Details of the Target

General Information of Target

Target ID LDTP03424
Target Name ATP-binding cassette sub-family D member 3 (ABCD3)
Gene Name ABCD3
Gene ID 5825
Synonyms
PMP70; PXMP1; ATP-binding cassette sub-family D member 3; EC 3.1.2.-; EC 7.6.2.-; 70 kDa peroxisomal membrane protein; PMP70
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVD
KVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRK
DFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVS
GLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLV
EHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEG
VQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKS
SLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAMARLFYHKPQFAILDECTSA
VSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHEYYLHMDGRGNYEFKQITEDTVEFGS
Target Bioclass
Enzyme
Family
ABC transporter superfamily, ABCD family, Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
Subcellular location
Peroxisome membrane
Function
Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation.
Uniprot ID
P28288
Ensemble ID
ENST00000315713.5
HGNC ID
HGNC:67

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F196C .
KNS42 Deletion: p.E419_I424del .
TE10 SNV: p.S5R .
WM2664 Insertion: p.V564GfsTer25 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.12  LDD0402  [1]
CHEMBL5175495
 Probe Info  		8.88  LDD0196  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y507(20.00); Y513(20.00); Y525(13.27)  LDD0260  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
ONAyne
 Probe Info  		N.A.  LDD0273  [6]
AHL-Pu-1
 Probe Info  		C472(2.00)  LDD0170  [7]
HPAP
 Probe Info  		3.26  LDD0063  [8]
DBIA
 Probe Info  		C477(13.37); C472(9.77)  LDD0080  [9]
ATP probe
 Probe Info  		K479(0.00); K260(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C24(0.00); C477(0.00); C472(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C24(0.00); C477(0.00); C472(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C24(0.00); C477(0.00); C472(0.00)  LDD0037  [11]
JW-RF-010
 Probe Info  		C472(0.00); C477(0.00)  LDD0026  [12]
NAIA_5
 Probe Info  		C24(0.00); C477(0.00)  LDD2224  [13]
TFBX
 Probe Info  		C477(0.00); C472(0.00)  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
Compound 10
 Probe Info  		N.A.  LDD2216  [15]
Compound 11
 Probe Info  		N.A.  LDD2213  [15]
IPM
 Probe Info  		C477(0.00); C472(0.00)  LDD0005  [14]
SF
 Probe Info  		N.A.  LDD0028  [16]
STPyne
 Probe Info  		K61(0.00); K39(0.00); K479(0.00)  LDD0009  [14]
VSF
 Probe Info  		N.A.  LDD0007  [14]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
W1
 Probe Info  		C472(0.00); C477(0.00)  LDD0236  [19]
AOyne
 Probe Info  		11.40  LDD0443  [20]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C232
 Probe Info  		40.50  LDD1905  [21]
C249
 Probe Info  		12.73  LDD1922  [21]
C296
 Probe Info  		16.56  LDD1966  [21]
C326
 Probe Info  		9.32  LDD1990  [21]
C338
 Probe Info  		10.41  LDD2001  [21]
FFF probe11
 Probe Info  		15.27  LDD0471  [22]
FFF probe13
 Probe Info  		16.93  LDD0475  [22]
FFF probe14
 Probe Info  		12.26  LDD0477  [22]
FFF probe2
 Probe Info  		13.49  LDD0463  [22]
FFF probe3
 Probe Info  		18.35  LDD0464  [22]
FFF probe9
 Probe Info  		6.38  LDD0470  [22]
JN0003
 Probe Info  		13.00  LDD0469  [22]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
Alk-rapa
 Probe Info  		2.84  LDD0213  [24]
DA-2
 Probe Info  		N.A.  LDD0072  [25]
OEA-DA
 Probe Info  		5.54  LDD0046  [26]
STS-1
 Probe Info  		N.A.  LDD0068  [27]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C472(2.00)  LDD0170  [7]
 LDCM0214  AC1 HCT 116 C472(1.33); C477(1.35)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C472(1.20); C477(1.21)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C472(1.14); C477(1.14)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C472(1.07); C477(1.24)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C472(1.04); C477(1.01)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C472(1.50); C477(1.49)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C472(1.21); C477(1.23)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C472(1.48); C477(1.33)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C472(1.30); C477(1.29)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C472(1.55); C477(1.32)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C472(1.03); C477(0.94)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C472(0.88); C477(0.84)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C472(1.27); C477(1.28)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C472(1.04); C477(1.03)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C472(1.03); C477(0.97)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C472(1.35); C477(1.20)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C472(0.98); C477(1.07)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C472(1.16); C477(1.30)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C472(1.47); C477(1.49)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C472(1.28); C477(1.36)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C472(1.10); C477(1.18)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C472(1.06); C477(1.09)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C472(1.21); C477(1.22)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C472(1.06); C477(1.13)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C472(1.22); C477(1.24)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C472(1.11); C477(1.15)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C472(1.14); C477(1.11)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C472(1.04); C477(1.11)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C472(0.94); C477(1.06)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C472(1.08); C477(1.17)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C472(1.31); C477(1.44)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C472(1.29); C477(1.43)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C472(1.71); C477(1.76)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C472(1.11); C477(1.17)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C472(1.62); C477(1.63)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C472(1.10); C477(1.12)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C472(1.24); C477(1.25)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C472(1.46); C477(1.47)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C472(1.70); C477(1.74)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C472(1.56); C477(1.58)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C472(1.31); C477(1.31)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C472(1.38); C477(1.39)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C472(1.90); C477(1.84)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C472(1.75); C477(1.72)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C472(1.16); C477(1.18)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C472(1.82); C477(1.84)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C472(1.68); C477(1.66)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C472(1.40); C477(1.35)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C472(1.21); C477(1.20)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C477(1.40); C472(1.55)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C477(1.18); C472(1.39)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C477(1.32); C472(1.40)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C477(1.46); C472(1.61)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C477(2.08); C472(2.28)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C477(1.63); C472(1.76)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C472(1.13); C477(1.15)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C477(1.12); C472(1.23)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C477(1.09); C472(1.25)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C477(1.59); C472(1.80)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C477(2.39); C472(2.74)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C472(1.49); C477(1.30)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C472(1.38); C477(1.19)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C472(1.10); C477(0.98)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C472(1.05); C477(1.12)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C99(0.81); C477(1.02); C472(1.06)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C99(0.60); C472(0.98); C477(1.04)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C99(0.60); C472(1.12); C477(1.20)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C472(1.16); C477(1.18)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C99(0.84); C472(1.12); C477(1.14)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C99(0.50); C477(0.93); C472(0.93)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C477(1.02); C99(1.03); C472(1.04)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C99(0.67); C477(1.06); C472(1.06)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C99(0.72); C477(0.99); C472(1.04)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C477(1.08); C472(1.09)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C477(1.22); C472(1.27)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C477(1.18); C472(1.22)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C477(1.25); C472(1.29)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C477(1.27); C472(1.32)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C477(1.19); C472(1.19)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C477(1.33); C472(1.40)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C477(1.26); C472(1.29)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C477(1.58); C472(1.65)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C477(1.48); C472(1.49)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C477(1.77); C472(1.81)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C99(0.53); C472(0.81); C477(0.84)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C99(0.49); C472(0.83); C477(0.86)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C99(0.63); C472(0.93); C477(0.93)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C99(0.69); C472(0.87); C477(0.90)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C99(0.72); C472(1.10); C477(1.13)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C472(1.28); C477(1.28)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C99(0.68); C472(1.16); C477(1.21)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C99(0.69); C477(1.00); C472(1.01)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C99(0.88); C472(1.04); C477(1.11)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C99(0.57); C477(1.08); C472(1.09)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C99(0.83); C472(0.98); C477(1.00)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C99(0.87); C472(1.29); C477(1.29)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C477(1.06); C472(1.11)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C477(1.09); C472(1.10)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C477(1.12); C472(1.18)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C477(1.53); C472(1.59)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C472(1.36); C477(1.47)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C477(1.48); C472(1.51)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C477(0.89); C472(0.92)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C477(1.12); C472(1.18)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C477(1.19); C472(1.21)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C477(1.23); C472(1.27)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C477(1.44); C472(1.46)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C477(1.94); C472(1.99)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C99(0.85); C477(1.39); C472(1.50)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C99(0.82); C477(1.40); C472(1.51)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C99(0.82); C477(1.45); C472(1.55)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C477(1.27); C472(1.28)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C99(0.70); C477(1.32); C472(1.40)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C99(0.70); C477(1.28); C472(1.48)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C99(0.64); C477(1.62); C472(1.81)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C99(0.66); C477(1.36); C472(1.38)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C99(0.84); C477(1.53); C472(1.74)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C99(0.99); C477(1.61); C472(1.81)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C99(0.99); C477(1.42); C472(1.57)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C99(0.90); C477(1.86); C472(2.20)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C472(0.87); C477(0.87)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C472(0.89); C477(0.89)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C472(1.18); C477(1.20)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C472(1.12); C477(1.12)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C472(0.73); C477(0.73)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C472(0.96); C477(0.96)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C472(1.01); C477(1.01)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C472(0.78); C477(0.78)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C472(1.09); C477(1.09)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C472(0.87); C477(0.87)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C472(1.07); C477(1.07)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C472(1.05); C477(1.05)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C472(0.99); C477(0.99)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C477(1.18); C472(1.19)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C472(0.89); C477(0.89)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C472(0.89); C477(0.89)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C472(0.86); C477(0.86)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C477(1.96); C472(2.06)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C472(1.61); C477(1.69)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C472(1.34); C477(1.47)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C472(1.29); C477(1.47)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C472(1.09); C477(1.16)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C472(1.23); C477(1.29)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C477(1.45); C472(1.56)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C477(1.18); C472(1.22)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C472(1.92); C477(2.02)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C477(1.81); C472(2.00)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C472(1.16); C477(1.22)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C472(1.00); C477(1.19)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C472(1.17); C477(1.27)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C477(1.44); C472(1.51)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C472(1.74); C477(1.75)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C472(2.02); C477(2.18)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C472(0.98); C477(1.06)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C472(1.00); C477(0.99)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C477(1.16); C472(1.17)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C477(1.59); C472(1.60)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C472(0.95); C477(0.95)  LDD2171  [9]
 LDCM0630  CCW28-3 231MFP C477(1.78)  LDD2214  [28]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C472(0.87); C477(0.94)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C477(1.16); C472(1.41)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C472(1.28); C477(1.30)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C477(1.16); C472(1.18)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C472(0.96); C477(1.00)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C472(1.00); C477(1.04)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C472(1.04); C477(1.07)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C99(0.50); C477(1.19); C472(1.30)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C99(0.42); C472(1.54); C477(1.68)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C99(0.55); C477(1.52); C472(1.65)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C99(0.59); C477(1.14); C472(1.18)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C99(0.52); C477(1.23); C472(1.25)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C477(1.29); C472(1.48)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C99(0.53); C477(1.20); C472(1.24)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C99(0.60); C477(1.08); C472(1.11)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C477(1.06); C472(1.08)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C477(1.56); C472(1.63)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C477(1.20); C472(1.29)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C477(1.19); C472(1.24)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C477(1.24); C472(1.26)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C99(0.74); C472(1.60); C477(1.62)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C99(0.62); C472(0.94); C477(0.96)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C99(0.83); C472(1.10); C477(1.13)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C477(1.35); C472(1.42)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C99(0.79); C472(1.02); C477(1.03)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C477(1.40); C472(1.43)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C477(1.15); C472(1.20)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C477(1.19); C472(1.25)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C477(1.47); C472(1.54)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C99(0.95); C472(1.08); C477(1.08)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C99(0.81); C477(1.02); C472(1.09)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C99(0.70); C477(1.10); C472(1.18)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C99(0.67); C477(1.28); C472(1.46)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C477(1.21); C472(1.28)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C477(0.96); C472(0.97)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C477(1.11); C472(1.18)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C477(0.98); C99(1.04); C472(1.23)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C99(0.66); C477(0.90); C472(0.99)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C99(0.70); C477(1.01); C472(1.20)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C99(1.00); C477(1.02); C472(1.20)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C472(0.94); C477(0.99)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C99(1.16); C477(1.30); C472(1.48)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C99(1.15); C477(1.42); C472(1.69)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C99(1.29); C477(1.72); C472(2.03)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C99(0.86); C477(1.08); C472(1.18)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C99(1.02); C477(1.27); C472(1.47)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C472(1.59); C477(1.29); C99(0.97)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C472(1.24); C477(1.09); C99(1.19)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C472(1.33); C477(1.16); C99(1.20)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C472(1.35); C477(1.15); C99(0.88)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C472(1.48); C477(1.26); C99(1.12)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C472(0.95); C477(0.92)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C472(1.01); C477(0.94); C99(1.14)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C472(1.19); C477(1.15); C99(0.66)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C472(1.25); C477(1.21); C99(0.66)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C472(1.11); C477(1.07); C99(0.66)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C472(1.77); C477(1.54); C99(0.72)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C472(1.56); C477(1.50); C99(0.86)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C472(1.37); C477(1.44); C99(1.08)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C472(1.69); C477(1.57); C99(0.74)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C472(1.59); C477(1.53); C99(0.79)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C472(0.92); C477(0.99)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C472(1.38); C477(1.30); C99(0.60)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C472(1.30); C477(1.34); C99(0.93)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C472(2.27); C477(2.14); C99(0.79)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C472(1.65); C477(1.58); C99(0.81)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C472(1.45); C477(1.37); C99(0.71)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C472(1.63); C477(1.48); C99(0.61)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C472(1.14); C477(0.96); C99(1.87)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C472(0.99); C477(0.83); C99(1.63)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C472(0.82); C477(0.89); C99(1.47)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C472(1.12); C477(1.02); C99(0.97)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C472(1.04); C477(0.96)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C472(1.04); C477(0.95); C99(1.01)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C472(1.19); C477(1.01); C99(1.22)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C472(1.31); C477(1.08); C99(1.65)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C472(1.10); C477(1.00); C99(1.44)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C472(1.04); C477(0.84); C99(1.80)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C472(1.03); C477(0.94); C99(1.77)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C472(1.17); C477(1.10); C99(1.50)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C472(1.19); C477(0.98); C99(0.97)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C472(0.99); C477(0.88); C99(1.59)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C472(0.99); C477(0.96); C99(1.13)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C472(1.13); C477(1.10)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C472(1.05); C477(1.01); C99(1.15)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C472(1.08); C477(1.23); C99(1.09)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C472(1.13); C477(1.20); C99(0.86)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C472(1.30); C477(1.42); C99(0.80)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C472(1.56); C477(1.56); C99(0.69)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C472(1.17); C477(1.28); C99(1.05)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C472(1.54); C477(1.62); C99(0.77)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C472(1.17); C477(1.39); C99(0.86)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C472(1.43); C477(1.44); C99(0.79)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C472(1.19); C477(1.19); C99(0.72)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C472(1.26); C477(1.19)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C472(1.07); C477(1.23); C99(0.87)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C472(1.26); C477(1.39); C99(0.71)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C472(1.14); C477(1.21); C99(0.77)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C472(1.16); C477(1.31); C99(0.74)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C472(1.33); C477(1.42); C99(0.79)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C472(1.05); C477(1.14)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C472(0.88); C477(1.13)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C472(1.04); C477(1.16)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C472(1.30); C477(1.53)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C472(1.47); C477(1.50)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C472(1.01); C477(1.06)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C472(1.09); C477(1.39)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C472(1.43); C477(1.76)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C472(1.37); C477(1.71)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C472(1.63); C477(1.97)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C472(1.04); C477(1.32)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C472(0.90); C477(1.18)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C472(1.16); C477(1.31)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C472(1.23); C477(1.47)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C472(1.62); C477(2.12)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C472(1.18); C477(1.28)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C472(0.76); C477(1.10)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C472(1.17); C477(1.17)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C472(1.09); C477(1.10)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C472(1.06); C477(1.09)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C472(1.22); C477(1.23)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C472(1.24); C477(1.26)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C472(1.18); C477(1.14)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C472(1.38); C477(1.30)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C472(1.46); C477(1.44)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C472(1.35); C477(1.31)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C99(0.93); C24(1.19); C613(0.96); C477(1.00)  LDD1698  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C477(4.42)  LDD1702  [30]
 LDCM0625  F8 Ramos C153(0.81); 1.58  LDD2187  [31]
 LDCM0573  Fragment11 Ramos C153(0.23); 5.62  LDD2190  [31]
 LDCM0574  Fragment12 Ramos 0.93  LDD2191  [31]
 LDCM0575  Fragment13 Ramos 1.09  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C153(0.46); 0.79  LDD2193  [31]
 LDCM0579  Fragment20 Ramos 2.47  LDD2194  [31]
 LDCM0580  Fragment21 Ramos 0.69  LDD2195  [31]
 LDCM0582  Fragment23 Ramos 1.34  LDD2196  [31]
 LDCM0578  Fragment27 Ramos 0.96  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C153(1.24); 0.67  LDD2198  [31]
 LDCM0588  Fragment30 Ramos 1.66  LDD2199  [31]
 LDCM0589  Fragment31 Ramos 0.95  LDD2200  [31]
 LDCM0590  Fragment32 Ramos 2.07  LDD2201  [31]
 LDCM0468  Fragment33 HCT 116 C472(1.11); C477(1.19); C99(0.85)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos 0.52  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C153(0.49); 0.96  LDD2184  [31]
 LDCM0427  Fragment51 HCT 116 C472(1.98); C477(1.80); C99(0.86)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos 1.18  LDD2204  [31]
 LDCM0614  Fragment56 Ramos 1.21  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C153(0.31); 1.77  LDD2186  [31]
 LDCM0571  Fragment9 Ramos 1.91  LDD2188  [31]
 LDCM0015  HNE MDA-MB-231 1.27  LDD0346  [31]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C477(13.37); C472(9.77)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C477(1.97); C472(2.20)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C477(13.75); C472(12.36)  LDD0082  [9]
 LDCM0109  NEM HeLa H350(0.00); H553(0.00); H444(0.00)  LDD0223  [18]
 LDCM0627  NUDT7-COV-1 HEK-293T C477(0.97)  LDD2206  [32]
 LDCM0628  OTUB2-COV-1 HEK-293T C477(0.64)  LDD2207  [32]
 LDCM0014  Panhematin K562 3.26  LDD0063  [8]
 LDCM0090  Rapamycin JHH-7 2.84  LDD0213  [24]
 LDCM0021  THZ1 HCT 116 C472(0.95); C477(0.95)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-binding cassette sub-family D member 1 (ABCD1) ABCD family P33897
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) G-alpha family P09471
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) Transcriptional coactivator PC4 family P53999

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
16 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
25 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
26 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
27 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
28 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
29 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
30 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.