Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name P11  Probe Info 
Probe concentration 0.1 mM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
SILAC
Competitor Name C45  Competitor Info 
Competitor Concentration 0.1 mM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 61 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13375  2-hydroxyacyl-CoA lyase 1 (HACL1) 20.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) 20.0
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) 20.0
 LDTP03109  Amine oxidase [flavin-containing] A (MAOA) 20.0
 LDTP03384  Amine oxidase [flavin-containing] B (MAOB) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP02216  Beta-hexosaminidase subunit beta (HEXB) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 20.0
 LDTP01769  Dihydrofolate reductase (DHFR) 20.0
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 20.0
 LDTP07979  FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) 20.0
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 20.0
 LDTP03511  Flavin reductase (NADPH) (BLVRB) 20.0
 LDTP09886  Gamma-glutamyl hydrolase (GGH) 20.0
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 20.0
 LDTP09186  Histone-lysine N-methyltransferase 2C (KMT2C) 20.0
 LDTP00408  Histone-lysine N-methyltransferase 2D (KMT2D) 20.0
 LDTP01759  Histone-lysine N-methyltransferase NSD2 (NSD2) 20.0
 LDTP06787  Inactive hydroxysteroid dehydrogenase-like protein 1 (HSDL1) 20.0
 LDTP00957  Lysine-specific histone demethylase 1A (KDM1A) 20.0
 LDTP02505  Lysosomal protective protein (CTSA) 20.0
 LDTP02799  N-acetylglucosamine-6-sulfatase (GNS) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP04203  Phosphatidylserine synthase 1 (PTDSS1) 20.0
 LDTP02366  Pro-cathepsin H (CTSH) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP09921  Regulator of nonsense transcripts 1 (UPF1) 20.0
 LDTP01419  Retinal dehydrogenase 2 (ALDH1A2) 20.0
 LDTP12056  Thiol S-methyltransferase TMT1A (TMT1A) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 19.6
 LDTP03163  Sterol carrier protein 2 (SCP2) 19.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 17.9
 LDTP02141  Alpha-galactosidase A (GLA) 17.9
 LDTP03560  Aldehyde dehydrogenase X, mitochondrial (ALDH1B1) 16.5
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) 15.9
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) 15.7
 LDTP05808  Transcription intermediary factor 1-beta (TRIM28) 15.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 14.8
 LDTP10862  Proteasome subunit beta type-7 (PSMB7) 14.6
 LDTP18414  5'-nucleotidase domain-containing protein 2 (NT5DC2) 12.7
 LDTP00611  E3 ubiquitin-protein ligase Midline-1 (MID1) 12.5
 LDTP03656  Cystathionine gamma-lyase (CTH) 12.4
 LDTP01699  Acyl-CoA 6-desaturase (FADS2) 12.4
 LDTP12757  E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) 12.2
 LDTP06139  Helicase-like transcription factor (HLTF) 12.1
 LDTP06839  NAD kinase 2, mitochondrial (NADK2) 12.1
 LDTP15725  Secernin-2 (SCRN2) 11.9
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 11.7
 LDTP11178  Chitobiosyldiphosphodolichol beta-mannosyltransferase (ALG1) 11.7
 LDTP07982  Lysine-specific demethylase 3B (KDM3B) 11.6
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) 11.6
 LDTP10877  E3 ubiquitin-protein ligase RING2 (RNF2) 11.5
 LDTP13989  Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) 11.5
 LDTP03350  DNA (cytosine-5)-methyltransferase 1 (DNMT1) 10.8
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) 8.2
 LDTP11319  Threonine--tRNA ligase, mitochondrial (TARS2) 8.0
 LDTP03433  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) 7.2
 LDTP00294  26S proteasome non-ATPase regulatory subunit 14 (PSMD14) 6.6
 LDTP10845  E3 ubiquitin-protein ligase UHRF1 (UHRF1) 6.3
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04463  H(+)/Cl(-) exchange transporter 7 (CLCN7) 20.0
 LDTP00636  High affinity copper uptake protein 1 (SLC31A1) 20.0
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 20.0
 LDTP12272  Prolactin regulatory element-binding protein (PREB) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP10816  Solute carrier family 49 member 4 (SLC49A4) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 14.7
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 11.8
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 11.8
 LDTP05642  Nuclear pore complex protein Nup160 (NUP160) 10.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 9.5
 LDTP01969  Transferrin receptor protein 1 (TFRC) 6.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 5.2
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP09694  Paraspeckle component 1 (PSPC1) 20.0
 LDTP08006  PHD finger-like domain-containing protein 5A (PHF5A) 20.0
 LDTP14411  Nascent polypeptide-associated complex subunit alpha, muscle-specific form (NACA) 5.7
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 16.0
Other
Click to Show/Hide to Show 20 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP13507  BAG family molecular chaperone regulator 5 (BAG5) 20.0
 LDTP12001  BCAS3 microtubule associated cell migration factor (BCAS3) 20.0
 LDTP10799  GPI transamidase component PIG-S (PIGS) 20.0
 LDTP10823  Paired amphipathic helix protein Sin3a (SIN3A) 20.0
 LDTP04395  RNA-binding protein FXR1 (FXR1) 20.0
 LDTP05898  Sequestosome-1 (SQSTM1) 20.0
 LDTP14787  Small ribosomal subunit protein mS25 (MRPS25) 20.0
 LDTP12396  Suppressor of SWI4 1 homolog (PPAN) 20.0
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 20.0
 LDTP13630  Neudesin (NENF) 15.6
 LDTP07602  Zinc finger CCCH domain-containing protein 14 (ZC3H14) 14.4
 LDTP05961  Four and a half LIM domains protein 1 (FHL1) 12.7
 LDTP05501  Fragile X messenger ribonucleoprotein 1 (FMR1) 11.4
 LDTP08760  Cell cycle and apoptosis regulator protein 2 (CCAR2) 11.2
 LDTP03767  Coatomer subunit beta' (COPB2) 10.4
 LDTP16017  Nucleolar protein 11 (NOL11) 10.3
 LDTP06385  Scaffold attachment factor B1 (SAFB) 7.7
 LDTP05977  Nascent polypeptide-associated complex subunit alpha (NACA) 5.7
 LDTP04434  Host cell factor 1 (HCFC1) 5.5
 LDTP02102  Non-histone chromosomal protein HMG-17 (HMGN2) 5.2

References

1 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.