info  		16.34  LDD2025  [22]
FFF probe11
 Probe Info  		20.00  LDD0471  [23]
FFF probe13
 Probe Info  		20.00  LDD0475  [23]
FFF probe3
 Probe Info  		10.22  LDD0464  [23]
FFF probe6
 Probe Info  		12.84  LDD0467  [23]
OEA-DA
 Probe Info  		11.95  LDD0046  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C151(0.75)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C151(1.02); C282(0.76)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C151(1.69)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C151(0.51)  LDD2132  [5]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C151(0.68)  LDD2131  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C270(2.89)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C109(1.29); C151(1.06); C270(1.13); C282(1.46)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C109(0.91); C270(1.29); C87(0.93)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C151(0.64); C270(1.18); C87(0.82)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C151(0.64); C270(1.62); C87(0.94)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C151(0.68); C270(1.23); C87(0.97)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C151(0.56); C270(1.81); C87(0.88)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C151(0.60); C270(0.97); C87(0.91)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C151(0.63); C270(1.57); C87(0.93)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C151(0.66); C270(1.76); C87(0.78)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C151(0.65); C270(1.41); C87(0.90)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C151(0.70); C270(1.16); C87(0.80)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C151(0.79); C270(0.97); C87(0.79)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C109(1.48); C270(2.06); C87(0.96)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C151(0.67); C270(1.63); C87(0.86)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C151(0.65); C270(1.46); C87(0.85)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C151(0.64); C270(1.61); C87(0.88)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C109(0.97); C270(0.99); C282(1.09); C87(0.98)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C109(1.20); C270(1.04); C282(1.04); C87(1.06)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C109(1.43); C270(1.23); C282(1.15); C87(1.04)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C109(1.37); C270(1.51); C282(1.07); C87(1.09)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C109(1.36); C270(1.24); C282(0.94); C87(1.05)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C109(1.27); C270(1.10); C282(1.17); C87(1.04)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C109(1.02); C270(1.11); C282(1.49); C87(1.06)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C109(1.34); C270(1.76); C87(0.90)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C109(1.30); C270(1.02); C282(1.06); C87(1.04)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C109(0.77); C270(1.06); C282(1.23); C87(1.17)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C109(1.15); C270(1.20); C282(1.30); C87(0.95)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C109(0.95); C270(1.00); C282(1.03); C87(1.10)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C109(1.22); C270(1.13); C282(1.19); C87(1.20)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C109(1.34); C270(1.30); C282(1.17); C87(1.02)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C109(1.73); C270(1.27); C282(1.26); C87(1.00)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C109(1.14); C270(1.34); C282(1.17); C87(1.16)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C270(0.79); C87(0.78)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C270(0.60); C87(1.02)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C270(0.72); C87(0.86)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C270(0.64); C87(1.05)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C270(0.70); C87(0.89)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C270(0.76); C87(0.82)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C270(0.88); C87(0.89)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C270(0.78); C87(0.81)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C270(0.76); C87(0.84)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C270(0.73); C87(0.86)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C270(0.87); C87(0.85)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C270(0.85); C87(0.92)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C109(1.17); C270(1.01); C87(0.98)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C270(0.91); C87(0.77)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C270(0.88); C87(0.89)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C270(0.73); C87(0.85)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C270(1.02); C87(1.30)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C270(0.86); C87(1.12)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C270(0.91); C87(1.11)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C270(0.94); C87(1.11)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C270(0.90); C87(1.13)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C270(1.00); C87(1.13)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C87(1.12); C270(1.14)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C87(0.95); C109(1.08); C270(1.24)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C270(0.77); C87(1.10)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C270(0.92); C87(1.10)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C270(0.92); C87(0.98)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C87(1.18); C270(1.19)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C270(1.01); C87(1.03)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C270(1.05); C87(1.07)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C270(1.10); C87(1.27)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C270(1.03); C87(1.28)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C270(0.55); C151(0.95); C87(1.09)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C270(0.62); C151(0.96); C87(1.33)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C270(0.54); C151(0.94); C87(1.29)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C87(0.90); C151(1.15); C282(1.42); C109(1.59)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C270(0.54); C151(0.88); C87(1.20)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C270(0.83); C151(0.88); C87(1.10)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C270(0.72); C151(0.88); C87(1.03)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C270(0.59); C151(0.89); C87(1.15)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C270(0.69); C151(0.92); C87(1.16)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C87(0.81); C109(0.93); C151(1.05)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C87(0.87); C151(1.17); C109(1.34)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C87(0.86); C109(1.02); C151(1.25)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C87(0.81); C109(0.85); C151(1.08)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C109(0.80); C87(0.89); C151(1.04)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C87(0.87); C151(1.24); C109(1.24); C282(1.38)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C87(0.90); C109(1.12); C151(1.14)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C87(0.82); C151(1.13); C109(1.19)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C87(0.86); C151(1.16); C109(1.38)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C87(0.89); C151(1.13); C109(1.44)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C87(0.93); C151(1.09); C109(1.56)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C87(1.01); C151(1.17)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C87(1.03); C151(1.16)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C151(1.19); C87(1.36)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C151(1.02); C87(1.14)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C87(0.88); C151(1.13)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C87(0.93); C151(1.21); C282(1.30); C109(1.49)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C151(1.05); C87(1.19)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C87(1.02); C151(1.11)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C151(1.00); C87(1.14)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C87(1.10); C151(1.11)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C151(1.04); C87(1.09)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C151(1.02); C87(1.13)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C282(0.78); C270(0.94); C151(0.98); C87(1.12)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C282(0.76); C87(0.99); C270(1.01); C151(1.01)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C282(0.56); C87(1.03); C151(1.09); C270(1.31)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C282(0.61); C270(0.78); C87(0.94); C151(1.02)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C87(0.93); C151(1.24); C282(1.30); C109(1.50)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C282(0.79); C270(0.81); C151(0.94); C87(1.05)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C282(0.79); C87(0.94); C151(1.04); C270(1.43)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C282(0.69); C151(0.95); C270(1.04); C87(1.27)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C151(0.97); C270(0.99); C282(1.00); C87(1.32)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C282(0.71); C270(0.86); C151(0.94); C87(1.30)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C270(0.80); C87(0.90); C151(1.00); C282(1.64)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C282(0.81); C270(0.85); C151(1.06); C87(1.20)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C270(0.59); C87(0.97); C151(1.04)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C270(0.57); C151(1.05); C87(1.27)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C270(0.58); C87(0.99); C151(1.05)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C87(0.99); C270(1.14); C109(1.56)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C270(0.63); C87(1.02); C151(1.12)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C270(0.85); C87(0.90); C151(1.09)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C270(0.49); C151(1.01); C87(1.03)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C270(0.61); C87(0.97); C151(0.99)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C270(0.54); C151(1.08); C87(1.12)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C270(0.44); C87(0.94); C151(1.24)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C270(0.45); C87(1.10); C151(1.26)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C270(0.40); C151(1.10); C87(1.12)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C282(0.83); C151(0.97); C87(1.00); C270(1.16)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C282(0.85); C87(0.95); C270(0.95); C151(0.97)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C87(0.90); C109(0.93); C270(1.14)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C151(0.87); C282(0.90); C87(1.02); C270(1.27)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C270(0.89); C282(0.99); C87(1.00); C151(1.03)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C151(0.87); C270(0.91); C87(0.93); C282(1.49)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C282(0.94); C87(0.97); C151(1.06); C270(1.32)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C282(0.92); C87(0.96); C151(1.03); C270(1.57)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C151(1.02); C282(1.03); C87(1.15); C270(1.31)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C151(0.89); C87(1.10); C282(1.18); C270(1.32)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C151(0.87); C282(0.92); C87(1.14); C270(1.22)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C270(0.96); C282(0.98); C151(1.01); C87(1.11)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C270(0.83); C282(0.86); C87(0.90); C151(1.06)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C87(1.07); C270(1.86); C109(2.13)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C282(0.82); C270(0.88); C151(0.94); C87(1.05)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C282(1.07); C151(1.25); C270(1.63); C87(1.70)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C282(0.88); C87(1.16); C151(1.33); C270(1.57)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C87(0.93); C282(1.00); C270(1.56)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C87(0.90); C282(0.91); C270(1.31)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C282(0.93); C87(1.03); C270(1.20)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C282(0.86); C87(0.91); C270(1.32)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C87(0.91); C282(1.13); C270(1.31)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C87(0.92); C282(0.94); C270(1.51)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C282(0.83); C87(1.01); C270(1.57)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C282(1.05); C87(1.32); C270(1.56)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C87(0.89); C282(0.89); C270(1.38)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C282(0.91); C87(1.00); C270(1.42)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C87(0.90); C282(1.00); C270(1.21)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C87(1.11); C282(1.12); C270(1.20)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C87(1.01); C282(1.11); C270(1.37)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C87(0.88); C282(1.07); C270(1.39)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C87(0.95); C282(1.11); C270(1.64)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C151(0.67); C87(0.82); C270(1.55)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C151(0.74); C87(0.82); C270(1.31)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C151(0.27)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C109(0.95); C270(2.10); C87(0.98)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C270(0.97); C87(1.03); C109(1.18)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C87(1.03); C270(1.64); C109(1.65)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 10.26  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C87(1.09); C151(1.00)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C151(0.55)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C109(1.61)  LDD2214  [25]
 LDCM0108  Chloroacetamide HeLa C270(0.00); C282(0.00); C151(0.00)  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C87(2.44); C151(1.58); C151(0.80); C282(0.69)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C87(0.91); C282(1.27)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C87(0.88); C282(1.08)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C87(0.91); C151(1.10); C282(1.35); C270(1.36)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C87(1.14); C109(1.30); C270(1.42)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C109(0.78); C87(1.06); C270(1.41)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C109(0.94); C87(1.01); C270(1.76)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C87(0.99); C109(1.24); C270(1.51)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C270(0.57); C151(0.90); C87(1.16)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C270(0.50); C151(0.97); C87(1.22)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C270(0.44); C151(0.96); C87(1.22)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C270(0.42); C151(0.92); C87(1.16)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C270(0.54); C151(0.86); C87(1.28)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C87(0.86); C282(0.92)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C270(0.48); C151(0.83); C87(1.13)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C270(0.66); C151(0.88); C87(1.23)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C109(0.67); C87(0.93); C151(1.03)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C87(0.89); C109(1.01); C151(1.06)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C87(0.70); C109(0.89); C151(0.99)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C87(0.93); C151(1.04); C109(1.24)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C87(0.87); C109(1.03); C151(1.09)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C87(1.14); C151(1.23)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C87(1.02); C151(1.12)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C87(1.07); C151(1.09)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C87(1.00); C282(1.08)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C87(0.98); C151(1.13)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C282(0.70); C151(0.92); C270(1.04); C87(1.08)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C282(0.85); C270(0.88); C151(1.02); C87(1.07)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C270(0.78); C87(0.95); C282(0.98); C151(0.98)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C282(0.83); C270(0.87); C151(1.00); C87(1.04)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C87(0.92); C270(0.96); C151(1.10)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C270(0.83); C151(1.07); C87(2.56)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C270(0.73); C87(0.99); C151(1.05)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C270(0.58); C87(1.02); C151(1.06)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C87(1.02); C282(1.12)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C87(1.19); C282(1.28)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C282(1.14); C87(1.43)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C282(0.81); C87(1.00); C270(1.23)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C270(0.85); C282(1.18); C87(1.31)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C87(1.08); C270(1.14); C282(1.35)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C87(0.97); C270(0.99); C282(1.34)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C87(0.87); C282(1.63)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C270(1.00); C87(1.07); C282(1.10)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C270(0.92); C87(1.09); C282(1.14)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C282(1.12); C87(1.22); C270(1.45)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C282(0.97); C270(0.99); C87(1.23)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C270(0.88); C87(0.99); C282(1.06)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C270(0.99); C282(1.37); C87(0.95)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C270(1.35); C282(1.90); C87(0.94)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C270(0.86); C282(1.22); C87(0.97)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C270(0.87); C282(1.14); C87(0.95)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C270(0.75); C282(1.11); C87(1.10)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C282(1.13); C87(0.88)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C270(1.01); C282(1.37); C87(0.94)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C151(0.97); C282(1.52); C87(0.92)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C151(1.06); C270(1.16); C282(1.09); C87(0.97)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C151(0.91); C270(0.66); C282(1.33); C87(1.17)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C151(0.91); C270(0.98); C282(1.34); C87(1.19)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C151(0.77); C270(0.66); C282(1.12); C87(1.10)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C151(0.84); C270(1.07); C282(1.05); C87(1.11)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C151(0.93); C270(1.00); C282(1.08); C87(0.97)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C151(0.75); C270(0.91); C282(1.26); C87(1.03)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C282(0.96); C87(0.87)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C151(0.79); C270(1.12); C282(1.15); C87(1.20)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C151(0.82); C270(0.99); C282(1.01); C87(1.02)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C151(0.97); C270(0.92); C282(0.97); C87(1.32)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C151(0.80); C270(0.95); C282(1.33); C87(1.28)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C151(0.89); C270(0.65); C282(1.24); C87(1.04)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C151(1.08); C270(0.72); C282(1.08); C87(1.91)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C270(1.00); C282(0.96); C87(0.99)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C270(1.05); C282(1.04); C87(0.86)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C270(1.30); C282(1.05); C87(0.91)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C270(0.79); C282(0.85); C87(1.13)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C282(1.12); C87(0.94)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C270(1.18); C282(0.89); C87(0.90)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C270(0.96); C282(0.86); C87(0.93)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C270(1.18); C282(0.98); C87(0.92)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C270(1.47); C282(0.95); C87(0.99)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C270(1.26); C282(0.96); C87(1.08)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C270(0.95); C282(1.01); C87(0.88)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C270(1.10); C282(0.98); C87(1.05)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C270(1.03); C282(0.90); C87(1.28)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C270(0.88); C282(1.07); C87(0.87)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C270(0.87); C282(0.98); C87(0.86)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C282(1.08); C87(0.88)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C270(1.07); C282(0.91); C87(1.07)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C151(0.92); C87(0.94)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C151(1.02); C87(1.05)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C151(0.92); C87(1.05)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C151(0.96); C87(1.13)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C151(0.88); C87(0.99)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C151(0.99); C87(1.05)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C151(0.86); C87(1.07)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C151(1.00); C87(1.06)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C151(1.05); C87(1.10)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C282(1.29); C87(0.96)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C151(0.98); C87(1.02)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C151(0.94); C87(1.09)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C151(1.05); C87(1.00)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C151(0.95); C87(1.50)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C151(0.91); C87(1.03)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C151(1.08); C270(0.96); C282(1.03); C87(1.00)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C151(0.98); C270(1.05); C282(0.90); C87(1.24)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C151(1.04); C270(0.96); C282(0.95); C87(1.05)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C151(1.09); C270(0.83); C282(0.81); C87(1.03)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C282(1.14); C87(1.38)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C151(1.05); C270(0.77); C282(0.98); C87(1.11)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C151(1.02); C270(0.65); C282(0.94); C87(1.00)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C151(1.24); C270(0.56); C282(1.13); C87(1.06)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C151(1.16); C270(0.86); C282(1.00); C87(1.05)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C151(1.19); C270(0.97); C282(0.89); C87(1.16)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C151(1.19); C270(0.97); C282(0.99); C87(1.03)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C151(0.96); C270(0.90); C282(1.01); C87(0.99)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C151(1.10); C270(0.59); C282(1.05); C87(1.03)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C151(1.25); C270(0.66); C282(1.12); C87(1.04)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C151(1.70); C270(0.71); C282(1.33); C87(1.16)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C282(1.06); C87(1.06)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C151(1.00); C270(0.63); C282(1.10); C87(0.90)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C109(1.11); C151(1.13); C270(0.70); C282(1.16)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C109(1.16); C151(1.05); C270(0.82); C282(0.83)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C109(1.66); C151(1.08); C270(1.85); C282(0.92)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C109(1.81); C151(1.12); C270(1.19); C282(0.97)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C109(1.59); C151(1.11); C270(1.13); C282(1.31)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C109(1.25); C151(1.27); C270(1.34); C282(1.18)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C109(1.87); C151(1.14); C270(1.17); C282(1.26)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C109(1.46); C151(1.15); C270(1.10); C282(1.26)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C109(2.26); C151(1.18); C270(1.36); C282(1.18)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C282(50.00)  LDD2228  [14]
 LDCM0028  Dobutamine HEK-293T 13.92  LDD0180  [7]
 LDCM0495  E2913 HEK-293T C151(0.90); C87(0.91); C270(1.08); C109(0.76)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C282(1.86)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C151(0.98); C87(1.05)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C151(0.98); C270(0.92); C282(1.01); C87(1.37)  LDD0744  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0022  KB02 HCT 116 C282(1.99); C87(1.24)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C282(1.69); C87(1.17)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C282(1.77); C87(1.17)  LDD0082  [9]
 LDCM0030  Luteolin HEK-293T 16.14  LDD0182  [7]
 LDCM0109  NEM HeLa H198(0.00); H420(0.00)  LDD0223  [19]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C151(0.48)  LDD2089  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C151(0.79)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C151(0.69)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C151(1.29)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C151(0.79)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C151(0.85)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C151(0.77)  LDD2100  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C151(0.86)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C151(0.89)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C151(0.96)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C151(0.93); C282(0.45)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C151(0.65)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C151(0.79); C282(0.89)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C151(1.05)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C151(0.68)  LDD2114  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C151(1.48)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C151(1.13)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C151(0.74)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C151(1.17)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C151(0.89)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C151(1.20)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C151(0.96)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C151(0.96)  LDD2129  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C151(0.45)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C151(0.80)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C151(1.07); C282(0.98)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C151(1.10)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C151(1.48)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C151(0.64); C282(0.75)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C151(0.89)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C151(4.83)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C151(1.08)  LDD2146  [5]
 LDCM0029  Quercetin HEK-293T 11.49  LDD0181  [7]
 LDCM0003  Sulforaphane MCF-7 4.14  LDD0042  [6]
 LDCM0021  THZ1 HCT 116 C87(1.25); C282(0.94)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytosolic purine 5'-nucleotidase (NT5C2) 5'(3')-deoxyribonucleotidase family P49902
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
Fructose-1,6-bisphosphatase 1 (FBP1) FBPase class 1 family P09467
Ferritin heavy chain (FTH1) Ferritin family P02794
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
Leucine carboxyl methyltransferase 1 (LCMT1) LCMT family Q9UIC8
Nucleoside diphosphate kinase A (NME1) NDK family P15531
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Serine/threonine-protein kinase pim-1 (PIM1) CAMK Ser/Thr protein kinase family P11309
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Cyclin-dependent kinase-like 3 (CDKL3) CMGC Ser/Thr protein kinase family Q8IVW4
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Pterin-4-alpha-carbinolamine dehydratase (PCBD1) Pterin-4-alpha-carbinolamine dehydratase family P61457
6-pyruvoyl tetrahydrobiopterin synthase (PTS) PTPS family Q03393
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) SAICAR synthetase family; AIR carboxylase family P22234
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Nuclear envelope pore membrane protein POM 121 (POM121) POM121 family Q96HA1
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Optineurin (OPTN) . Q96CV9
Synaptotagmin-like protein 4 (SYTL4) . Q96C24
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 22 (ZBTB22) Krueppel C2H2-type zinc-finger protein family O15209
Zinc finger protein 232 (ZNF232) Krueppel C2H2-type zinc-finger protein family Q9UNY5
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Bystin (BYSL) Bystin family Q13895
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
Chromatin modification-related protein MEAF6 (MEAF6) EAF6 family Q9HAF1
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Fragile X messenger ribonucleoprotein 1 (FMR1) FMR1 family Q06787
RNA-binding protein FXR1 (FXR1) FMR1 family P51114
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Protein LDOC1 (LDOC1) LDOC1 family O95751
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Large ribosomal subunit protein mL43 (MRPL43) Mitochondrion-specific ribosomal protein mL43 family Q8N983
RNA polymerase II-associated factor 1 homolog (PAF1) PAF1 family Q8N7H5
Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B) WAL family Q9UIF8
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
LIM and SH3 domain protein 1 (LASP1) . Q14847
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
MAP3K12-binding inhibitory protein 1 (MBIP) . Q9NS73
Microspherule protein 1 (MCRS1) . Q96EZ8
Mortality factor 4-like protein 1 (MORF4L1) . Q9UBU8
Multiple myeloma tumor-associated protein 2 (MMTAG2) . Q9BU76
PML-RARA-regulated adapter molecule 1 (PRAM1) . Q96QH2
Sciellin (SCEL) . O95171
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Ubiquitin-associated protein 2-like (UBAP2L) . Q14157
Uncharacterized protein C10orf62 (C10orf62) . Q5T681
Zinc finger matrin-type protein 2 (ZMAT2) . Q96NC0

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
25 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402