Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name DA-P3  Probe Info 
Probe concentration 15 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Dobutamine  Competitor Info 
Competitor Concentration 150 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 62 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08799  Lysophosphatidylserine lipase ABHD12 (ABHD12) 50.5
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 35.9
 LDTP03679  Dual specificity protein kinase TTK (TTK) 34.2
 LDTP06713  DNA excision repair protein ERCC-6-like (ERCC6L) 29.5
 LDTP06142  Squalene monooxygenase (SQLE) 23.4
 LDTP00598  Serine palmitoyltransferase 2 (SPTLC2) 18.0
 LDTP09188  Lysophosphatidylcholine acyltransferase 1 (LPCAT1) 15.8
 LDTP03540  Heme oxygenase 2 (HMOX2) 11.8
 LDTP01435  Phospholipase DDHD2 (DDHD2) 11.7
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 11.4
 LDTP18130  Phosphotriesterase-related protein (PTER) 11.2
 LDTP10935  Kinesin-like protein KIF2C (KIF2C) 10.4
 LDTP08378  Serine/threonine-protein kinase VRK2 (VRK2) 10.3
 LDTP06214  Kinesin-like protein KIF22 (KIF22) 9.7
 LDTP06104  Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) 9.5
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 9.2
 LDTP11152  Cancer-related nucleoside-triphosphatase (NTPCR) 8.3
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) 8.2
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 8.2
 LDTP01028  Protein arginine N-methyltransferase 3 (PRMT3) 8.0
 LDTP07227  Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1) 7.7
 LDTP00366  Dihydropyrimidinase-related protein 4 (DPYSL4) 7.4
 LDTP12599  Ubiquitin-like-conjugating enzyme ATG3 (ATG3) 7.2
 LDTP02935  Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) 7.0
 LDTP00497  Cyclin-G-associated kinase (GAK) 6.9
 LDTP01004  Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) 6.7
 LDTP01410  Unconventional prefoldin RPB5 interactor 1 (URI1) 6.4
 LDTP04398  Ras-related protein Rab-5C (RAB5C) 6.4
 LDTP08023  Elongation factor-like GTPase 1 (EFL1) 6.3
 LDTP10930  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1) 6.3
 LDTP08615  Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (RPAP2) 6.2
 LDTP14051  Ubiquitin carboxyl-terminal hydrolase 15 (USP15) 6.0
 LDTP09517  Ubiquitin carboxyl-terminal hydrolase 33 (USP33) 5.9
 LDTP04435  Interleukin-1 receptor-associated kinase 1 (IRAK1) 5.6
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) 5.2
 LDTP06270  Signal peptidase complex subunit 2 (SPCS2) 5.1
 LDTP08684  Phosphatase and actin regulator 4 (PHACTR4) 5.1
 LDTP03481  DNA-3-methyladenine glycosylase (MPG) 5.1
 LDTP18530  Protein NDRG3 (NDRG3) 5.0
 LDTP07596  E3 ubiquitin-protein ligase TRIM65 (TRIM65) 4.9
 LDTP11298  ATPase family gene 2 protein homolog B (AFG2B) 4.9
 LDTP02000  3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) 4.9
 LDTP12312  Ras-related protein Rab-18 (RAB18) 4.8
 LDTP11819  STE20-like serine/threonine-protein kinase (SLK) 4.7
 LDTP14064  TNF receptor-associated factor 6 (TRAF6) 4.6
 LDTP10500  Lymphokine-activated killer T-cell-originated protein kinase (PBK) 4.5
 LDTP06190  Ubiquitin carboxyl-terminal hydrolase 10 (USP10) 4.5
 LDTP02770  Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) 4.5
 LDTP00225  26S proteasome non-ATPase regulatory subunit 9 (PSMD9) 4.5
 LDTP02984  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) 4.5
 LDTP08231  E3 ubiquitin-protein ligase ZNF598 (ZNF598) 4.4
 LDTP12983  Sentrin-specific protease 1 (SENP1) 4.3
 LDTP07967  Lysophosphatidylcholine acyltransferase 2 (LPCAT2) 4.3
 LDTP01474  Ubiquitin carboxyl-terminal hydrolase 19 (USP19) 4.2
 LDTP06536  Serine/threonine-protein kinase N2 (PKN2) 4.2
 LDTP04401  Ras-related protein Rab-13 (RAB13) 4.2
 LDTP03186  E3 ubiquitin-protein ligase CBL (CBL) 4.1
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 4.1
 LDTP01503  Mitofusin-2 (MFN2) 4.1
 LDTP07290  Lysophospholipid acyltransferase LPCAT4 (LPCAT4) 4.1
 LDTP05228  Calcium-transporting ATPase type 2C member 1 (ATP2C1) 4.1
 LDTP09792  Inositol hexakisphosphate kinase 1 (IP6K1) 4.0
Transporter and channel
Click to Show/Hide to Show 28 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP02330  Signal recognition particle 19 kDa protein (SRP19) 24.8
 LDTP04770  Syntaxin-17 (STX17) 17.5
 LDTP13243  Translocation protein SEC63 homolog (SEC63) 17.3
 LDTP10181  Protein Aster-A (GRAMD1A) 13.5
 LDTP12191  Vezatin (VEZT) 12.2
 LDTP08881  Transmembrane protein 199 (TMEM199) 11.9
 LDTP12281  Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC) 10.9
 LDTP03839  Nuclear pore glycoprotein p62 (NUP62) 10.9
 LDTP06633  Reticulon-1 (RTN1) 6.8
 LDTP12292  Junctophilin-1 (JPH1) 6.6
 LDTP09204  Nucleoporin NUP35 (NUP35) 6.4
 LDTP11609  Endoplasmic reticulum junction formation protein lunapark (LNPK) 6.2
 LDTP11161  Extended synaptotagmin-1 (ESYT1) 6.0
 LDTP09352  DnaJ homolog subfamily B member 14 (DNAJB14) 5.9
 LDTP12533  Ubiquilin-4 (UBQLN4) 5.8
 LDTP01380  Wolframin (WFS1) 5.7
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) 5.6
 LDTP07002  Transport and Golgi organization protein 1 homolog (MIA3) 5.4
 LDTP12966  Vesicle-associated membrane protein-associated protein A (VAPA) 5.3
 LDTP12272  Prolactin regulatory element-binding protein (PREB) 5.2
 LDTP04227  Guided entry of tail-anchored proteins factor CAMLG (CAMLG) 5.1
 LDTP09165  PDZ domain-containing protein 8 (PDZD8) 5.0
 LDTP12874  ADP-ribosylation factor-binding protein GGA3 (GGA3) 4.9
 LDTP01185  V-type proton ATPase subunit G 1 (ATP6V1G1) 4.8
 LDTP00198  Synaptosomal-associated protein 23 (SNAP23) 4.2
 LDTP01133  Copine-3 (CPNE3) 4.1
 LDTP14131  CD2-associated protein (CD2AP) 4.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 4.0
Transcription factor
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10501  DnaJ homolog subfamily C member 1 (DNAJC1) 24.5
 LDTP03043  Transcription factor BTF3 (BTF3) 20.0
 LDTP06748  Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) 12.0
 LDTP05254  Nuclear factor NF-kappa-B p100 subunit (NFKB2) 10.4
 LDTP05248  Transcriptional activator protein Pur-alpha (PURA) 8.8
 LDTP12129  MLX-interacting protein (MLXIP) 7.6
 LDTP16817  TSC22 domain family protein 2 (TSC22D2) 7.2
 LDTP05654  Alpha-globin transcription factor CP2 (TFCP2) 4.8
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09680  Palladin (PALLD) 12.6
Other
Click to Show/Hide to Show 104 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10849  Regulator of microtubule dynamics protein 3 (RMDN3) 34.4
 LDTP07522  Centrosomal protein of 85 kDa (CEP85) 31.2
 LDTP07476  RAD50-interacting protein 1 (RINT1) 29.7
 LDTP01021  Perilipin-3 (PLIN3) 23.3
 LDTP12306  ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) 23.0
 LDTP15057  TBC1 domain family member 9B (TBC1D9B) 17.1
 LDTP01177  Hyaluronan mediated motility receptor (HMMR) 16.9
 LDTP13304  Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) 15.9
 LDTP07005  WD repeat-containing protein 44 (WDR44) 15.7
 LDTP07345  Cell division cycle-associated protein 2 (CDCA2) 15.5
 LDTP07742  Rab11 family-interacting protein 1 (RAB11FIP1) 14.8
 LDTP17214  Protein odr-4 homolog (ODR4) 14.4
 LDTP19787  RING finger protein 214 (RNF214) 14.2
 LDTP04396  RNA-binding protein FXR2 (FXR2) 13.9
 LDTP05172  TATA element modulatory factor (TMF1) 13.2
 LDTP10435  PRKC apoptosis WT1 regulator protein (PAWR) 13.2
 LDTP09242  Kinetochore scaffold 1 (KNL1) 13.0
 LDTP19933  Uncharacterized protein KIAA1671 (KIAA1671) 12.6
 LDTP13007  Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) 11.8
 LDTP11533  Oxysterol-binding protein-related protein 6 (OSBPL6) 10.9
 LDTP06681  Inverted formin-2 (INF2) 10.8
 LDTP06515  Coiled-coil domain-containing protein 6 (CCDC6) 10.8
 LDTP13414  ADP-ribosylation factor-binding protein GGA2 (GGA2) 10.0
 LDTP01684  BAG family molecular chaperone regulator 3 (BAG3) 9.6
 LDTP11925  Protein FAM83D (FAM83D) 9.6
 LDTP14104  NEDD8 ultimate buster 1 (NUB1) 9.4
 LDTP08950  ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) 9.2
 LDTP19569  Uncharacterized protein FLJ45252 9.2
 LDTP05655  A-kinase anchor protein 13 (AKAP13) 9.1
 LDTP14228  Transforming acidic coiled-coil-containing protein 3 (TACC3) 8.9
 LDTP08795  GH3 domain-containing protein (GHDC) 8.4
 LDTP08830  MICAL-like protein 1 (MICALL1) 8.2
 LDTP06886  Centrosomal protein of 55 kDa (CEP55) 8.2
 LDTP11367  Oxysterol-binding protein-related protein 11 (OSBPL11) 8.2
 LDTP01151  Serine/threonine-protein phosphatase 6 regulatory subunit 2 (PPP6R2) 8.1
 LDTP12443  Anillin (ANLN) 8.1
 LDTP10802  Ran-binding protein 9 (RANBP9) 8.1
 LDTP10111  Proline-rich AKT1 substrate 1 (AKT1S1) 8.0
 LDTP12432  Inner centromere protein (INCENP) 7.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) 7.7
 LDTP10834  RUN and FYVE domain-containing protein 1 (RUFY1) 7.7
 LDTP08535  MAP7 domain-containing protein 3 (MAP7D3) 7.7
 LDTP16261  PALM2-AKAP2 fusion protein (PALM2AKAP2) 7.7
 LDTP00737  Centriolar coiled-coil protein of 110 kDa (CCP110) 7.6
 LDTP01742  B-cell lymphoma/leukemia 10 (BCL10) 7.4
 LDTP11530  Tether containing UBX domain for GLUT4 (ASPSCR1) 7.3
 LDTP05557  Golgin subfamily A member 2 (GOLGA2) 7.3
 LDTP01522  Reticulon-3 (RTN3) 7.0
 LDTP18272  Transmembrane protein 209 (TMEM209) 7.0
 LDTP13383  Protein Hook homolog 1 (HOOK1) 6.8
 LDTP04112  Microtubule-associated protein 1B (MAP1B) 6.7
 LDTP06268  Condensin complex subunit 2 (NCAPH) 6.6
 LDTP05556  Golgin subfamily A member 3 (GOLGA3) 6.5
 LDTP09049  NHL repeat-containing protein 2 (NHLRC2) 6.5
 LDTP01233  PC4 and SFRS1-interacting protein (PSIP1) 6.4
 LDTP05418  UBX domain-containing protein 1 (UBXN1) 6.3
 LDTP12216  Chromobox protein homolog 8 (CBX8) 6.1
 LDTP06527  Alpha-internexin (INA) 6.1
 LDTP10361  BLOC-1-related complex subunit 6 (BORCS6) 6.1
 LDTP03079  Calpastatin (CAST) 6.1
 LDTP09828  Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) 6.0
 LDTP04092  Crk-like protein (CRKL) 6.0
 LDTP08770  Serine/threonine-protein kinase 11-interacting protein (STK11IP) 5.9
 LDTP09806  UBX domain-containing protein 4 (UBXN4) 5.9
 LDTP08095  Coiled-coil domain-containing protein R3HCC1L (R3HCC1L) 5.8
 LDTP10417  DISP complex protein LRCH3 (LRCH3) 5.8
 LDTP16155  Opioid growth factor receptor (OGFR) 5.8
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 5.7
 LDTP02263  Signal recognition particle receptor subunit alpha (SRPRA) 5.7
 LDTP13916  Calcium-regulated heat-stable protein 1 (CARHSP1) 5.6
 LDTP13710  Trinucleotide repeat-containing gene 6B protein (TNRC6B) 5.5
 LDTP15235  G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) 5.5
 LDTP03151  Oxysterol-binding protein 1 (OSBP) 5.3
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) 5.3
 LDTP04356  Emerin (EMD) 5.1
 LDTP12865  G2 and S phase-expressed protein 1 (GTSE1) 5.1
 LDTP10656  Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3) 5.0
 LDTP07124  Rho GTPase-activating protein 21 (ARHGAP21) 5.0
 LDTP10864  Calponin-2 (CNN2) 4.8
 LDTP05249  Cdc42 effector protein 1 (CDC42EP1) 4.8
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 4.8
 LDTP08058  Mitochondrial antiviral-signaling protein (MAVS) 4.8
 LDTP09820  La-related protein 4B (LARP4B) 4.8
 LDTP00039  SH3 and PX domain-containing protein 2B (SH3PXD2B) 4.8
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) 4.7
 LDTP08735  Spartin (SPART) 4.7
 LDTP01210  Transforming acidic coiled-coil-containing protein 1 (TACC1) 4.6
 LDTP06378  Disks large-associated protein 5 (DLGAP5) 4.6
 LDTP15842  RANBP2-like and GRIP domain-containing protein 5/6 (RGPD5; RGPD6) 4.6
 LDTP07205  Telomere-associated protein RIF1 (RIF1) 4.6
 LDTP07348  Cytospin-A (SPECC1L) 4.5
 LDTP10753  Sperm-associated antigen 5 (SPAG5) 4.5
 LDTP07297  Microtubule-associated protein 1S (MAP1S) 4.4
 LDTP12640  Gamma-taxilin (TXLNG) 4.4
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) 4.4
 LDTP13863  DnaJ homolog subfamily C member 16 (DNAJC16) 4.3
 LDTP12001  BCAS3 microtubule associated cell migration factor (BCAS3) 4.2
 LDTP07132  Ubiquitin-associated protein 2 (UBAP2) 4.2
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 4.2
 LDTP01285  TIP41-like protein (TIPRL) 4.1
 LDTP11539  Regulator of nonsense transcripts 3B (UPF3B) 4.1
 LDTP13913  Inner nuclear membrane protein Man1 (LEMD3) 4.0
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 4.0
 LDTP09397  Centrosome-associated protein ALMS1 (ALMS1) 4.0

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348