Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C249  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 110 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01803  Adenosine deaminase (ADA) 99.7
 LDTP13972  Oligoribonuclease, mitochondrial (REXO2) 68.1
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 56.1
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 46.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 43.4
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 42.5
 LDTP09074  UDP-glucuronic acid decarboxylase 1 (UXS1) 37.3
 LDTP08728  Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) 37.0
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 36.3
 LDTP12586  Phenylalanine--tRNA ligase beta subunit (FARSB) 35.0
 LDTP02223  Cathepsin B (CTSB) 34.5
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 32.9
 LDTP10495  Ubiquitin carboxyl-terminal hydrolase 47 (USP47) 32.9
 LDTP02359  Heme oxygenase 1 (HMOX1) 32.2
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 31.6
 LDTP02713  Macrophage migration inhibitory factor (MIF) 30.5
 LDTP02505  Lysosomal protective protein (CTSA) 29.4
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 28.2
 LDTP10032  7-methylguanosine phosphate-specific 5'-nucleotidase (NT5C3B) 28.1
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 27.9
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 27.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 26.9
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 26.5
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 26.5
 LDTP12873  CDGSH iron-sulfur domain-containing protein 1 (CISD1) 26.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 25.8
 LDTP00697  Cytochrome b5 type B (CYB5B) 25.8
 LDTP08177  Dehydrodolichyl diphosphate synthase complex subunit DHDDS (DHDDS) 25.3
 LDTP02006  Tissue alpha-L-fucosidase (FUCA1) 24.8
 LDTP01241  Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) 24.6
 LDTP03198  Ferrochelatase, mitochondrial (FECH) 23.3
 LDTP05905  Acid ceramidase (ASAH1) 21.9
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 21.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 21.0
 LDTP10550  Dehydrogenase/reductase SDR family member 1 (DHRS1) 20.4
 LDTP10163  m7GpppX diphosphatase (DCPS) 20.4
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.4
 LDTP07831  Transmembrane protein with metallophosphoesterase domain (TMPPE) 20.4
 LDTP09096  Carbohydrate sulfotransferase 14 (CHST14) 20.3
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 20.1
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 19.6
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 19.4
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 19.4
 LDTP12679  Trimethyllysine dioxygenase, mitochondrial (TMLHE) 19.4
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 19.0
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 18.0
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 17.9
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 17.8
 LDTP02005  Lysosomal acid glucosylceramidase (GBA1) 17.4
 LDTP02169  Beta-hexosaminidase subunit alpha (HEXA) 17.3
 LDTP06849  Prolyl endopeptidase-like (PREPL) 17.3
 LDTP16040  Glyoxalase domain-containing protein 4 (GLOD4) 17.1
 LDTP13358  Leucyl-cystinyl aminopeptidase (LNPEP) 17.0
 LDTP06139  Helicase-like transcription factor (HLTF) 16.9
 LDTP00988  Protein O-GlcNAcase (OGA) 16.6
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 16.6
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 16.2
 LDTP04634  Alpha-N-acetylglucosaminidase (NAGLU) 15.9
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 15.7
 LDTP07525  Protein arginine N-methyltransferase 9 (PRMT9) 15.6
 LDTP09925  COP9 signalosome complex subunit 5 (COPS5) 15.5
 LDTP11215  Plasma alpha-L-fucosidase (FUCA2) 15.2
 LDTP09256  Putative phospholipase B-like 2 (PLBD2) 15.2
 LDTP14218  Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) 14.8
 LDTP00486  Cytochrome b-c1 complex subunit 8 (UQCRQ) 14.7
 LDTP11703  Histone deacetylase complex subunit SAP130 (SAP130) 14.7
 LDTP05066  Signal peptidase complex catalytic subunit SEC11A (SEC11A) 14.4
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 14.3
 LDTP05632  Mitochondrial-processing peptidase subunit alpha (PMPCA) 14.1
 LDTP01768  Glutamate dehydrogenase 1, mitochondrial (GLUD1) 14.0
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 14.0
 LDTP06333  Serum paraoxonase/arylesterase 2 (PON2) 14.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 13.7
 LDTP02385  Leukotriene A-4 hydrolase (LTA4H) 13.5
 LDTP09155  Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) 13.5
 LDTP05588  RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) 13.5
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) 13.5
 LDTP10612  Lysophospholipid acyltransferase 7 (MBOAT7) 13.4
 LDTP04581  Holocytochrome c-type synthase (HCCS) 13.0
 LDTP12720  Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14) 13.0
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 13.0
 LDTP03523  Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) 13.0
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 12.9
 LDTP10020  Ras-related protein Rab-24 (RAB24) 12.9
 LDTP05408  Antigen peptide transporter 1 (TAP1) 12.8
 LDTP08455  Palmitoyltransferase ZDHHC13 (ZDHHC13) 12.8
 LDTP03424  ATP-binding cassette sub-family D member 3 (ABCD3) 12.7
 LDTP10329  Ceramide synthase 2 (CERS2) 12.7
 LDTP12959  NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13) 12.7
 LDTP02141  Alpha-galactosidase A (GLA) 12.6
 LDTP10699  E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) 12.6
 LDTP02679  Prolyl 4-hydroxylase subunit alpha-1 (P4HA1) 12.6
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 12.6
 LDTP09395  Signal peptide peptidase-like 2A (SPPL2A) 12.4
 LDTP07813  Sulfhydryl oxidase 2 (QSOX2) 12.4
 LDTP11152  Cancer-related nucleoside-triphosphatase (NTPCR) 12.3
 LDTP06427  Translin (TSN) 12.3
 LDTP03787  Choline kinase alpha (CHKA) 12.2
 LDTP12524  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) 12.2
 LDTP11199  DCN1-like protein 5 (DCUN1D5) 12.1
 LDTP11268  Acireductone dioxygenase (ADI1) 12.0
 LDTP05638  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (ST3GAL4) 12.0
 LDTP01787  Phosphoglycerate kinase 1 (PGK1) 12.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 12.0
 LDTP08790  Mitochondrial cardiolipin hydrolase (PLD6) 12.0
 LDTP05446  Ubiquitin-protein ligase E3A (UBE3A) 12.0
 LDTP09251  Atlastin-2 (ATL2) 11.9
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 11.9
 LDTP11209  Phosphatidylinositol 4-kinase type 2-alpha (PI4K2A) 11.9
Transporter and channel
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 50.9
 LDTP16813  Tetraspanin-3 (TSPAN3) 43.4
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 39.9
 LDTP05900  Metaxin-1 (MTX1) 37.3
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 36.3
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 35.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 34.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 33.8
 LDTP07156  Protein wntless homolog (WLS) 33.1
 LDTP04956  Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10) 31.6
 LDTP07236  Protein GPR107 (GPR107) 30.9
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 28.6
 LDTP15481  Transmembrane protein 87A (TMEM87A) 28.2
 LDTP02215  Prosaposin (PSAP) 27.5
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 26.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 25.5
 LDTP15948  Transmembrane protein 126A (TMEM126A) 25.5
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 24.8
 LDTP20002  Transmembrane protein 160 (TMEM160) 24.4
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 23.8
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 23.1
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 22.6
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 21.9
 LDTP11116  45 kDa calcium-binding protein (SDF4) 21.6
 LDTP01100  Iron-sulfur clusters transporter ABCB7, mitochondrial (ABCB7) 21.3
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.8
 LDTP13833  Integral membrane protein 2B (ITM2B) 19.7
 LDTP13983  Mitochondrial import inner membrane translocase subunit TIM16 (PAM16) 19.2
 LDTP11615  Protein tweety homolog 3 (TTYH3) 18.6
 LDTP09968  V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) 18.1
 LDTP08878  ER membrane protein complex subunit 5 (MMGT1) 17.6
 LDTP00010  Intraflagellar transport protein 56 (IFT56) 16.9
 LDTP01542  Golgi SNAP receptor complex member 1 (GOSR1) 16.7
 LDTP11531  Oxysterol-binding protein-related protein 8 (OSBPL8) 15.2
 LDTP09333  Golgin subfamily A member 5 (GOLGA5) 15.0
 LDTP11162  Solute carrier family 25 member 33 (SLC25A33) 14.4
 LDTP10669  Melanoma inhibitory activity protein 2 (MIA2) 14.3
 LDTP03905  Peroxisomal biogenesis factor 19 (PEX19) 14.3
 LDTP01745  Putative lipid scramblase CLPTM1 (CLPTM1) 14.1
 LDTP01671  STARD3 N-terminal-like protein (STARD3NL) 14.1
 LDTP16190  Protein FAM8A1 (FAM8A1) 13.6
 LDTP03559  High affinity cationic amino acid transporter 1 (SLC7A1) 13.5
 LDTP00592  Surfeit locus protein 4 (SURF4) 13.5
 LDTP00821  Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) 13.4
 LDTP15648  BRI3-binding protein (BRI3BP) 13.0
 LDTP18448  Transmembrane 9 superfamily member 3 (TM9SF3) 13.0
 LDTP00541  NPC intracellular cholesterol transporter 1 (NPC1) 12.8
 LDTP06365  Transmembrane emp24 domain-containing protein 2 (TMED2) 12.7
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 12.4
 LDTP06221  StAR-related lipid transfer protein 3 (STARD3) 12.4
 LDTP05667  Syntaxin-4 (STX4) 12.4
 LDTP01380  Wolframin (WFS1) 12.4
 LDTP18459  StAR-related lipid transfer protein 7, mitochondrial (STARD7) 12.2
 LDTP13969  Transmembrane emp24 domain-containing protein 7 (TMED7) 12.1
 LDTP09294  Proton-coupled zinc antiporter SLC30A5 (SLC30A5) 11.9
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05065  Y-box-binding protein 1 (YBX1) 12.6
Other
Click to Show/Hide to Show 95 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11076  Apolipoprotein L2 (APOL2) 83.9
 LDTP01075  Protein CutA (CUTA) 52.0
 LDTP13606  Mammalian ependymin-related protein 1 (EPDR1) 50.6
 LDTP14939  Membralin (TMEM259) 41.4
 LDTP13902  Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) 38.1
 LDTP12891  Glycolipid transfer protein (GLTP) 37.5
 LDTP13311  Poly(U)-binding-splicing factor PUF60 (PUF60) 37.5
 LDTP05160  Nucleobindin-2 (NUCB2) 34.1
 LDTP13245  Zinc finger CCCH domain-containing protein 7B (ZC3H7B) 31.6
 LDTP00281  Golgi integral membrane protein 4 (GOLIM4) 28.4
 LDTP00986  Syntaxin-10 (STX10) 28.2
 LDTP08796  Protein SYS1 homolog (SYS1) 27.9
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 27.7
 LDTP02124  Keratin, type I cytoskeletal 18 (KRT18) 26.7
 LDTP06097  Reticulocalbin-2 (RCN2) 26.7
 LDTP13086  Syntaxin-18 (STX18) 26.5
 LDTP00850  ER lumen protein-retaining receptor 3 (KDELR3) 26.0
 LDTP07368  Tetratricopeptide repeat protein 19, mitochondrial (TTC19) 24.1
 LDTP14486  Clustered mitochondria protein homolog (CLUH) 23.9
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 23.9
 LDTP19780  Keratinocyte-associated transmembrane protein 2 (KCT2) 22.9
 LDTP16006  Optic atrophy 3 protein (OPA3) 22.6
 LDTP02927  Ganglioside GM2 activator (GM2A) 21.9
 LDTP06068  MAGUK p55 subfamily member 2 (MPP2) 21.6
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 21.0
 LDTP09870  Signal transducing adapter molecule 1 (STAM) 20.1
 LDTP03775  RNA-binding protein FUS (FUS) 20.0
 LDTP12623  Zinc finger CCHC domain-containing protein 3 (ZCCHC3) 19.6
 LDTP00199  HCLS1-associated protein X-1 (HAX1) 18.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 18.5
 LDTP09069  Kinetochore protein Spc24 (SPC24) 18.3
 LDTP16080  Protein FAM114A2 (FAM114A2) 17.8
 LDTP13656  Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) 17.6
 LDTP00887  Calumenin (CALU) 17.3
 LDTP10056  Protein FAM162A (FAM162A) 16.9
 LDTP10213  Anaphase-promoting complex subunit 16 (ANAPC16) 16.7
 LDTP00573  Prefoldin subunit 6 (PFDN6) 16.4
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 16.4
 LDTP14458  Tetraspanin-6 (TSPAN6) 16.3
 LDTP11978  HAUS augmin-like complex subunit 4 (HAUS4) 16.2
 LDTP19372  Tetratricopeptide repeat protein 38 (TTC38) 16.2
 LDTP01600  BAG family molecular chaperone regulator 4 (BAG4) 16.1
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 15.9
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 15.9
 LDTP19924  Protein PBDC1 (PBDC1) 15.8
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 15.6
 LDTP02297  Vimentin (VIM) 15.6
 LDTP01466  HAUS augmin-like complex subunit 5 (HAUS5) 15.5
 LDTP18373  Thioredoxin-related transmembrane protein 4 (TMX4) 15.3
 LDTP12287  Ran guanine nucleotide release factor (RANGRF) 15.0
 LDTP10735  Transcription elongation factor, mitochondrial (TEFM) 15.0
 LDTP04902  Actin-related protein 3 (ACTR3) 14.9
 LDTP02180  Neurofilament light polypeptide (NEFL) 14.8
 LDTP16078  Heme-binding protein 1 (HEBP1) 14.6
 LDTP18883  Protein CEBPZOS (CEBPZOS) 14.5
 LDTP19963  TraB domain-containing protein (TRABD) 14.5
 LDTP01359  Dynactin subunit 3 (DCTN3) 14.4
 LDTP15240  LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3) 14.4
 LDTP13309  Prefoldin subunit 2 (PFDN2) 14.4
 LDTP13019  Vacuolar protein sorting-associated protein 18 homolog (VPS18) 14.4
 LDTP06391  Protein transport protein Sec23B (SEC23B) 14.3
 LDTP07318  HAUS augmin-like complex subunit 3 (HAUS3) 14.1
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 14.0
 LDTP13922  Tudor and KH domain-containing protein (TDRKH) 14.0
 LDTP11643  Superkiller complex protein 8 (SKIC8) 13.9
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 13.8
 LDTP12025  UPF0488 protein C8orf33 (C8orf33) 13.8
 LDTP04714  Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) 13.7
 LDTP08420  BLOC-2 complex member HPS6 (HPS6) 13.6
 LDTP09989  Pre-rRNA-processing protein TSR2 homolog (TSR2) 13.5
 LDTP10860  Tubulin-folding cofactor B (TBCB) 13.5
 LDTP00991  Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) 13.4
 LDTP05226  RNA-binding protein 3 (RBM3) 13.4
 LDTP19785  Transmembrane protein 35B (TMEM35B) 13.4
 LDTP06022  Cold-inducible RNA-binding protein (CIRBP) 13.2
 LDTP03729  General transcription factor IIF subunit 1 (GTF2F1) 13.1
 LDTP05318  RNA-binding protein EWS (EWSR1) 13.1
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) 13.0
 LDTP00417  Programmed cell death protein 5 (PDCD5) 13.0
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 12.9
 LDTP04241  Nuclear autoantigenic sperm protein (NASP) 12.9
 LDTP11825  Phosducin-like protein 3 (PDCL3) 12.9
 LDTP12982  Mitochondrial import receptor subunit TOM7 homolog (TOMM7) 12.7
 LDTP06587  Survival motor neuron protein (SMN1; SMN2) 12.6
 LDTP09938  Far upstream element-binding protein 2 (KHSRP) 12.6
 LDTP09850  Proline-rich protein PRCC (PRCC) 12.5
 LDTP06060  Ubiquitin-associated protein 2-like (UBAP2L) 12.5
 LDTP10078  Far upstream element-binding protein 1 (FUBP1) 12.3
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) 12.3
 LDTP14259  Testis-expressed protein 264 (TEX264) 12.3
 LDTP00223  26S proteasome non-ATPase regulatory subunit 11 (PSMD11) 12.2
 LDTP05113  T-complex protein 1 subunit beta (CCT2) 12.2
 LDTP08904  Protein jagunal homolog 1 (JAGN1) 12.1
 LDTP09410  Protein bicaudal D homolog 2 (BICD2) 12.0
 LDTP03213  Tubulin gamma-1 chain (TUBG1) 12.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587