Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0090
Competitor Name
Rapamycin
Synonyms
(-)-Rapamycin; 53123-88-9; AY 22989; AY-22989; I 2190A; I-2190A; I2190A; NSC 226080; RAPA; Rapammune; Rapamune; Rapamycin; SIIA 9268A; Sirolimus; Wy 090217; rapalimus; Supralimus; WY-090217; HYFTOR; sirolimusum; Cypher; Rapamycin (Sirolimus); Antibiotic AY 22989; Rapamycin (GMP); FYARRO; CCRIS 9024; CHEBI:9168; SILA 9268A; W36ZG6FT64; HSDB 7284; L04AA10; Npc-12g; Rapamycin (GMP Like); SM-88 COMPONENT SIROLIMUS; DE-109; NSC-226080; UNII-W36ZG6FT64; DTXSID5023582; MFCD00867594; Rapamycin Immunosuppressant Drug; NAB-RAPAMYCIN COMPONENT RAPAMYCIN; Rapamycin (>85%); SIROLIMUS (MART.); SIROLIMUS [MART.]; EC 610-965-5; SIROLIMUS (USP-RS); SIROLIMUS [USP-RS]; NSC226080; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0(4,9)]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; EVEROLIMUS IMPURITY A (EP IMPURITY); EVEROLIMUS IMPURITY A [EP IMPURITY]; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; DTXCID503582; Perceiva; 1fkb; 1pbk; NCGC00021305-05; Rapamycin/Sirolimus; LCP-Siro; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((2S)-1-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-((2R)-1-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)propan-2-yl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido(2,1-c)(1,4)oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-(methyloxy)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-10,21-bis(methyloxy)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone; RAP; RPM; S1039; Rapamycin (Sirolimus)?; SIROLIMUS [INN]; SIROLIMUS [JAN]; RAPAMYCIN [MI]; Human Blood - Sirolimus; SIROLIMUS [HSDB]; SIROLIMUS [USAN]; SIROLIMUS [VANDF]; BiomolKI2_000084; SCHEMBL3463; SIROLIMUS [WHO-DD]; Rapamycin,Sirolimus,Rapamune; BIDD:PXR0165; SIROLIMUS [EMA EPAR]; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; MLS006010168; Sirolimus [USAN:INN:BAN]; GTPL6031; SIROLIMUS [ORANGE BOOK]; BDBM36609; MS-R001; S01XA23; HMS2089A21; HMS3403F11; HMS3884C03; HY-10219GL; EX-A1044; AC-722; BDBM50064359; HY-10219G; STL570275; AKOS015850976; AKOS015961618; CCG-100684; CS-0063; DB00877; NCGC00021305-06; NCGC00021305-07; Rapamycin from Streptomyces hygroscopicus; AS-11687; HY-10219; SMR004701276; Fyarro (sirolimus albumin-bound particles); UNM-0000358684; A-275; CS-0626126; CS-1010374; R0097; Rapamycin, VETRANAL(TM), analytical standard; M02444; Q32089; Q-201659; BRD-K84937637-001-04-0; BRD-K84937637-001-06-5; BRD-K89626439-001-01-0; Z2568665260; 24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypy; Rapamycin from Streptomyces hygroscopicus, >=95% (HPLC), powder; Rapamycin from Streptomyces hygroscopicus, Vetec(TM) reagent grade, >=95%; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone; (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone; (3 S ,6 R ,7 E ,9 R ,10 R ,12 R ,14 S ,15 E ,17 E , 19 E ,21 S ,23 S ,26 R ,27 R ,34a S )-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34 aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hex adecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydro xy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy- 6,8,12,14,20,26-hexamethyl-23,27-ep; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-4,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-223,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-ep; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-(methyloxy)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-10,21-bis(methyloxy)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,; 1,18-Dihydroxy-12-[2-(4-hydroxy-3-methoxy-cyclohexyl)-1-methyl-ethyl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-aza-tricyclo[30.3.1.0*4,9*]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone (Rapamycin); 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2
Structure
2D MOL
Ro5 Violations (Lipinski): 3 Molecular Weight (mw) 914.2
Lipid-water partition coefficient (xlogp) 6
Rotatable Bond Count (rotbonds) 6
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 13
Chemical Identifiers
Formula
C51H79NO13
IUPAC Name
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Canonical SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
InChI
InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChIKey
QFJCIRLUMZQUOT-HPLJOQBZSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
Alk-rapa
 Probe Info  		20 mM Human hepatocellular carcinoma cell lysate (JHH-7) [1]

Target(s) List of this Competitor

69 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1) LDTP11012 10.77  LDD0213 
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) LDTP00543 3.73  LDD0213 
26S proteasome non-ATPase regulatory subunit 14 (PSMD14) LDTP00294 5.29  LDD0213 
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) LDTP04619 2.63  LDD0213 
All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) LDTP08401 11.07  LDD0213 
Androgen-induced gene 1 protein (AIG1) LDTP12697 6.53  LDD0213 
Atlastin-2 (ATL2) LDTP09251 2.42  LDD0213 
ATP-binding cassette sub-family B member 6 (ABCB6) LDTP12303 8.13  LDD0213 
ATP-binding cassette sub-family D member 3 (ABCD3) LDTP03424 2.84  LDD0213 
Bifunctional glutamate/proline--tRNA ligase (EPRS1) LDTP02222 3.12  LDD0213 
CAAX prenyl protease 1 homolog (ZMPSTE24) LDTP01328 7.09  LDD0213 
Carboxypeptidase D (CPD) LDTP01372 2.36  LDD0213 
Catechol O-methyltransferase (COMT) LDTP03145 4.39  LDD0213 
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT) LDTP00416 2.74  LDD0213 
Cell division cycle protein 23 homolog (CDC23) LDTP13408 6.49  LDD0213 
Chromodomain-helicase-DNA-binding protein 4 (CHD4) LDTP06219 7.56  LDD0213 
Cytochrome b5 type B (CYB5B) LDTP00697 6.16  LDD0213 
DCN1-like protein 5 (DCUN1D5) LDTP11199 6.22  LDD0213 
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) LDTP05724 3.38  LDD0213 
Diacylglycerol kinase kappa (DGKK) LDTP07030 3.30  LDD0213 
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A) LDTP04120 3.81  LDD0213 
Dolichyl-phosphate beta-glucosyltransferase (ALG5) LDTP14214 4.04  LDD0213 
E3 ubiquitin-protein ligase listerin (LTN1) LDTP01430 2.23  LDD0213 
E3 ubiquitin-protein ligase RNF213 (RNF213) LDTP07283 9.93  LDD0213 
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1) LDTP03170 4.30  LDD0213 
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1) LDTP13466 6.98  LDD0213 
Endoplasmic reticulum metallopeptidase 1 (ERMP1) LDTP08017 3.31  LDD0213 
FAST kinase domain-containing protein 4 (TBRG4) LDTP10049 41.70  LDD0213 
FAST kinase domain-containing protein 5, mitochondrial (FASTKD5) LDTP07979 3.50  LDD0213 
Glucosidase 2 subunit beta (PRKCSH) LDTP02718 9.95  LDD0213 
Glycerol kinase (GK) LDTP03628 5.73  LDD0213 
GPN-loop GTPase 3 (GPN3) LDTP16204 3.81  LDD0213 
Heme oxygenase 2 (HMOX2) LDTP03540 3.88  LDD0213 
Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1) LDTP07990 6.44  LDD0213 
Histone acetyltransferase type B catalytic subunit (HAT1) LDTP00479 4.98  LDD0213 
Lysophosphatidylcholine acyltransferase 1 (LPCAT1) LDTP09188 3.53  LDD0213 
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) LDTP07967 2.93  LDD0213 
Lysophosphatidylserine lipase ABHD12 (ABHD12) LDTP08799 2.91  LDD0213 
Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50) LDTP06810 7.15  LDD0213 
Mitochondrial ribonuclease P catalytic subunit (PRORP) LDTP00536 7.36  LDD0213 
Mitochondrial ubiquitin ligase activator of NFKB 1 (MUL1) LDTP10038 6.95  LDD0213 
Multifunctional protein CAD (CAD) LDTP03401 4.45  LDD0213 
Nuclear pore complex protein Nup98-Nup96 (NUP98) LDTP04547 5.21  LDD0213 
Nucleoside diphosphate kinase 3 (NME3) LDTP05795 7.02  LDD0213 
Plasma membrane calcium-transporting ATPase 1 (ATP2B1) LDTP03024 2.03  LDD0213 
Probable arginine--tRNA ligase, mitochondrial (RARS2) LDTP07092 6.06  LDD0213 
Probable ATP-dependent RNA helicase DDX20 (DDX20) LDTP13285 6.71  LDD0213 
Puromycin-sensitive aminopeptidase (NPEPPS) LDTP04712 4.09  LDD0213 
Replication factor C subunit 3 (RFC3) LDTP03911 3.83  LDD0213 
Retinol dehydrogenase 10 (RDH10) LDTP08722 5.35  LDD0213 
Rho-related GTP-binding protein RhoB (RHOB) LDTP05000 3.84  LDD0213 
Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) LDTP15484 8.40  LDD0213 
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) LDTP02860 2.93  LDD0213 
Serine palmitoyltransferase 3 (SPTLC3) LDTP12647 3.28  LDD0213 
Serine-protein kinase ATM (ATM) LDTP05822 2.56  LDD0213 
Serine/threonine-protein kinase ATR (ATR) LDTP05914 3.94  LDD0213 
Serine/threonine-protein kinase mTOR (MTOR) LDTP03980 2.70  LDD0213 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) LDTP03522 6.54  LDD0213 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) LDTP03523 2.63  LDD0213 
Signal peptidase complex catalytic subunit SEC11A (SEC11A) LDTP05066 3.37  LDD0213 
Sphingomyelin phosphodiesterase 4 (SMPD4) LDTP12776 5.56  LDD0213 
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) LDTP00931 3.80  LDD0213 
TATA-binding protein-associated factor 172 (BTAF1) LDTP00502 4.92  LDD0213 
Triokinase/FMN cyclase (TKFC) LDTP06779 2.28  LDD0213 
Tyrosine-protein kinase Yes (YES1) LDTP02231 2.93  LDD0213 
Ubiquitin carboxyl-terminal hydrolase 24 (USP24) LDTP13720 11.43  LDD0213 
Ubiquitin conjugation factor E4 A (UBE4A) LDTP06047 2.01  LDD0213 
UDP-glucuronosyltransferase 2A3 (UGT2A3) LDTP17417 12.15  LDD0213 
Very long chain fatty acid elongase 2 (ELOVL2) LDTP12773 5.36  LDD0213 
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⏷ Show the Full List of 69 Enzyme
43 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Aladin (AAAS) LDTP12510 4.09  LDD0213 
AP-1 complex subunit beta-1 (AP1B1) LDTP05625 4.14  LDD0213 
AP-1 complex subunit gamma-1 (AP1G1) LDTP00855 2.41  LDD0213 
AP-2 complex subunit beta (AP2B1) LDTP05038 4.33  LDD0213 
Bcl-2 homologous antagonist/killer (BAK1) LDTP06573 3.85  LDD0213 
Cation-dependent mannose-6-phosphate receptor (M6PR) LDTP03061 2.22  LDD0213 
Cationic amino acid transporter 2 (SLC7A2) LDTP04512 2.82  LDD0213 
Chloride channel CLIC-like protein 1 (CLCC1) LDTP10804 5.06  LDD0213 
Exocyst complex component 5 (EXOC5) LDTP00287 3.30  LDD0213 
Exportin-T (XPOT) LDTP00810 2.40  LDD0213 
Golgi SNAP receptor complex member 1 (GOSR1) LDTP01542 3.80  LDD0213 
Guanine nucleotide-binding protein subunit alpha-11 (GNA11) LDTP03506 6.06  LDD0213 
Importin subunit beta-1 (KPNB1) LDTP06242 7.30  LDD0213 
Metaxin-1 (MTX1) LDTP05900 6.89  LDD0213 
MFS-type transporter SLC18B1 (SLC18B1) LDTP07462 4.70  LDD0213 
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1) LDTP13698 2.94  LDD0213 
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) LDTP05384 2.67  LDD0213 
Mitochondrial carrier homolog 2 (MTCH2) LDTP14235 7.00  LDD0213 
Mitochondrial import inner membrane translocase subunit TIM44 (TIMM44) LDTP00821 11.95  LDD0213 
Neutral amino acid transporter A (SLC1A4) LDTP04013 2.29  LDD0213 
NPC intracellular cholesterol transporter 1 (NPC1) LDTP00541 4.18  LDD0213 
Nuclear pore complex protein Nup85 (NUP85) LDTP11310 2.03  LDD0213 
Nucleoporin NUP188 (NUP188) LDTP07064 3.19  LDD0213 
Phosphatidylinositol transfer protein beta isoform (PITPNB) LDTP04213 4.05  LDD0213 
Protein GPR107 (GPR107) LDTP07236 3.20  LDD0213 
Protein spinster homolog 1 (SPNS1) LDTP11844 3.35  LDD0213 
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) LDTP04932 4.50  LDD0213 
Protein transport protein Sec61 subunit beta (SEC61B) LDTP04866 5.78  LDD0213 
Putative lipid scramblase CLPTM1 (CLPTM1) LDTP01745 4.87  LDD0213 
Sodium-coupled neutral amino acid symporter 1 (SLC38A1) LDTP11824 5.30  LDD0213 
Sodium-dependent multivitamin transporter (SLC5A6) LDTP13834 3.56  LDD0213 
Solute carrier family 25 member 32 (SLC25A32) LDTP11813 2.99  LDD0213 
Solute carrier family 25 member 33 (SLC25A33) LDTP11162 2.98  LDD0213 
Solute carrier family 35 member E1 (SLC35E1) LDTP18177 3.75  LDD0213 
THO complex subunit 2 (THOC2) LDTP09279 3.17  LDD0213 
Transferrin receptor protein 1 (TFRC) LDTP01969 7.45  LDD0213 
Translocon-associated protein subunit alpha (SSR1) LDTP04033 6.03  LDD0213 
Transmembrane protein 160 (TMEM160) LDTP20002 7.48  LDD0213 
Transmembrane protein 33 (TMEM33) LDTP04787 3.20  LDD0213 
Trimeric intracellular cation channel type B (TMEM38B) LDTP12695 6.12  LDD0213 
Vacuole membrane protein 1 (VMP1) LDTP10343 10.65  LDD0213 
Voltage-dependent anion-selective channel protein 2 (VDAC2) LDTP04071 6.67  LDD0213 
Zinc transporter 7 (SLC30A7) LDTP09180 7.10  LDD0213 
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⏷ Show the Full List of 43 Transporter and channel
4 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Carbohydrate-responsive element-binding protein (MLXIPL) LDTP12311 7.64  LDD0213 
General transcription factor II-I (GTF2I) LDTP05101 6.47  LDD0213 
Signal transducer and activator of transcription 3 (STAT3) LDTP03903 9.38  LDD0213 
Sterol regulatory element-binding protein 1 (SREBF1) LDTP03828 8.80  LDD0213 
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1 GPCR Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Golgi pH regulator B (GPR89B) LDTP14610 3.16  LDD0213 
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96 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) LDTP08950 4.02  LDD0213 
Afadin (AFDN) LDTP04679 2.91  LDD0213 
Angiotensinogen (AGT) LDTP01813 9.98  LDD0213 
AP-3 complex subunit beta-1 (AP3B1) LDTP00212 3.12  LDD0213 
Arfaptin-1 (ARFIP1) LDTP04558 11.51  LDD0213 
Arfaptin-2 (ARFIP2) LDTP04557 8.61  LDD0213 
Armadillo repeat-containing protein 6 (ARMC6) LDTP15101 3.33  LDD0213 
Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1) LDTP13304 5.59  LDD0213 
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (ARFGEF2) LDTP14237 6.34  LDD0213 
CCR4-NOT transcription complex subunit 1 (CNOT1) LDTP00078 6.47  LDD0213 
Centrosomal protein 43 (CEP43) LDTP01652 4.06  LDD0213 
CLIP-associating protein 1 (CLASP1) LDTP08062 2.51  LDD0213 
Clusterin (CLU) LDTP02526 2.05  LDD0213 
Coatomer subunit alpha (COPA) LDTP04571 3.48  LDD0213 
Coatomer subunit beta (COPB1) LDTP04570 3.42  LDD0213 
Coatomer subunit gamma-2 (COPG2) LDTP13110 2.95  LDD0213 
Cohesin subunit SA-2 (STAG2) LDTP08842 3.91  LDD0213 
Conserved oligomeric Golgi complex subunit 1 (COG1) LDTP09549 4.92  LDD0213 
Conserved oligomeric Golgi complex subunit 4 (COG4) LDTP12094 5.81  LDD0213 
CYFIP-related Rac1 interactor A (CYRIA) LDTP19951 3.89  LDD0213 
Cytoskeleton-associated protein 5 (CKAP5) LDTP06021 6.89  LDD0213 
Dynactin subunit 2 (DCTN2) LDTP05922 4.47  LDD0213 
Eukaryotic translation initiation factor 3 subunit A (EIF3A) LDTP06055 2.03  LDD0213 
Eukaryotic translation initiation factor 3 subunit L (EIF3L) LDTP13813 2.21  LDD0213 
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) LDTP05098 4.01  LDD0213 
Exocyst complex component 6B (EXOC6B) LDTP13851 5.00  LDD0213 
F-BAR domain only protein 2 (FCHO2) LDTP05605 4.67  LDD0213 
Fanconi anemia group I protein (FANCI) LDTP12680 5.30  LDD0213 
FIGNL1-interacting regulator of recombination and mitosis (FIRRM) LDTP19992 4.41  LDD0213 
Glycine cleavage system H protein, mitochondrial (GCSH) LDTP03227 11.42  LDD0213 
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) LDTP00729 4.36  LDD0213 
Golgi phosphoprotein 3 (GOLPH3) LDTP11911 4.67  LDD0213 
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1) LDTP09783 3.17  LDD0213 
GPI transamidase component PIG-S (PIGS) LDTP10799 4.53  LDD0213 
GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1) LDTP06255 3.44  LDD0213 
Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) LDTP04342 2.58  LDD0213 
HEAT repeat-containing protein 1 (HEATR1) LDTP11948 4.75  LDD0213 
HEAT repeat-containing protein 3 (HEATR3) LDTP15253 14.19  LDD0213 
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) LDTP05259 5.22  LDD0213 
Hippocalcin-like protein 1 (HPCAL1) LDTP03841 6.44  LDD0213 
Inner nuclear membrane protein Man1 (LEMD3) LDTP13913 3.54  LDD0213 
Integrator complex subunit 1 (INTS1) LDTP08785 5.70  LDD0213 
Integrator complex subunit 10 (INTS10) LDTP16111 2.55  LDD0213 
Integrator complex subunit 5 (INTS5) LDTP07551 4.61  LDD0213 
Integrator complex subunit 7 (INTS7) LDTP12678 2.43  LDD0213 
Intron Large complex component GCFC2 (GCFC2) LDTP02841 2.57  LDD0213 
Inverted formin-2 (INF2) LDTP06681 18.43  LDD0213 
Large ribosomal subunit protein uL14 (RPL23) LDTP05008 2.30  LDD0213 
MAU2 chromatid cohesion factor homolog (MAU2) LDTP14304 6.70  LDD0213 
Mediator of RNA polymerase II transcription subunit 16 (MED16) LDTP13924 2.80  LDD0213 
Mediator of RNA polymerase II transcription subunit 23 (MED23) LDTP13559 8.12  LDD0213 
Mediator of RNA polymerase II transcription subunit 29 (MED29) LDTP12766 10.80  LDD0213 
Mini-chromosome maintenance complex-binding protein (MCMBP) LDTP11197 4.54  LDD0213 
Nucleolar complex protein 4 homolog (NOC4L) LDTP11287 6.35  LDD0213 
Nucleolar protein 9 (NOP9) LDTP15283 9.20  LDD0213 
Origin recognition complex subunit 5 (ORC5) LDTP00900 3.85  LDD0213 
Paralemmin-1 (PALM) LDTP01307 6.01  LDD0213 
Plexin-B2 (PLXNB2) LDTP00513 2.66  LDD0213 
Pre-mRNA-splicing factor SPF27 (BCAS2) LDTP01358 3.95  LDD0213 
Proteasome activator complex subunit 2 (PSME2) LDTP13519 2.76  LDD0213 
Protein Dr1 (DR1) LDTP05306 3.84  LDD0213 
Protein FAM3C (FAM3C) LDTP09773 3.16  LDD0213 
Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2) LDTP13656 2.88  LDD0213 
Protein MMS22-like (MMS22L) LDTP07814 7.35  LDD0213 
Protein MON2 homolog (MON2) LDTP08041 5.40  LDD0213 
Protein Njmu-R1 (C17orf75) LDTP16028 5.50  LDD0213 
Protein S100-A14 (S100A14) LDTP12277 2.98  LDD0213 
Protein unc-45 homolog A (UNC45A) LDTP11890 2.75  LDD0213 
Rab GTPase-activating protein 1 (RABGAP1) LDTP14000 2.81  LDD0213 
Replication factor C subunit 1 (RFC1) LDTP03727 2.27  LDD0213 
Reticulon-3 (RTN3) LDTP01522 5.08  LDD0213 
Reticulophagy regulator 3 (RETREG3) LDTP08300 4.12  LDD0213 
RNA-binding protein 26 (RBM26) LDTP15012 5.97  LDD0213 
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (PPP6R3) LDTP06983 7.11  LDD0213 
Serotransferrin (TF) LDTP01970 2.67  LDD0213 
SH3 domain-binding protein 1 (SH3BP1) LDTP13994 4.80  LDD0213 
Structural maintenance of chromosomes protein 1A (SMC1A) LDTP06181 4.93  LDD0213 
Superkiller complex protein 3 (SKIC3) LDTP07574 4.93  LDD0213 
SURP and G-patch domain-containing protein 2 (SUGP2) LDTP08578 7.44  LDD0213 
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) LDTP10353 5.41  LDD0213 
Syntaxin-7 (STX7) LDTP00632 2.98  LDD0213 
T-complex protein 1 subunit alpha (TCP1) LDTP02934 4.01  LDD0213 
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) LDTP14263 3.08  LDD0213 
TELO2-interacting protein 1 homolog (TTI1) LDTP00691 8.21  LDD0213 
Tetratricopeptide repeat protein 27 (TTC27) LDTP19505 4.96  LDD0213 
Tetratricopeptide repeat protein 38 (TTC38) LDTP19372 13.40  LDD0213 
Trafficking protein particle complex subunit 3 (TRAPPC3) LDTP00822 6.27  LDD0213 
Translation initiation factor eIF2B subunit epsilon (EIF2B5) LDTP05765 4.41  LDD0213 
Transmembrane protein 161A (TMEM161A) LDTP12762 2.89  LDD0213 
Tubulin beta-4A chain (TUBB4A) LDTP02037 3.07  LDD0213 
Tumor protein D54 (TPD52L2) LDTP00759 6.42  LDD0213 
U2 snRNP-associated SURP motif-containing protein (U2SURP) LDTP00517 6.13  LDD0213 
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) LDTP05033 4.49  LDD0213 
Unhealthy ribosome biogenesis protein 2 homolog (URB2) LDTP17034 6.54  LDD0213 
Vacuolar protein sorting-associated protein 51 homolog (VPS51) LDTP13338 3.36  LDD0213 
ZW10 interactor (ZWINT) LDTP01532 3.30  LDD0213 
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⏷ Show the Full List of 96 Other

Full Information of The Labelling Profiles of This Competitor

Alk-rapa
 Probe Info 
Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 20 mM
Quantitative Method SILAC
Competitor Name Rapamycin
Competitor Concentration 200 mM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Liver
Disease Model Hepatocellular carcinoma [ICD-11:2C12]
Model Name Human hepatocellular carcinoma cell lysate (JHH-7)
Interaction Atlas ID  LDD0213  Download The Altas

References

1 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.