Details of the Target

General Information of Target

Target ID LDTP12001
Target Name BCAS3 microtubule associated cell migration factor (BCAS3)
Gene Name BCAS3
Gene ID 54828
Synonyms
BCAS3 microtubule associated cell migration factor; Breast carcinoma-amplified sequence 3; GAOB1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN
FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE
SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL
KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE
LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER
AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR
TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI
DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS
SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT
VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD
FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK
KRYGG
Target Bioclass
Other
Family
BCAS3 family
Subcellular location
Nucleus
Function
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin. Plays a regulatory role in autophagic activity. In complex with PHAF1, associates with the preautophagosomal structure during both non-selective and selective autophagy. Probably binds phosphatidylinositol 3-phosphate (PtdIns3P) which would mediate the recruitment preautophagosomal structures.
Uniprot ID
Q9H6U6
Ensemble ID
ENST00000390652.9
HGNC ID
HGNC:14347

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K277(0.47)  LDD0277  [2]
P11
 Probe Info  		20.00  LDD0201  [3]
DBIA
 Probe Info  		C139(1.73)  LDD3323  [4]
DA-P3
 Probe Info  		4.23  LDD0180  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		C139(0.00); C442(0.00); C211(0.00); C192(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C139(0.00); C16(0.00); C211(0.00); C152(0.00)  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
IPM
 Probe Info  		C479(0.00); C417(0.00); C16(0.00); C258(0.00)  LDD2156  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
AOyne
 Probe Info  		10.20  LDD0443  [10]
NAIA_5
 Probe Info  		C258(0.00); C211(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C186
 Probe Info  		8.94  LDD1864  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C479(3.52)  LDD0372  [12]
 LDCM0214  AC1 HEK-293T C442(0.85); C258(1.03); C836(1.06); C16(1.23)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C442(1.02); C258(1.01); C16(1.18); C139(1.19)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C442(0.91); C258(1.20); C836(1.06); C16(1.17)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C442(1.02); C258(0.96); C836(1.09); C16(1.22)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C442(0.95); C258(1.06); C836(1.03); C16(1.02)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C442(1.02); C258(0.92); C836(0.73); C16(1.12)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C442(0.97); C258(0.98); C836(1.02); C16(1.04)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C442(1.00); C258(0.96); C16(1.11); C139(1.07)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C442(0.87); C258(1.05); C836(1.00); C16(1.10)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C442(0.93); C258(0.99); C16(1.11); C139(1.20)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C442(1.09); C258(1.03); C836(0.94); C16(1.14)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C442(1.08); C258(0.94); C836(1.18); C16(1.06)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C442(1.04); C258(1.09); C836(1.01); C16(1.08)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C442(1.06); C258(0.93); C836(0.89); C16(0.87)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C479(0.95); C442(1.08); C258(0.97); C16(0.97)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C442(1.11); C258(1.02); C836(0.89); C16(1.19)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C442(0.93); C258(0.97); C16(1.02); C139(1.08)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C442(0.92); C258(1.07); C836(1.16); C16(1.13)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C442(1.17); C258(1.02); C836(1.09); C16(0.99)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C442(0.88); C258(0.96); C836(1.13); C16(1.16)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C442(1.10); C258(1.12); C836(1.39); C16(1.18)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C442(1.08); C258(1.05); C836(1.27); C16(1.07)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C442(1.17); C258(0.86); C836(0.57); C16(1.03)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C479(0.93); C442(1.18); C258(1.05); C16(0.98)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C442(0.88); C258(1.01); C836(1.02); C16(1.20)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C442(0.94); C258(1.01); C16(1.10); C139(1.30)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C442(0.92); C258(1.04); C836(1.11); C16(1.12)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C442(1.12); C258(1.00); C836(0.90); C16(1.05)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C442(1.16); C258(0.97); C836(1.19); C16(1.16)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C442(0.96); C258(0.99); C836(1.56); C16(1.04)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C442(0.98); C258(0.98); C836(0.83); C16(1.02)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C442(0.99); C258(1.00); C836(0.97); C16(1.13)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C479(1.03); C442(1.07); C258(1.06); C16(0.97)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C442(0.93); C258(1.05); C836(1.11); C16(1.04)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C442(1.01); C258(0.96); C16(1.30); C139(1.29)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C442(0.99); C258(1.19); C836(1.04); C16(1.19)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C442(1.22); C258(1.03); C836(0.81); C16(1.22)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C442(1.13); C258(0.92); C836(1.07); C16(1.09)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C442(0.93); C258(1.04); C836(0.95); C16(0.99)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C442(1.10); C258(1.04); C836(0.96); C16(1.19)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C479(0.93); C442(1.16); C258(1.15); C16(0.98)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C442(0.96); C258(1.06); C836(1.08); C16(1.14)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C442(0.97); C258(1.03); C836(1.17); C16(1.20)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C442(1.05); C258(1.03); C16(1.15); C139(1.18)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C442(1.10); C258(1.10); C836(0.87); C16(1.19)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C442(1.03); C258(0.98); C836(0.89); C16(1.10)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C442(0.98); C258(0.97); C836(1.03); C16(1.15)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C442(0.98); C258(1.06); C836(1.03); C16(1.13)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C442(1.02); C258(0.97); C836(0.77); C16(0.97)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C479(1.00); C442(1.05); C258(1.05); C16(1.04)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C442(1.10); C258(1.01); C836(1.07); C16(1.14)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C442(0.99); C258(0.93); C16(1.03); C139(1.13)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C442(0.89); C258(1.19); C836(1.47); C16(1.05)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C442(1.03); C258(1.00); C836(0.99); C16(1.13)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C442(0.86); C258(1.00); C836(0.89); C16(0.88)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C442(0.98); C258(0.98); C836(1.18); C16(1.14)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C442(0.97); C258(1.03); C836(1.10); C16(1.16)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C442(0.98); C258(0.99); C836(0.60); C16(1.03)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C479(0.85); C442(0.99); C258(0.96); C16(1.16)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C442(1.03); C258(0.91); C836(0.95); C16(0.97)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C479(1.13); C442(1.19); C258(1.08); C16(0.91)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C442(1.06); C258(0.92); C836(1.22); C16(0.97)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C442(0.99); C258(0.99); C836(1.06); C16(1.09)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C479(0.96); C442(1.11); C258(1.04); C16(1.20)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 11.42  LDD0403  [1]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [3]
 LDCM0632  CL-Sc Hep-G2 C139(2.09); C479(1.22)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C442(0.93); C258(0.97); C836(1.09); C16(1.09)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C442(1.03); C258(0.94); C836(0.73); C16(0.89)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C442(1.03); C258(1.05); C16(1.24); C225(1.03)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C442(0.96); C258(1.06); C836(1.24); C16(1.15)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C442(1.19); C258(0.95); C836(0.84); C16(1.01)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C442(0.94); C258(0.98); C836(0.91); C16(1.25)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C442(1.15); C258(0.89); C16(1.13); C225(0.86)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C442(1.03); C258(0.97); C836(1.21); C16(1.14)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C442(1.19); C258(0.80); C836(1.04); C16(1.14)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C442(1.08); C258(0.94); C836(1.06); C16(1.09)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C442(1.11); C258(1.00); C16(1.07); C225(0.72)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C442(0.93); C258(1.01); C836(1.05); C16(1.36)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C442(1.14); C258(0.99); C836(0.88); C16(0.91)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C442(1.12); C258(0.89); C836(1.04); C16(1.20)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C442(0.86); C258(0.90); C836(0.95); C16(1.21)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C442(1.11); C258(0.97); C16(1.25); C225(0.96)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C442(1.12); C258(1.10); C836(1.20); C16(0.99)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C442(1.06); C258(0.95); C836(0.99); C16(1.33)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C442(0.79); C258(0.90); C836(1.02); C16(1.19)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C442(0.96); C258(1.09); C16(0.97); C225(0.77)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C442(1.04); C258(1.11); C836(1.27); C16(1.08)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C442(1.23); C258(0.93); C836(1.03); C16(1.00)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C442(0.79); C258(0.92); C836(0.92); C16(1.11)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C479(0.82); C442(1.44); C258(1.00); C16(0.96)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C442(1.12); C258(1.14); C16(1.06); C225(0.96)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C442(0.97); C258(1.05); C836(1.29); C16(1.13)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C442(1.14); C258(1.07); C836(0.99); C16(0.87)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C442(0.95); C258(0.80); C836(0.90); C16(1.06)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C442(0.99); C258(1.00); C16(1.48); C225(0.89)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C442(0.99); C258(1.09); C836(1.25); C16(1.27)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C442(1.07); C258(1.06); C836(1.00); C16(1.10)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C442(1.00); C258(1.07); C836(1.24); C16(1.04)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C442(1.00); C258(1.11); C16(1.04); C225(1.17)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C442(1.00); C258(1.02); C836(1.31); C16(1.54)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C442(1.20); C258(0.97); C836(1.04); C16(0.94)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C442(0.84); C258(0.85); C836(0.98); C16(1.00)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C442(1.13); C258(1.01); C16(1.04); C225(0.70)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C442(0.97); C258(0.91); C836(0.90); C16(1.33)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C442(1.10); C258(1.07); C16(1.15); C139(1.29)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C442(1.12); C258(1.17); C836(1.21); C16(1.13)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C442(1.12); C258(1.13); C836(1.04); C16(1.11)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C442(1.04); C258(1.12); C836(1.17); C16(1.01)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C442(1.13); C258(0.92); C836(0.81); C16(2.11)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C442(1.01); C258(1.05); C836(0.94); C16(0.99)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C442(1.00); C258(0.95); C836(0.80); C16(1.01)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C479(0.91); C442(1.47); C258(1.17); C16(1.01)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C442(0.88); C258(0.95); C836(1.29); C16(1.17)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C442(1.09); C258(1.01); C836(1.03); C16(1.02)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C442(0.90); C258(0.90); C836(1.03); C16(1.07)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C442(0.19); C258(1.10); C16(1.05); C225(0.79)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C442(0.94); C258(1.04); C836(1.12); C16(1.20)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C442(1.09); C258(1.11); C836(1.06); C16(1.11)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C442(0.87); C258(1.05); C16(1.05); C139(1.21)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C442(0.99); C258(1.08); C836(1.32); C16(1.08)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C442(1.03); C258(1.06); C836(1.11); C16(1.05)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C442(1.00); C258(0.87); C836(0.96); C16(1.05)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C442(1.03); C258(1.06); C836(1.04); C16(0.94)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C442(1.15); C258(1.00); C836(1.07); C16(1.12)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C479(0.73); C442(1.32); C258(0.97); C16(0.85)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C442(1.00); C258(1.02); C836(1.14); C16(1.08)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C442(0.72); C258(0.70); C836(1.11); C16(1.08)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C442(0.92); C258(1.06); C16(0.90); C225(0.49)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C442(0.97); C258(1.19); C16(0.97); C225(1.19)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C442(0.86); C258(0.91); C836(1.03); C16(1.08)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C442(1.05); C258(1.01); C16(1.06); C139(1.17)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C442(1.19); C258(1.11); C836(0.89); C16(1.05)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C442(1.03); C258(1.08); C836(1.13); C16(0.96)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C442(0.98); C258(0.95); C836(1.08); C16(0.98)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C442(1.16); C258(1.05); C836(0.89); C16(1.03)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C442(1.03); C258(0.87); C836(1.02); C16(1.09)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C479(0.77); C442(1.42); C258(1.07); C16(0.97)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C442(1.05); C258(1.04); C836(1.43); C16(1.00)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C442(1.09); C258(1.11); C836(0.95); C16(1.31)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C442(1.22); C258(1.09); C836(1.02); C16(1.54)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C442(1.44); C258(1.05); C16(1.02); C225(0.80)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C442(0.93); C258(0.97); C836(0.86); C16(1.04)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C442(0.84); C258(0.82); C16(1.05); C139(1.37)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C442(1.02); C258(1.17); C836(0.88); C16(1.19)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C442(1.10); C258(0.97); C836(1.10); C16(1.17)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C442(0.95); C258(0.86); C836(1.07); C16(0.89)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C442(1.14); C258(1.09); C836(0.96); C16(1.05)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C442(1.22); C258(0.92); C836(0.82); C16(1.16)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C442(1.02); C258(0.91); C16(1.19); C139(1.21)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C479(0.95); C442(1.41); C258(1.05); C16(1.03)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C442(1.05); C258(1.01); C836(1.28); C16(1.43)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C442(1.10); C258(1.03); C836(1.08); C16(1.02)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C442(0.93); C258(0.98); C836(1.06); C16(1.06)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C442(1.17); C258(0.98); C16(1.09); C225(0.68)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C442(1.02); C258(1.05); C836(0.89); C16(1.18)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C442(0.93); C258(1.01); C16(1.23); C139(1.18)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C442(1.07); C258(1.09); C836(1.09); C16(1.07)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C442(1.02); C258(1.00); C836(0.91); C16(0.92)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C442(0.91); C258(0.96); C836(0.97); C16(1.10)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C442(1.01); C258(1.10); C836(1.07); C16(1.00)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C442(1.08); C258(1.09); C836(1.32); C16(0.91)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C442(1.00); C258(0.98); C836(0.65); C16(1.17)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C479(0.76); C442(1.30); C258(1.03); C16(0.80)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C442(0.90); C258(1.00); C836(1.06); C16(1.11)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C442(1.38); C258(1.03); C836(1.08); C16(1.01)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C442(1.21); C258(0.94); C16(1.00); C225(1.09)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C442(1.02); C258(0.88); C836(0.98); C16(1.58)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C442(1.04); C258(0.97); C16(1.02); C139(1.26)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C442(0.94); C258(1.12); C836(1.21); C16(1.11)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C442(0.74); C258(0.82); C836(1.04); C16(1.12)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C442(1.06); C258(1.06); C836(1.00); C16(1.15)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C442(1.04); C258(0.96); C836(1.41); C16(1.10)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C442(1.02); C258(1.06); C836(1.25); C16(1.07)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C442(1.26); C258(0.94); C836(0.98); C16(1.01)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C479(0.72); C442(1.12); C258(1.02); C16(0.97)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C442(0.93); C258(1.10); C836(1.18); C16(1.07)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C442(1.10); C258(1.06); C836(1.05); C16(1.19)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C442(0.86); C258(1.09); C836(1.10); C16(1.13)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C442(1.09); C258(1.11); C16(1.08); C225(1.04)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C442(0.87); C258(1.02); C836(1.21); C16(1.08)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C442(1.13); C258(1.04); C836(1.21); C16(1.07)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C442(0.75); C258(0.93); C16(1.14); C139(1.10)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C442(1.14); C258(1.23); C836(0.97); C16(1.20)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C442(0.92); C258(1.00); C836(0.80); C16(1.05)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C442(1.07); C258(0.99); C836(0.98); C16(0.97)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C442(0.98); C258(1.06); C836(0.81); C16(1.08)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C442(0.87); C258(0.98); C836(1.55); C16(1.43)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C479(0.70); C442(1.13); C258(1.08); C16(1.28)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C442(0.97); C258(0.96); C836(1.13); C16(1.54)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C442(1.07); C258(0.97); C836(1.03); C16(1.38)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C442(0.88); C258(0.82); C836(0.99); C16(1.33)  LDD1697  [13]
 LDCM0634  CY-0357 Hep-G2 C479(0.35)  LDD2228  [7]
 LDCM0028  Dobutamine HEK-293T 4.23  LDD0180  [5]
 LDCM0495  E2913 HEK-293T C442(1.22); C258(0.85); C836(0.98); C16(1.21)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C442(0.88); C258(0.97); C836(1.04); C16(1.06)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C442(1.21); C258(1.03); C836(0.90); C16(0.94)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C442(1.01); C836(1.07); C258(1.00); C417(0.92)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C442(0.93); C836(1.04); C258(1.03); C417(1.03)  LDD1497  [13]
 LDCM0024  KB05 SKMEL24 C139(1.73)  LDD3323  [4]
 LDCM0029  Quercetin HEK-293T 5.04  LDD0181  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
Phagosome assembly factor 1 (PHAF1) PHAF1 family Q9BSU1
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402