Details of the Target

General Information of Target

Target ID LDTP06139
Target Name Helicase-like transcription factor (HLTF)
Gene Name HLTF
Gene ID 6596
Synonyms
HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1; Helicase-like transcription factor; EC 2.3.2.27; EC 3.6.4.-; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPRFEFQDVIPPDDFLTSDEEVDSVLF
GSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALA
YIMDNKLAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGF
NLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDKLFEDLKEDDKTHEMEPAEAIETPL
LPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGK
TLTAIAVILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRC
SEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIESSDSEEIETSELPQKMKGKLKNVQ
SETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKGACAVEGSKKTDVEERPRTTLI
ICPLSVLSNWIDQFGQHIKSDVHLNFYVYYGPDRIREPALLSKQDIVLTTYNILTHDYGT
KGDSPLHSIRWLRVILDEGHAIRNPNAQQTKAVLDLESERRWVLTGTPIQNSLKDLWSLL
SFLKLKPFIDREWWHRTIQRPVTMGDEGGLRRLQSLIKNITLRRTKTSKIKGKPVLELPE
RKVFIQHITLSDEERKIYQSVKNEGRATIGRYFNEGTVLAHYADVLGLLLRLRQICCHTY
LLTNAVSSNGPSGNDTPEELRKKLIRKMKLILSSGSDEECAICLDSLTVPVITHCAHVFC
KPCICQVIQNEQPHAKCPLCRNDIHEDNLLECPPEELARDSEKKSDMEWTSSSKINALMH
ALTDLRKKNPNIKSLVVSQFTTFLSLIEIPLKASGFVFTRLDGSMAQKKRVESIQCFQNT
EAGSPTIMLLSLKAGGVGLNLSAASRVFLMDPAWNPAAEDQCFDRCHRLGQKQEVIITKF
IVKDSVEENMLKIQNKKRELAAGAFGTKKPNADEMKQAKINEIRTLIDL
Target Bioclass
Enzyme
Family
SNF2/RAD54 helicase family, RAD16 subfamily
Subcellular location
Cytoplasm
Function
Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters. These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.
Uniprot ID
Q14527
Ensemble ID
ENST00000310053.10
HGNC ID
HGNC:11099

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.T390I DBIA    Probe Info 
DU145 SNV: p.A795T DBIA    Probe Info 
KPL1 SNV: p.V287F DBIA    Probe Info 
MCF7 SNV: p.V287F .
MELJUSO SNV: p.P135S DBIA    Probe Info 
OVCAR8 SNV: p.N920S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.03  LDD0402  [1]
STPyne
 Probe Info  		K682(0.94)  LDD0277  [2]
P11
 Probe Info  		12.14  LDD0201  [3]
BTD
 Probe Info  		C461(0.71)  LDD2099  [4]
AHL-Pu-1
 Probe Info  		C442(2.64)  LDD0168  [5]
DBIA
 Probe Info  		C461(1.17); C360(0.90); C942(0.89)  LDD0078  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C360(0.00); C812(0.00); C942(0.00); C442(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C812(0.00); C942(0.00); C461(0.00); C896(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C812(0.00); C482(0.00); C942(0.00); C896(0.00)  LDD0037  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		C360(0.00); C442(0.00); C461(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		C360(0.00); C442(0.00); C461(0.00)  LDD2213  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
NPM
 Probe Info  		N.A.  LDD0016  [9]
VSF
 Probe Info  		C442(0.00); C461(0.00); C360(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C442(0.00); C360(0.00); C461(0.00)  LDD0018  [11]
Acrolein
 Probe Info  		C461(0.00); C812(0.00); H560(0.00)  LDD0217  [12]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
NAIA_5
 Probe Info  		C896(0.00); C442(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [14]
HHS-475
 Probe Info  		Y72(0.80)  LDD2238  [15]
HHS-482
 Probe Info  		Y195(1.05); Y72(0.89)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C249
 Probe Info  		16.91  LDD1922  [16]
C339
 Probe Info  		5.03  LDD2002  [16]
C373
 Probe Info  		7.89  LDD2033  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C442(2.64)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C442(2.95)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C360(0.94); C783(0.92); C785(0.92); C942(1.02)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C360(0.91); C783(0.96); C785(0.96); C942(1.10)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C360(0.87); C783(1.15); C785(1.15); C942(1.07)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C360(0.82); C783(1.08); C785(1.08); C942(0.97)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C360(0.71); C783(1.18); C785(1.18); C942(1.03)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C360(0.91); C783(1.21); C785(1.21); C942(1.05)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C360(0.75); C783(1.19); C785(1.19); C942(0.93)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C360(0.99); C783(1.16); C785(1.16); C942(0.93)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C360(0.98); C783(1.19); C785(1.19); C942(1.07)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C360(0.92); C783(1.44); C785(1.44); C942(0.91)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C360(0.85); C783(1.23); C785(1.23); C942(1.04)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C360(0.73); C783(1.25); C785(1.25); C942(1.01)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C360(1.06); C783(1.31); C785(1.31); C942(0.99)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C360(0.75); C783(1.25); C785(1.25); C942(0.93)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C360(0.72); C783(1.37); C785(1.37); C942(0.98)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C360(0.82); C783(1.26); C785(1.26); C942(1.00)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C783(0.96); C785(0.96); C942(0.86)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C783(1.05); C785(1.11); C942(0.80)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C783(1.03); C785(1.06); C942(0.86)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C783(0.97); C785(1.06); C942(0.79)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C783(1.03); C785(1.06); C942(0.77)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C783(1.05); C785(1.15); C942(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C783(1.00); C785(1.11); C942(0.88)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C360(0.96); C783(0.93); C785(0.93); C942(1.09)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C783(1.02); C785(1.29); C942(0.69)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C783(0.97); C785(0.96); C942(0.71)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C783(1.08); C785(1.11); C942(0.81)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C783(1.03); C785(0.83); C942(0.71)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C783(1.01); C785(1.01); C942(0.64)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C783(1.00); C785(1.07); C942(0.86)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C783(1.07); C785(1.09); C942(0.67)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C783(1.04); C785(0.99); C942(0.75)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C360(0.23); C783(1.12); C785(1.12); C942(0.97)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C360(0.25); C783(1.13); C785(1.13); C942(0.79)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C360(0.26); C783(1.07); C785(1.07); C942(0.86)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C360(0.25); C783(1.06); C785(1.06); C942(1.08)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C360(0.28); C783(0.98); C785(0.98); C942(1.01)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C360(0.27); C783(1.05); C785(1.05); C942(0.86)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C360(0.30); C783(1.29); C785(1.29); C942(1.08)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C360(0.31); C783(1.18); C785(1.18); C942(0.86)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C360(0.31); C783(1.16); C785(1.16); C942(1.07)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C360(0.29); C783(1.32); C785(1.32); C942(0.95)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C360(0.30); C783(1.33); C785(1.33); C942(0.97)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C360(0.31); C783(1.31); C785(1.31); C942(0.91)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C360(0.82); C783(0.98); C785(0.98); C942(1.09)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C360(0.33); C783(1.21); C785(1.21); C942(1.07)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C360(0.32); C783(1.39); C785(1.39); C942(0.87)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C360(0.29); C783(1.12); C785(1.12); C942(1.12)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C360(1.20); C783(1.14); C785(1.14); C942(0.92)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C942(0.94); C783(1.07); C360(1.09); C785(1.11)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C942(0.83); C360(0.84); C783(0.97); C785(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C360(0.69); C785(0.95); C783(1.01); C942(1.09)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C360(0.90); C785(0.95); C783(0.95); C942(1.04)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C360(0.63); C942(1.07); C785(1.09); C783(1.63)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C360(0.69); C942(0.97); C785(1.05); C783(1.28)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C360(0.77); C783(1.04); C785(1.04); C942(1.21)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C785(0.95); C783(0.96); C360(1.04); C942(1.06)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C360(0.74); C785(0.98); C783(0.99); C942(1.10)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C360(0.71); C942(0.80); C785(1.12); C783(1.14)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C360(0.66); C785(1.14); C942(1.14); C783(1.32)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C360(0.72); C783(0.98); C785(0.99); C942(0.97)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C360(0.70); C783(1.09); C785(1.03); C942(0.99)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C360(0.76); C783(1.00); C785(1.00); C942(0.97)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C360(0.80); C783(0.91); C785(0.90); C942(0.88)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C360(0.47); C783(0.93); C785(0.93)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C360(0.50); C783(0.99); C785(0.99)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C360(0.41); C783(1.01); C785(1.01)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C360(0.99); C783(1.03); C785(1.03); C942(1.16)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C360(0.50); C783(1.11); C785(1.11)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C360(0.47); C783(1.13); C785(1.13)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C360(0.44); C783(1.26); C785(1.26)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C360(0.42); C783(1.05); C785(1.05)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C360(0.39); C783(1.01); C785(1.01)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C942(0.90); C783(0.94); C785(0.94)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C942(0.80); C783(0.99); C785(0.99)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C942(0.72); C783(0.98); C785(0.98)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C942(0.86); C783(0.99); C785(0.99)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C942(0.80); C783(0.98); C785(0.98)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C783(0.89); C785(0.89); C360(0.91); C942(1.20)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C942(0.96); C783(1.09); C785(1.09)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C942(0.88); C783(0.92); C785(0.92)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C942(0.75); C783(0.96); C785(0.96)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C942(0.84); C783(1.03); C785(1.03)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C942(0.84); C783(0.96); C785(0.96)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C783(0.78); C785(0.78); C942(0.87)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C783(0.82); C785(0.82); C942(0.82)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C783(0.76); C785(0.76); C942(0.85)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C783(0.83); C785(0.83); C942(1.03)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C783(0.74); C785(0.74); C942(1.07)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C360(0.90); C783(0.93); C785(0.93); C942(1.12)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C783(0.67); C785(0.67); C942(1.01)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C783(0.77); C785(0.77); C942(1.00)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C942(0.87); C783(0.88); C785(0.88)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C783(0.86); C785(0.86); C942(1.10)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C783(0.86); C785(0.86); C942(1.18)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C783(0.65); C785(0.65); C942(0.95)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C942(1.22); C783(1.33); C785(1.33)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C942(1.09); C783(1.10); C785(1.10)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C942(1.04); C783(1.12); C785(1.12)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C942(1.07); C783(1.12); C785(1.12)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C360(0.85); C783(0.91); C785(0.91); C942(1.11)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C942(1.03); C783(1.12); C785(1.12)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C942(1.23); C783(1.30); C785(1.30)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C942(0.88); C783(1.09); C785(1.09)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C783(1.02); C785(1.02); C942(1.03)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C783(1.02); C785(1.02); C942(1.15)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C783(1.14); C785(1.14); C942(1.19)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C783(1.09); C785(1.09); C942(1.15)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C783(0.95); C785(0.95); C360(1.07); C942(1.35)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C942(0.96); C783(1.06); C785(1.06); C360(1.45)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C783(0.95); C785(0.95); C942(1.01); C360(1.15)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C360(0.87); C942(0.96); C783(1.13); C785(1.13)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C783(1.12); C785(1.12); C942(1.14); C360(1.23)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C360(1.08); C783(1.14); C785(1.14); C942(1.14)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C783(1.03); C785(1.03); C942(1.09); C360(1.29)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C942(0.93); C360(1.03); C783(1.05); C785(1.05)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C783(1.01); C785(1.01); C942(1.05); C360(1.18)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C360(0.50); C783(1.05); C785(1.05); C942(1.28)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C360(0.45); C942(1.19); C783(1.24); C785(1.24)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C360(0.53); C783(1.02); C785(1.02); C942(1.04)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C942(0.78); C783(1.03); C785(1.03); C360(1.24)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C942(0.91); C783(1.01); C785(1.01); C360(1.11)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C360(0.77); C783(1.08); C785(1.08); C942(1.17)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C783(1.05); C785(1.05); C942(1.07); C360(1.20)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C942(0.78); C783(0.87); C785(0.87); C360(1.13)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C783(0.83); C785(0.83); C942(1.06); C360(1.48)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C783(1.02); C785(1.02); C942(1.02); C360(2.06)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C783(0.92); C785(0.92); C942(0.93); C360(1.79)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C942(0.98); C783(1.04); C785(1.04); C360(2.25)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C942(0.83); C783(0.90); C785(0.90); C360(1.56)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C942(0.79); C783(1.18); C785(1.18); C360(1.54)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C783(0.95); C785(0.95); C942(0.95); C360(1.18)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C783(0.91); C785(0.91); C942(1.06); C360(1.24)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C360(1.02); C783(1.06); C785(1.06); C942(1.10)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C942(0.88); C783(0.99); C785(0.99); C360(1.39)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C942(0.91); C360(1.01); C783(1.20); C785(1.20)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C942(0.99); C783(1.08); C785(1.08); C360(2.08)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C783(1.13); C785(1.13); C942(1.18); C360(1.95)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C942(1.06); C783(1.15); C785(1.15); C360(1.69)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C783(0.98); C785(0.98); C942(1.28); C360(1.41)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C942(1.09); C783(1.18); C785(1.18); C360(1.59)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C783(0.92); C785(0.92); C942(1.08); C360(1.52)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C942(1.08); C783(1.16); C785(1.16); C360(1.74)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C942(1.13); C783(1.19); C785(1.19); C360(1.59)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C942(1.14); C783(1.19); C785(1.19); C360(1.48)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C942(1.12); C783(1.16); C785(1.16); C360(1.77)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C942(1.15); C783(1.54); C785(1.54); C360(1.95)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C783(0.97); C785(0.97); C942(1.07); C360(1.43)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C783(0.92); C785(0.92); C942(1.23); C360(1.39)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C783(0.96); C785(0.96); C942(1.25); C360(1.56)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C783(1.02); C785(1.02); C942(1.14); C360(1.48)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C783(1.01); C785(1.01); C942(1.17); C360(1.88)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C942(0.83); C360(1.13); C783(1.29); C785(1.29)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C360(0.76); C942(0.98); C783(1.28); C785(1.28)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C360(0.94); C783(1.04); C785(1.04); C942(0.90)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C783(0.90); C785(0.90); C942(1.01); C360(1.17)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C360(0.87); C783(0.96); C785(0.96); C942(1.18)  LDD0592  [6]
 LDCM0020  ARS-1620 HCC44 C461(1.17); C360(0.90); C942(0.89)  LDD0078  [6]
 LDCM0088  C45 HEK-293T 12.14  LDD0201  [3]
 LDCM0108  Chloroacetamide HeLa C942(0.00); C812(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C461(20.00); C442(20.00); C461(0.47)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C360(1.14); C783(1.14); C785(1.14); C942(1.19)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C942(1.16); C783(1.23); C785(1.23); C360(1.35)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C942(1.02); C783(1.03); C785(1.03); C360(1.03)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C360(0.78); C942(1.00); C783(1.07); C785(1.07)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C360(0.88); C942(0.94); C783(1.04); C785(1.04)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C360(0.79); C783(0.95); C785(0.95); C942(1.14)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C360(0.77); C783(0.96); C785(0.96); C942(1.16)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C360(0.50); C783(1.03); C785(1.03)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C360(0.44); C783(1.00); C785(1.00)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C360(0.50); C783(1.03); C785(1.03)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C360(0.46); C783(0.94); C785(0.94)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C360(0.50); C783(1.10); C785(1.10)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C783(1.07); C785(1.07); C360(1.12); C942(1.22)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C360(0.47); C783(1.22); C785(1.22)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C360(0.48); C783(1.12); C785(1.12)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C942(0.69); C783(0.96); C785(0.96)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C942(0.76); C783(1.23); C785(1.23)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C942(0.81); C783(1.23); C785(1.23)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C942(0.80); C783(1.06); C785(1.06)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C942(0.71); C783(1.01); C785(1.01)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C783(0.65); C785(0.65); C942(0.91)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C783(0.83); C785(0.83); C942(0.94)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C783(0.83); C785(0.83); C942(0.86)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C783(1.04); C785(1.04); C360(1.18); C942(1.25)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C783(0.84); C785(0.84); C942(1.10)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C783(1.09); C785(1.09); C942(1.21)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C942(1.04); C783(1.07); C785(1.07)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C942(0.91); C783(1.21); C785(1.21)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C783(1.06); C785(1.06); C942(1.09)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C360(0.77); C942(0.93); C783(1.16); C785(1.16)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C360(0.71); C942(1.01); C783(1.18); C785(1.18)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C360(0.96); C783(1.04); C785(1.04); C942(1.06)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C783(1.00); C785(1.00); C942(1.08); C360(1.18)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C783(0.92); C785(0.92); C360(1.08); C942(1.20)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C783(0.98); C785(0.98); C360(1.04); C942(1.16)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C360(0.89); C783(0.96); C785(0.96); C942(1.25)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C942(0.92); C360(0.99); C783(1.11); C785(1.11)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C942(0.90); C360(1.00); C783(1.13); C785(1.13)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C942(0.92); C360(1.13); C783(1.17); C785(1.17)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C360(0.94); C783(1.00); C785(1.00); C942(1.09)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C360(0.89); C942(1.26); C783(1.35); C785(1.35)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C360(0.96); C942(0.96); C783(1.07); C785(1.07)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C360(0.88); C783(0.92); C785(0.92); C942(0.97)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C360(0.85); C783(1.04); C785(1.04); C942(1.05)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C942(1.00); C783(1.07); C785(1.07); C360(1.11)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C942(1.04); C783(1.07); C785(1.07); C360(1.08)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C360(1.08); C783(1.18); C785(1.18); C942(0.99)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C360(1.13); C783(1.11); C785(1.11); C942(0.99)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C360(0.96); C783(1.06); C785(1.06); C942(1.03)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C360(1.11); C783(1.01); C785(1.01); C942(0.97)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C360(1.06); C783(1.22); C785(1.22); C942(0.98)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C360(1.05); C783(1.00); C785(1.00); C942(0.91)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C360(1.03); C783(1.23); C785(1.23); C942(0.91)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C783(0.91); C785(0.91); C942(1.11)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C360(0.88); C783(1.02); C785(1.02); C942(1.00)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C360(0.94); C783(0.99); C785(0.99); C942(0.96)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C360(1.09); C783(0.89); C785(0.89); C942(1.06)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C360(1.00); C783(0.76); C785(0.76); C942(1.15)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C360(0.72); C783(0.77); C785(0.77); C942(1.05)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C360(0.94); C783(0.83); C785(0.83); C942(0.99)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C360(0.93); C783(0.77); C785(0.77); C942(1.11)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C360(0.83); C783(0.97); C785(0.97); C942(1.01)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C360(0.99); C783(0.87); C785(0.87); C942(0.98)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C360(0.74); C783(0.79); C785(0.79); C942(1.04)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C360(0.70); C783(0.85); C785(0.85); C942(1.17)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C360(0.99); C783(0.82); C785(0.82); C942(1.10)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C360(0.91); C783(0.80); C785(0.80); C942(0.97)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C360(0.91); C783(0.80); C785(0.80); C942(1.06)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C360(1.00); C783(1.14); C785(1.20); C942(0.98)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C360(0.98); C783(1.23); C785(1.31); C942(0.93)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C360(0.99); C783(1.05); C785(1.11); C942(0.85)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C360(1.03); C783(1.16); C785(1.18); C942(0.97)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C360(0.94); C783(0.97); C785(0.97); C942(1.09)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C360(0.97); C783(0.99); C785(0.98); C942(0.95)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C360(1.15); C783(1.06); C785(1.09); C942(0.99)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C360(1.02); C783(1.30); C785(1.33); C942(1.04)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C360(1.13); C783(1.12); C785(1.14); C942(0.85)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C360(0.90); C783(1.06); C785(1.08); C942(0.90)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C360(0.89); C783(1.12); C785(1.18); C942(0.86)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C360(0.90); C783(1.08); C785(1.12); C942(0.97)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C360(0.87); C783(0.99); C785(1.02); C942(0.83)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C360(1.03); C783(1.23); C785(1.25); C942(1.56)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C360(1.07); C783(1.20); C785(1.21); C942(1.00)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C360(0.93); C783(1.08); C785(1.08); C942(1.09)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C360(0.94); C783(1.26); C785(1.25); C942(0.95)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C783(0.81); C785(0.81); C942(0.93)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C783(0.99); C785(0.99); C942(0.90)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C783(0.74); C785(0.74); C942(0.80)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C783(0.75); C785(0.75); C942(0.85)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C783(0.73); C785(0.73); C942(0.84)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C783(0.74); C785(0.74); C942(1.01)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C783(0.74); C785(0.74); C942(0.88)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C783(0.87); C785(0.87); C942(0.96)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C783(0.90); C785(0.90); C942(0.79)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C360(0.93); C783(0.99); C785(0.99); C942(1.16)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C783(0.83); C785(0.83); C942(0.88)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C783(0.81); C785(0.81); C942(0.94)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C783(0.97); C785(0.97); C942(0.94)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C783(0.74); C785(0.74); C942(0.89)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C783(0.79); C785(0.79); C942(0.88)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C360(0.85); C783(1.00); C785(1.00); C942(0.88)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C360(0.91); C783(0.99); C785(0.99); C942(0.84)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C360(0.92); C783(1.02); C785(1.02); C942(0.83)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C360(1.00); C783(1.00); C785(1.00); C942(1.02)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C360(0.94); C783(0.96); C785(0.96); C942(1.13)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C360(0.99); C783(0.91); C785(0.91); C942(0.78)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C360(0.92); C783(0.89); C785(0.89); C942(0.87)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C360(0.92); C783(0.99); C785(0.99); C942(1.11)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C360(0.89); C783(1.04); C785(1.04); C942(1.00)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C360(1.14); C783(1.17); C785(1.17); C942(1.02)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C360(1.00); C783(1.14); C785(1.14); C942(1.01)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C360(1.04); C783(0.93); C785(0.93); C942(0.85)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C360(0.94); C783(1.02); C785(1.02); C942(0.89)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C360(1.00); C783(1.02); C785(1.02); C942(0.94)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C360(0.88); C783(1.18); C785(1.18); C942(1.02)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C360(1.14); C783(1.03); C785(1.03); C942(1.13)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C360(0.85); C783(0.87); C785(0.87); C942(0.82)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C360(0.87); C783(0.98); C785(0.98); C942(1.06)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C360(0.89); C783(0.89); C785(0.89); C942(1.06)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C360(0.90); C783(0.87); C785(0.87); C942(1.00)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C360(0.95); C783(0.93); C785(0.93); C942(1.05)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C360(0.98); C783(1.00); C785(1.00); C942(0.98)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C360(0.84); C783(1.01); C785(1.01); C942(0.98)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C360(0.91); C783(0.97); C785(0.97); C942(1.15)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C360(1.06); C783(0.84); C785(0.84); C942(1.10)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C360(0.98); C783(0.94); C785(0.94); C942(1.06)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C360(1.70); C461(0.26)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C942(0.98); C442(1.06); C896(1.06); C360(1.00)  LDD1698  [18]
 LDCM0468  Fragment33 HCT 116 C783(0.88); C785(0.88); C942(0.94)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C360(0.91); C783(0.91); C785(0.91); C942(1.10)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C442(2.58); C360(1.78); C942(1.80)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C442(1.72); C360(1.25); C942(1.68)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C442(1.85); C360(1.58); C942(1.27)  LDD0082  [6]
 LDCM0109  NEM HeLa H66(0.00); H547(0.00)  LDD0223  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C461(0.71)  LDD2099  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RAD18 (RAD18) RAD18 family Q9NS91
Ubiquitin-conjugating enzyme E2 N (UBE2N) Ubiquitin-conjugating enzyme family P61088
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein S100-A10 (S100A10) S-100 family P60903
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proliferating cell nuclear antigen (PCNA) PCNA family P12004

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402